{"id":11120,"date":"2024-05-21T16:49:06","date_gmt":"2024-05-21T14:49:54","guid":{"rendered":"https:\/\/www.estiv.org\/congress2022\/accepted-posters-copy\/"},"modified":"2026-06-08T16:38:04","modified_gmt":"2026-06-08T14:38:04","slug":"posters","status":"publish","type":"page","link":"https:\/\/www.estiv.org\/congress2024\/posters\/","title":{"rendered":"Posters 2024"},"content":{"rendered":"\n<h2 class=\"block-heading\">Instructions for Poster Presenters<\/h2>\n\n\n\n<p class=\"has-text-color\" style=\"color:#ff0004\">Please note that unlike what is written in the instructions for poster presentations, you will not be required to stand next to your poster during coffee and lunch breaks. There will be two dedicated poster presentation sessions:<\/p>\n\n\n\n<p class=\"has-text-color\" style=\"color:#ff0004\"><strong>Even poster numbers<\/strong> (not abstract numbers!) will present on <strong>Tuesday 4 June during Poster Session II <\/strong>(18:30 to 19:30)<\/p>\n\n\n\n<p class=\"has-text-color\" style=\"color:#ff0004\"><strong>Odd poster numbers<\/strong> will present on <strong>Wednesday 5 June during Poster Session III<\/strong> (18:30 to 19:30)<\/p>\n\n\n\n<div class=\"block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 block-columns-is-layout-flex\">\n<div class=\"block-column is-layout-flow block-column-is-layout-flow\">\n<div class=\"block-buttons is-layout-flex block-buttons-is-layout-flex\"><\/div>\n<\/div>\n\n\n\n<div class=\"block-column is-layout-flow block-column-is-layout-flow\">\n<div class=\"block-buttons is-layout-flex block-buttons-is-layout-flex\">\n<div class=\"block-button\"><a class=\"block-button__link\" href=\"https:\/\/www.estiv.org\/content\/uploads\/2024\/05\/estiv-2024-instructions-for-poster-presenters-v4.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Poster presentations<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"block-column is-layout-flow block-column-is-layout-flow\">\n<div class=\"block-buttons is-layout-flex block-buttons-is-layout-flex\">\n<div class=\"block-button\"><a class=\"block-button__link\" href=\"https:\/\/www.estiv.org\/content\/uploads\/2024\/06\/20240604-estiv-2024-poster-list-ad-v6.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Poster list<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"block-separator\"\/>\n\n\n\n<p><strong>Poster print service:<\/strong><\/p>\n\n\n\n<p>We offer a convenient local print service through Exposale for all your poster printing needs.<\/p>\n\n\n\n<p><strong>Pricing:<\/strong><\/p>\n\n\n\n<ul class=\"block-list\"><li>The cost for print and onsite delivery is \u20ac80.00 excluding VAT if ordered before the deadline of May 17th.<\/li><li>After May 17<sup>th<\/sup>&nbsp;please ask a confirmation that the poster can be still printed depending on date of receiving the print file. The price for late poster printing is \u20ac120.00 excluding VAT.<\/li><\/ul>\n\n\n\n<p><strong>Payment Information:<\/strong><\/p>\n\n\n\n<p>Please note that payment must be completed before the poster is printed.<\/p>\n\n\n\n<p><strong>Preparing Print Files for Large Format Prints:<\/strong><\/p>\n\n\n\n<p>To ensure optimal results, please adhere to the following guidelines when preparing your print files:<\/p>\n\n\n\n<ul class=\"block-list\"><li>All posters must be designed in portrait orientation.<\/li><li>Poster format should be A0 (width: 84.1cm \/ 33.1in; height: 118.9cm \/ 46.8in).<\/li><li>Accepted file type: standard print PDF.<\/li><li>Ensure all print files are ideally 1:1 scale.<\/li><li>Name your print files descriptively for easy identification.<\/li><li>Convert all fonts into curves to avoid font compatibility issues.<\/li><li>Ideal bitmap resolution is 100-150 DPI at final size; additionally, please keep individual file sizes under 100MB if possible.<\/li><li>Include bleeds and correct crop marks for optimal printing.<\/li><li>Use\/send files in CMYK color space only.<\/li><\/ul>\n\n\n\n<p><strong>Contact Information:<\/strong><\/p>\n\n\n\n<p>To order your printed poster or for any inquiries, please contact Josef \u0160vec of Exposale:<\/p>\n\n\n\n<ul class=\"block-list\"><li>Email:&nbsp;<a href=\"mailto:josef.svec@exposale.cz\">josef.svec@exposale.cz<\/a><\/li><\/ul>\n\n\n\n<h2 class=\"block-heading\" id=\"Goback\">TOPICS<\/h2>\n\n\n\n<p><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#Bio-engineering, stem cells and disease models\" class=\"ek-link\">Bio-engineering, stem cells and disease models<\/a><\/span> <br><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#cardiotoxicity\" class=\"ek-link\">Cardiotoxicity and cardiac efficacy models&nbsp;<\/a><\/span><br><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#casestudies\" class=\"ek-link\">Case studies for successful use and implementation of complex in vitro models<\/a><\/span><br><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#challengescosmeticssafety\" class=\"ek-link\">Challenges in cosmetics safety<\/a><\/span> <br><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#Computational toxicology\" class=\"ek-link\">Computational toxicology \u2013 in silico modelling, read-across, artificial intelligence and machine learning<\/a><\/span><a href=\"#Computational toxicology\" class=\"ek-link\"> <\/a>  <br><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#medical-devices\" class=\"ek-link\">In vitro and in silico methods for safety assessment of medical devices<\/a><\/span><br> <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#In%20vitro%20systems%20to%20assess%20respiratory%20toxicity\" class=\"ek-link\">In vitro systems to assess respiratory toxicity<\/a><br> <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Knowledge%20sharing%20and%20education\" class=\"ek-link\">Knowledge sharing and education<\/a><br> <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#localtoxicity\">Local toxicity testing (safety and efficacy)<\/a><br> <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Modelsandmethods\">Models and methods<\/a><br> <a href=\"#modelsbiomarkerstoxicity\" class=\"ek-link\">Models, biomarkers and assays for developmental toxicity<\/a><br> <a href=\"#modelsbiomarkersdisruption\" class=\"ek-link\">Models, biomarkers and assays for endocrine disruption<\/a> <br> <a href=\"#modelsbiomarkersimmune\" class=\"ek-link\">Models, biomarkers and assays for systemic and immune toxicity<\/a>  <br> <a href=\"#nonanimal\" class=\"ek-link\">Non-animal methods for safety testing of biopharmaceuticals\/biotherapies\/vaccines<\/a><br> <a href=\"#nonanimal\" class=\"ek-link\">Organ-on-a-chip &amp; Microphysiological Systems<\/a> <br> <a href=\"#other\" class=\"ek-link\">Other NAMs relevant topics<\/a>     <\/p>\n\n\n\n<p> <a href=\"#Goback\" class=\"ek-link\">Go back<\/a>  <\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"Bio-engineering, stem cells and disease models\"><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#ngineering, stem cells and disease models\" class=\"ek-link\"><span class=\"has-inline-color has-green-color\">Bio-engineering, stem cells and disease models<\/span><\/a>&nbsp;<\/span><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P1<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Hepatic programming of human skin-derived precursor cells into functional hepatocyte-like cells for in vitro liver research<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marth Stinckens<\/span><\/span><sup>P1<\/sup>, Matthias&nbsp; Rombaut<sup>2<\/sup>, Alexandra Gatzios<sup>1<\/sup>, Robim Marcelino Rodrigues<sup>1<\/sup>, Tamara Vanhaecke<sup>1<\/sup>, Joery De Kock<sup>2<\/sup><br><sup>1<\/sup> In Vitro Liver Disease Modelling Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium<br><sup>2<\/sup> Liver Therapy &amp; Evolution Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P2<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>3D bioprinting of human skin and squamous cell tumors as advanced models for precision medicine<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Stefano Lorenzetti<\/span><\/span><sup>P1<\/sup>, Milena Mikhail<sup>1<\/sup>, Laura Di Benedetto<sup>1<\/sup>, Valeria Bartolocci<sup>2<\/sup>, Rosanna Monetta<sup>2<\/sup>, Sofia Raniolo<sup>3<\/sup>, Isabella De Angelis<sup>1<\/sup>, Elena Dellambra<sup>2<\/sup>, Cristina Maria Failla<sup>2<\/sup>, Sara Maria Giannitelli<sup>3<\/sup><br><sup>1<\/sup> ISS &#8211; Istituto Superiore di Sanit\u00e0<br><sup>2<\/sup> IDI-IRCCS<br><sup>3<\/sup> University Campus Biomedico<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P3<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>3D human stem-cell-derived neurons to complement the in vitro neurotoxicity testing for Methylglyoxal<\/a><\/h3>\n\n\n\n<p>Uliana De Simone<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Francesca Caloni<\/span><\/span><sup>P2<\/sup>, Laura Villani<sup>3<\/sup>, Luciana Alessandra Russo<sup>3<\/sup>, Teresa Coccini<sup>1<\/sup><br><sup>1<\/sup> Istituti Clinici Scientifici Maugeri IRCCS SpA-SB, Laboratory of Clinical and Experimental Toxicology, Toxicology Unit, Pavia, Italy<br><sup>2<\/sup> Universit\u00e0 degli Studi di Milano (ESP)<br><sup>3<\/sup> Istituti Clinici Scientifici Maugeri IRCCS, Pathology Unit, Pavia, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P4<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>IN VITRO 2D AND 3D KIDNEY MODELS TO STUDY THE NEPHROTOXIC RESPONSE OF URANIUM EXPOSURE<\/a><\/h3>\n\n\n\n<p>Marie frerejacques<sup>1<\/sup>, Victoria Powell<sup>1<\/sup>, Sebastien&nbsp; Giraud<sup>2<\/sup>, Annabelle Manoury<sup>1<\/sup>, Cl\u00e9mence Finet<sup>1<\/sup>, C\u00e9line Bouvier-Capely<sup>1<\/sup>, Clara&nbsp; Steichen<sup>2,3<\/sup>, Thierry Hauet<sup>2,3,4<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Yann&nbsp; GUEGUEN<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Institut de Radioprotection et de S\u00fbret\u00e9 Nucl\u00e9aire (IRSN), PSE-SANTE, SESANE, Fontenay-aux-Roses, F-92262 France.<br><sup>2<\/sup> Inserm U1313 \u2013 IRMETIST (Isch\u00e9mie Reperfusion, M\u00e9tabolisme et Inflammation St\u00e9rile en Transplantation), Poitiers, F-860000, France<br><sup>3<\/sup> Universit\u00e9 de Poitiers, Facult\u00e9 de m\u00e9decine et de pharmacie, Poitiers, F-86000, France<br><sup>4<\/sup> CHU de Poitiers, service de biochimie, Poitiers, F-86000, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P5<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DEVELOPMENT OF A NOVEL RIBOSWITCH-BASED CELLULAR MODEL OF TDP-43 PROTEINOPATHY<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Vito D&#8217;Alessandro<\/span><\/span><sup>P1,2<\/sup>, Eleonora De Vitis<sup>1,2<\/sup>, Alessia Foscarini<sup>2<\/sup>, Velia&nbsp; La Pesa<sup>3<\/sup>, Angelo Quattrini<sup>3<\/sup>, Alessandro Romano<sup>3<\/sup>, Sarah Mizielinska<sup>4<\/sup>, Francesca Gervaso<sup>2<\/sup>, Alessandro Polini<sup>2<\/sup>, Giuseppe Gigli<sup>1,2<\/sup><br><sup>1<\/sup> Dipartimento di Matematica e Fisica E. De Giorgi, Universit\u00e0 del Salento, Lecce, Italy<br><sup>2<\/sup> Institute of Nanotechnology, CNR Nanotec, Lecce, Italy<br><sup>3<\/sup> Division of Neuroscience, Institute of Experimental Neurology, IRCCS San Raffaele, Milan, Italy<br><sup>4<\/sup> UK Dementia Research Institute at King\u2019s College London, London, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P6<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Next -Generation Full-Thickness Human Skin Models Produced using 3D Electrospun Scaffolds and Animal-Component-Free Culture Media<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Patrick Hayden<\/span><\/span><sup>P1<\/sup>, Rayan Hodroj<sup>1<\/sup>, Jayashree Chakravarty<sup>1<\/sup>, Lisa Fitzgerald<sup>1<\/sup>, Jake Pierson<sup>1<\/sup>, Elizabeth Labbe<sup>1<\/sup>, Jacob Le Do<sup>1<\/sup>, Kyle Golden<sup>1<\/sup>, Nathaniel Long<sup>1<\/sup>, Matthew Phaneuf<sup>1<\/sup><br><sup>1<\/sup> BioSurfaces, Inc.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p> <a href=\"#Goback\" class=\"ek-link\">Go back<\/a>  <\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"Models,biomarkers\"><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#cardiotoxicity\" class=\"ek-link\">Cardiotoxicity and cardiac efficacy models<\/a><\/span><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P7<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Assessment of the proarrhythmic effects of repurposed antimalarials for COVID-19 treatment using a comprehensive in vitro proarrhythmia assay (CiPA)<\/a><\/h3>\n\n\n\n<p>Seung Hyun Yoon<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ki-Suk Kim<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Korea Institute of Toxicology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P8<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>INTERPLAY BETWEEN CARDIOMYOCYTES AND CARDIAC FIBROBLASTS IN CARDIOTOXICITY CAUSED BY ANTHRACYCLINES, INVOLVEMENT OF THE ANGIOTENSIN-SIGNALLING PATHWAY<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ray Alsuhaibani<\/span><\/span><sup>P1,2<\/sup>, Gavin Richardson<sup>3<\/sup>, Jason Gill<sup>1<\/sup><br><sup>1<\/sup> Transitional and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom<br><sup>2<\/sup> Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Kingdom of Saudi Arabia<br><sup>3<\/sup> Biosciences Institute, Newcastle University, United Kingdom\u200b<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P9<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Qualification of a 3D beating heart-on-chip platform for drug-induced cardiac contractility alterations analyses<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Caterina Pernici<\/span><\/span><sup>P1<\/sup>, Marco Mondini<sup>1<\/sup>, Eva Vermersch<sup>2<\/sup>, Ambroise Garry<sup>2<\/sup>, Roberta Visone<sup>1<\/sup>, Marco Rasponi<sup>3<\/sup>, Paola Occhetta<sup>1,3<\/sup><br><sup>1<\/sup> BiomimX Srl<br><sup>2<\/sup> Global Investigative Toxicology Group Sanofi<br><sup>3<\/sup> Politecnico di Milano<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p> <a href=\"#Goback\" class=\"ek-link\">Go back<\/a> <\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"Challenges in cosmetics safety\"><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#casestudies\" class=\"ek-link\">Case studies for successful use and implementation of complex in vitro models<\/a><\/span><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P10<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Decision making in Next Generation Risk Assessment (NGRA) for Skin Sensitisation: How Useful Read-Across Analogue Data Can Be<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nathalie Al\u00e9p\u00e9e<\/span><\/span><sup>P1<\/sup>, Aynur Aptula<sup>2<\/sup>, Dagmar Bury<sup>1<\/sup>, Els DeConinck<sup>3<\/sup>, Johanna Ebmeyer<sup>4<\/sup>, Francoise Gautier<sup>1<\/sup>, Nicola Gilmour<sup>2<\/sup>, Sebastian Hoffmann<sup>5<\/sup>, Petra Kern<sup>3<\/sup>, Jochen K\u00fchnl<sup>4<\/sup>, Cathy Lester<sup>6<\/sup>, Masaaki Miyazawa<sup>7<\/sup>, Kanako Nakayama<sup>7<\/sup>, Hayato Nishida<sup>8<\/sup>, Erwin van Vliet<sup>9<\/sup>, Gang Yan Yan<sup>6<\/sup><br><sup>1<\/sup> L&#8217;Oreal R&amp;I, France<br><sup>2<\/sup> Unilever, United Kingdom<br><sup>3<\/sup> Procter &amp; Gamble Services NV\/SA, Belgium<br><sup>4<\/sup> Beiersdorf AG, Germany<br><sup>5<\/sup> seh consulting + services, Germany<br><sup>6<\/sup> The Procter &amp; Gamble Company, USA<br><sup>7<\/sup> Kao, Japan<br><sup>8<\/sup> Shiseido Global Innovation Center, Japan<br><sup>9<\/sup> Innovitox Consulting &amp; Services, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P11<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>TOPICAL PROBIOTIC FORMULATION PROMOTES RAPID HEALING IN DOG KERATINOCYTE CELLS: A PROMISING APPROACH FOR WOUND MANAGEMENT<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Manon Barthe<\/span><\/span><sup>P1<\/sup>, Lionel&nbsp; Gillot<sup>2<\/sup>, Laurie Perdigon <sup>1<\/sup>, Aline Jacobs<sup>2<\/sup>, Gregory Schoonbroodt<sup>2<\/sup>, Paul Mauhin<sup>2<\/sup>, Emna Bouhajja<sup>2<\/sup>, Hanan Osman-Ponchet<sup>1<\/sup><br><sup>1<\/sup> PKDERM Laboratories, 45 Boulevard Marcel Pagnol, 06130 Grasse \u2013 France<br><sup>2<\/sup> Probiotic Group Luxembourg S.A., Research and Development Department, 9944Weiswampach, Luxembourg<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P12<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Beneficial effect of hydrolysed marine collagen on physiology of skin models<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lorenzo Dondero<\/span><\/span><sup>P1<\/sup>, Giulia De Negri Atanasio<sup>1<\/sup>, Erica Lertora<sup>1<\/sup>, Giorgia&nbsp; Allaria<sup>1<\/sup>, Francesca Rispo<sup>1<\/sup>, Francesca Tardanico<sup>1<\/sup>, Federica Robino<sup>2<\/sup>, Elisabetta Perata<sup>2<\/sup>, Raffaella Boggia<sup>3<\/sup>, Federica Turrini<sup>3<\/sup>, Damien Dupin<sup>4<\/sup>, Juliana De Souza Nunes<sup>4<\/sup>, Natividad Diaz<sup>4<\/sup>, Matteo Zanotti-Russo<sup>2<\/sup>, Sara Ferrando<sup>1<\/sup>, Elena Grasselli<sup>1,5<\/sup><br><sup>1<\/sup> Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy&nbsp;<br><sup>2<\/sup> ANGEL CONSULTING S.a.s. , Italy<br><sup>3<\/sup> Department of Pharmacy (DIFAR), University of Genoa, 16132 Genoa, Italy<br><sup>4<\/sup> CIDETEC, Basque Research and Technology Alliance (BRTA), Parque Cient\u00edfico y Tecnol\u00f3gico de Gipuzkoa, Donostia-San Sebasti\u00e1n, Spain<br><sup>5<\/sup> Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P13<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>NEW APPROACH METHODS \u2013 WHAT DETERMINES VALIDATED? A CASE STUDY USING THE IN VITRO BHAS42 CELL TRANSFORMATION ASSAY FOR CARCINOGENICITY PREDICTION<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Darren KIDD<\/span><\/span><sup>P1<\/sup>, Daniel BRAMHAM<sup>1<\/sup>, Robel MEDHANE<sup>1<\/sup>, Joanne LARNER<sup>1<\/sup><br><sup>1<\/sup> Labcorp Early Development Laboratories Ltd, In Vitro Toxicology Group, Harrogate, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P14<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A BARRIER-ON-CHIP PLATFORM FOR CLINICALLY RELEVENAT SAFETY AND TOXICITY ASSESSMENT: A CASE STUDY OVERVIEW<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Janick Stucki<\/span><\/span><sup>P1<\/sup>, Giulia&nbsp; Raggi<sup>1<\/sup>, Lea Lara de Maddalena<sup>1<\/sup>, Laur\u00e8ne Froment<sup>1<\/sup>, Nicole Albrecher<sup>1<\/sup>, Andreas Hugi<sup>1<\/sup>, L\u00e9a Todeschini<sup>1<\/sup>, Nina Hobi<sup>1<\/sup><br><sup>1<\/sup> AlveoliX AG, Swiss Organs-on-Chip Innovation, Bern, Switzerland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P15<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>BREAKING BARRIERS: IMPEDANCE-BASED ASSESSMENT OF CELLULAR FUNCTIONALITY IN COPD MIMICS<\/a><\/h3>\n\n\n\n<p>Thanh Huyen Phan<sup>1<\/sup>, Huaikai Shi<sup>2,3<\/sup>, Christopher E. Denes<sup>4<\/sup>, Alexander J. Cole<sup>5,6<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Eline Geervliet<\/span><\/span><sup>P7<\/sup>, Yiwei Wang<sup>2,8<\/sup>, Yuen Yee Cheng<sup>3,9<\/sup>, Daniel Hesselson<sup>5,6<\/sup>, Susan H. Roelofs<sup>7<\/sup>, Graham Gregory Neely<sup>4,5<\/sup>, Jun\u2011Hyeog Jang<sup>10<\/sup>, Wojciech Chrzanowski<sup>1<\/sup><br><sup>1<\/sup> The University of Sydney, Sydney Nano Institute, Faculty of Medicine and Health, Sydney School of Pharmacy, Pharmacy and Bank Building A15, Camperdown, NSW 2006, Australia.<br><sup>2<\/sup> Burns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia.<br><sup>3<\/sup> Asbestos Disease Research Institute, Concord Hospital, Sydney, Australia.<br><sup>4<\/sup> The Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre and School of Life &amp; Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.<br><sup>5<\/sup> Centenary Institute, The University of Sydney, Sydney, NSW 2006, Australia.y Institute, The University of Sydney, Sydney, NSW 2006, Australia.<br><sup>6<\/sup> Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.<br><sup>7<\/sup> Locsense B.V., Locsense B.V., Enschede, The Netherlands.<br><sup>8<\/sup> Jiangsu Provincial Engineering Research Centre of TCM External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing, China.<br><sup>9<\/sup> Institute for Biomedical Materials and Devices (IBMD), School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Broadway, NSW 2007, Australia.<br><sup>10<\/sup> Department of Biochemistry, College of Medicine, Inha University, Incheon 400\u2011712, South Korea.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P16<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A MULTIMODEL WORKFLOW TO TACKLE THE TOXICITY OF&nbsp; FOODBORNE COMPOUNDS AT INTESTINAL LEVEL<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Janice Bergen<\/span><\/span><sup>P1,2,3<\/sup>, Francesco Crudo<sup>1<\/sup>, Doris Marko<sup>1<\/sup>, Franz&nbsp; Berthiller<sup>4<\/sup>, Giorgia Del Favero<sup>1,2<\/sup><br><sup>1<\/sup> Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria<br><sup>2<\/sup> Core Facility Multimodal Imaging, Faculty of Chemistry, University of Vienna, Vienna, Austria<br><sup>3<\/sup> Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, Vienna, Austria<br><sup>4<\/sup> Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences, Vienna (BOKU), Austria<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P17<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>TAILORMADE SOLUTIONS FOR CHALLENGES IN TESTING SKIN IRRITATION WITH MEDICAL DEVICES USING IN VITRO 3D SKIN MODELS<\/a><\/h3>\n\n\n\n<p>Ramona Gillere<sup>1<\/sup>, Ulrike Theisen<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Constantin Brinkmann<\/span><\/span><sup>P1<\/sup>, Helge Gehrke<sup>1<\/sup><br><sup>1<\/sup> Eurofins BioPharma Product Testing Munich GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P204<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EX VIVO EVALUATION OF THE OPHTHALMIC BIODISTRIBUTION OF THE PESTICIDES TEBUCONAZOLE AND PYRACLOSTROBIN<\/a><\/h3>\n\n\n\n<p>Asley&nbsp; Thalia Medeiros Souza1<sup>1<\/sup>, Leila&nbsp; Bastos Leal<sup>1<\/sup>, Davi&nbsp; Pereira de Santana<sup>1<\/sup>, La\u00eds&nbsp; Matias da Silva<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Juliana Falcato Vecina<\/span><\/span><sup>P2<\/sup><br><sup>1<\/sup> Federal University of Pernambuco, Pharmaceutical and Cosmetics Development Center (NUDFAC)<br><sup>2<\/sup> M\u00e9rieux NutriSciences<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P210<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Hepatic 3D cell models for assessment of genotoxic effects induced by BPA, BPC, BPAP and their complex mixtures<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Martina \u0160tampar<\/span><\/span><sup>P1<\/sup>, Tim Ravnjak<sup>1,2<\/sup>, Alja&nbsp; \u0160tern<sup>1<\/sup>, Bojana \u017degura<sup>1,2<\/sup><br><sup>1<\/sup> Department for genetic toxicology and cancer biology, National Institute of Biology, Slovenia;<br><sup>2<\/sup> Jozef Stefan International Postgraduate School, Slovenia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P214<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DEVELOPMENT OF IN-VITRO 3D OSTEOARTHRITIS MODEL FOR DRUG SCREEING<\/a><\/h3>\n\n\n\n<p>Eun-Ji Gwak<sup>1<\/sup>, Chaeyeon Lee<sup>1<\/sup>, Hyuna Lee<sup>1<\/sup>, Suhhee Yeom<sup>1<\/sup>, Su-Hyon&nbsp; Lee<sup>1<\/sup>, Jungsun Lee<sup>1<\/sup><br><sup>1<\/sup> R&amp;D Institute, Biosolution Co.,Ltd., Seoul, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p> <a href=\"#Goback\" class=\"ek-link\">Go back<\/a> <\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"immune toxicity\"><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#challengescosmeticssafety\" class=\"ek-link\">Challenges in cosmetics safety&nbsp;<\/a><a class=\"ek-link\">&nbsp;<\/a><\/span><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P18<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Predicting eye irritation for wash-off products using in vitro testing methods<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Minseok Choi<\/span><\/span><sup>P1<\/sup>, Go Un Kim<sup>1<\/sup><br><sup>1<\/sup> Safety and Microbiology Lab, R&amp;I Center, AMOREPACIFIC, Yongin, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P19<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Safety Assessments Of Cosmetic Ingredients Exclusively Based On Data From New Approach Methodologies<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Thorsten Diedam<\/span><\/span><sup>P1<\/sup>, Martina Hermann<sup>1<\/sup>, Simone Hoffmann-Doerr<sup>1<\/sup>, Detlef&nbsp; Keller<sup>1<\/sup><br><sup>1<\/sup> Henkel AG &amp; Co. KGaA, D\u00fcsseldorf, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P20<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Read-across supported by new approach methodologies for assessing repeated-dose systemic toxicity : a case study with octisalate<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ann Detroyer<\/span><\/span><sup>P1<\/sup>, Gladys Ouedraogo<sup>1<\/sup>, Audrey Noel-Voisin<sup>1<\/sup>, Anne Riu<sup>1<\/sup>, Fran\u00e7oise Gautier<sup>1<\/sup>, Sebastien&nbsp; Gregoire<sup>1<\/sup>, Nazanin Golbamaki<sup>1<\/sup>, Anne Moustie<sup>1<\/sup>, Romain Grall<sup>1<\/sup>, Matthew Burbank<sup>1<\/sup><br><sup>1<\/sup> L&#8217;Oreal R&amp;I, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P21<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>CHEMICAL CHARACTERIZATION, VIABILITY, AND OXIDATIVE DAMAGE PREVENTION IN MACROPHAGES WITH Ocimum gratissimum OIL NANOEMULSION<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Julia Salles Gava<\/span><\/span><sup>P1<\/sup>, Hildegardo Seibert Fran\u00e7a<sup>2,3<\/sup>, Iana Soares Pessoa<sup>4<\/sup>, Tamires&nbsp; Cruz dos Santos<sup>4<\/sup>, Marcio&nbsp; Fronza<sup>1,4<\/sup><br><sup>1<\/sup> Pharmaceutical Sciences Graduate Program, Vila Velha University, Vila Velha, ES, Brazil<br><sup>2<\/sup> Federal Institute of Esp\u00edrito Santo, Vila Velha, ES, Brazil<br><sup>3<\/sup> Multiuser Biomolecular Analysis Laboratory, Federal University of Esp\u00edrito Santo Vit\u00f3ria, ES, Brazil<br><sup>4<\/sup> Postgraduate Program in Plant Biotechnology, Vila Velha University, Vila Velha, ES, Brazil<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P22<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>NEXT GENERATION RISK ASSESSMENT (NGRA) FOR SKIN SENSITISATION: A CASE STUDY INCORPORATING READ-ACROSS<\/a><\/h3>\n\n\n\n<p>Petra Kern<sup>1<\/sup>, Nathalie Al\u00e9p\u00e9e<sup>2<\/sup>, Nora Aptula<sup>3<\/sup>, Dagmar Bury<sup>4<\/sup>, Els DeConinck<sup>5<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Johanna Ebmeyer<\/span><\/span><sup>P6<\/sup>, Francoise Gautier<sup>4<\/sup>, Nicola Gilmour<sup>3<\/sup>, Sebastian Hoffmann<sup>7<\/sup>, Jochen&nbsp; K\u00fchnl<sup>6<\/sup>, Cathy Lester<sup>8<\/sup>, Masaaki Miyazawa<sup>9<\/sup>, Kanako Nakayama<sup>9<\/sup>, Hayato Nishida<sup>10<\/sup>, Erwin van Vliet<sup>11<\/sup>, Gang Yan<sup>8<\/sup><br><sup>1<\/sup> Procter &amp; Gamble Services NV\/SA, Strombeek-Bever<br><sup>2<\/sup> L\u2019Or\u00e9al, Aulnaysous-Bois, France<br><sup>3<\/sup> Unilever, Bedford, United Kingdom<br><sup>4<\/sup> L\u2019Or\u00e9al, Clichy, France<br><sup>5<\/sup> Procter &amp; Gamble Services NV\/SA<br><sup>6<\/sup> Beiersdorf AG, Hamburg, Germany<br><sup>7<\/sup> seh consulting + services, Paderborn, Germany<br><sup>8<\/sup> The Procter &amp; Gamble Company, Mason, OH<br><sup>9<\/sup> Kao, Tochigi, Japan<br><sup>10<\/sup> Shiseido Global Innovation Center, Takashima, Japan<br><sup>11<\/sup> Innovitox Consulting &amp; Services<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p> <a href=\"#Goback\" class=\"ek-link\">Go back<\/a> <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Computational%20toxicology\" class=\"ek-link\">Computational toxicology \u2013 in silico modelling, read-across, artificial intelligence and machine learning<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P23<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A STRUCTURE-BASED VIEW ON THYROID HORMONE HOMEOSTASIS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Julia Kandler<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> University of Vienna<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P24<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Enriched Systemic Fingerprints for Predicting Drug-Induced Cholestasis<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Palle Helmke<\/span><\/span><sup>P1<\/sup>, Gerhard Ecker<sup>1<\/sup><br><sup>1<\/sup> Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek Platz 2, 1090 Vienna, Austria<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P25<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Application of induced-fit docking for elucidation of a molecular initiating event at the human cytochrome b-c1 complex<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Karin Grillberger<\/span><\/span><sup>P1<\/sup>, Gerhard F. Ecker<sup>1<\/sup><br><sup>1<\/sup> University of Vienna<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P26<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EVALUATION OF THE HEALING CAPACITY OF AN AMPHIBIAN SKIN PEPTIDE IN TWO-DIMENSIONAL CELLULAR MODELS AND ANALYSIS THROUGH AUTOMATIC SEGMENTATION<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Erica Lertora<\/span><\/span><sup>P1<\/sup>, Lorenzo Dondero<sup>1<\/sup>, Giulia De Negri Atanasio<sup>1<\/sup>, Francesca Tardanico<sup>1<\/sup>, Francesca Rispo<sup>1<\/sup>, Giorgia Allaria<sup>1<\/sup>, Vito Paolo Pastore<sup>2<\/sup>, Alessandro Catenazzi<sup>3<\/sup>, Matteo Zanotti-Russo<sup>4<\/sup>, Elena Grasselli<sup>1,5<\/sup><br><sup>1<\/sup> Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132, Genoa, Italy<br><sup>2<\/sup> Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, 16132, Genoa, Italy<br><sup>3<\/sup> Department of Biological Sciences, Florida International University, Miami, FL, USA<br><sup>4<\/sup> Angel Consulting, 20122 Milano, Italy<br><sup>5<\/sup> Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P27<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Data-driven approaches to elucidate toxicological effects at different scales in zebrafish embryos<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Wibke Busch<\/span><\/span><sup>P1<\/sup>, Paul Michaelis<sup>1<\/sup>, Nils Kl\u00fcver<sup>1<\/sup><br><sup>1<\/sup> UFZ<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P28<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>ProtoPRED: a fast tool to predict physicochemical, (eco)toxicological and pharmacokinetic properties of chemicals with QSAR models<\/a><\/h3>\n\n\n\n<p>Salvador Moncho<sup>1<\/sup>, Laureano E. Carpio<sup>1<\/sup>, Addel Goya<sup>1<\/sup>, Eva Serrano-Candelas<sup>1<\/sup>, Rafael Gozalbes<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Simon Perera del Rosario<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> ProtoQSAR<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P29<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Bridging AI\/ML Advancements with Risk Assessment Needs: A Journey Towards Effective Use and Regulatory Acceptance<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Serhii Kolesnyk<\/span><\/span><sup>P1,2<\/sup>, Nicolas Roth<sup>1,2<\/sup>, Angela Bearth<sup>1,2<\/sup>, Martin Wilks<sup>1,2<\/sup><br><sup>1<\/sup> Swiss Centre for Applied Human Toxicology, University of Basel, Switzerland<br><sup>2<\/sup> Department of Pharmaceutical Sciences, University of Basel, Switzerland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P30<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>In silico profile of 14 microcystins (MCs): data regarding hepatoxicity and carcinogenicity to help prioritize MCs of concern<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Enzo Moreira Silva<\/span><\/span><sup>P1,2<\/sup>, Cynthia Bomfim Pestana<sup>1<\/sup>, Marize Marzo Solano<sup>2<\/sup>, Philip Marx-Stoelting<sup>2<\/sup>, Daniela Morais Leme<sup>1,2<\/sup><br><sup>1<\/sup> Department of Genetics, Federal University of Parana, Curitiba, PR, Brazil<br><sup>2<\/sup> German Federal Institute for Risk Assessment<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P31<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>GENOITS: A WEB-BASED TOOL IMPLEMENTING A PREDICTIVE GENOTOXICITY INTEGRATED TESTING STRATEGY USING QSAR-BASED TOOLS.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jos\u00e9 Luis Vall\u00e9s Pardo<\/span><\/span><sup>P1<\/sup>, Donna S. MacMillan<sup>2<\/sup>, Mar Crespo<sup>3<\/sup>, Salvador Moncho<sup>1<\/sup>, Addel A. Goya-Jorge<sup>1<\/sup>, Eva Serrano-Candelas<sup>1<\/sup>, Rafael Gozalbes<sup>1,4<\/sup><br><sup>1<\/sup> ProtoQSAR<br><sup>2<\/sup> Humane Society International<br><sup>3<\/sup> Toxiconsultant S.L.<br><sup>4<\/sup> MolDrug AI Systems SL<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P32<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Improving understanding of toxicologically relevant molecular and cellular targets: The ICCS Higher Tier Evaluation Working Group<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Matthew Burbank<\/span><\/span><sup>P1<\/sup>, Amaia&nbsp; Irizar<sup>2<\/sup>, Predrag&nbsp; Kukic<sup>3<\/sup>, Silja Vo\u00df<sup>4<\/sup>, Torben Koenig<sup>5<\/sup>, Gladys Ouedraogo<sup>1<\/sup>, Catherine Mahony<sup>6<\/sup><br><sup>1<\/sup> L\u2019Or\u00e9al Research &amp; Innovation, Aulnay-sous-Bois, France<br><sup>2<\/sup> The International Fragrance Association (IFRA), Switzerland.<br><sup>3<\/sup> Unilever, Colworth Science Park, Bedford, UK<br><sup>4<\/sup> Beiersdorf AG, Hamburg, Germany<br><sup>5<\/sup> International Collaboration on Cosmetics Safety (ICCS), NJ, USA.<br><sup>6<\/sup> Procter &amp; Gamble Technical Centers LTD, Reading, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P33<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>The nephron physiological map and associated disease ontologies: developing NAMs for chemical risk assessment in the kidney<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alessio Gamba<\/span><\/span><sup>P1<\/sup>, Luiz Ladeira<sup>1<\/sup>, Devon A. Barnes<sup>2<\/sup>, Manoe J. Janssen<sup>2<\/sup>, Marc Teunis<sup>3<\/sup>, Rosalinde Masereeuw<sup>2<\/sup>, Liesbet Geris<sup>1,4<\/sup>, Bernard Staumont<sup>1<\/sup><br><sup>1<\/sup> Biomechanics Research Unit, GIGA In Silico Medicine, University of Li\u00e8ge, Belgium<br><sup>2<\/sup> Utrecht Institute for Pharmaceutical Sciences, Div. Pharmacology, Utrecht University, The Netherlands<br><sup>3<\/sup> Innovative Testing in Life Sciences &amp; Chemistry, Utrecht University of Applied Sciences, The Netherlands<br><sup>4<\/sup> Skeletal Biology and Engineering Research Center, KU Leuven, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P34<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Ecotoxicological Evaluation of Bisphenol A and alternatives: A Comprehensive in silico Modelling Approach<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Liadys Mora Lagares<\/span><\/span><sup>P1<\/sup>, Marjan Vra\u010dko<sup>1<\/sup><br><sup>1<\/sup> National Institute of Chemistry<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P35<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Development of a generic physiologically based kinetic model to compare internal exposure to organophosphate pesticides in rats and humans<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Thijs Moerenhout<\/span><\/span><sup>P1<\/sup>, Jiaqi Chen<sup>1<\/sup>, Hans Bouwmeester<sup>1<\/sup>, Ivonne M.C.M. Rietjens<sup>1<\/sup>, Nynke I. Kramer<sup>1<\/sup><br><sup>1<\/sup> Division of Toxicology, Wageningen University and Research<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P36<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Mapping Physiology As A Basis For Building Disease Ontology Maps<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Bernard Staumont<\/span><\/span><sup>P1<\/sup>, Luiz Ladeira<sup>1<\/sup>, Alessio Gamba<sup>1<\/sup>, Anouk Verhoeven<sup>2<\/sup>, Julen Sanz Serrano<sup>2<\/sup>, Eli\u0161ka Kuchovsk\u00e1<sup>3<\/sup>, Job Berkhout<sup>4<\/sup>, Devon A. Barnes<sup>5<\/sup>, Manoe J. Janssen<sup>5<\/sup>, Marc Teunis<sup>6<\/sup>, Thomas H. Luechtefeld<sup>7<\/sup>, Thomas Hartung<sup>8<\/sup>, Ramiro Jover<sup>9<\/sup>, Tamara Vanhaecke<sup>2<\/sup>, Ellen Fritsche<sup>10<\/sup>, Harm J. Heusinkveld<sup>4<\/sup>, Aldert Piersma<sup>11<\/sup>, Rosalinde Masereeuw<sup>5<\/sup>, Mathieu Vinken<sup>2<\/sup>, Liesbet Geris<sup>12<\/sup><br><sup>1<\/sup> Biomechanics Research Unit, GIGA In Silico Medicine, University of Li\u00e8ge, Li\u00e8ge, Belgium<br><sup>2<\/sup> Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Brussels, Belgium<br><sup>3<\/sup> IUF &#8211; Leibniz Research Institute for Environmental Medicine, D\u00fcsseldorf, Germany<br><sup>4<\/sup> Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands<br><sup>5<\/sup> Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands<br><sup>6<\/sup> Innovative Testing in Life Sciences &amp; Chemistry, University of Applied Sciences Utrecht, The Netherlands<br><sup>7<\/sup> ToxTrack, Baltimore, MD, USA<br><sup>8<\/sup> Center for Alternatives to Animal Testing (CAAT) &#8211; Europe, University of Konstanz, Germany; CAAT, Johns Hopkins University, Baltimore, MD, USA; Johns Hopkins University, Doerenkamp-Zbinden Chair for Evidence-based Toxicology, Baltimore, MD, USA<br><sup>9<\/sup> Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Universidad de Valencia, Valencia, Spain; Experimental Hepatology and Liver Transplant Unit, Health Research Institute La Fe, Valencia, Spain; Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain<br><sup>10<\/sup> IUF &#8211; Leibniz Research Institute for Environmental Medicine, D\u00fcsseldorf, Germany; Medical Faculty, Heinrich-Heine University, D\u00fcsseldorf, Germany<br><sup>11<\/sup> Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands<br><sup>12<\/sup> Biomechanics Research Unit, GIGA In Silico Medicine, University of Li\u00e8ge, Li\u00e8ge, Belgium; Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P37<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>In silico prediction and real-life exposure to a chemical mixture of pesticides<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Yana Kolianchuk<\/span><\/span><sup>P1<\/sup>, Inna&nbsp; Rashkivska<sup>1<\/sup>, Mojmir Mach<sup>1<\/sup><br><sup>1<\/sup> Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovakia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P38<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>In Silico Predictions of Toxicological Effects and Real-Life Exposure Risks of Common Food Additives<\/a><\/h3>\n\n\n\n<p>Inna Rashkivska<sup>P1<\/sup>, Yana Kolianchuk<sup>1<\/sup>, Mojmir Mach<sup>1<\/sup><br><sup>1<\/sup> Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovakia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P209<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Prediction of bird reproduction study endpoints via toxicokinetic-toxicodynamic modelling of in ovo exposure data<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">David Heckmann<\/span><\/span><sup>P1<\/sup>, Thomas Martin<sup>2<\/sup>, Barbara Bauer<sup>2<\/sup>, Vanessa Baier<sup>3<\/sup>, Alicia Paini<sup>3<\/sup>, Stephan Schaller<sup>3<\/sup>, Patrick Hubbard<sup>4<\/sup>, Markus Ebeling<sup>1<\/sup>, Andr\u00e9 Gergs<sup>1<\/sup><br><sup>1<\/sup> Bayer AG, Crop Science Division, Monheim, Germany<br><sup>2<\/sup> Rifcon GmbH, Goldbeckstra\u00dfe 13, 69493 Hirschberg an der Bergstra\u00dfe, Germany<br><sup>3<\/sup> esqLABS GmbH, Am Sportplatz 7, 26683 Saterland, Germany<br><sup>4<\/sup> Eurofins EAG Agroscience, LLC, Easton, MD, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p>  <a href=\"#Goback\" class=\"ek-link\">Go back<\/a>  <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#medical-devices\">In vitro and in silico methods for safety assessment of medical devices<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P39<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Exploring the acceptance of non-animal methods within the global regulatory landscape of medical devices<\/a><\/h3>\n\n\n\n<p>Charlotte Laupheimer<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Arne Jaksch<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Department of Biocompatibility and Toxicology, JAKSCH LIFESCIENCE CONSULTING GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P40<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>New Approach Methods for Challenging Toxicological Risk Assessments of Medical Devices: A Case Study of Phenyl Propyl Carbonate<\/a><\/h3>\n\n\n\n<p>Charlotte Laupheimer<sup>1<\/sup>, Shaheena Parween<sup>1<\/sup>, Yana&nbsp; Kolianchuk<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Arne Jaksch<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Department of Biocompatibility and Toxicology, JAKSCH LIFESCIENCE CONSULTING GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P41<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>IN VITRO EVALUATION OF ABSORPTION PROFILE AND EFFICACY OF LACTOFERRIN CONTAINED IN A NASAL SPRAY FORMULATION<\/a><\/h3>\n\n\n\n<p>Alessandra Zerboni<sup>1<\/sup>, Sara Stoilova<sup>1<\/sup>, Daniele Colombo<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Michela Mori<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> 1MED SA, Via Campagna 13, CH-6982 Agno Switzerland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P42<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>IN VITRO EVALUATION OF INNOVATIVE BIOMATERIALS FOR TISSUE ENGINEERING: WHEY PROTEIN ISOLATE AND CHITOSAN DERIVATES INTERACTION PRODUCTS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Daiana Ianev<\/span><\/span><sup>P1<\/sup>, Barbara Vigani<sup>1<\/sup>, Michela Mori<sup>2<\/sup>, Caterina Valentino<sup>1<\/sup>, Marco Ruggeri<sup>1<\/sup>, Giuseppina Sandri<sup>1<\/sup>, Silvia Rossi<sup>1<\/sup><br><sup>1<\/sup> Department of Drug Science, University of Pavia, Via T. Taramelli 12, 27100, Pavia<br><sup>2<\/sup> 1MED SA, Via Campagna 13, CH-6982 Agno Switzerland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P43<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>IN VITRO IRRITATION OF MEDICAL DEVICES INTENDED FOR APPLICATION TO THE ORAL, VAGINAL OR RECTAL MUCOSA<\/a><\/h3>\n\n\n\n<p>Barbara De Servi<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Christian Pellevoisin<\/span><\/span><sup>P2<\/sup>, Marisa Meloni<sup>3<\/sup><br><sup>1<\/sup> VitroScreen, Milan, Italy<br><sup>2<\/sup> Urbilateria, Tours, France<br><sup>3<\/sup> VitroScreen<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P44<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>USE OF AN IN VITRO-TO-IN VIVO EXTRAPOLATION (IVIVE) APPROACH TO DERIVE COMPOUND-SPECIFIC TOLERABLE iINTAKE (TI) VALUES FOR PHTHALATE ESTERS<\/a><\/h3>\n\n\n\n<p>Anh Nguyen<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ronald Brown<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Risk Science Consortium, LLC<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P45<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Development of an in vitro test method for irritation of medical devices used in the oral cavity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marek Puskar<\/span><\/span><sup>P1<\/sup>, Jennifer Molignano<sup>2<\/sup>, Christian Pellevoisin<sup>2<\/sup>, Silvia Letasiova<sup>1<\/sup>, Mitchell Klausner<sup>2<\/sup><br><sup>1<\/sup> MatTek In Vitro Life Science Laboratories, Mlynske nivy 73, 821 05 Bratislava, Slovakia<br><sup>2<\/sup> MatTek Corporation, 200 Homer Ave, MA 01721&nbsp; Ashland, Massachusetts, United States of America<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P46<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Identification of compounds with weak skin irritation potential using human 3D reconstructed epidermis model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jan Markus<\/span><\/span><sup>P1<\/sup>, Jana Halajova<sup>1<\/sup>, Lenka Hudecova<sup>1<\/sup>, Christian Pellevoisin<sup>2<\/sup>, Marek Puskar<sup>1<\/sup>, Mitchell Klausner<sup>2<\/sup>, Silvia Letasiova<sup>1<\/sup><br><sup>1<\/sup> MatTek In Vitro Life Science Laboratories, Mlynske Nivy 73, 82105 Bratislava, Slovakia<br><sup>2<\/sup> MatTek Corporation, 200 Homer Ave, Ashland, MA, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P47<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Integrated Risk Assessment and Compliance Strategies for Nanomaterials in Medical Devices<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Chiara Gazerro<\/span><\/span><sup>P1<\/sup>, Maria Labianca<sup>1<\/sup>, Carla&nbsp; Landolfi<sup>1<\/sup><br><sup>1<\/sup> ToxHub Srl<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p>   <a href=\"#Goback\" class=\"ek-link\">Go back<\/a>   <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#In%20vitro%20systems%20to%20assess%20respiratory%20toxicity\">In vitro systems to assess respiratory toxicity<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P48<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Dosing concepts in air-liquid interface (ALI) in vitro inhalation approaches.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Detlef Ritter<\/span><\/span><sup>P1<\/sup>, Tanja Hansen<sup>1<\/sup><br><sup>1<\/sup> Fraunhofer ITEM, Hannover, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P49<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>The effects of nicotine base on oxidative stress and autophagy in the alveolar-capillary barrier in vitro show similarities with the pathophysiological features of COPD<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Amelia-Naomi SABO<\/span><\/span><sup>P1<\/sup>, Emma FILAUDEAU<sup>1<\/sup>, Guillaume BECKER<sup>1<\/sup>, Laurent&nbsp; MONASSIER<sup>1<\/sup>, V\u00e9ronique KEMMEL<sup>1<\/sup><br><sup>1<\/sup> Laboratoire de Pharmacologie et Toxicologie Neurocardiovasculaire, University of Strasbourg, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P50<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>ADVANCING AEROSOL NANOPARTICLE CYTOTOXICITY ASSESSMENT THROUGH A NOVEL &#8220;CELLS ON PARTICLES&#8221; IN VITRO MODEL<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Edvinas Krugly<\/span><\/span><sup>P1<\/sup>, Edvardas Bagdonas<sup>2<\/sup>, Jovil\u0117 Raudoni\u016bt\u0117<sup>2<\/sup>, Preethi Ravikumar<sup>1<\/sup>, Aist\u0117 Pupi\u016bt\u0117<sup>1<\/sup>, Darius \u010ciu\u017eas<sup>1<\/sup>, Tadas Prasauskas<sup>1<\/sup>, R\u016bta Aldonyt\u0117<sup>2<\/sup>, Dainius Martuzevi\u010dius<sup>1<\/sup><br><sup>1<\/sup> Faculty of Chemical Technology, Kaunas University of Technology, Lithuania<br><sup>2<\/sup> Centre for Innovative Medicine, Vilnius, Lithuania<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P51<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Evaluation of the predictiveness of the acellular inhalation bioaccessibility test of ultrafine combustion particle-bound polycyclic aromatic hydrocarbons for assessing particulate matter lung toxicity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Albana Boutamba Mbina<\/span><\/span><sup>P1<\/sup>, Tiphaine Rogez-Florent<sup>2<\/sup>, Christelle Monteil<sup>2<\/sup><br><sup>1<\/sup>&nbsp;&nbsp; Univ Rouen Normandie, Universit\u00e9 Caen Normandie, Normandie Univ, ABTE UR 4651, F-76000 Rouen, France<br><sup>2<\/sup> Univ Rouen Normandie, Universit\u00e9 Caen Normandie, Normandie Univ, ABTE UR 4651, F-76000 Rouen, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P52<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Chemical analysis and cytotoxicity studies of different berry e-liquid flavors according to two exposure methods on an alveolar-capillary barrier cell model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Emma Filaudeau<\/span><\/span><sup>P1<\/sup>, Amelia-Naomi&nbsp; Sabo<sup>1,2<\/sup>, Anita&nbsp; Lebert <sup>1<\/sup>, Laurent&nbsp; Monassier<sup>1<\/sup>, V\u00e9ronique&nbsp; Kemmel<sup>1,2<\/sup><br><sup>1<\/sup> Laboratoire de Pharmacologie et Toxicologie Neurocardiovasculaire, UR 7296, Facult\u00e9 de M\u00e9decine&nbsp; de Ma\u00efeutique et des M\u00e9tiers de la Sant\u00e9, Centre de Recherche en Biom\u00e9decine de Strasbourg (CRBS),&nbsp; 67085, Strasbourg, France<br><sup>2<\/sup> Laboratoire de Biochimie et Biologie Mol\u00e9culaire, H\u00f4pitaux Universitaires de Strasbourg, 67200,&nbsp; Strasbourg, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P53<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Assessing lung metabolic competency for in vitro inhalation toxicology applications: a single-cell RNA sequencing strategy<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nuria Roldan<\/span><\/span><sup>P1<\/sup>, Vivek S Patel<sup>2<\/sup>, Joseph Hughes<sup>2<\/sup>, M\u00e9ry Marimoutou<sup>2<\/sup>, Jose Alvarez<sup>2<\/sup>, McKenzie Obermok<sup>2<\/sup>, Carlos Rodriguez<sup>2<\/sup>, Thomas Kallarakal<sup>2<\/sup>, Andreas O Stucki<sup>1<\/sup>, Amy J Clippinger<sup>1<\/sup>, Holger P Behrsing<sup>2<\/sup><br><sup>1<\/sup> PETA Science Consortium International e.V., Stuttgart, DE<br><sup>2<\/sup> Institute for In Vitro Sciences, Inc., Gaithersburg, MD, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P54<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Advanced immunocompetent in vitro primary human lung models for toxicity assessment and infectious disease research<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Samuel Constant<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Epithelix<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P55<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>TOXICITY OF REAL-WORLD SUBWAY EMISSIONS IN A MOBILE ALI EXPOSURE MODEL<\/a><\/h3>\n\n\n\n<p>Micol Introna<sup>P1<\/sup>, Ana T.&nbsp; Ju\u00e1rez-Facio<sup>1<\/sup>, Sarah S. Steimer<sup>1<\/sup>, Minghui Tu<sup>2<\/sup>, Ulf Olofsson <sup>2<\/sup>, Hanna L.&nbsp; Karlsson<sup>3<\/sup>, N. V. Srikanth&nbsp; Vallabani<sup>3<\/sup>, Karine Elihn<sup>1<\/sup><br><sup>1<\/sup> Stockholm University<br><sup>2<\/sup> KTH Royal Institute of Technology<br><sup>3<\/sup> Institute of Environmental Medicine, Karolinska Institutet<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P56<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>In situ exposure of human lung epithelial cells cultured in air-liquid interface to assess effect of air pollution of different influences<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Suen Boul\u00e9<\/span><\/span><sup>P1<\/sup>, Fabrice Cazier<sup>2<\/sup>, Dominique Courcot<sup>1<\/sup>, Yann Landkocz<sup>1<\/sup><br><sup>1<\/sup> Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant, UCEiV UR4492, Univ. Littoral C\u00f4te d\u2019Opale (ULCO), Dunkerque, France.<br><sup>2<\/sup> Centre Commun de Mesures, Univ. Littoral C\u00f4te d\u2019Opale (ULCO), Dunkerque, France.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P57<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Impact of airborne particulate matter from port, industrial and urban areas on epithelial-to-mesenchymal transition on lung cells.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Yann Landkocz<\/span><\/span><sup>P1<\/sup>, Margaux Cochard<sup>1<\/sup>, Fr\u00e9deric Ledoux<sup>1<\/sup><br><sup>1<\/sup> Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant, UCEiV UR4492, Univ. Littoral C\u00f4te d\u2019Opale (ULCO), Dunkerque, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P58<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DEVELOPMENT OF A MOBILE ALI EXPOSURE SYSTEM FOR TOXICITY TESTING OF EMISSIONS FROM DIFFERENT TRANSPORTATION MODES<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ana Teresa Ju\u00e1rez Facio<\/span><\/span><sup>P1<\/sup>, Micol Introna<sup>1<\/sup>, Sara S. Steimer<sup>1<\/sup>, Karine Elihn<sup>1<\/sup><br><sup>1<\/sup> Stockholm University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P59<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>An integrated human-in vitro approach to explore the role of miRNAs in the allergic asthma<\/a><\/h3>\n\n\n\n<p>Valentina Galbiati<sup>1<\/sup>, Filippo Liviero<sup>2<\/sup>, Gloria Melzi<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Francesca Carlotta Passoni<\/span><\/span><sup>P1<\/sup>, Emanuela Corsini<sup>1<\/sup>, Marina Marinovich<sup>1<\/sup><br><sup>1<\/sup> Universit\u00e0 degli Studi di Milano<br><sup>2<\/sup> Azienda Ospedale &#8211; Universit\u00e0 di Padova<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P60<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Effects of repeated exposure of human 3D bronchial tissue to fresh smoke and aerosol from heated tobacco products and electronic vapour products<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sarah Jean Pour<\/span><\/span><sup>P1<\/sup>, Roman Wieczorek<sup>1<\/sup>, Edgar Trelles Sticken<sup>1<\/sup>, Fiona Chapman<sup>2<\/sup>, Liam Simms<sup>2<\/sup>, Matthew Stevenson<sup>2<\/sup><br><sup>1<\/sup> Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company<br><sup>2<\/sup> Imperial Brands PLC<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P61<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Assessment of a Heated Tobacco Product in the ToxTracker and ToxProfiler assays reveal marked reductions in biological activity compared to a combustible cigarette<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ourania Komini<\/span><\/span><sup>P1<\/sup>, Remco&nbsp; Derr<sup>2<\/sup>, Inger&nbsp; Brandsma<sup>2<\/sup>, Bas&nbsp; ter Braak<sup>2<\/sup>, Liesanne&nbsp; Wolters<sup>2<\/sup>, Edgar Trelles&nbsp; Sticken<sup>3<\/sup>, Roman&nbsp; Wieczorek<sup>3<\/sup>, Sarah&nbsp; Jean Pour<sup>3<\/sup>, Fiona&nbsp; Chapman<sup>1<\/sup>, Liam Simms<sup>1<\/sup>, Matthew Stevenson<sup>1<\/sup><br><sup>1<\/sup> Imperial Brands PLC<br><sup>2<\/sup> Mimetas BV<br><sup>3<\/sup> Reemtsma Cigarettenfabriken GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P62<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>MULTIPLEX ENDPOINT FOR LONGITUDINAL CHARACTERIZATION OF OXIDATIVE STRESS USING IN VITRO 3D LUNG EPITHELIAL CULTURES<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jorge Pereira<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> PMI R&amp;D, Philip Morris Products S.A., Switzerland.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P63<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Contemporary in vitro Toxicology Assessment of a Novel Herbal Heated Product (HHP) Compared to Cigarette Smoke<\/a><\/h3>\n\n\n\n<p>Emma Bishop<sup>1<\/sup>, Fan Yu<sup>1<\/sup>, Stela Bozhilova<sup>1<\/sup>, Fabio Miazzi<sup>1<\/sup>, Yihe Li<sup>1<\/sup>, Lauren Smith<sup>1<\/sup>, David&nbsp; Smart<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Damien Breheny<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> B.A.T. (Investments) Ltd.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P64<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EXPLORING THE POTENTIAL OF EPIGENOTOXICITY TO ASSESS RESPIRATORY EFFECTS OF NANOMATERIALS TOWARDS THEIR RISK ASSESSMENT AND REGULATION<\/a><\/h3>\n\n\n\n<p>C\u00e9lia Ventura<sup>1,2<\/sup>, Lu\u00eds Vieira<sup>1,2<\/sup>, Catarina&nbsp; C. Silva<sup>1,2<\/sup>, Henriqueta Louro<sup>1,2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Maria Jo\u00e3o Silva<\/span><\/span><sup>P1,2<\/sup><br><sup>1<\/sup> National Institute of Health Doutor Ricardo Jorge (INSA), Department of Human Genetics, Lisbon, Portugal<br><sup>2<\/sup> Centre for Toxicogenomics and Human Health (ToxOmics), NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P65<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>FLAVOURS IN E-LIQUIDS \u2013 TOXICOLOGICAL INVESTIGATIONS ON RELEVANT IN VITRO LUNG MODELS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Leonie Gloger<\/span><\/span><sup>P1<\/sup>, Jan Heide<sup>2<\/sup>, Sebastian Malke<sup>3<\/sup>, Johannes Becker<sup>1<\/sup>, Evelyn Kuhn<sup>1<\/sup>, Anja Huber<sup>1<\/sup>, Sven Ehlert<sup>2<\/sup>, Selina Rinaldi<sup>3<\/sup>, Elke Pieper<sup>3<\/sup>, Mathilde N. Delaval<sup>1<\/sup>, Ralf Zimmermann<sup>1,2<\/sup><br><sup>1<\/sup> Munich, Germany<br><sup>2<\/sup> Rostock, Germany<br><sup>3<\/sup> Berlin, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P66<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Coupling an atmospheric simulation chamber to an air\/liquid interface cell exposure device to study the toxicity of prenol, a second-generation biofuel, and its ozonolysis products<\/a><\/h3>\n\n\n\n<p>Reem Al Mawla<sup>1,2<\/sup>, C\u00e9cile Coeur<sup>1<\/sup>, Nicolas Houzel<sup>1<\/sup>, Antoine Truffier<sup>2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sylvain Billet<\/span><\/span><sup>P2<\/sup><br><sup>1<\/sup> Laboratoire de Physico-Chimie de l\u2019Atmosph\u00e8re (LPCA), Universit\u00e9 du Littoral C\u00f4t\u00e9 d&#8217;Opale, Dunkerque, France<br><sup>2<\/sup> Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Universit\u00e9 du Littoral C\u00f4te d&#8217;Opale, Dunkerque, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P201<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Use of 3D Airway Tissue Models Cultured from Rat, Primate, or Human Cells for Translational Inhalation Studies<\/a><\/h3>\n\n\n\n<p>Seyoum Ayehunie<sup>1<\/sup>, Robert Jackson<sup>1<\/sup>, Kaitlyn Coen<sup>1<\/sup>, Timothy Landry<sup>1<\/sup>,&nbsp; Jan Markus<sup>2<\/sup>, Silvia Letasiova<sup>2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Emily Reis<\/span><\/span><sup>P2<\/sup>, Alex&nbsp; Armento<sup>1<\/sup><br><sup>1<\/sup> MatTek Corporation, Ashland, MA, USA<br><sup>2<\/sup> MatTek Europe, Bratislava, Slovakia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p>    <a href=\"#Goback\" class=\"ek-link\">Go back<\/a>    <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Knowledge%20sharing%20and%20education\">Knowledge sharing and education<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P67<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A new animal product free defined universal cell culture medium: Easy to use, do-it-yourself and beneficial for 2D and 3D culturing of normal and cancer cells<\/a><\/h3>\n\n\n\n<p>Stina Oredsson<sup>1<\/sup>, Atena&nbsp; Malakpour-Permlid<sup>2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tilo Weber<\/span><\/span><sup>P3<\/sup>, Jeffrey&nbsp; Bajramovic<sup>4<\/sup><br><sup>1<\/sup> Department of Biology, Lund University, Lund, Sweden<br><sup>2<\/sup> Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, Lyngby, Denmark<br><sup>3<\/sup> Animal Welfare Academy of the German Animal Welfare Federation, Neubiberg, Germany<br><sup>4<\/sup> 3Rs Centre Utrecht, Utrecht University, Utrecht, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P68<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Fun with NAMs<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Fran\u00e7ois Busquet<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Altertox academy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P69<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Pioneering a Human-Centric Biology Research Database: The Age of Human Biology-Based Research.<\/a><\/h3>\n\n\n\n<p>Fabrizio Rossi<sup>1<\/sup>, Wynand Alkema<sup>2<\/sup>, Fran\u00e7ois Busquet<sup>3<\/sup>, Tomas Novotny<sup>4<\/sup>, Nils&nbsp; Hijlkema<sup>2<\/sup>, Giuseppe Castro<sup>5<\/sup>, Pierre Deceuninck<sup>6<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marco Straccia<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> FRESCI by SCIENCE&amp;STRATEGY SL<br><sup>2<\/sup> Tenwise BV<br><sup>3<\/sup> AlterTox srl<br><sup>4<\/sup> EcoMole sro<br><sup>5<\/sup> Ready2Use srl<br><sup>6<\/sup> European Commission Joint Research Centre<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P70<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DEVELOPING AND EMBEDDING EDUCATION PROGRAMMES IN CO-CREATION WITH RELEVANT STAKEHOLDERS: THE TRANSITION TO ANIMAL-FREE INNOVATION UTRECHT EXPERIENCE (TPI UTRECHT)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Daniela Salvatori<\/span><\/span><sup>P1,2<\/sup>, Cyrille Krul<sup>3<\/sup>, Anne Kienhuis<sup>4<\/sup>, Merel&nbsp; Ritskes-Hoitinga<sup>1<\/sup>, Paul, L. Carmichael <sup>5<\/sup>, Janneke Hogervorst<sup>6<\/sup><br><sup>1<\/sup> Veterinary Faculty, Utrecht University. The Netherlands<br><sup>2<\/sup> on behalf of Transition to Animal-free Innovations Utrecht<br><sup>3<\/sup> University of Applied Sciences, Utrecht. The Netherlands<br><sup>4<\/sup> RIVM (Dutch National Institute for Public Health and Environment)<br><sup>5<\/sup> Safety and Environmental Assurance Centre, Unilever, United Kingdom<br><sup>6<\/sup> PETA UK, United Kingdom<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P202<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>APPLICATION OF HEPATIC 3D SPHEROID MODEL IN ASSESSMENT OF LONG-TERM REPEAT DOSE HEPATOTOXICITY AND NON-ALCOHOLIC STEATOHEPATITIS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Priyanka Mishra<\/span><\/span><sup>P1<\/sup>, Kirti&nbsp; Shitiz<sup>1<\/sup>, Rahul Date<sup>1<\/sup>, Abhay Deshpande<sup>1<\/sup><br><sup>1<\/sup> Jai Research Foundation, India<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P215<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Promoting ethical science through education: Bridging the gap with the 3Rs<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Axelle Cooreman<\/span><\/span><sup>P1<\/sup>, Tamara Vanhaecke<sup>1<\/sup>, Vera Rogiers<sup>1<\/sup><br><sup>1<\/sup> Laboratory of In Vitro Toxicology and Dermato-cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p> <a href=\"#Goback\" class=\"ek-link\">Go back<\/a>   <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#localtoxicity\">Local toxicity testing (safety and efficacy)<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P71<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>NEW APPROACH METHODOLOGY TO SKIN EVALUATION FOR PESTICIDES: ADVANTAGES AND LIMITATIONS<\/a><\/h3>\n\n\n\n<p>Julio Cesar&nbsp; Cianci<sup>1<\/sup>, Thatiane&nbsp; Nunes Santana<sup>1<\/sup>, Leandro Fernando Felix<sup>2<\/sup>, Let\u00edcia Braggion Bacchin Lara<sup>3<\/sup>, Carla Carolina&nbsp; Munari<sup>1<\/sup>, Bruna&nbsp; Assun\u00e7\u00e3o Bechtold<sup>4<\/sup>, N\u00e1dia Aline&nbsp; Corroqu\u00e9<sup>5<\/sup>, Carlos Alberto&nbsp; Goia<sup>4<\/sup>, Daniela&nbsp; Viana<sup>1<\/sup>, Luis Paulo&nbsp; Fava<sup>6<\/sup>,&nbsp; Marcelo&nbsp; Toledo<sup>7<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Juliana Falcato Vecina<\/span><\/span><sup>P5<\/sup><br><sup>1<\/sup> Laboratory Analyst &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>2<\/sup> Laboratory Assistant &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>3<\/sup> Trainee &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>4<\/sup> Specialist &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>5<\/sup> Researcher &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>6<\/sup> Laboratory Coordinator &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>7<\/sup> Test Facility Manager &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P72<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EYE DAMAGE, WHAT IS THE BEST STRATEGY TO REGULATE MY PESTICIDE?<\/a><\/h3>\n\n\n\n<p>Thatiane&nbsp; Nunes Santana<sup>1<\/sup>, Julio Cesar&nbsp; Cianci<sup>1<\/sup>, Let\u00edcia&nbsp; Braggion Bacchin Lara<sup>2<\/sup>, Leandro&nbsp; Fernando Felix<sup>3<\/sup>, Carla&nbsp; Carolina Munari<sup>1<\/sup>, Bruna&nbsp; Assun\u00e7\u00e3o Bechtold<sup>4<\/sup>, N\u00e1dia Aline&nbsp; Corroqu\u00e9<sup>5<\/sup>, Daniela&nbsp; Viana<sup>1<\/sup>, Luis&nbsp; Paulo Fava<sup>6<\/sup>, Marcelo Toledo<sup>7<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Juliana Falcato Vecina<\/span><\/span><sup>P5<\/sup><br><sup>1<\/sup> Laboratory Analyst &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>2<\/sup> Trainee &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>3<\/sup> Laboratory Assistent &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>4<\/sup> Specialist &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>5<\/sup> Researcher &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>6<\/sup> Coordinator &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>7<\/sup> Test Facility Manager &#8211; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P73<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EPIGENETICS BIOMARKERS TO EVALUATE EARLY TOXICITY EFFECTS:&nbsp; A DERMAL TOXICITY CASE STUDY OF ALUMINUM DIETHYLPHOSPHINATE<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Enzo&nbsp; Zini Moreira Silva<\/span><\/span><sup>P1<\/sup>, Irisdoris Rodrigues de Souza<sup>1<\/sup>, Daniela&nbsp; Fiori Gradia<sup>1<\/sup>, Daniel&nbsp; Pacheco Bruschi<sup>1<\/sup>, Danielle&nbsp; Palma de Oliveira<sup>2,3<\/sup>, Cynthia&nbsp; Bomfim Pestana<sup>1<\/sup>, Daniela&nbsp; Morais Leme<sup>1,3<\/sup><br><sup>1<\/sup> Department of Genetics, Federal University of Parana (UFPR), Curitiba-PR\/Brazil<br><sup>2<\/sup> School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto-SP\/Brazil<br><sup>3<\/sup> National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Institute of Chemistry, Araraquara-SP\/Brazil<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P74<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>SKIN HYDRATION MEASUREMENT: AN IN VITRO APPROACH WITH TEER MEASUREMENT OF HUMAN EPIDERMIS RECONSTRUCTED COMPARED WITH IN VIVO METHODS<\/a><\/h3>\n\n\n\n<p>Guillaume LACOSTE<sup>1<\/sup>, Alexandra&nbsp; DIVET<sup>2<\/sup>, Justine PENNEL<sup>2<\/sup>, Charles REINIER<sup>2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sophie CATOIRE<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> CELL ALTERNATIV, 60350 Trosly Breuil, FRANCE<br><sup>2<\/sup> COSMEPAR, 44000 Nantes, FRANCE<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P75<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DEVELOPMENT OF A METHOD FOR ASSESSING THE IRRITANT AND SOOTHING EFFECT OF GINGIVAL PRODUCTS USING RECONSTRUCTED HUMAN GINGIVAL EPITHELIUM<\/a><\/h3>\n\n\n\n<p>La\u00ebtitia BEAUDEQUIN<sup>1<\/sup>, Adeline JOSSEAUME<sup>1<\/sup>, Fabien GUILLON<sup>2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sophie CATOIRE<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> CELL ALTERNATIV, 60350 Trosly Breuil, FRANCE<br><sup>2<\/sup> STERLAB, 06224 Sophia-Antipolis, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P76<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>RELEVANT END-POINTS TO DEFINE AN IN VITRO STUDY STRATEGY FOR NASAL APPLICATION PRODUCTS USING HUMAN NASAL EPITHELIUM RECONSTRUCTED<\/a><\/h3>\n\n\n\n<p>Adeline JOSSEAUME<sup>1<\/sup>, La\u00ebtitia BEAUDEQUIN<sup>1<\/sup>, Johan GARDERES<sup>2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sophie CATOIRE<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> CELL ALTERNATIV, 60350 Trosly Breuil, FRANCE<br><sup>2<\/sup> LABORATOIRES GILBERT, 14200 Herouville Saint clair, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P77<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>VALORIZING MARINE BYPRODUCTS FOR NUTRACEUTICAL APPLICATION<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Giorgia Allaria<\/span><\/span><sup>P1<\/sup>, Lorenzo Dondero<sup>1<\/sup>, Francesca Tardanico<sup>1<\/sup>, Francesca Rispo<sup>1<\/sup>, Giulia De Negri Atanasio<sup>1<\/sup>, Federica Robino<sup>2<\/sup>, Elisabetta Perata<sup>2<\/sup>, Raffaella Boggia<sup>3<\/sup>, Federica Turrini<sup>3<\/sup>, Rebeca V\u00e1zquez Sobrado<sup>4<\/sup>, Mar\u03afa Mercedes Alonso Mart\u03afnez<sup>4<\/sup>, Celina Costas Iglesias<sup>4<\/sup>, Matteo Zanotti Russo<sup>2<\/sup>, Elena Grasselli<sup>1<\/sup><br><sup>1<\/sup> Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy<br><sup>2<\/sup> Angel Consulting, 20122 Milano, Italy<br><sup>3<\/sup> Department of Pharmacy, University of Genoa, 16148 Genoa, Italy<br><sup>4<\/sup> ANFACO-CECOPESCA, Colexio Universitario, 36310 Vigo, Spain<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P78<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>UPCOMING ADOPTION OF A DEFINED APPROACH FOR EYE HAZARD IDENTIFICATION OF NEAT SOLIDS UNDER OECD TG 467?<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">NATHALIE ALEPEE<\/span><\/span><sup>P1<\/sup>, ELS ADRIAENS<sup>2<\/sup><br><sup>1<\/sup> L&#8217;Oreal R&amp;I<br><sup>2<\/sup> Adriaens Consulting bv<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P79<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>In vitro Hepatotoxicity Test for the Multiple Exposure to Functional Ingredients using AML-12 cells<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sohee LIM<\/span><\/span><sup>P1<\/sup>, Minho SHIN<sup>1<\/sup>, Hoonjeong KWON<sup>1,2<\/sup><br><sup>1<\/sup> Department of Food and Nutrition, Seoul National University, Seoul, Republic of Korea<br><sup>2<\/sup> Research Institute of Human Ecology, Seoul National University, Seoul, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P80<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Unraveling the Interplay of chemicals and UVA Light: Inflammatory Cytokines as biomarkers of photosafety assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Adriana S Maddaleno<\/span><\/span><sup>P1<\/sup>, Elisabet Teixid\u00f3<sup>2<\/sup>, M Pilar Vinardell<sup>1<\/sup>, Montserrat Mitjans<sup>1<\/sup><br><sup>1<\/sup> Fisiologia, Departament de Bioqu\u00edmica i Fisiologia, Universitat de Barcelona, Spain<br><sup>2<\/sup> Toxicologia, Departament de Farmacologia, Toxicologia i Qu\u00edmica Terap\u00e8utica, Universitat de Barcelona, Spain<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P81<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>In vitro tolerance evaluation of cosmetic products: an overview of cutaneous and ocular irritation potential among different product categories<\/a><\/h3>\n\n\n\n<p>Charl\u00e8ne LEJAMTEL<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nathan STOCKMAN<\/span><\/span><sup>P1<\/sup>, Coralie PLACENTI<sup>1<\/sup>, Eva-Anne SUBILEAU<sup>2<\/sup>, Christophe CHESNE<sup>1,2<\/sup><br><sup>1<\/sup> Eurosafe, Parc d\u2019Affaires de la Bret\u00e8che, 35760 Saint-Gr\u00e9goire, France<br><sup>2<\/sup> Biopredic International, Parc d\u2019Affaires de la Bret\u00e8che, 35760 Saint-Gr\u00e9goire, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P82<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>IN VITRO TEAR FILM INSTABILITY: A NEW PHYSICO-CHEMICAL APPROACH TO EVALUATE EYE DISCOMFORT<\/a><\/h3>\n\n\n\n<p>Laurent Guillet-Revol<sup>1<\/sup>, Swati Kaushik<sup>1<\/sup>, Thanh Pham<sup>1<\/sup>, Koji Endo<sup>2<\/sup>, Masanori Orita<sup>2<\/sup>, Ingrid Gamba<sup>1<\/sup>, Romain Cornet<sup>1<\/sup>, Yoshimune Nonomura<sup>3<\/sup>, Caroline Rouas<sup>1<\/sup>, Fr\u00e9d\u00e9ric Amaral<sup>1<\/sup>, No\u00e9mie de Croz\u00e9<sup>1<\/sup>, Nathalie Al\u00e9p\u00e9e<sup>4<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Fleur Tourneix<\/span><\/span><sup>P5<\/sup><br><sup>1<\/sup> L\u2019Or\u00e9al Research &amp; Innovation, France<br><sup>2<\/sup> L\u2019Or\u00e9al Research &amp; Innovation, Japan<br><sup>3<\/sup> Yamagata University Faculty of Engineering, Japan<br><sup>4<\/sup> L&#8217;Oreal R&amp;I<br><sup>5<\/sup> L&#8217;Or\u00e9al Research &amp; Innovation<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P83<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>3D toxicology models in animal-free nanofibrillar cellulose hydrogels.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Johanna Lampe<\/span><\/span><sup>P1<\/sup>, Darren Heywood<sup>2<\/sup>, Piia Mikkonen<sup>1<\/sup><br><sup>1<\/sup> UPM Biomedicals, Finland<br><sup>2<\/sup> Promega, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P84<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Skin sensitization assessment of pesticide formulations and their active components using the Integrated Testing Strategy<\/a><\/h3>\n\n\n\n<p>Mariela Lenze<sup>1,2<\/sup>, Martina Daniela&nbsp; Benedetti <sup>1,2<\/sup>, Juan Ignacio&nbsp; Pina <sup>3<\/sup>, Julieta&nbsp; Roco<sup>1,2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mar\u00eda Laura Guti\u00e9rrez<\/span><\/span><sup>P1,2<\/sup><br><sup>1<\/sup> National Research and Technological Council of Argentina (CONICET)<br><sup>2<\/sup> Institute of Pharmacology, Buenos Aires University Medical School<br><sup>3<\/sup> Atanor S.C.A<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P85<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Harnessing Fish Side-Streams for Sustainable Cosmetics: The EcoeFISHent Project<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Elena Grasselli<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> University of Genoa<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P86<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Unveiling Lung Cell Responses to Nanolignin Particles Contributing to New Insights<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Dalia de la Fuente-Vivas<\/span><\/span><sup>P1<\/sup>, Emanuela&nbsp; Bellinetto<sup>2<\/sup>, Eleonora&nbsp; Ruffini<sup>2<\/sup>, Sofia P. Makri<sup>3<\/sup>, Sara Collado<sup>1<\/sup>, Tanja&nbsp; Meyer<sup>4<\/sup>, Gianmarco E. Griffini<sup>2<\/sup>, Laura&nbsp; G\u00f3mez-Cuadrado<sup>1<\/sup>, Sonia&nbsp; Martel<sup>1<\/sup>, Roc\u00edo&nbsp; Barros<sup>1<\/sup>, Carlos&nbsp; Rumbo<sup>1<\/sup><br><sup>1<\/sup> University of Burgos-ICCRAM<br><sup>2<\/sup> Politecnico di Milano<br><sup>3<\/sup> Creative Nano PC<br><sup>4<\/sup> Bio Base Europe Pilot Plant<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P87<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Inter-species different effect of anticoagulant rodenticides. An in vitro approach.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">David Hern\u00e1ndez-Moreno<\/span><\/span><sup>P1<\/sup>, Ana Valdehita<sup>1<\/sup>, Azucena Bermejo-Nogales<sup>1<\/sup><br><sup>1<\/sup> Department of Environment and Agronomy, National Institute for Agriculture and Food Research and Technology (INIA, CSIC)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P88<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Technical applicability of polymers to in vitro test methods \u2013 the skin irritation test (SIT)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ayse Aktalay Hippchen<\/span><\/span><sup>P1<\/sup>, Susanne&nbsp; Kolle<sup>1<\/sup>, Dorothee Funk-Weyer<sup>1<\/sup>, Robert Landsiedel<sup>1,2<\/sup><br><sup>1<\/sup> BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany<br><sup>2<\/sup> Free University of Berlin, Pharmacy, Pharmacology and Toxicology, Berlin, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P89<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EpiOcular time-to-toxicity \u2013 a test method for subcategorization of eye irritants<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Silvia Letasiova<\/span><\/span><sup>P1<\/sup>, Lenka Hudecova<sup>1<\/sup>, Jan Markus<sup>1<\/sup>, Yulia Kaluzhny<sup>2<\/sup>, Els Adriaens<sup>3<\/sup>, Mitch Klausner<sup>2<\/sup><br><sup>1<\/sup> MatTek In Vitro Life Science Laboratories, Mlynske Nivy 73, 82105 Bratislava, Slovakia<br><sup>2<\/sup> MatTek Corporation, 200 Homer Ave, Ashland, MA, USA<br><sup>3<\/sup> Adriaens Consulting BVBA, Bellemdorpweg 95, 9981 Aalter, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P90<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>BETULINIC ACID GAMMA-CYCLODEXTRIN SUPRAMOLECULAR SYSTEM \u2013 AN IN VITRO ASSESSMENT ON 2D LUNG CELLS AND 3D RESPIRATORY TISSUE MODEL<\/a><\/h3>\n\n\n\n<p>Iasmina Marcovici<sup>1,2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Iulia Pinzaru<\/span><\/span><sup>P1,2<\/sup>, Cristina Dehelean<sup>1,2<\/sup><br><sup>1<\/sup> Toxicology, Drug Industry, Management and legislation University Clinic, &#8220;Victor Babes&#8221; University of Medicine and Pharmacy from Timisoara, 2 Sq. E. Murgu, 300041, RO<br><sup>2<\/sup> Research Center for Pharmaco-toxicological Evaluations, &#8220;Victor Babes&#8221; University of Medicine and Pharmacy from Timisoara, 2 Sq. E. Murgu, 300041, RO<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P91<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Aerosol Chemistry and in vitro evaluation of a Novel Herbal Heated Product Relative to Cigarette Smoke<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ian Crooks<\/span><\/span><sup>P1<\/sup>, Elinor Marwick<sup>1<\/sup>, Amy Heath<sup>1<\/sup>, Andrew Baxter<sup>1<\/sup>, Maria Pinto<sup>1<\/sup>, Kelly Pereira<sup>1<\/sup>, Simone Hadley<sup>1<\/sup>, Damien Breheny<sup>1<\/sup>, Carolina Garcia-Canton<sup>1<\/sup><br><sup>1<\/sup> B.A.T (Investments) Ltd.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P92<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>c-SRC phosphorylation predicts skin irritation potential of chemicals using a tissue engineered skin model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Md Zobaer&nbsp; Hasan<sup>P1<\/sup><\/span><\/span>, Amy Leigh Harding<sup>2<\/sup>, Hirofumi Nakanishi<sup>1<\/sup>, Kiichiro Sohara<sup>1<\/sup>, Tetsuo Furuno<sup>1<\/sup>, Craig Murdoch<sup>2<\/sup>, Helen Colley<sup>2<\/sup><br><sup>1<\/sup> Rohto Pharmaceutical CO., Ltd<br><sup>2<\/sup> University of Sheffield<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P207<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>In vitro Phototoxicity: Reconstructed Human Epidermis Phototoxicity test method \u2013 OECD 498 \u2013 Blinded Test<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Christina Spohr<\/span><\/span><sup>P1<\/sup>, Markus&nbsp; Schulz<sup>1<\/sup><br><sup>1<\/sup> ICCR-Ro\u00dfdorf GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P213<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EVALUATION OF SKIN CORROSIVITY PREDICTION USING THE 3D RECONSTRUCTED HUMAN EPIDERMIS MODEL, KeraSkin\u2122<\/a><\/h3>\n\n\n\n<p>Jung-Eun&nbsp; Park<sup>1<\/sup>, Jiyoung Lee<sup>2<\/sup>, Sanghee Lee<sup>2<\/sup>, Su-Hyon&nbsp; Lee<sup>1<\/sup>, Lim Kyung-Min<sup>3<\/sup><br><sup>1<\/sup> R&amp;D Institute, Biosolution Co., Ltd., Republic of Korea<br><sup>2<\/sup> Environmental Health Research Department, NIER, Republic of Korea<br><sup>3<\/sup> College of Pharmacy, Ewha Womans University, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p> <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go back<\/a> <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Modelsandmethods\">Models and methods<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P93<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Beyond the Ink: Understanding Cellular and Molecular Effects of Iron-Based Tattoo Pigments on Macrophages<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marianne Vitipon<\/span><\/span><sup>P1<\/sup>, V\u00e9ronique&nbsp; Collin-Faure <sup>1<\/sup>, Bastien&nbsp; Dalzon<sup>1<\/sup>, Thierry&nbsp; Rabilloud <sup>1<\/sup><br><sup>1<\/sup> Chemistry and biology of metals, UMR 5249 CNRS\/CEA\/UGA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P94<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>TOXICOLOGICAL IMPACT OF DEGRADED ORGANIC TATTOO PIGMENTS ON HUMAN CULTURED KERATINOCYTES<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lise Aubry<\/span><\/span><sup>P1<\/sup>, Lucie&nbsp; Breuill\u00e9<sup>1<\/sup>, Thierry Douki<sup>1<\/sup><br><sup>1<\/sup> Univ. Grenoble Alpes, CEA, CNRS, IRIG, SyMMES, F-38000 Grenoble<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P95<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Is Schild method and the Gaddum equation still valid for receptor antagonist research?<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Martin Ezechi\u00e1\u0161<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Institute of Microbiology of the Czech Academy of Sciences, V\u00edde\u0148sk\u00e1 1083, Prague, 142 20, Czech Republic<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P96<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>IMAGE-BASED PHENOTYPIC PROFILING OF FISH GILL CELLS UNDERGOING CHEMICAL EXPOSURE<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Barbara Jozef<\/span><\/span><sup>P1<\/sup>, Sven Mosimann<sup>1,2<\/sup>, Miha Tome<sup>3<\/sup>, Anze Zupanic<sup>3<\/sup>, Kristin Schirmer<sup>1,2,4<\/sup><br><sup>1<\/sup> Eawag: Swiss Federal Institute of Aquatic Science and Technology, D\u00fcbendorf, Switzerland<br><sup>2<\/sup> ETH Zurich: Swiss Federal Institute of Technology, Z\u00fcrich, Switzerland<br><sup>3<\/sup> NIB: National Institute of Biology, Ljubljana, Slovenia<br><sup>4<\/sup> EPFL: Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P97<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Impact of Ellagic Acid and Pomegranate Extract on Oxidative Stress in In Vitro and In Vivo Models<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Francesca Tardanico<\/span><\/span><sup>P1<\/sup>, Giulia&nbsp; De Negri Atanasio<sup>1<\/sup>, Lorenzo Dondero<sup>1<\/sup>, Francesca Rispo<sup>1<\/sup>, Giorgia&nbsp; Allaria<sup>1<\/sup>, Guendalina&nbsp; Olivero<sup>2<\/sup>, Annamaria Pittaluga<sup>2<\/sup>, Federica&nbsp; Turrini<sup>2<\/sup>, Raffaella Boggia<sup>2<\/sup>, Erica Lertora<sup>1<\/sup>, Sara Ferrando<sup>1<\/sup>, Gianluca Damonte<sup>3<\/sup>, Annalisa Salis<sup>3<\/sup>, Katia Cortese<sup>3<\/sup>, Elena Grasselli<sup>1,4<\/sup><br><sup>1<\/sup> Department of Earth, Environment and Life Science, University of Genoa, Italy<br><sup>2<\/sup> Department of Pharmacy, University of Genoa, Genoa, Italy<br><sup>3<\/sup> Department of Experimental Medicine, University of Genoa, Italy<br><sup>4<\/sup> Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P98<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Daphnia magna model in the toxicity assessment of gliotoxin, ochratoxin A and its combination<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Raquel Penalva-Olcina<\/span><\/span><sup>P1,2<\/sup>, Cristina Juan<sup>1<\/sup>, Monica Fern\u00e1ndez-Franz\u00f3n<sup>1<\/sup>, Ana&nbsp; Juan-Garc\u00eda<sup>1<\/sup>, Eeva-Riikka Vehni\u00e4inen<sup>2<\/sup><br><sup>1<\/sup> Laboratory of food Chemistry and Toxicology, University of Valencia<br><sup>2<\/sup> Department of Biological and Environmental Science, University of Jyv\u00e4skyl\u00e4<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P99<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Application of miniaturized Ames assays to assess mutagenicity of nitrosamine impurities<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Csaba Bogl\u00e0ri<\/span><\/span><sup>P1<\/sup>, C\u00e9cile Koelbert<sup>1<\/sup><br><sup>1<\/sup> Xenometrix AG<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P100<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>TOXICITY ASSESSMENT OF HIGH MOLECULAR WEIGHT POLYCYCLIC AROMATIC HYDROCARBONS ISOMERS: A STUDY FROM CYTOTOXICITY TO OXIDATIVE STRESS WITH DNA DAMAGE<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lara Ferreira Azevedo <\/span><\/span><sup>P1<\/sup>, Cecilia&nbsp; Cristina de Souza Rocha <sup>1<\/sup>, Mar\u00edlia Cristina Oliveira Souza <sup>1<\/sup>, Ana Rita Thomazela Machado <sup>1<\/sup>, Paula&nbsp; P\u00edcoli Dev\u00f3z <sup>1<\/sup>, Bruno&nbsp; Alves Rocha <sup>1<\/sup>, Lusania Maria Greggi Antunes <sup>1<\/sup>, Andres&nbsp; Campiglia <sup>2<\/sup>, Fernando&nbsp; Barbosa J\u00fanior <sup>1<\/sup><br><sup>1<\/sup> University of Sao Paulo, School of Pharmaceutical Sciences of Ribeirao Preto, Department of Clinical Analyses, Toxicology, and Food Sciences. Av. do Caf\u00e9 s\/n\u00ba, 14040-903, Ribeirao Preto, Sao Paulo, Brazil<br><sup>2<\/sup> Department of Chemistry, University of Central Florida, Orlando, FL 32816, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#modelsbiomarkerstoxicity\">Models, biomarkers and assays for developmental toxicity<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P101<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Epidemio-Toxicological profile of Colima. RESAS National Strategies in Government of Mexico.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Oliver Mendoza-Cano<\/span><\/span><sup>P1,2<\/sup>, Ana Luz Quintanilla-Montoya<sup>1,2<\/sup>, Irma E. Gonz\u00e1lez-Curiel<sup>3<\/sup>, M\u00f3nica R\u00edos-Silva<sup>1<\/sup>, Octavio Gaspar-Ramirez<sup>4<\/sup>, Andrea&nbsp; Camacho-de la Cruz<sup>5<\/sup>, Maria Fernanda Romo-Garc\u00eda<sup>6<\/sup><br><sup>1<\/sup> Universidad de Colima<br><sup>2<\/sup> CONAHCYT CEIBAAS Colima<br><sup>3<\/sup> Universidad Aut\u00f3noma de Zacatecas<br><sup>4<\/sup> CIATEJ<br><sup>5<\/sup> acamacho.tox@gmail.com<br><sup>6<\/sup> Affmna@gmail.com<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P102<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EVALUATION of EMBRYOTOXICITY of THIRAM with ALTERNATIVE METHODOLOGIES<\/a><\/h3>\n\n\n\n<p>Yu-Chi&nbsp; Ho<sup>1<\/sup>, Chun-Wei&nbsp; Tung<sup>2<\/sup>, Ming-Hsien&nbsp; Tsai<sup>1<\/sup>, Chen-Yi&nbsp; Weng<sup>1<\/sup>, Ju-Hsin&nbsp; Hsu<sup>1<\/sup>, Hsien-Jen&nbsp; Cheng<sup>1<\/sup>, B Linju&nbsp; Yen<sup>3<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Pinpin&nbsp; Lin<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> National Institute of Environmental Health Sciences, National Health Research&nbsp; Institutes, Zhunan, Taiwan, R.O.C.<br><sup>2<\/sup> Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan, R.O.C.<br><sup>3<\/sup> Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan, R.O.C<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P103<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>APPLICATION OF QUANTITATIVE IN VITRO-TO-IN VIVO EXTRAPOLATION TO REPROTRACKER DATA PROVIDES CONSERVATIVE ESTIMATES OF IN VIVO DEVELOPMENTAL TOXICITY<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Amer Jamalpoor<\/span><\/span><sup>P1<\/sup>, Sabine Hartvelt<sup>1<\/sup>, Marjory Moreau<sup>2<\/sup>, Jeffrey Fisher<sup>2<\/sup>, Andy Nong<sup>2<\/sup>, Giel Hendriks<sup>1<\/sup><br><sup>1<\/sup> Toxys B.V.<br><sup>2<\/sup> ScitoVation<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P104<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>NEW APPROACH METHODOLOGIES FOR THE TERATOGENIC POTENTIAL: WHAT IF THE SOLUTION CAME FROM MECHANISTIC NETWORKS?<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Matthew Burbank<\/span><\/span><sup>P1<\/sup>, Florian Gautier<sup>1<\/sup>, Nicky Hewitt<sup>2<\/sup>, Audrey Noel-Voisin<sup>1<\/sup>, Nazanin Golbamaki<sup>1<\/sup>, S\u00e9bastien Gr\u00e9goire<sup>1<\/sup>, Anne Riu<sup>1<\/sup>, Ann Detroyer<sup>1<\/sup>, Typhaine Bringel<sup>1<\/sup>, Laurent Guillet-Revol<sup>1<\/sup>, L\u00e9opold Carron<sup>1<\/sup>, Emilie Le Mevel<sup>1<\/sup>, No\u00e9mie De Croze<sup>1<\/sup>, Gladys Ou\u00e9draogo<sup>1<\/sup><br><sup>1<\/sup> L\u2019Or\u00e9al Research &amp; Innovation, Aulnay-sous-Bois, France<br><sup>2<\/sup> Cosmetics Europe, Brussels, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P105<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A GLOBAL APPROACH TO EVALUATE TERATOGENICITY, THYROID DISRUPTION, AND DEVELOPMENTAL NEUROTOXICITY PRODUCED BY ORGANIC CHEMICALS IN ZEBRAFISH EMBRYOS<\/a><\/h3>\n\n\n\n<p>Andrea Weiner<sup>1<\/sup>, Ander Arbelaiz<sup>1<\/sup>, Christoph Rummel<sup>1<\/sup>, Arantza Muriana<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Celia Rodriguez<\/span><\/span><sup>P<\/sup><br><sup>1<\/sup> BBD BioPhenix S.L.U (Biobide)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P106<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Chemical Mixture Calculator 2.0: A Web-Based Tool Combining Predicted Human Exposures with High-Throughput In Vitro Toxicity Data to Support Mixture Risk Assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ehab Mustafa<\/span><\/span><sup>P1<\/sup>, Veronica von Saint Paul<sup>2<\/sup>, Hilmar Ilgenfritz<sup>2<\/sup>, Martin Scholze<sup>3<\/sup>, Anne Marie Vinggaard<sup>1<\/sup><br><sup>1<\/sup> National Food Institute, Technical University of Denmark, Denmark<br><sup>2<\/sup> Labvantage \u2013 Biomax GmbH, Germany<br><sup>3<\/sup> Centre for Pollution Research and Policy, Environmental Sciences Division, Brunel University London, United Kingdom<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P107<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>High throughput platform for the validation and application of zebrafish embryo for ICH S5 (R3)<\/a><\/h3>\n\n\n\n<p>Claudia&nbsp; Miguel-Sanz<sup>1<\/sup>, Irina Su\u00e1rez <sup>1<\/sup>, Sofia&nbsp; Barreiro<sup>1<\/sup>, Valentina Schiavone<sup>1<\/sup>, Vincenzo Di Donato<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Anna Navarro<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> ZeClinics, SL<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P108<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Bisphenol and its analogues induce neuroinflammation in BV2 microglial cells through the ROS-NF-\u03baB signaling pathway<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jeong Doo Heo<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Korea Institute of Toxicology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P109<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Developmental neurotoxic effects induced by PHMB exposure via oxidative stress mechanism: Integrated approaches with neuronal cells and zebrafish embryo models<\/a><\/h3>\n\n\n\n<p>Ha-Na Oh<sup>1<\/sup>, Donggon&nbsp; Yoo<sup>1<\/sup>, Seungmin&nbsp; Park<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sangwoo Lee<\/span><\/span><sup>P1<\/sup>, Woo-Keun&nbsp; Kim<sup>1<\/sup><br><sup>1<\/sup> Korea Institute of Toxicology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P110<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Cytotoxic and Neurotoxic Effects of Copper Pyrithione and Zinc Pyrithione on Neuronal\/Astrocytic Co-Cultured Cells Through Oxidative Stress<\/a><\/h3>\n\n\n\n<p>Ha-Na Oh<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Woo-Keun Kim<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Korea Institute of Toxicology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P111<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Validation of a human 3D high-throughput vasculogenesis model for developmental toxicity screening<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ashwin Shah<\/span><\/span><sup>P1<\/sup>, Nicholas Dennison<sup>1,2<\/sup>, Maximilian Fusenig<sup>1<\/sup>, Solveig Klier<sup>1<\/sup>, Tina Marie Hauser<sup>1<\/sup>, Linda Sturm<sup>1<\/sup>, Maria Alejandra Ramirez Martinez<sup>1<\/sup>, Jannik Irmai<sup>3<\/sup>, Uwe Freudenberg<sup>1<\/sup>, Carsten Werner<sup>1,3<\/sup><br><sup>1<\/sup> Leibniz Institute of Polymer Research Dresden, 01069 Dresden, Germany<br><sup>2<\/sup> NeuronD, 01307 Dresden, Germany<br><sup>3<\/sup> Technische Unversitaet Dresden<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P112<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>New insight into long-term effects of phthalates microplastics in developing zebrafish: Evidence from genomic alteration and organ development<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Abdulkhalik Mansuri<\/span><\/span><sup>P1<\/sup>, Krupa&nbsp; Kansara<sup>2<\/sup>, Dixit&nbsp; Raiyani<sup>1<\/sup>, Dhairya Mazmudar<sup>1<\/sup><br><sup>1<\/sup> Biological and Life Sciences, School of Arts &amp; Sciences, Ahmedabad University, Central Campus, Navrangpura, Ahmedabad 380009, Gujarat, India<br><sup>2<\/sup> Biological and Engineering Discipline, Indian Institute of Technology \u2013 Gandhinagar (IITGN), Palaj 382355, Gujarat, India<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P211<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>THE METABOLOME OF CELL CULTURE SUPERNATANT AS A PROMISING COMPREHENSIVE BIOMARKER SOURCE FOR IN VITRO TOXICOLOGY<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Christoph Magnes<\/span><\/span><sup>P1<\/sup>, Elmar Z\u00fcgner<sup>1<\/sup>, Fernanda Monedeiro<sup>1<\/sup>, Heinz Hammerlindl<sup>2<\/sup>, Helmut Schaider<sup>2<\/sup><br><sup>1<\/sup> JOANNEUM RESEARCH, Institute for Biomedical Research and Technologies, Graz Austria<br><sup>2<\/sup> Frazer Institute, The University of Queensland, Brisbane, QLD, Australia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P212<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Screening of Developmental Toxicity Using IPSCs for Agrochemicals<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Kathryn Rudd<\/span><\/span><sup>P1<\/sup>, Yeyejide&nbsp; Adeleye<sup>1<\/sup>, Richard Currie<sup>1<\/sup>, Theresa&nbsp; Placke<sup>2<\/sup><br><sup>1<\/sup> Syngenta, Jealott\u2019s Hill International Research Centre, Bracknell, UK<br><sup>2<\/sup> Syngenta Crop Protection AG, Basel, Switzerland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p> <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go back<\/a> <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#modelsbiomarkersdisruption\">Models, biomarkers and assays for endocrine disruption<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P113<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>TIME FRAME COMPARISON IN STEROIDOGENESIS ASSAY<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Andrea RIVERO ARZE<\/span><\/span><sup>P1<\/sup>, Elise&nbsp; GRIGNARD<sup>1<\/sup>, Pauline LELANDAIS<sup>1<\/sup>, Philippe HUBERT<sup>1<\/sup><br><sup>1<\/sup> PEPPER &#8211; Paris (FR)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P114<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EVALUATION OF CYTOTOXICITY AND METABOLISM OF T-2 TOXIN IN HEPATIC SPHEROIDS CULTURED IN MICROFLUIDIC DEVICES<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mercedes Taroncher<\/span><\/span><sup>P1<\/sup>, Jose M. de Hoyos-Vega<sup>2<\/sup>, Alan M. Gonzalez-Suarez<sup>2<\/sup>, Kihak Gwon<sup>2<\/sup>, Yelko Rodr\u00edguez-Carrasco<sup>1<\/sup>, Maria Jose Ruiz<sup>1<\/sup>, Alexander Revzin<sup>2<\/sup><br><sup>1<\/sup> Research Group in Alternative Methods for Determining Toxics Effects and Risk Assessment of Contaminants and Mixtures (RiskTox). Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andr\u00e9s Estell\u00e9s s\/n, 46100, Valencia, Spain<br><sup>2<\/sup> Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P115<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>BUILDING CONFIDENCE IN IN VITRO BATTERIES FOR ENDOCRINE DISRUPTION TESTING<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Vera Engelbrecht<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> PETA Science Consortium International e.V.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P116<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>ASSESSING THE IMPACT OF PHYTOESTROGENS ON SKIN VIA NEXT-GENERATION RISK ASSESSMENT<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Francesca Rispo<\/span><\/span><sup>P1<\/sup>, Lorenzo Dondero<sup>1<\/sup>, Giulia De Negri Atanasio<sup>1<\/sup>, Giorgia Allaria<sup>1<\/sup>, Francesca Tardanico<sup>1<\/sup>, Erica&nbsp; Lertora<sup>1<\/sup>, Ilaria&nbsp; Demori<sup>2<\/sup>, Giosu\u00e8&nbsp; Costa<sup>3<\/sup>, Emanuela Marchese<sup>3<\/sup>, Sim\u00f3n Perera-del-Rosario<sup>4,5<\/sup>, Eva Serrano-Candelas<sup>4<\/sup>, Martina Palomino-Sch\u00e4tzlein<sup>4<\/sup>, Elisabetta&nbsp; Perata<sup>6<\/sup>, Federica&nbsp; Robino<sup>6<\/sup>, Pier Francesco Ferrari<sup>7<\/sup>, Sara Ferrando<sup>1<\/sup>, Matteo Zanotti-Russo<sup>6<\/sup>, Jan Markus<sup>8<\/sup>, Silvia Letasiova<sup>8<\/sup>, Elena Grasselli<sup>9,10<\/sup><br><sup>1<\/sup> Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy<br><sup>2<\/sup> Department of Pharmacy, University of Genoa, Genova, Italy\u202f<br><sup>3<\/sup> Department of Health Sciences, University \u201cMagna Graecia\u201d, 88100 Catanzaro, Italy\u202f<br><sup>4<\/sup> ProtoQSAR SL, Centro Europeo de Empresas Innovadoras (CEEI), Parque Tecnol\u00f3gico de Valencia, 46980 Valencia, Spain<br><sup>5<\/sup> Departament de Medicina i Ci\u00e8ncies de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain\u202f<br><sup>6<\/sup> Angel Consulting S.a.s. 20122 Milano Italy<br><sup>7<\/sup> Department of Civil, Chemical and Environmental Engineering, University of Genoa, via Opera Pia, 15, 16145 Genoa, Italy\u202f&nbsp;&nbsp;&nbsp;<br><sup>8<\/sup> MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia&nbsp;<br><sup>9<\/sup> Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy<br><sup>10<\/sup> Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy&nbsp;<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P117<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>sodium iodide symporter as target for endocrine disruptors &#8211; novel in vitro bioassays with optional biotransformation step<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Puja Kumari<\/span><\/span><sup>P1<\/sup>, Sebastian Lungu&nbsp; Mitea<sup>2,3,4<\/sup>, Ji\u0159\u00ed&nbsp; Nov\u00e1k<sup>1<\/sup>, Kl\u00e1ra&nbsp; Hilscherov\u00e1<sup>1<\/sup><br><sup>1<\/sup> RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic&nbsp;&nbsp;<br><sup>2<\/sup> RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic<br><sup>3<\/sup> Department of Pharmaceutical Biosciences, Drug Safety and Toxicology, Uppsala University (UU), SE-75124 Uppsala, Sweden<br><sup>4<\/sup> Department of Biology and Environmental Science, Linnaeus University (LNU), SE-39182 Kalmar, Sweden<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P118<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>IDENTIFICATION OF MIXTURE RISK DRIVERS OF ANTIANDROGENICITY IN EUROPEAN BLOOD SAMPLES USING HIGH-THROUGHPUT EFFECT-DIRECTED ANALYSIS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Maria Jo\u00e3o Valente<\/span><\/span><sup>P1<\/sup>, Maria Margalef<sup>2<\/sup>, Christina R\u00f8rbye<sup>3<\/sup>, Marja Lamoree<sup>2<\/sup>, Anne Marie Vinggaard<sup>1<\/sup><br><sup>1<\/sup> National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark<br><sup>2<\/sup> Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands<br><sup>3<\/sup> Hvidovre Hospital, Hvidovre, Denmark<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P119<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>CLIMBAZOLE AND BISPHENOL A MIXTURE EFFECT ON STEROIDOGENESIS IN MAMMALIAN CELLS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Dieynaba NDIAYE<\/span><\/span><sup>P1<\/sup>, Myl\u00e8ne LORCIN<sup>1<\/sup>, Marie PERCEAU<sup>1<\/sup>, Flavien DENIS<sup>1<\/sup>, Laurent GATE<sup>1<\/sup><br><sup>1<\/sup> French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), Toxicology and Biomonitoring Division, 1 rue Morvan, F-54519 Vandoeuvre les Nancy, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P120<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Pancreatic beta cell signaling and function disruption by metabolic disrupting chemicals.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Katreece Feiertag<\/span><\/span><sup>P1<\/sup>, Philip&nbsp; Marx-St\u00f6lting<sup>1<\/sup>, Tewes Tralau<sup>1<\/sup><br><sup>1<\/sup> The German Federal Institute for Risk Assessment (BfR)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P121<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Battery of in vitro testing of deiodinases inhibition by thyroid hormone disrupting chemicals and environmental pollutant mixtures<\/a><\/h3>\n\n\n\n<p>Veronika Jane\u010dkov\u00e1<sup>1<\/sup>, Tereza Ne\u0161porov\u00e1<sup>1<\/sup>, Ond\u0159ej&nbsp; Br\u00f3zman<sup>1<\/sup>, Sabina H\u0159ibov\u00e1<sup>1<\/sup>, Ji\u0159\u00ed Nov\u00e1k<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Kl\u00e1ra Hilscherov\u00e1<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Masaryk University, Faculty of Science, RECETOX<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P122<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Refinement of a classical in vitro endocrine activity assay by integrating skin barrier function and skin metabolism to mimic topical application<\/a><\/h3>\n\n\n\n<p>Emery Sylvie<sup>1<\/sup>, Sayah Ines<sup>2<\/sup>, Lereaux Guillaume<sup>2<\/sup>, Viallard Chlo\u00e9<sup>2<\/sup>, Gregoire Sebastien<sup>2<\/sup>, Burbank Matthew<sup>2<\/sup>, Bury Dagmar<sup>3<\/sup>, Rigaudeau Anne-Sophie<sup>4<\/sup>, Rouas Caroline<sup>3<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Grall Romain<\/span><\/span><sup>P1<\/sup>, Riu Anne<sup>1<\/sup><br><sup>1<\/sup> L\u2019Or\u00e9al Research and Innovation, Aulnay-sous-Bois, France<br><sup>2<\/sup> L\u2019Or\u00e9al Research and Innovation, Aulnay-sous-bois, France<br><sup>3<\/sup> L\u2019Or\u00e9al Research and Innovation, Clichy, France<br><sup>4<\/sup> EPISKIN, Lyon, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P123<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Different metabolizing systems improved the informative value of in vitro endocrine disruption assays: a comparative study<\/a><\/h3>\n\n\n\n<p>Emery Sylvie<sup>1<\/sup>, Budin Clemence<sup>2<\/sup>, de Boer Tjalf<sup>2<\/sup>, Brouwer Abraham<sup>2<\/sup>, Lereaux Guillaume<sup>3<\/sup>, Burbank Matthew<sup>3<\/sup>, Gregoire Sebastien<sup>3<\/sup>, Bury Dagmar<sup>4<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Grall Romain<\/span><\/span><sup>P1<\/sup>, Riu Anne<sup>1<\/sup><br><sup>1<\/sup> L\u2019Or\u00e9al Research and Innovation, Aulnay-sous-Bois, France<br><sup>2<\/sup> BioDetection Systems, Amsterdam, The Netherlands<br><sup>3<\/sup> L\u2019Or\u00e9al Research and Innovation, Aulnay-sous-bois, France<br><sup>4<\/sup> L\u2019Or\u00e9al Research and Innovation, Clichy, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P124<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Poly-fluoroalkyl substances (PFASs) detectable in waste of electrical and electronic equipment (WEEE) plants \u2013 preliminary metabolomics and toxicological data from the VAISAL project.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Stefano Lorenzetti<\/span><\/span><sup>P1<\/sup>, Milena Mikhail<sup>1<\/sup>, Laura Di Benedetto<sup>1<\/sup>, Anton Vremere<sup>1<\/sup>, Stefano Di Bona<sup>2<\/sup>, Alessandra Di Veroli<sup>2<\/sup>, Emanuele Artino<sup>2<\/sup>, Carolina Barola<sup>3<\/sup>, Francesca Buiarelli<sup>4<\/sup>, Patrizia Di Filippo<sup>5<\/sup>, Roberta Galarini<sup>3<\/sup>, Franco Lucarelli<sup>6<\/sup>, Simone Moretti<sup>3<\/sup>, Giulia Pazzi<sup>6<\/sup>, Donatella Pomata<sup>5<\/sup>, Carmela Riccardi<sup>5<\/sup>, Gabriele Cruciani<sup>2<\/sup>, Laura Goracci<sup>2<\/sup><br><sup>1<\/sup> ISS &#8211; Istituto Superiore di Sanit\u00e0<br><sup>2<\/sup> University of Perugia<br><sup>3<\/sup> Istituto Zooprofilattico Sperimentale dell\u2019Umbria e delle Marche<br><sup>4<\/sup> University Sapienza of Rome<br><sup>5<\/sup> DIT-INAIL<br><sup>6<\/sup> University of Florence<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P125<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Increases in disinfection byproduct generation potentiate to trigger anti-estrogenic endocrine disruption in zebrafish estrogen receptor alpha<\/a><\/h3>\n\n\n\n<p>Sang-Ah Lee<sup>1<\/sup>, Maranda&nbsp; Esterhuizen<sup>2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Chang Seon Ryu<\/span><\/span><sup>P3<\/sup>, Hyunki&nbsp; Cho<sup>3<\/sup>, Indong Jun<sup>3<\/sup><br><sup>1<\/sup> Jeju National University<br><sup>2<\/sup> University of Helsinki<br><sup>3<\/sup> KIST Europe<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P126<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Adipocytes 3D scaffold free microtissues for toxicology and preclinical applications<\/a><\/h3>\n\n\n\n<p>Francesca Rescigno<sup>1<\/sup>, Francesco Carriero<sup>1<\/sup>, Christian Pellevoisin<sup>2<\/sup>, Marisa Meloni<sup>1<\/sup><br><sup>1<\/sup> VitroScreen, Milan, Italy<br><sup>2<\/sup> Urbilateria, Tours, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P127<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>REPURPOSING TRANSGENDER TESTICULAR TISSUE: ANDROGENIC TESTICULAR ORGANOIDS FOR HIGH-THROUGHPUT APPLICATIONS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Samuel Madureira Silva<\/span><\/span><sup>P1<\/sup>, Guillaume Richer<sup>1<\/sup>, Andrea Errico<sup>2<\/sup>, Katerina Papageorgiou<sup>1,3<\/sup>, Tamara Vanhaecke<sup>3<\/sup>, Ellen Goossens<sup>1<\/sup>, Yoni Baert<sup>1,3<\/sup><br><sup>1<\/sup> Biology of the Testis laboratory &#8211; Genetics, Reproduction and Development, Vrije Universiteit Brussel, Belgium<br><sup>2<\/sup> Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy<br><sup>3<\/sup> In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P128<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Toxicity of microplastics and additives in a complex cellular liver model.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lucas Gaillard<\/span><\/span><sup>P1,2<\/sup>, L\u00e9o&nbsp; Sportes-Milot<sup>1,2<\/sup>, B\u00e9atrice Legrand<sup>1,2<\/sup>, K\u00e9vin&nbsp; Bernal <sup>1,2<\/sup>, Jules&nbsp; Imler<sup>1,2<\/sup>, Etienne Blanc<sup>1,2<\/sup>, Antonietta Messina<sup>3<\/sup>, Jean-Charles Duclos-Vall\u00e9e<sup>3<\/sup>, Xavier&nbsp; Coumoul<sup>1,2<\/sup>, Karine&nbsp; Andr\u00e9au<sup>1,2<\/sup><br><sup>1<\/sup> INSERM UMR-S 1124 &#8211; T3S, environmental Toxicity, Therapeutic Targets, cellular Signaling and Biomarkers, 45 rue des Saints-P\u00e8res, 75006 Paris, France<br><sup>2<\/sup> Universit\u00e9 Paris Cit\u00e9, UFR des Sciences Fondamentales et Biom\u00e9dicales, 45 rue des Saints-P\u00e8res, 75006 Paris, France<br><sup>3<\/sup> INSERM UMR-S 1193, Physiopathog\u00e9n\u00e8se et Traitement des Maladies du Foie, Centre H\u00e9patobiliaire, H\u00f4pital Paul Brousse, 94800 Villejuif, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P129<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Assessment of endocrine disruptor impacts on carbohydrate metabolism in the HepaRG human hepatic cell line<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">K\u00e9vin Bernal<\/span><\/span><sup>P1,2<\/sup>, B\u00e9atrice Le-Grand<sup>2,1<\/sup>, Arnaud T\u00eate<sup>2,1<\/sup>, Min Ji Kim<sup>3,1<\/sup>, Xavier Coumoul<sup>2,1<\/sup>, Etienne Blanc<sup>2,1<\/sup><br><sup>1<\/sup> INSERM UMRS 1124, Team Metatox, Paris, France<br><sup>2<\/sup> Universit\u00e9 Paris Cit\u00e9, Paris, France<br><sup>3<\/sup> Universit\u00e9 Sorbonne Paris Nord, Paris, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P130<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Impact of endocrine disruptors on prostate organoid structure and integrity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jules Imler<\/span><\/span><sup>P1<\/sup>, Amel Ait Mouffok<sup>2<\/sup>, Sylvie Bortoli<sup>1<\/sup>, Stephan&nbsp; Clavel<sup>2<\/sup>, Xavier Coumoul<sup>1<\/sup>, Arnaud T\u00eate<sup>1<\/sup><br><sup>1<\/sup> Inserm UMR S-1124, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France<br><sup>2<\/sup> CNRS UMR 7275, Institut de Pharmacologie Cellulaire et Mol\u00e9culaire, 06560 Valbonne, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P131<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>THYROID HORMONE DISRUPTING POTENTIAL OF ENVIRONMENTAL POLLUTANTS AND SAMPLES ASSESSED BY MOLECULAR-INITIATING EVENTS-BASED IN VITRO SCREENING BATTERY<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jiri Novak<\/span><\/span><sup>P1<\/sup>, Marie Smutna<sup>1<\/sup>, Zuzana Tousova<sup>1<\/sup>, Puja Kumari<sup>1<\/sup>, Saskia Finckh<sup>2,3<\/sup>, Werner Brack<sup>2,3<\/sup>, Klara Hilscherova<sup>1<\/sup><br><sup>1<\/sup> RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic<br><sup>2<\/sup> Department of Effect-Directed Analysis, UFZ \u2013 Helmholtz Centre for Environmental Research, Leipzig, Germany<br><sup>3<\/sup> Department of Evolutionary Ecology and Environmental Toxicology, Faculty of Biological Sciences, Goethe University Frankfurt, Max-Von-Laue-Strasse 13, Frankfurt am Main, 60438, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P132<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DEVELOPMENT OF A HUMAN STEM CELL-BASED IN VITRO MODEL TO ASSESS DEVELOPMENTAL LIVER TOXICITY INDUCED BY THYROID HORMONE DISRUPTORS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lorna Marchandise<\/span><\/span><sup>P1<\/sup>, Robim Marcelino Rodrigues<sup>1<\/sup>, Yoni Baert<sup>1<\/sup>, Tamara Vanhaecke<sup>1<\/sup><br><sup>1<\/sup> In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p>  <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go back<\/a>  <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#modelsbiomarkersimmune\">Models, biomarkers and assays for systemic and immune toxicity<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P133<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Human Cells as New Approach Methodologies for Immunotoxicity Testing<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Victor Johnson<\/span><\/span><sup>P1<\/sup>, Emanuela&nbsp; Corsini<sup>2<\/sup>, Fenna&nbsp; Sill\u00e9<sup>3<\/sup>, Norbert&nbsp; Kaminski<sup>4<\/sup><br><sup>1<\/sup> Burleson Research Technologies, Inc.<br><sup>2<\/sup> Universit\u00e0 degli Studi di Milano<br><sup>3<\/sup> Johns Hopkins University, Bloomberg School of Public Health &amp; Center for Alternatives to Animal Testing<br><sup>4<\/sup> Michigan State University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P134<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>IN VITRO ASSESSMENT OF mRNA-DRUGS OFF-TARGET EFFECTS: FOCUS ON OXIDATIVE STRESS, ENDOPLASMIC RETICULUM STRESS, MITOCHONDRIAL STRESS AND AUTOPHAGY<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Gloria Melzi<\/span><\/span><sup>P1<\/sup>, Valeria Bettinsoli<sup>1,2<\/sup>, Valentina Galbiati<sup>1<\/sup>, Marina Marinovich<sup>1<\/sup>, Emanuela Corsini<sup>1<\/sup><br><sup>1<\/sup> Department of Pharmacological and Biomolecular Science (DiSFeB) \u201cRodolfo Paoletti\u201d, Universit\u00e0 degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.<br><sup>2<\/sup> Department of Pharmacy, Universit\u00e0 degli Studi di Napoli Federico II, Naples, Italy.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P135<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Micro-\/nano-plastics activate the NF-\u03baB pathway in an in vitro model of inflammatory bowel disease.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alice&nbsp; De Groote<\/span><\/span><sup>P1,2<\/sup>, Julie Laloy<sup>2<\/sup>, Vincent&nbsp; Maloteau<sup>2<\/sup>, Jonathan Decarpentrie<sup>1,2<\/sup>, Jean-Michel Dogn\u00e9<sup>1,2<\/sup><br><sup>1<\/sup> Clinical Pharmacology and Toxicology Research Unit (URPC), University of Namur, 5000 Namur, Belgium<br><sup>2<\/sup> Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P136<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Evaluation of the impact of microplastics on neutrophil activation.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alice De Groote<\/span><\/span><sup>P1,2<\/sup>, Jean-Michel Dogn\u00e9<sup>1,2<\/sup>, Jonathan Douxfils<sup>1,2,3<\/sup>, Constant Gillot<sup>1,2<\/sup><br><sup>1<\/sup> Clinical Pharmacology and Toxicology Research Unit (URPC), University of Namur, 5000 Namur, Belgium<br><sup>2<\/sup> Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, Belgium<br><sup>3<\/sup> Qualiblood s.a., QUALIresearch, 5000 Namur, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P137<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Assessment of the respiratory sensitizing potential of substances on in vitro macrophage model<\/a><\/h3>\n\n\n\n<p>Rhamiya Mahendran<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Louis Scott<\/span><\/span><sup>P1<\/sup>, Ewelina&nbsp; Hoffman<sup>1<\/sup>, Victoria Hutter<sup>1,2<\/sup><br><sup>1<\/sup> ImmuONE Limited, Sycamore House, Stevenage, Herts, UK, SG1 2BP\u202f\u202f<br><sup>2<\/sup> Centre for Topical Drug Delivery and Toxicology, University of Hertfordshire, Hatfield, Herts, UK, AL10 9AB\u202f<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P138<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EVALUATION OF SENESCENCE GLYCOBIOMARKERS IN TWO DIFFERENT IN VITRO AGING MODELS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lucia Rackova<\/span><\/span><sup>P1,2<\/sup>, Rebeka Kodrikova<sup>2<\/sup>, Maria Sediva<sup>2<\/sup>, Marek Nemcovic<sup>2<\/sup>, Zuzana Brnoliakova<sup>1<\/sup>, Zuzana Pakanova<sup>2<\/sup><br><sup>1<\/sup> Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, D\u00fabravsk\u00e1 cesta 9, 841 04 Bratislava, Slovak Republic<br><sup>2<\/sup> Institute of Chemistry, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 845 38 Bratislava, Slovak Republic<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P139<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>BIOACTIVE COMPOUNDS EXTRACTED FROM TUNA BY-PRODUCTS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">M\u00aa Mercedes Alonso Mart\u00ednez<\/span><\/span><sup>P1<\/sup>, Rebeca V\u00e1zquez Sobrado<sup>1<\/sup>, Diego M\u00e9ndez Paz<sup>1<\/sup>, Giorgia&nbsp; Allaria<sup>2<\/sup>, Elena Grasselli<sup>2<\/sup>, Celina Costas Iglesias<sup>1<\/sup><br><sup>1<\/sup> ANFACO-CECOPESCA, Ctra Colexio Universitario 16, 36310 Vigo, Spain<br><sup>2<\/sup> Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P140<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Human Cell Line Activation Test (h-CLAT) with alternative experimental design and fluorophores<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Eliska&nbsp; Pacalova<\/span><\/span><sup>P1<\/sup>, Lada Svobodova<sup>1<\/sup>, Marketa Dvorakova<sup>1<\/sup>, Kristina Kejlova<sup>1<\/sup>, Alena Vlkova<sup>1<\/sup>, Marian Rucki<sup>1<\/sup>, Hana Bendova<sup>1<\/sup>, Dagmar Jirova<sup>1<\/sup>, Gabriela Goffova<sup>1<\/sup><br><sup>1<\/sup> Centre of Toxicology and Health Safety, National Institute of Public Health, Prague, Czech Republic<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P141<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>The BMDC model, a performant cell-based test to assess the sensitizing potential and potency of chemicals<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Fabrice Battais<\/span><\/span><sup>P1<\/sup>, Sandrine JACQUENET<sup>1<\/sup>, M\u00e9lanie Mourot-Bousquenaud<sup>1<\/sup><br><sup>1<\/sup> French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p>   <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go back<\/a>   <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#nonanimal\">Non-animal methods for safety testing of biopharmaceuticals\/biotherapies\/vaccines<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P142<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Implementation of primary culture systems to investigate substance related toxicity in steatotic hepatocytes<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tanja Krimmling<\/span><\/span><sup>P1<\/sup>, Anett Ullrich<sup>1<\/sup>, Tim Brecklinghaus<sup>2<\/sup>, Jan G. Hengstler<sup>2<\/sup>, Dieter Runge<sup>1<\/sup><br><sup>1<\/sup> PRIMACYT Cell Culture Technology GmbH, Schwerin, Germany<br><sup>2<\/sup> Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Dortmund, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P143<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>CELL PAINTING ASSAY AS HAZARD ASSESSMENT TOOL IN THE EARLY DRUG DISCOVERY PIPELINE<\/a><\/h3>\n\n\n\n<p>Jeroen&nbsp; Esselink<sup>1<\/sup>, Gurvan&nbsp; Mahe<sup>1<\/sup>, Andre van Marle<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ludovico Buti<\/span><\/span><sup>P1<\/sup>, Peter Imre Racz<sup>1<\/sup><br><sup>1<\/sup> Charles River Laboratories<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P144<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>When high-resolution chemical imaging bridges toxicology testing: the example of PFOA<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Charlotte B. A. Stoffels<\/span><\/span><sup>P1,2<\/sup>, S\u00e9bastien Cambier<sup>2<\/sup>, Tom Wirtz<sup>1<\/sup>, Muriel&nbsp; Mercier-Bonin<sup>3<\/sup>, Arno C. Gutleb<sup>2<\/sup>, Jean-Nicolas Audinot<sup>1<\/sup><br><sup>1<\/sup> Advanced Instrumentation for Nano-Analytics, Materials Research and Technology (MRT) department, Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg<br><sup>2<\/sup> Environmental Health, Environmental Research and Innovation (ERIN) department, Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg<br><sup>3<\/sup> Toxalim, Universit\u00e9 de Toulouse, INRAE, INP-ENVT, INP-EI-Purpan, Universit\u00e9 de Toulouse 3 Paul Sabatier, Toulouse, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P145<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Size-dependent pulmonary mucus penetration and cellular uptake of liposomes: insights for application in pulmonary drug delivery<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Juliana&nbsp; Carrillo Romero<\/span><\/span> <sup>P1,2<\/sup>, Laura&nbsp; Fern\u00e1ndez M\u00e9ndez <sup>2,3,4<\/sup>, Alberto&nbsp; Katsumiti <sup>1<\/sup>, Jes\u00fas&nbsp; Ruiz-Cabello <sup>2,3,5<\/sup>, Susana&nbsp; Carregal Romero <sup>2,3,5<\/sup>, Felipe&nbsp; Go\u00f1i-de-Cerio <sup>1<\/sup><br><sup>1<\/sup> GAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, 48170 Spain<br><sup>2<\/sup> Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebasti\u00e1n, 20014 Spain<br><sup>3<\/sup> CIBER de Enfermedades Respiratorias (CIBERES), Madrid, 28029 Spain<br><sup>4<\/sup> Euskal Herriko Unibertsitatea (UPV\/EHU), Donostia, 20018 Spain<br><sup>5<\/sup> Ikerbasque, Basque Foundation for Science, Bilbao, 48013 Spain<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P146<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DEVELOPMENT OF RECONSTRUCTED INTESTINAL MICRONUCLEI CYTOME (RICYT) ASSAY IN 3D HUMAN GUT MODEL FOR GENOTOXICITY ASSESSMENT OF ORALLY INGESTED SUBSTANCES<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Hui Kheng&nbsp; LIM<\/span><\/span><sup>P1,2<\/sup>, Christopher Owen&nbsp; HUGHES<sup>1,2<\/sup>, Choon Wee Joseph&nbsp; TAN<sup>1<\/sup>, Michelle Jing Sin&nbsp; LIM<sup>2<\/sup>, Jia\u2019En Jasmine&nbsp; LI<sup>3<\/sup>, Moumita&nbsp; RAKSHIT<sup>4<\/sup>, Calvin&nbsp; YEO<sup>3<\/sup>, Kern Rei&nbsp; CHNG<sup>3<\/sup>, Angela&nbsp; LI<sup>3<\/sup>, Joanne Sheot Harn&nbsp; CHAN<sup>3<\/sup>, Kee Woei&nbsp; NG<sup>4,5,6<\/sup>, David Ian&nbsp; LEAVESLEY<sup>2,7<\/sup>, Benjamin Paul Chapman&nbsp; SMITH<sup>1,2<\/sup><br><sup>1<\/sup> Future Ready Food Safety Hub (a joint initiative of A*STAR, SFA &amp; NTU), Nanyang Technological University, Singapore<br><sup>2<\/sup> Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research, Singapore<br><sup>3<\/sup> National Centre for Food Science, Singapore Food Agency, Singapore<br><sup>4<\/sup> School of Materials Science &amp; Engineering, Nanyang Technological University, Singapore<br><sup>5<\/sup> Environmental Chemistry &amp; Materials Centre, Nanyang Environment and Water Research Institute, Singapore<br><sup>6<\/sup> Harvard T. H. Chan School of Public Health, Harvard University, USA<br><sup>7<\/sup> Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research, Singapore<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P147<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Assessing Immune-Related Toxicity Using a 3D In Vitro Hepatotoxic Model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mi-lang Kyun<\/span><\/span><sup>P1<\/sup>, Hyewon Jung<sup>1,2<\/sup>, Inhye Kim<sup>1,3<\/sup>, Ji-in&nbsp; Kwon<sup>1,3<\/sup>, Jeong Ha&nbsp; Kim<sup>1<\/sup>, Ju-Kang&nbsp; Kim<sup>1<\/sup>, Myeongjin&nbsp; Choi<sup>1<\/sup>, Jung Yun&nbsp; Lee<sup>1<\/sup>, Minseong&nbsp; Jo<sup>1,4<\/sup>, Seungyeon&nbsp; Lim<sup>1<\/sup>, Dong Ho&nbsp; Woo<sup>1<\/sup>, Chang Hoon&nbsp; Choi<sup>1<\/sup>, Seo Yule&nbsp; Jeong<sup>1<\/sup>, Hyun-A&nbsp; Oh<sup>1<\/sup>, Ye-Ji&nbsp; Kim<sup>1,2<\/sup>, Yu Yeong&nbsp; Jeong<sup>1,5<\/sup>, Hye-Won&nbsp; Lim<sup>1<\/sup>, Daeui&nbsp; Park<sup>6<\/sup>, Yu Bin Lee<sup>1<\/sup>, Kyoung-Sik&nbsp; Moon<sup>1<\/sup><br><sup>1<\/sup> Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea<br><sup>2<\/sup> Human and Environmental Toxicology, University of Science and Technology, Daejeon 34113, Republic of Korea<br><sup>3<\/sup> Department of Food and Nutrition, Hannam University<br><sup>4<\/sup> Department of Microbiology and Molecular Biology, Chungnam National University<br><sup>5<\/sup> Department of Biological Science, Chungnam National University<br><sup>6<\/sup> Department of Predictive Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P148<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>EVALUATION OF CYTOTOXICITY AND REGENERATION CAPACITY OF ARTSKIN\u2122, A NOVEL HUMAN DERMAL SKIN SUBSTITUTE<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Manuella Godoi<\/span><\/span><sup>P1<\/sup>, Caroline&nbsp; Peruzzi<sup>2<\/sup>, Guilherme&nbsp; Colla<sup>2<\/sup>, Jo\u00e3o&nbsp; Hoepers<sup>1<\/sup>, Janice Koepp<sup>2<\/sup>, Juliano Ferreira<sup>1<\/sup><br><sup>1<\/sup> UFSC<br><sup>2<\/sup> Biocelltis<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P149<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A primary human podocyte assay enables sensitive in vitro detection of dedifferentiation and effacement by high-content imaging<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nicholas&nbsp; Brittain<\/span><\/span><sup>P1<\/sup>, Ben Coker<sup>1<\/sup>, Kirsten Ramsay<sup>1<\/sup>, Kate Gilroy<sup>1<\/sup>, Kathryn Garner<sup>1<\/sup><br><sup>1<\/sup> Newcells Biotech Limited, The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P150<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A high-throughput, human in vitro proximal tubule cell model for drug safety assessment in the kidney.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Keith Pye<\/span><\/span><sup>P1<\/sup>, Jamie Jordan<sup>1<\/sup>, Robert Liang<sup>1<\/sup>, Kathryn Garner<sup>1<\/sup>, Colin&nbsp; Brown<sup>1<\/sup><br><sup>1<\/sup> Newcells Biotech<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P151<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Silkworms as a novel invertebrate model for toxicity testing: bridging the gap between traditional and alternative methods<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Atsushi Miyashita<\/span><\/span><sup>P1<\/sup>, Masaki Ishii<sup>2<\/sup>, Kazuhisa Sekimizu<sup>1<\/sup><br><sup>1<\/sup> Teikyo University<br><sup>2<\/sup> Musashino University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p>   <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go back<\/a>   <\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#nonanimal\">Organ-on-a-chip &amp; Microphysiological Systems<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P152<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A novel exposure device for airborne materials to investigate toxic potential and uptake after inhalation exposure using innovative organ-on-a-chip technology<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tanja Hansen<\/span><\/span><sup>P1<\/sup>, Detlef Ritter<sup>1<\/sup>, Nico Sonnenschein<sup>1<\/sup>, Carsten Brodbeck<sup>2<\/sup>, Cristian&nbsp; Hoyer<sup>3,4<\/sup>, Uwe Marx<sup>4<\/sup>, Katharina Schimek<sup>4<\/sup><br><sup>1<\/sup> Fraunhofer ITEM, Hannover, Germany<br><sup>2<\/sup> Fraunhofer SCAI, Sankt Augustin, Germany<br><sup>3<\/sup> TU Berlin, Berlin, Germany<br><sup>4<\/sup> TissUse GmbH, Berlin, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P153<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>COMPARATIVE STUDY OF SPHEROIDS (3D) AND MONOLAYERS CULTURE (2D) FOR EVALUATING THE TOXICITY OF CYCLOPIAZONIC ACID IN in vitro USING HUMAN NEUROBLASTOMA SH-SY5Y CELLS<\/a><\/h3>\n\n\n\n<p>Carmen Mart\u00ednez-Alonso <sup>1,2<\/sup>, Yelko Rodr\u00edguez-Carrasco<sup>1,2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Maria-Jose Ruiz<\/span><\/span><sup>P1,2<\/sup><br><sup>1<\/sup> Research Group in Alternative Methods for Determining Toxics Effects and Risk Assessment of Contaminants and Mixtures (RiskTox)<br><sup>2<\/sup> Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P154<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>IN VITRO IMMUNE-COMPETENT, VASCULARIZED SKIN MODEL DEVELOPED IN PHYSIOXIA CONDITIONS USING A MICROPHYSIOLOGICAL SYSTEM FOR TESTING AND EVALUATION OF SKIN SENSITIVITY<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Edith&nbsp; Filaire<\/span><\/span><sup>P1,2<\/sup>, Marina Simon<sup>1<\/sup>, Pierre Gaudriault<sup>3<\/sup>, Dario Fassini<sup>3<\/sup>, Christian Poinsot<sup>1<\/sup><br><sup>1<\/sup> ICARE Group<br><sup>2<\/sup> UMR 1019 INRAE-University Clermont-Auvergne<br><sup>3<\/sup> CherryBiotech<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P155<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>TRACK-ETCHED MEMBRANES FOR DRUG PHARMACEUTICAL RESEARCH<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Karina Cuanalo-Contreras<\/span><\/span><sup>P1<\/sup>, Dennis Benkmann<sup>1<\/sup><br><sup>1<\/sup> SABEU GmbH &amp; Co. KG<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P156<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>COMPARATIVE STUDY OF THE IMPACT OF STATIC AND DYNAMIC CULTIVATION CONDITIONS ON THE CYTOTOXICITY INDUCED BY THE MYCOTOXIN PATULIN ON SH-SY5Y SPHEROIDS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Veronica Zingales<\/span><\/span><sup>P1,2,3<\/sup>, Elisa Cimetta<sup>2,3<\/sup>, Mar\u00eda-Jos\u00e9 Ruiz<sup>1<\/sup><br><sup>1<\/sup> Laboratory of Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andr\u00e9s Estell\u00e9s s\/n, 46100, Valencia, Spain.<br><sup>2<\/sup> Department of Industrial Engineering (DII), University of Padua, Via Marzolo 9, 35131, Padova, Italy.<br><sup>3<\/sup> Fondazione Istituto di Ricerca Pediatrica Citt\u00e1 Della Speranza (IRP) \u2013 Lab BIAMET, Corso Stati Uniti 4, 35127, Padova, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p>   <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go back<\/a>    <\/p>\n\n\n\n<h2 class=\"block-heading\"><\/h2>\n\n\n\n<h2 class=\"block-heading\" id=\"other\">Other NAMs relevant topics <\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P157<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DYES UNDER THE REACH REGULATION: A STRATEGY FOR GENOTOXICITY ASSESSMENT USING NAMs<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Elena Campagnoli<\/span><\/span><sup>P1<\/sup>, Monica Locatelli<sup>1<\/sup>, Andrea Mauri<sup>2<\/sup><br><sup>1<\/sup> Kahlberg Consulting srl<br><sup>2<\/sup> Alvascience<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P158<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A CRITICAL REVIEW ON THE UTILISATION AND CHARACTERISATION OF EXTERNAL BIOTRANSFORMATION SYSTEMS IN IN VITRO TOXICOLOGY<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sebastian Lungu-Mitea<\/span><\/span><sup>P1,2,3<\/sup>, Matilda&nbsp; Stein \u00c5slund<sup>4<\/sup>, Inska&nbsp; Reichstein<sup>5<\/sup>, Felipe&nbsp; Vidal<sup>3<\/sup>, Andreas&nbsp; Schiwy<sup>5,6<\/sup>, Henner&nbsp; Hollert<sup>5,6<\/sup>, Miriam Naomi&nbsp; Jacobs<sup>7<\/sup>, Kl\u00e1ra&nbsp; Hilscherov\u00e1<sup>3<\/sup><br><sup>1<\/sup> Linnaeus University, Department of Biology and Environmental Science, Kalmar, Sweden<br><sup>2<\/sup> Uppsala University, Department of Pharmaceutical Biosciences, Toxicology and Drug Safety, Sweden<br><sup>3<\/sup> Masaryk University, Faculty of Science, RECETOX, Brno, Czech Republic<br><sup>4<\/sup> Swedish University of Agricultural Sciences, Department of Forest Mycology and Plant Pathology, Uppsala, Sweden<br><sup>5<\/sup> Goethe University Frankfurt, Department of Evolutionary Ecology and Environmental Toxicology, Germany<br><sup>6<\/sup> Department of Environmental Media Related Ecotoxicology, Fraunhofer Institute for Molecular Biology and Applied Ecology (FhG-IME), Schmallenberg, Germany<br><sup>7<\/sup> UK Health Security Agency, Harwell Science and Innovation Campus, Chilton, OXON, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P159<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Centro 3R: Advancing 3Rs Principles in Education, Research, and Beyond<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Elena&nbsp; Grasselli<\/span><\/span><sup>P1<\/sup>, Arti Ahluwalia <sup>1<\/sup>, Valeria Chiono <sup>1<\/sup>, Paolo Fabene<sup>1<\/sup>, Gianfranco Fiore<sup>1<\/sup>, Monica Mattioli Belmonte <sup>1<\/sup>, Gabriella&nbsp; Nicolini<sup>1<\/sup>, Alberto Rainer<sup>1<\/sup>, Sonia Scarf\u00ec<sup>1<\/sup>, Livia Visai<sup>1<\/sup><br><sup>1<\/sup> 3R Centre, Inter-University Centre for the Promotion of the 3R Principles in Education and Research, University of Pisa, Pisa, Italy.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P160<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>TOWARDS THE APPLICATION OF NEW APPROACH METHODOLOGIES (NAMs) TO FOOD MIXTURES<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Maricel&nbsp; Marin-Kuan<\/span><\/span><sup>P1<\/sup>, Breanne Holmes<sup>1<\/sup>, Paul Rogeboz<sup>1<\/sup>, Helia Latado<sup>1<\/sup>, Anna Voiland<sup>1<\/sup>, Claudine Cottet-Fontannaz<sup>1<\/sup>, Bastien Gentili<sup>1<\/sup>, Julie Mollergues<sup>1<\/sup>, Virginie Bechmann<sup>1<\/sup>, Danilo Basili<sup>1<\/sup>, Amaury Patin<sup>1<\/sup><br><sup>1<\/sup> Soci\u00e9t\u00e9 des Produits Nestl\u00e9<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P161<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Julia Huchthausen<\/span><\/span><sup>P1<\/sup>, Beate I. Escher<sup>1,2<\/sup>, Nico Grasse<sup>3<\/sup>, Maria K\u00f6nig<sup>1<\/sup>, Stephan Beil<sup>4<\/sup>, Luise Henneberger<sup>1<\/sup><br><sup>1<\/sup> Helmholtz Centre for Environmental Research \u2013 UFZ, Department of Cell Toxicology, Permoserstr. 15, 04318 Leipzig, Germany<br><sup>2<\/sup> Eberhard Karls University T\u00fcbingen, Environmental Toxicology, Center for Applied Geosciences, 72076 T\u00fcbingen, Germany<br><sup>3<\/sup> Helmholtz Centre for Environmental Research \u2013 UFZ, Department of Analytical Chemistry, Permoserstr. 15, 04318 Leipzig, Germany<br><sup>4<\/sup> Technische Universit\u00e4t Dresden, Institute of Water Chemistry, 01069 Dresden, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P162<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DEVELOPMENT OF SKINPIX, A HUMAN SKIN PERMEABILITY DATASET<\/a><\/h3>\n\n\n\n<p>Lisa Chedik<sup>1<\/sup>, Shamkhal&nbsp; Baybekov<sup>2<\/sup>, Fr\u00e9d\u00e9ric Cosnier<sup>1<\/sup>, Gilles Marcou<sup>2<\/sup>, Alexandre&nbsp; Varnek<sup>2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Catherine Champmartin<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> Institut national de recherche et de s\u00e9curit\u00e9 pour la pr\u00e9vention des accidents du travail et des maladies professionnelles (INRS), Dept Toxicologie et Biom\u00e9trologie, 1 rue du Morvan, 54519 Vand\u0153uvre-l\u00e8s-Nancy, France<br><sup>2<\/sup> University of Strasbourg, Laboratory of Chemoinformatics UMR 7140 CNRS, 4, rue B. Pascal, Strasbourg 67081, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P163<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Impact of Tiger Nut products on the bioavailability of mycotoxins: An In Vitro Assessment Using Caco-2 Cells<\/a><\/h3>\n\n\n\n<p>Paula Llorens<sup>1<\/sup>, Paloma Arjona-Mudarra<sup>2<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Raquel Penalva-Olcina<\/span><\/span><sup>P1<\/sup>, Olga Pardo<sup>2<\/sup>, Ana Juan-Garc\u00eda<sup>1<\/sup>, Juan Carlos Molt\u00f3<sup>1<\/sup>, Cristina Juan<sup>1<\/sup><br><sup>1<\/sup> Laboratory of Food Chemistry and Toxicology, University of Valencia<br><sup>2<\/sup> Department of Analytical Chemistry, University of Valencia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P164<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Acceleration of scientific confidence-building in non-animal approaches in Germany<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tina Stibbe<\/span><\/span><sup>P1<\/sup>, Annette&nbsp; Bitsch<sup>2<\/sup>, Simin Chelopaz Amini<sup>3<\/sup>, Jan Hengstler<sup>4<\/sup>, Robert Landsiedel<sup>3,5<\/sup>, Marcel Leist<sup>6,7<\/sup>, Andreas Schepky<sup>8<\/sup>, Andreas Stucki<sup>1<\/sup><br><sup>1<\/sup> PETA Science Consortium International e.V., Stuttgart, Germany<br><sup>2<\/sup> Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany<br><sup>3<\/sup> BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany<br><sup>4<\/sup> Technical University Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany<br><sup>5<\/sup> German Toxicology Society (GT e.V.), Mainz, Germany<br><sup>6<\/sup> University of Konstanz, CAAT-Europe, Konstanz, Germany<br><sup>7<\/sup> University of Konstanz, Department of In Vitro Toxicology and Biomedicine, Konstanz, German<br><sup>8<\/sup> Beiersdorf AG, Hamburg, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P165<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>SKIN IRRITATION AND GENOTOXICITY OF MICROFIBRILLATED CELLULOSE AND SILICA NANOPARTICLES<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Juliana Varella Cruz<\/span><\/span><sup>P1,2<\/sup>, Viviana Costa Gagosian<sup>1<\/sup>, Emanoela&nbsp; Lundgren Th\u00e1<sup>1<\/sup>, Washington&nbsp; Luiz Esteves Magalh\u00e3es<sup>3<\/sup>, Pedro Henrique Gonzalez de Cademartori<sup>4<\/sup>, Cynthia&nbsp; Bonfim Pestana<sup>1<\/sup>, Danielle&nbsp; Palma de Oliveira<sup>2<\/sup>, Daniela&nbsp; Morais Leme<sup>1<\/sup><br><sup>1<\/sup> Department of Genetics, Federal University of Paran\u00e1, Curitiba, PR, Brazil<br><sup>2<\/sup> School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, SP, Brazil<br><sup>3<\/sup> Embrapa Florestas, Colombo, PR, Brazil<br><sup>4<\/sup> Graduate Program in Engineering and Science of Materials \u2013 PIPE, Federal University of Paran\u00e1, Curitiba, PR, Brazil<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P166<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Chemical and biological assessment of a Heated Herbal Product reveals marked reductions in aerosol toxicants and in vitro toxicity compared cigarette smoke<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Robert-Daniel Vasile<\/span><\/span><sup>P1<\/sup>, Ourania Komini<sup>1<\/sup>, Georgiana Cava<sup>1<\/sup>, Fiona Chapman<sup>1<\/sup>, Mike Brown<sup>1<\/sup>, Roman Wieczorek<sup>2<\/sup>, Edgar Trelles Sticken<sup>2<\/sup>, Ole Dethloff<sup>2<\/sup>, Liam Simms<sup>1<\/sup>, Matthew Stevenson<sup>1<\/sup><br><sup>1<\/sup> Imperial Brands PLC<br><sup>2<\/sup> Reemtsma Cigarettenfabriken GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P167<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Policy for science in 3Rs: What was done? What is ahead of us? What changes can we expect?<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Francois Busquet<\/span><\/span><sup>P1,2<\/sup>, Leonie K Mueller<sup>3<\/sup><br><sup>1<\/sup> altertox<br><sup>2<\/sup> caat-europe<br><sup>3<\/sup> Altertox<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P168<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>GENOMARK: a transcriptomic biomarker in human HepaRG cells to modernize genotoxicity assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Anouck Thienpont<\/span><\/span><sup>P1<\/sup>, Eunnara&nbsp; Cho<sup>2<\/sup>, Andrew&nbsp; Williams<sup>2<\/sup>, Matthew J. Meier<sup>2<\/sup>, Carole L. Yauk<sup>3<\/sup>, Vera Rogiers<sup>1<\/sup>, Tamara&nbsp; Vanhaecke<sup>1<\/sup>, Birgit Mertens<sup>4<\/sup><br><sup>1<\/sup> Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium<br><sup>2<\/sup> Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada<br><sup>3<\/sup> Department of Biology, University of Ottawa, Ottawa, ON, Canada<br><sup>4<\/sup> Department of Chemical and Physical Health Risks, Sciensano, Juliette Wytsmanstraat 14, 1050 Brussels, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P169<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>ALTERTOX MARKETPLACE: UNITING THE HEROES OF 3RS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">francois busquet<\/span><\/span><sup>P1<\/sup><br><sup>1<\/sup> altertox<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P170<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>The COST Action Networking Activity IMPROVE: 3Rs concepts to improve the quality of biomedical science<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">WINFRIED NEUHAUS<\/span><\/span><sup>P1,2<\/sup><br><sup>1<\/sup> AIT Austrian Institute of Technology GmbH, Competence Unit Molecular Diagnostics, 1210 Vienna, Austria<br><sup>2<\/sup> Danube Private University (DPU), Department of Medicine, 3500 Krems, Austria<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P171<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>In vitro based testing strategy for the identification of non-genotoxic carcinogens<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mariam SALEH<\/span><\/span><sup>P1<\/sup>, Ludovic LE HEGARAT <sup>1<\/sup>, Kevin HOGEVEEN <sup>1<\/sup><br><sup>1<\/sup> ANSES: French Agency for Food, Environmental and Occupational Health and Safety, Fougeres Laboratory, Toxicology of Contaminants Unit, Foug\u00e8res, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P172<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Toxicological assessment of porous silica nanoparticles: cytotoxicity, genotoxicity and immunogenicity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Trisha Patel<\/span><\/span><sup>P1<\/sup>, Zeeshan Ahmad<sup>2<\/sup>, Umakhanth Venkatraman Girija<sup>1<\/sup>, Tarsem Sahota<sup>2<\/sup>, Neenu Singh<sup>1<\/sup><br><sup>1<\/sup> De Montfort University, Leicester School of Allied Health Sciences, Leicester, UK<br><sup>2<\/sup> De Montfort University, Leicester School of Pharmacy, Leicester, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P173<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>CHARACTERIZATION OF HUMAN ISOGENIC EPITHELIAL CELL LINES AS A RELEVANT TOOL TO STUDY COLON CARCINOGENESIS AND INTERACTION BETWEEN GENES AND ENVIRONMENT<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Arnaud T\u00eate<\/span><\/span><sup>P1<\/sup>, Arnaud Liana<sup>2<\/sup>, H\u00e9l\u00e8ne Le Mentec<sup>3<\/sup>, Nathalie Poupin<sup>2<\/sup>, Isabelle Gallais<sup>3<\/sup>, No\u00e9mie Tournade<sup>3<\/sup>, Carolina Duarte-Hospital<sup>1<\/sup>, Yannick Lippi<sup>2<\/sup>, Fanny Mathevet<sup>4<\/sup>, Gaelle Lefort<sup>4<\/sup>, Catherine Lavau<sup>3<\/sup>, Agn\u00e8s Burel<sup>5<\/sup>, Reggie Surya<sup>6<\/sup>, Jerry W. Shay<sup>7<\/sup>, Xavier Coumoul<sup>1<\/sup>, Nathalie Vialaneix<sup>4<\/sup>, Sylvie Bortoli<sup>1<\/sup>, Dominique Lagadic-Gossmann<sup>8<\/sup>, Laurence Huc<sup>9,3<\/sup><br><sup>1<\/sup> INSERM UMRS1124 &#8211; Universit\u00e9 Paris Cit\u00e9<br><sup>2<\/sup> INRAE UMR 1331 ToxAlim<br><sup>3<\/sup> Universit\u00e9 de Rennes &#8211; INSERM &#8211; EHESP &#8211; IRSET &#8211; UMRS 1085<br><sup>4<\/sup> INRAE UR875 MIA-T<br><sup>5<\/sup> Universit\u00e9 de Rennes &#8211; Biosit &#8211; UMS 3480<br><sup>6<\/sup> Department of Food Technology &#8211; Faculty of Engineering &#8211; Bina Nusantara University<br><sup>7<\/sup> Department of Cell Biology &#8211; University of Texas Southwestern Medical Center<br><sup>8<\/sup> Universit\u00e9 de Rennes &#8211; INSERM &#8211; EHESP &#8211; IRSET &#8211; UMR_S 1085<br><sup>9<\/sup> LISIS UMR CNRS INRAE &#8211; Universit\u00e9 Eiffel UGE<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P174<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Comparison of neurotoxic organophosphorous compounds through in vitro determination of the biochemical half maximal inhibitory concentration<\/a><\/h3>\n\n\n\n<p>Manon&nbsp; Verger<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Elsa Cantabella<\/span><\/span><sup>P1<\/sup>, Jennifer Millerioux<sup>1<\/sup>, Anne Boss\u00e9e<sup>2<\/sup><br><sup>1<\/sup> DGA CBRN Defence, Toxicology Department<br><sup>2<\/sup> DGA CBRN Defence, Chemistry Division<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P175<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>A toxic Western diet that causes liver damage can also lead to Alzheimer&#8217;s disease.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Anna Mietelska-Porowska<\/span><\/span><sup>P1<\/sup>, Angelika&nbsp; Wi\u0119ckowska-Gacek<sup>1<\/sup>, Justyna Doma\u0144ska<sup>1<\/sup>, Dominika Tkaczyk<sup>1<\/sup>, Dominik Chutora\u0144ski<sup>1<\/sup>, Urszula Wojda<sup>1<\/sup><br><sup>1<\/sup> Nencki Institue of Experimental Biology Polish Academy of Scences in Warsaw<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P176<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>DRUG INDUCED FATTY LIVER DISEASE (DIFLD): A REVIEW OF THE MOST REPORTED CLINICAL MANIFESTATIONS AND MECHANISMS, AND THEIR CONSISTENCY WITH CURRENT ADVERSE OUTCOME PATHWAYS.<\/a><\/h3>\n\n\n\n<p>Ernesto&nbsp; Lopez<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Anna&nbsp; Rapisarda<\/span><\/span><sup>P1<\/sup>, Ivan Rienda<sup>2<\/sup>, Thomas Luechtefeld<sup>3<\/sup>, Jos\u00e9 Vicente Castell<sup>1<\/sup>, Ramiro Jover<sup>1<\/sup><br><sup>1<\/sup> Joint Research Unit in Experimental Hepatology, University of Valencia, Health Research Institute Hospital La Fe &amp; CIBEREHD, Spain.<br><sup>2<\/sup> Pathological Anatomy Service, La Fe University and Polytechnic Hospital, Valencia, Spain.<br><sup>3<\/sup> ToxTrack, Baltimore, MD, USA.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P177<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Comparing the transcriptomes of Daphnia and zebrafish for the evolutionary conservation of a gene network for fatty liver disease<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Shaleen Glasgow<\/span><\/span><sup>P1<\/sup>, Yavor&nbsp; Hadzhiev<sup>1<\/sup>, Ferenc&nbsp; Mueller<sup>1<\/sup>, John .K Colbourne<sup>1<\/sup><br><sup>1<\/sup> University of Birmingham<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P178<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Applicability of Standard in vitro Alternative Testing Method for Acute Fish Toxicity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jing Yang<\/span><\/span><sup>P1<\/sup>, Xiaoqian Chen<sup>1<\/sup>, Feng Tao<sup>1<\/sup><br><sup>1<\/sup> Shanghai Academy of Public Measurement<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P179<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Exploring the use of NAMs for the identification and characterisation of biomarkers of effect applied in risk assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Georgia Bompola<\/span><\/span><sup>P1<\/sup>, Sara Levorato<sup>1<\/sup>, Lucian Farcal<sup>1<\/sup>, Claudia Rocancio-Pe\u00f1a.<sup>1<\/sup><br><sup>1<\/sup> European Food Safety Authority (EFSA)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P203<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Unlocking the intestinal transport of low molecular mass AGEs: Insights from a new approach methodology<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Xiyu Li<\/span><\/span><sup>P1,2<\/sup>, Sebastiaan Wesseling<sup>1<\/sup>, Yaxin Sang<sup>2<\/sup>, Ivonne Rietjens<sup>1<\/sup><br><sup>1<\/sup> Wageningen University &amp; Research<br><sup>2<\/sup> Hebei Agricultural University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P205<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Investigating the impacts of hyperglycemia and gemcitabine co-exposure on mitochondrial genotype in human lymphoblastoid cell lines<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Shaurya Mathur<\/span><\/span><sup>P1<\/sup>, Katherine Chapman<sup>1<\/sup><br><sup>1<\/sup> In Vitro Toxicology Group, Swansea University, Swansea, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P206<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>Influence of Static and Dynamic Conditions on the Morphology and Viability of Cell and Tissue Cultures<\/a><\/h3>\n\n\n\n<p>J\u00falia&nbsp; Kubalcova<sup>1,2<\/sup>, Peter P\u00f4bi\u0161<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Helena Kandarova<\/span><\/span><sup>P1,2<\/sup><br><sup>1<\/sup> Center of Experimental Medicine, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 841 04 Bratislava, Slovakia<br><sup>2<\/sup> Faculty of Chemical and Food Technology, Slovak Technical University, Radlinsk\u00e9ho 9, 812 37&nbsp; Bratislava, Slovakia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P208<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>PHYSIOLOGICALLY BASED KINETIC MODELING REVEALS AN INFLUENCE OF DOSE AND STRUCTURAL CHARACTERISTICS ON THE RELATIVE POTENCY (REP) VALUES FOR PA N-OXIDES.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Yasser Alhejji<\/span><\/span><sup>P1,2<\/sup>, Frances Widjaja<sup>1<\/sup>, Sebastiaan Wesseling<sup>1<\/sup>, Ivonne Rietjens<sup>1<\/sup><br><sup>1<\/sup> Division of Toxicology, Wageningen University, PO Box 8000, Wageningen, 6700 EA, The Netherlands<br><sup>2<\/sup> Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, 51452, Saudi Arabia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P216<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a>NAMs for EFSA\u2019s Nano regulatory risk assessment<\/a><\/h3>\n\n\n\n<p>Adriana Scattareggia Marchese<sup>1<\/sup>, <span style=\"text-decoration: underline;\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">Maria Chiara Astuto<\/span><\/span><sup>P1<\/sup>, Irene&nbsp; Cattaneo<sup>1<\/sup>, Claudia Roncancio-Pe\u00f1a<sup>1<\/sup><br><sup>1<\/sup> European Food Safety Authority (EFSA)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p>   <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go back<\/a>     <\/p>\n\n\n\n<!--Start of Tawk.to Script-->\n<script type=\"text\/javascript\">\nvar Tawk_API=Tawk_API||{}, Tawk_LoadStart=new Date();\n(function(){\nvar s1=document.createElement(\"script\"),s0=document.getElementsByTagName(\"script\")[0];\ns1.async=true;\ns1.src='https:\/\/embed.tawk.to\/62e8dd7f54f06e12d88c776d\/1g9eq2f9d';\ns1.charset='UTF-8';\ns1.setAttribute('crossorigin','*');\ns0.parentNode.insertBefore(s1,s0);\n})();\n<\/script>\n<!--End of Tawk.to Script-->\n","protected":false},"excerpt":{"rendered":"<p>Instructions for Poster Presenters Please note that unlike what is written in the instructions for poster presentations, you will not&#8230;<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":8017,"menu_order":27,"ping_status":"closed","template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":47,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_searchwp_excluded":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[0],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_core_expirator_enabled":"","_core_expirator_date":"","_yoast_wpseo_redirect":"","rank_math_redirect":"","redirect":"","_core_expirator_redirect_url":"","footnotes":""},"class_list":["post-11120","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages\/11120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/users\/5"}],"version-history":[{"count":20,"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages\/11120\/revisions"}],"predecessor-version":[{"id":15042,"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages\/11120\/revisions\/15042"}],"up":[{"embeddable":true,"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages\/8017"}],"wp:attachment":[{"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/media?parent=11120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}