If you already belong to the EU-NETVAL network and would like to be listed here with the expertise of your laboratory, kindly contact the ESTIV secretariat or the ESTIV president. We will be happy to present your valuable expertise here.<\/span> <\/span>To be added to the EU-NETVAL, please contact EURL ECVAM<\/a> <\/p>\n\n\n\n Address: \u0160rob\u00e1rova 49\/48, 100 00 Prague Czech Republic Address: Faculty of Medicine and Health technology Arvo Ylp\u00f6n katu 34, 33520 Tampere Finland Expertise: FHAIVE is a mulM-disciplinary research group whose mission is to develop and validate integrated approaches (IATA) and models for chemical safety assessment and drug development by integraMng advanced in vitro techniques along with AI-based data analyMcs and predicMve modelling. FHAIVE focuses on advancing the \ufb01elds of systems toxicology and predicMve pharmacology using big data modelling, knowledge graphs, and machine learning algorithms. We have a unique combinaMon of experMse that spans systems biology, toxicology, cheminformaMcs, and bioinformaMcs.<\/p>\n\n\n\n Special equipment:<\/p>\n\n\n\n Website: hdps:\/\/research.tuni.\ufb01\/faive\/<\/a> Address: Carl-Bosch-Strasse 38, 67056 Ludwigshafen am Rhein, Germany Expertise: BASF is one of the world\u2019s leading chemical companies. Its Experimental Toxicology and Ecology unit performs tests to ensure the safety of all products addressing all relevant areas of toxicology and ecology. Since the late 1990s, this has encompassed the development and use of new testing methods \u2013 especially methods that reduce or fully replace animal testing. The institute has been experimentally involved in developing and validation of the methods and approaches adopted as OECD guidelines nos. 431, 439, 442C and D, 443, 492, 497 and EU NETVAL TM2019-10 (DIO1-SKR).<\/p>\n\n\n\n Website: https:\/\/www.basf.com<\/a><\/p>\n\n\n\n Address: Hagenower Str. 73, 19061 Schwerin, Germany Expertise: Production of primary liver cells from human and animals including non-human primates, rodents, farm animals, birds and fish. A validated technology platform to assay transporter activities in stably transfected HEK293-cells and hepatocytes, drug-drug interaction studies in hepatocytes. Medical device testing according to ISO 10993-5.<\/p>\n\n\n\n Special equipment: Fully certified cell culture laboratory<\/p>\n\n\n\n Website: https:\/\/primacyt.com<\/a> Address: Via Mos\u00e9 Bianchi, 103 \u2013 20149 Milan (Italy) Website: www.vitroscreen.com<\/a> Address: Institute of Experimental Pharmacology and Toxicology at Centre of Experimental Medicine, Dubravsk\u00e1 cesta 9, 821 06 Bratislava, Slovakia Special equipment: Vitrocell Alpha cloud<\/a>, SOL-500 Lamp with H1\/H2 filters<\/a> (OECD TG 432\/498), Microplate readers for measuring absorbance, luminescence, and \ufb02uorescence.<\/span> Fluorescence Microscopy, HPLC, MIVO – Microfluidic platform, three fully equipped in vitro cell culture laboratories. Via collaboration with the other institutes at the CEM and SAS, it has access to advanced analytical and microscopy equipment at Slovak Academy of Sciences. <\/p>\n\n\n\n Website: https:\/\/uef.sav.sk\/en<\/a> Expertise: The laboratory specialises in the validation and performance of biocompatability studies of medical devices as well as in the validation of new in vitro methods for toxicity\/endocrine testing of chemicals, and medical devices. RISE has been involved with ECVAM and PEPPER in the validation of methods such as AR-CALUX (TG458), AUR-TPO (TM2019-04 (EU)) and H295R Steroidogenesis Assay (TG456). In addition to the GLP facility, RISE has well-equipped cell-, microbiology and molecular laboratories as well as a large infrastructure for chemical analysis. RISE is also appointed as one of the EURL reference laboratories for testing IVD products.<\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n
\n\n\n\n![\"SZU](\"https:\/\/static.wixstatic.com\/media\/c9a0a0_25a4e9211174434aaaa653378cb9cb09~mv2.png\/v1\/fill\/w_340,h_218,al_c,q_85,usm_0.66_1.00_0.01,enc_auto\/NIPH.png\")
<\/figure><\/div>\n\n\n\nCZECH REPUBLIC
National Reference Laboratory for Experimental Immunotoxicology<\/strong> <\/h3>\n\n\n\n
Accreditation: GLP and EN ISO\/IEC 17025:2005
Member of EU-NETVAL since 2013
Expertise: the National Reference Laboratory for Experimental Immunotoxicology is focused mainly on the development, implementation and validation of in vitro toxicological methods, employing mainly cell and tissue cultures in order to replace conventional animal testing in the field of immunotoxicity and neuroendocrine toxicity. The Laboratory actively participates in a number of research tasks, providing preclinical tests of immunotoxic effects of chemical substances and other environmental factors according to the requirements of health institutes, manufacturers and other organizations, using experimental studies in vitro. One of the tasks of the Laboratory is to create specialized professional materials for intervention programs with regard to the possible influence of the health status of the population, and assistance in resolving epidemiologically or hygienically serious situations, carrying out assessment, consulting, coordination and methodological activities<\/p>\n\n\n\n
Website: https:\/\/archiv.szu.cz\/national-reference-laboratory-for-experimental-toxicology<\/a>
Contact: Dr. Marketa Dvo\u0159\u00e1kov\u00e1, Head of the NRL for Experimental Immumology, marketa.dvorakova@szu.cz<\/a><\/p>\n\n\n\n
\n\n\n\n![\"\"](\"https:\/\/research.tuni.fi\/uploads\/2021\/04\/bb2360af-frontpage-1920x894.jpg\")
<\/figure><\/div>\n\n\n\nFHAIVE<\/h3>\n\n\n\n
Accreditation: FHAIVE is a GLP accredited laboratory.
Member of EU-NETVAL: <\/strong>2013<\/p>\n\n\n\n
Contact: Dario Greco PhD, Professor , Email: dario.greco@tuni.\ufb01<\/a>, Phone: +358 50 318 2106<\/p>\n\n\n\n
\n\n\n\n![\"\"](\"https:\/\/www.estiv.org\/content\/uploads\/2024\/04\/image-4.png\")
<\/figure><\/div>\n\n\n\nGERMANY
<\/h2>\n\n\n\nBASF SE, Experimental Toxicology and Ecology,
Laboratory for Development of Alternative Methods<\/h3>\n\n\n\n
Accreditations and Certifications:
\u2022 GLP (Good laboratory practice)
\u2022 AAALAC (American Association for Accreditation of Laboratory Animal Care)
\u2022 GIVIMP (Good in vitro method practice)
\u2022 ISO 17020 (to demonstrate their technical competence, independence, impartiality, and the ability to provide reliable services)
Member of EU-NETVAL since 2014<\/p>\n\n\n\n
\n\n\n\n![\"\"](\"https:\/\/www.estiv.org\/content\/uploads\/2022\/11\/primacyt_logo_banner_alternativ.jpg\"){kind=logo}
<\/figure><\/div>\n\n\n\nGERMANY<\/h3>\n\n\n\n
PRIMACYT Cell Culture Technology GmbH <\/h3>\n\n\n\n
Accreditation: GLP
Member of EU-NETVAL since 2013<\/p>\n\n\n\n
Contact: sales@primacyt.de<\/a><\/p>\n\n\n\n
\n\n\n\n![\"\"](\"https:\/\/www.estiv.org\/content\/uploads\/2024\/03\/image-1.png\")
<\/figure><\/div>\n\n\n\nITALY
VitroScreen SrL<\/strong> <\/h3>\n\n\n\n
Accreditation:
\u2022 Since 2010: GLP certification for in vitro Toxicity studies (OECD area 2), Biocompatibility studies (OECD area 9.3), Parmacokinetics\/toxicokinetics and ADME studies (OECD area 9.7) ( last certificate N\u00b02022-24)
\u2022 Since 2023: Certified ISO 13485:2021 EA:34* and ISO 9001:2015 to design and develop in Vitro pre-clinical studies for the assessment of the safety, efficacy, mechanism of action and ADME for Medical Devices, Pharmaceuticals and Cosmetics.EA 34<\/em><\/strong> certifies the compliance of the processes of a Research organization for R&D and innovation<\/em>
\u2022 CIR Cr\u00e9dit d’Imp\u00f4t Recherche – CIR: French Minister of Higher Education, Research and Innovation agreement
Expertise:
-Quality-oriented approach for NON CLINICAL method standardization and experience in validation trials
-Application of OECD TG 428 to ADME studies applied to different industrial sectors <\/p>\n\n\n\n
Contact: Dr. Marisa Meloni, Facility manager, marisa.meloni@vitroscreen.com<\/a><\/p>\n\n\n\n
\n\n\n\n![\"\"](\"https:\/\/www.estiv.org\/content\/uploads\/2023\/05\/cem-sas-logo.jpg\"){kind=logo}
<\/figure><\/div>\n\n\n\nSLOVAK REPUBLIC
SK-NETVAL Laboratory at CEM SAS<\/strong> <\/h3>\n\n\n\n
Accreditation: GLP by SNAS – scope toxicological studies
Member of EU-NETVAL since 2020
Expertise: SK-NETVAL laboratory specialises in the topical toxicity testing of chemicals, cosmetics, medical devices and pharmaceuticals according to the OECD TGs 431, 432, 439, 492, 498 and ISO 10993:5 and ISO 10993:23. In the area of systemic toxicity, it conducts in vitro inhalation and intestinal studies using 3D reconstructed human models of lung and small intestine<\/p>\n\n\n\n
Contact: Dr. Helena Kandarova, IEPT Director, helena.kandarova@savba.sk<\/a> <\/p>\n\n\n\n
\n\n\n\n![\"\"](\"https:\/\/www.estiv.org\/content\/uploads\/2024\/04\/image-3.png\")
<\/figure><\/div>\n\n\n\nSPAIN <\/h2>\n\n\n\n
GAIKER Technology Centre<\/h3>\n\n\n\n
Address: Parque Tecnol\u00f3gico, Edif. 202 48170 Zamudio, Bizkaia, Spain.
Accreditation: GLP compliance
Member of EU-NETVAL since 2014
Expertise: GAIKER has wide experience in the pharma, cosmetics, chemical and food industries. We specialise in human health and environmental studies, employing in silico, in vitro and ex vivo models for safety and efficacy studies. For human health studies, different target systems are used depending on the exposure route of the test item: respiratory, gastrointestinal, dermal, immune and central nervous systems. For environmental studies, GAIKER employs in vitro models from marine (e.g. fish and mussels), freshwater (e.g. fish) and soil organisms (e.g. earthworms). GAIKER has a lot of experience in the application of standard and regulatory in vitro methods (OECD, ISO, CEN) and in the development of New Approach Methodologies (NAMs) to replace conventional animal testing. The safety assays performed at GAIKER are used both for the Safe and Sustainable by Design of chemicals and advanced materials (including nanomaterials) and for regulatory purposes.
Website: http:\/\/www.gaiker.es\/ing\/index.aspx<\/a>
Contact: Alberto Katsumiti, katsumiti@gaiker.es<\/a><\/p>\n\n\n\n
\n\n\n\n![\"\"](\"https:\/\/www.estiv.org\/content\/uploads\/2024\/03\/image-4.png\")
<\/figure><\/div>\n\n\n\nSWEDEN<\/h2>\n\n\n\n
EU-NETVAL GLP Laboratory at RISE, Research Institute of Sweden AB<\/h3>\n\n\n\n
Address: Brinellgatan 4, Box 857, SE-501 15 Bor\u00e5s, Sweden
Accreditation:
\u2022 ISO 17025 Accreditation (ISO10993-5, ISO10993-12, ISO10993-18)
\u2022 GLP compliance (ISO10993-5, ISO10993-12, ISO10993-23)
Member of EU-NETVAL since 2014<\/p>\n\n\n\n
Website: https:\/\/www.ri.se<\/a>
Contact: Sara Bogren, GLP Facility Manager, sara.bogren@ri.se<\/a><\/p>\n\n\n\n
\n\n\n\nFull list of the EU-NETVAL laboratories: Source EURL-ECVAM website<\/a><\/h2>\n\n\n
Test facility<\/strong> <\/td> Endorsed by NCPs*<\/strong> <\/td> Date<\/strong><\/td><\/tr> 1<\/td> European Commission (Coordinator)<\/strong> European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) Ispra, Italy <\/td> 03\/07\/2013 <\/td><\/tr> 2<\/td> Belgium<\/strong> Sciensano, Quality of Vaccines and Blood Products Brussels <\/td> 03\/07\/2013 <\/td><\/tr> 3<\/td> Belgium<\/strong> VITO-ABS (Flemish Institute for Technological Research, Research team Applied Bio & molecular Systems) Mol <\/td> 10\/01\/2014 <\/td><\/tr> 4<\/td> Czech Republic<\/strong> National Reference Laboratory for Experimental Immunotoxicology Praha <\/td> 03\/07\/2013 <\/td><\/tr> 5<\/td> Finland<\/strong> FHAIVE – Finnish Hub for Development and Validation of Integrated Approaches Tampere <\/td> 03\/07\/2013 <\/td><\/tr> 6<\/td> France<\/strong> EUROSAFE Saint-Gr\u00e9goire <\/td> 07\/12\/2015 <\/td><\/tr> 7<\/td> France<\/strong> INERIS (Institut National de l’Environnement Industriel et des Risques) Verneuil en Halatte <\/td> 03\/07\/2013 <\/td><\/tr> 8<\/td> Germany<\/strong> BASF SE Experimental Toxicology and Ecology. Laboratory for Development of Alternative Methods Ludwigshafen<\/td> 10\/01\/2014 <\/td><\/tr> 9<\/td> Germany<\/strong> Eurofins BioPharma Product Testing Munich GmbH Munich<\/td> 10\/01\/2014 <\/td><\/tr> 10<\/td> Germany<\/strong> ICCR-Ro\u00dfdorf GmbH Rossdorf<\/td> 03\/07\/2013 <\/td><\/tr> 11<\/td> Germany<\/strong> Laboratory for Biogerontology, Dermato-Pharmacology and Dermato-Endocrinology, Staedtisches Klinikum Dessau, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg Dessau <\/td> 10\/01\/2014 <\/td><\/tr> 12<\/td> Germany<\/strong> PRIMACYT Cell Culture Technology GmbH Schwerin <\/td> 03\/07\/2013 <\/td><\/tr> 13<\/td> Hungary<\/strong> ATRC Aurigon Toxicological Research Center Limited Liability Company (ATRC Aurigon Ltd.) Budapest <\/td> 10\/01\/2014 <\/td><\/tr> 14<\/td> Italy<\/strong> ABICH S.r.l. Verbania <\/td> 07\/12\/2015 <\/td><\/tr> 15<\/td> Italy<\/strong> ACCELERA S.r.l. Nerviano <\/td> 07\/12\/2015 <\/td><\/tr> 16<\/td> Italy<\/strong> Aptuit s.r.l., an Evotec Company Verona <\/td> 07\/12\/2015 <\/td><\/tr> 17<\/td> Italy<\/strong> Eurofins Biolab srl Vimodrone <\/td> 10\/01\/2014 <\/td><\/tr> 18<\/td> Italy<\/strong> European Research Biology Center S.r.l. (ERBC) Pomezia <\/td> 07\/12\/2015 <\/td><\/tr> 19<\/td> Italy<\/strong> Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna. Brescia <\/td> 03\/07\/2013 <\/td><\/tr> 20<\/td> Italy<\/strong> VitroScreen Srl Milano <\/td> 10\/01\/2014 <\/td><\/tr> 21<\/td> Italy<\/strong> VITROX (c\/o sezione provinciale Bologna, ARPA ER) Bologna <\/td> 07\/12\/2015 <\/td><\/tr> 22<\/td> Netherlands<\/strong> Charles River Laboratories Den Bosch B.V. s-Hertogenbosch <\/td> 01\/06\/2021 <\/td><\/tr> 23<\/td> Netherlands<\/strong> Wageningen Food Safety Research Wageningen <\/td> 03\/07\/2013 <\/td><\/tr> 24<\/td> Norway<\/strong> Norwegian Institute for Water Research (NIVA) Oslo <\/td> 12\/11\/2020 <\/td><\/tr> 25<\/td> Poland<\/strong> Nofer Institute of Occupational Medicine \u0141\u00f3d\u017a <\/td> 07\/12\/2015 <\/td><\/tr> 26<\/td> Poland<\/strong> Selvita S.A. Krak\u00f3w<\/td> 07\/12\/2015 <\/td><\/tr> 27<\/td> Portugal<\/strong> Labfit <\/strong>– HPRD Health Products Research and Development Lda Covilh\u00e3<\/td> 02\/03\/2016 <\/td><\/tr> 28<\/td> Slovakia<\/strong> \u00dastav experiment\u00e1lnej farmakol\u00f3gie a toxikol\u00f3gie, Centrum experiment\u00e1lnej medic\u00edny SAV Bratislava <\/td> 30\/10\/2020<\/td><\/tr> 29<\/td> Spain<\/strong> Eurofins BioPharma Product Testing Spain SL Barcelona <\/td> 03\/07\/2013 <\/td><\/tr> 30<\/td> Spain<\/strong> Fundaci\u00f3n GAIKER Vizcaya <\/td> 10\/01\/2014 <\/td><\/tr> 31<\/td> Spain<\/strong> Spanish National Centre for Microbiology – Instituto de Salud Carlos III Madrid<\/td> 03\/07\/2013 <\/td><\/tr> 32<\/td> Sweden<\/strong> RISE Research Institutes of Sweden Bor\u00e5s<\/td> 03\/07\/2013 <\/td><\/tr> 33<\/td> Switzerland<\/strong> B’SYS GmbH Witterswil <\/td> 07\/12\/2015 <\/td><\/tr><\/tbody><\/table> Test Facility<\/strong><\/strong><\/td> Endorsed by NCPs*<\/strong><\/strong><\/td><\/tr> 1.<\/td> European Commission (Coordinator)<\/strong> European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) Ispra, Italy<\/td> 03\/07\/2013<\/td><\/tr> 2.<\/td> Belgium<\/strong><\/strong> Sciensano, Quality of Vaccines and Blood Products Brussels<\/td> 03\/07\/2013<\/td><\/tr> 3.<\/td> Belgium<\/strong><\/strong> VITO-ABS (Flemish Institute for Technological Research, Research team Applied Bio & molecular Systems) Mol<\/td> 10\/01\/2014<\/td><\/tr> 4.<\/td> Czech Republic<\/strong><\/strong> National Reference Laboratory for Experimental Immunotoxicology Praha<\/td> 03\/07\/2013<\/td><\/tr> 5.<\/td> Finland<\/strong><\/strong> FHAIVE – Finnish Hub for Development and Validation of Integrated Approaches Tampere<\/td> 03\/07\/2013<\/td><\/tr> 6.<\/td> France<\/strong><\/strong> EUROSAFE Saint-Gr\u00e9goire<\/td> 07\/12\/2015<\/td><\/tr> 7.<\/td> France<\/strong><\/strong> INERIS (Institut National de l’Environnement Industriel et des Risques) Verneuil en Halatte<\/td> 03\/07\/2013<\/td><\/tr> 8.<\/td> Germany<\/strong><\/strong> BASF SE Experimental Toxicology and Ecology. Laboratory for Development of Alternative Methods Ludwigshafen<\/td> 10\/01\/2014<\/td><\/tr> 9.<\/td> Germany<\/strong><\/strong> Eurofins BioPharma Product Testing Munich GmbH Munich<\/td> 10\/01\/2014<\/td><\/tr> 10<\/td> Germany<\/strong><\/strong> ICCR-Ro\u00dfdorf GmbH Rossdorf<\/td> 03\/07\/2013<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div>\n\n 11<\/td> Germany<\/strong><\/strong> Laboratory for Biogerontology, Dermato-Pharmacology and Dermato-Endocrinology, Staedtisches Klinikum Dessau, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg Dessau<\/td> 10\/01\/2014<\/td><\/tr> 12<\/td> Germany<\/strong><\/strong> PRIMACYT Cell Culture Technology GmbH Schwerin<\/td> 03\/07\/2013<\/td><\/tr> 13<\/td> Hungary<\/strong><\/strong> ATRC Aurigon Toxicological Research Center Limited Liability Company (ATRC Aurigon Ltd.) Budapest<\/td> 10\/01\/2014<\/td><\/tr> 14<\/td> Italy<\/strong><\/strong> ABICH S.r.l. Verbania<\/td> 07\/12\/2015<\/td><\/tr> 15<\/td> Italy<\/strong><\/strong> ACCELERA S.r.l. Nerviano<\/td> 07\/12\/2015<\/td><\/tr> 16<\/td> Italy<\/strong><\/strong> Aptuit s.r.l., an Evotec Company Verona<\/td> 07\/12\/2015<\/td><\/tr> 17<\/td> Italy<\/strong>