{"id":14576,"date":"2026-05-01T08:42:46","date_gmt":"2026-05-01T06:42:42","guid":{"rendered":"https:\/\/www.estiv.org\/congress2024\/posters-2\/"},"modified":"2026-05-11T09:24:00","modified_gmt":"2026-05-11T07:24:00","slug":"posters","status":"publish","type":"page","link":"https:\/\/www.estiv.org\/congress2026\/posters\/","title":{"rendered":"Posters"},"content":{"rendered":"\n<h2 class=\"block-heading\">Instructions for Poster Presenters<\/h2>\n\n\n\n<p class=\"has-text-color editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\" style=\"color:#ff0004\">Please note that unlike what is written in the instructions for poster presentations, you will not be required to stand next to your poster during coffee and lunch breaks. There will be two dedicated poster presentation sessions:<\/p>\n\n\n\n<p class=\"has-text-color editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\" style=\"color:#ff0004\"><strong>Even poster numbers<\/strong> (not abstract numbers!) will present on&#8230;&#8230;.<strong> during Poster Session II <\/strong><\/p>\n\n\n\n<p class=\"has-text-color editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\" style=\"color:#ff0004\"><strong>Odd poster numbers<\/strong> will present on <strong>&#8230;&#8230;. June during Poster Session III<\/strong> <\/p>\n\n\n\n<div class=\"block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 block-columns-is-layout-flex\">\n<div class=\"block-column is-layout-flow block-column-is-layout-flow\">\n<div class=\"block-buttons is-layout-flex block-buttons-is-layout-flex\"><\/div>\n<\/div>\n\n\n\n<div class=\"block-column is-layout-flow block-column-is-layout-flow\">\n<div class=\"block-buttons is-layout-flex block-buttons-is-layout-flex\">\n<div class=\"block-button\"><a class=\"block-button__link wp-element-button\" href=\"https:\/\/www.estiv.org\/content\/uploads\/2026\/02\/estiv-2026-poster-speaker-instructions.pdf\">Poster instructions<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"block-column is-layout-flow block-column-is-layout-flow\">\n<div class=\"block-buttons is-layout-flex block-buttons-is-layout-flex\">\n<div class=\"block-button editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\"><a class=\"block-button__link wp-element-button\">Poster list<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"block-separator has-css-opacity\"\/>\n\n\n\n<p class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\"><strong>Poster print service:<\/strong><\/p>\n\n\n\n<p class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\">We offer a convenient local print service through Exposale for all your poster printing needs.<\/p>\n\n\n\n<p class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\"><strong>Pricing:<\/strong><\/p>\n\n\n\n<ul class=\"block-list\">\n<li class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\">The cost for print and onsite delivery is \u20ac&#8230;. excluding VAT if ordered before the deadline of &#8230;&#8230;..<\/li>\n\n\n\n<li class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\">After&nbsp;&#8230;&#8230; please ask a confirmation that the poster can be still printed depending on date of receiving the print file. The price for late poster printing is \u20ac&#8230;.. excluding VAT.<\/li>\n<\/ul>\n\n\n\n<p class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\"><strong>Payment Information:<\/strong><\/p>\n\n\n\n<p class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\">Please note that payment must be completed before the poster is printed. You will receive a payment link from the organiser. Once payment is confirmed, your order will be processed.<\/p>\n\n\n\n<p class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\"><strong>Preparing Print Files for Large Format Prints:<\/strong><\/p>\n\n\n\n<p class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\">To ensure optimal results, please adhere to the following guidelines when preparing your print files:<\/p>\n\n\n\n<ul class=\"block-list editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\">\n<li>All posters must be designed in portrait orientation.<\/li>\n\n\n\n<li>Poster format should be A0 (width: 84.1cm \/ 33.1in; height: 118.9cm \/ 46.8in).<\/li>\n\n\n\n<li>Accepted file type: standard print PDF.<\/li>\n\n\n\n<li>Ensure all print files are ideally 1:1 scale.<\/li>\n\n\n\n<li>Name your print files descriptively for easy identification.<\/li>\n\n\n\n<li>Convert all fonts into curves to avoid font compatibility issues.<\/li>\n\n\n\n<li>Ideal bitmap resolution is 100-150 DPI at final size; additionally, please keep individual file sizes under 100MB if possible.<\/li>\n\n\n\n<li>Include bleeds and correct crop marks for optimal printing.<\/li>\n\n\n\n<li>Use\/send files in CMYK color space only.<\/li>\n<\/ul>\n\n\n\n<p class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\"><strong>Contact Information:<\/strong><\/p>\n\n\n\n<p class=\"editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\">To order your printed poster or for any inquiries, please contact Impreso:<\/p>\n\n\n\n<ul class=\"block-list editorskit-no-desktop editorskit-no-tablet editorskit-no-mobile\">\n<li>Contact persons: Hai Harings &amp; Nico Eerens <\/li>\n\n\n\n<li>Email: <a href=\"mailto:info@impreso.nl\" class=\"ek-link\">info@impreso.nl<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"block-heading\" id=\"topics\">TOPICS<\/h2>\n\n\n\n<p><a href=\"#bio-engineering\" class=\"ek-link\">Bio-engineering, stem cells and disease models <\/a><br><a href=\"#cardiotoxicity\" class=\"ek-link\">Cardiotoxicity and cardiac efficacy models <\/a><br><a href=\"#case_studies\" class=\"ek-link\">Case studies for successful use and implementation of complex in vitro models <\/a><br><a href=\"#challenges\" class=\"ek-link\">Challenges in cosmetics safety<\/a><br><a href=\"#computational\" class=\"ek-link\">Computational toxicology \u2013 in silico modelling, read-across, artificial intelligence and machine learning <\/a><br><a href=\"#echa\" class=\"ek-link\">ECHA, EMA and EFSA perspectives on the use of NAMs <\/a><br><a href=\"#funding\" class=\"ek-link\">Funding the development, validation and implementation of NAMs <\/a><br><a href=\"#silico\" class=\"ek-link\">In vitro and in silico methods for safety assessment of medical devices <\/a><br><a href=\"#respiratory\" class=\"ek-link\">In vitro systems to assess respiratory toxicity<\/a><br><a href=\"#knowledge\" class=\"ek-link\">Knowledge sharing and education <\/a><br><a href=\"#testing\" class=\"ek-link\">Local toxicity testing (safety and efficacy) <br><\/a><a href=\"#developmental\" class=\"ek-link\">Models, biomarkers and assays for developmental toxicity <\/a><br><a href=\"#endocrine\" class=\"ek-link\">Models, biomarkers and assays for endocrine disruption <\/a><br><a href=\"#systemic\" class=\"ek-link\">Models, biomarkers and assays for systemic and immune toxicity <\/a><br><a href=\"#vaccines\" class=\"ek-link\">Non-animal methods for safety testing of biopharmaceuticals\/biotherapies\/vaccines<\/a> <br><a href=\"#organ\" class=\"ek-link\">Organ-on-a-chip &amp; Microphysiological Systems <\/a><br><a href=\"#other\" class=\"ek-link\">Other<\/a> <br><a href=\"#considerations\" class=\"ek-link\">Regulatory considerations for complex NAMs <\/a><br><a href=\"#3r\" class=\"ek-link\">Role of 3R centres in the dissemination and implementation of NAMs <\/a><br><a href=\"#serum\" class=\"ek-link\">Serum-free approaches<\/a> <br><a href=\"#toxicokinetics\" class=\"ek-link\">Toxicokinetics and in vitro \u2013 in vivo extrapolation<\/a><\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"bio-engineering\"><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"http:\/\/'\" class=\"ek-link\">Bio-engineering, stem cells and disease models&nbsp;<\/a><\/span><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P1<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Advanced lung organoids mimicking proximal and distal regions for viral infection and drug screening<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">PhD. Alicia Reyes Valenzuela<\/span><sup>P1,2<\/sup>, PhD. Mark&nbsp; Turner<sup>3<\/sup>, PhD. Silvia Vidal<sup>2<\/sup>, PhD. Luc Mongeau<sup>2<\/sup><br><sup>1<\/sup> PulmonaVat<br><sup>2<\/sup> McGill University<br><sup>3<\/sup> Health Canada<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P2<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Assessment of hepatic fibrosis through impedance technology using a three-dimensional cell model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ye Jin Do<\/span><sup>P1,2<\/sup>, Soojin Kim<sup>1<\/sup>, Jung-Hwa Oh<sup>1,2<\/sup>, Seokjoo Yoon<sup>1,2<\/sup><br><sup>1<\/sup> Korea Institute of Toxicology, Republic of Korea<br><sup>2<\/sup> University of Science and Technology, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P3<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Characterization of stage I retinal organoids: a proteomic approach<\/a><\/h3>\n\n\n\n<p>Sara&nbsp; Tirendi<sup>1,2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Anna Maria&nbsp;Bassi<\/span><sup>P1,2<\/sup>, Mariapaola&nbsp; Nitti<sup>1<\/sup>, Nicole Grinovero<sup>3<\/sup>, Sonia&nbsp; Scarfi<sup>4,2<\/sup>, Serena&nbsp; Mirata<sup>4,2<\/sup>, Mario Passalacqua<sup>1,2<\/sup>, Fabrizio Loiacono<sup>5<\/sup>, Andrea&nbsp; Petretto<sup>3<\/sup>, Stefania Vernazza<sup>1,2<\/sup><br><sup>1<\/sup> Department of Experimental Medicine (DIMES), University of Genoa, Italy.&nbsp;<br><sup>2<\/sup> Italian Center3R<br><sup>3<\/sup> Core Facilities \u2013 Clinical Proteomics and Metabolomics, IRCCS Istituto Giannina Gaslini, Genoa, Italy<br><sup>4<\/sup> Department of Earth, Environment and Life Sciences (DISTAV), University of Genoa, Italy<br><sup>5<\/sup> IRCCS Ospedale Policlinico San Martino, Genoa, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P4<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Chicken-derived R-spondin1, Wnt3a, Nrg1 and FGF1 allow branched growth of embryonal and adult chicken intestinal organoid cultures<\/a><\/h3>\n\n\n\n<p>Jean Paul Ten Klooster<sup>1<\/sup>, Kitty Van Summeren<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Raymond Pieters<\/span><sup>P1<\/sup><br><sup>1<\/sup> University of Applied Sciences Utrecht (UASU)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P5<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Bridging complexity and accessibility: A simplified organoid-derived cell model for advanced in vitro applications<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Kitty van Summeren<\/span><sup>P1<\/sup>, Raymond Pieters<sup>1,2<\/sup>, Jean Paul ten Klooster<sup>1<\/sup><br><sup>1<\/sup> Innovative Testing in Life Sciences and Chemistry (INT), University of Applied Sciences Utrecht (UASU)<br><sup>2<\/sup> Institute for Risk Assessment Sciences, Population Health Sciences Division, Utrecht University, Utrecht<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P6<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Chronic pain in a dish: modelling molecular pain mechanisms for transforming toxicity testing and drug development<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Kathrin Laemmerhirt<\/span><sup>P1<\/sup>, Lisa Maria Haiber<sup>1<\/sup>, Bettina Seeger<sup>1<\/sup><br><sup>1<\/sup> Institute for Food Quality and Food Safety, Research Group Food Toxicology and Alternative\/Complementary Methods to Animal Experiments, University of Veterinary Medicine Hannover, Foundation, 30173 Hannover, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P7<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Reproducible generation of robust human iPSC-derived alveolar macrophage, for in vitro lung toxicology<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Shogo Nagata<\/span><sup>P1<\/sup>, Erik Johansson<sup>1<\/sup>, Ariko Fuke<sup>1<\/sup>, Masako Kishihata<sup>1<\/sup>, Kensuke Matsumoto<sup>1<\/sup>, Arun Kumar<sup>1<\/sup>, Harry Choi<sup>1<\/sup>, Toshio Suzuki<sup>1<\/sup>, Tetsuharu Nagamoto<sup>1<\/sup>, Yuki Yamamoto<sup>1<\/sup><br><sup>1<\/sup> HiLung Inc.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P8<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development of an in vitro assessment for drug-induced peripheral neuropathy using hiPSC-derived sensory neurons<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Malina Graf<\/span><sup>P1<\/sup>, Frida Eriksson<sup>1<\/sup>, Paul Fitzpatrick<sup>1<\/sup><br><sup>1<\/sup> AstraZeneca, R&amp;D BioPharmaceuticals, Clinical Pharmacology &amp; Safety Sciences<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P9<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Scalable and well-defined human CNS co-culture platforms suitable for modelling excitatory-inhibitory neuron imbalances in drug discovery and safety studies<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tony Oosterveen<\/span><sup>P1<\/sup>, Mitzy Rios de Anda<sup>1<\/sup>, Tulin Tatar Ozkan<sup>1<\/sup>, Sarah Hussain<sup>1<\/sup>, Aurora Veteleanu<sup>1<\/sup>, Stefan Milde<sup>1<\/sup>, Mariangela Iovino<sup>1<\/sup>, Dario Magnani<sup>1<\/sup>, Tom Harris-Brown<sup>1<\/sup>, Rebecca Northeast<sup>1<\/sup>, In\u00eas Ferreira<sup>1<\/sup>, Amanda Turner<sup>1<\/sup>, Will Bernard<sup>1<\/sup><br><sup>1<\/sup> bit.bio<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P10<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Comparative study of CYP450 gene regulation in human pluripotent stem cell-derived liver 2D cell and 3D organoid models<\/a><\/h3>\n\n\n\n<p>Ji-Woo Kim<sup>1<\/sup>, Seongyea Jo<sup>1<\/sup>, Ji Hyeon Ryu<sup>1<\/sup>, Haneul Noh<sup>1<\/sup>, Han-Jin Park<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Hyemin Kim<\/span><sup>P1<\/sup><br><sup>1<\/sup> Korea Institute of Toxicology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P11<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Application of scalable hiPSC-derived liver organoids for chemical hazard screening<\/a><\/h3>\n\n\n\n<p>Ji-Woo Kim Kim<sup>1<\/sup>, Seongyea&nbsp; Jo<sup>1<\/sup>, Ji Hyeon Ryu<sup>1<\/sup>, Haneul&nbsp; Noh<sup>1<\/sup>, Hyemin&nbsp; Kim<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Han-Jin Park<\/span><sup>P1<\/sup><br><sup>1<\/sup> Korea Institute of Toxicology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P12<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Engineering a human hiPSC-derived 3D liver model to predict early innate immune toxicity to AAV gene therapy<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Isabella Ramella Gal<\/span><sup>P1,2<\/sup>, In\u00eas Pereira Correia<sup>1,2<\/sup>, Francisca Arez<sup>1,2<\/sup>, Maria Fran\u00e7a Pereira<sup>1,2<\/sup>, In\u00eas Saldanha<sup>1,2<\/sup>, Giacomo&nbsp; Domenici<sup>1,2<\/sup>, Sofia Fernandes<sup>1,2<\/sup>, Catarina Freitas<sup>1,2<\/sup>, Paula Marques Alves<sup>1,2<\/sup>, Udo Maier<sup>3<\/sup>, Ana Sofia Coroadinha<sup>1,2<\/sup>, Fran\u00e7ois du Plessis<sup>3<\/sup>, Catarina Brito<sup>1,2<\/sup><br><sup>1<\/sup> iBET &#8211; Institute of Experimental Biology and Technology<br><sup>2<\/sup> Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa<br><sup>3<\/sup> Boehringer Ingelheim Pharma GmbH &amp; Co. KG<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"cardiotoxicity\"><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#cardiotoxicity\" class=\"ek-link\">Cardiotoxicity and cardiac efficacy models<\/a><\/span><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P13<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Beauvericin-induced cardiotoxicity in H9C2 cardiomyocytes and zebrafish embryos<\/a><\/h3>\n\n\n\n<p>Ming-Yuan&nbsp; Liu<sup>1<\/sup>, Jui-Feng&nbsp; Tsai<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Biing-Hui Liu<\/span><sup>P1<\/sup><br><sup>1<\/sup> Graduate Institute of Toxicology, National Taiwan University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P14<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Could succination lead to cardiotoxcity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Afaf FIZAZI<\/span><sup>P1,2<\/sup>, Clo\u00e9&nbsp; SCHOELING<sup>1<\/sup>, Anne-Emilie DECLEVES<sup>2<\/sup>, Jean-Marie COLET<sup>1<\/sup><br><sup>1<\/sup> Human biology and toxicology laboratory. University of Mons. Belgium<br><sup>2<\/sup> Metabolic and Molecular Biochemistry Laboratory. University of Mons. Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P15<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Action potential waveform analysis in human iPSC-cardiomyocytes enables mechanistic assessment of multichannel cardiac effects<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Charlotte Hill<\/span><sup>P1<\/sup>, Robert Kirby<sup>1<\/sup><br><sup>1<\/sup> Metrion Biosciences<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P16<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development and characterization of a high-throughput in vitro human heart model: implications for future pre-clinical cardiac safety screening<\/a><\/h3>\n\n\n\n<p>Annina Roelofsen<sup>1,2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Nicole&nbsp;Pinckaers<\/span><sup>P1,3<\/sup>, Matthijs Blankesteijn<sup>1,2<\/sup>, Misha Vrolijk<sup>1,3<\/sup>, Martijn Hoes<sup>2,4,5<\/sup><br><sup>1<\/sup> Department of Pharmacology and Toxicology, Maastricht University, The Netherlands<br><sup>2<\/sup> Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands<br><sup>3<\/sup> Research Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands<br><sup>4<\/sup> Department of Clinical Genetics, Maastricht University, Maastricht, Netherlands<br><sup>5<\/sup> Department of Cardiology, Maastricht University Medical Center, Maastricht, Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"case_studies\"><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#casestudies\" class=\"ek-link\">Case studies for successful use and implementation of complex in vitro models<\/a><\/span><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P17<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Advanced integrated human in vitro approach to explore gut-brain barrier interactions with gut microbiota metabolites and pesticides<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Juliette Poiriez<\/span><sup>P1<\/sup>, Maria Abou Diwan<sup>1,2<\/sup>, Av\u00e9nie Huet<sup>2,3<\/sup>, Claire Joly Condette <sup>2<\/sup>, Emmanuel&nbsp; Sevin <sup>1<\/sup>, St\u00e9phane Delanaud<sup>2<\/sup>, Halima Ouadid-Ahidouch<sup>3<\/sup>, V\u00e9ronique&nbsp; Bach<sup>2<\/sup>, Fabien Gosselet<sup>1<\/sup>, Hafida Khorsi-Cauet<sup>2<\/sup>, Pietra Candela<sup>1<\/sup><br><sup>1<\/sup> Laboratoire de la Barri\u00e8re H\u00e9mato-Enc\u00e9phalique (LBHE), UR 2465, Universit\u00e9 d\u2019Artois, 62300 Lens, France<br><sup>2<\/sup> PERITOX\u2014P\u00e9rinatalit\u00e9 et Risques Toxiques\u2014UMR_I 01 UPJV\/INERIS, Centre Universitaire de Recherche en Sant\u00e9, CURS-UPJV, Universit\u00e9 Picardie Jules Verne, CEDEX 1, 80054 Amiens, France<br><sup>3<\/sup> Laboratoire de physiologie cellulaire et mol\u00e9culaire (LPCM), UR UPJV 4667, Universit\u00e9 Picardie Jules Verne, UPJV, 80039 Amiens, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P<\/a><a class=\"ek-link\" href=\".\">18<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Use of advanced NAMs for food-related nanotoxicology: a case study to investigate synthetic amorphous silica (SAS) toxicity in a liver organoid model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Pierre-Jean Ferron<\/span><sup>P1<\/sup>, Anne-Louise Blier<sup>1<\/sup>, Noa Oluyn<sup>2<\/sup>, Eveline Verleysen<sup>2<\/sup>, Jan Mast<sup>2<\/sup>, Andrea Haase<sup>3<\/sup>, Francesco Cubadda<sup>4<\/sup>, Kevin Hogeveen<sup>1<\/sup>, Val\u00e9rie Fessard<sup>1<\/sup><br><sup>1<\/sup> French Agency for Food, Environmental and Occupational Health &amp; Safety (ANSES), Foug\u00e8res, FRANCE<br><sup>2<\/sup> Sciensano, Groeselenbergstraat 99, 1180 Uccle, Belgium<br><sup>3<\/sup> German Federal Institute for Risk Assessment (BfR), Berlin, Germany<br><sup>4<\/sup> Istituto Superiore di Sanita, National Institute of Health (ISS), 00161 Rome, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><mark style=\"background-color:rgba(0, 0, 0, 0);color:#1e73be\" class=\"has-inline-color\"><a class=\"ek-link\">P<\/a>19<\/mark><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">A 3D co-culture model simulating the human hepatic microenvironment<\/a><\/h3>\n\n\n\n<p>Julia B\u00f6hme<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Dajana Lichtenstein<\/span><sup>P1<\/sup>, Neele Wewer<sup>1<\/sup>, Linda B\u00f6hmert<sup>1<\/sup>, Maxi B. Paul<sup>1<\/sup><br><sup>1<\/sup> German Federal Institute for Risk Assessment<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a><\/a><a href=\"http:\/\/0\" class=\"ek-link\">P2<\/a><mark style=\"background-color:rgba(0, 0, 0, 0);color:#1e73be\" class=\"has-inline-color\"><a href=\"http:\/\/0\" class=\"ek-link\">0<\/a><\/mark><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Understanding regulatory uptake of NAMs: a multicriteria review of 20 case methods<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Felipe Augusto Pinto-Vidal<\/span><sup>P1<\/sup>, Bastiaan&nbsp; van Ravenhorst<sup>2<\/sup>, Laure&nbsp; Geoffroy<sup>3<\/sup>, Noelia&nbsp; Dom\u00ednguez-Morueco<sup>4<\/sup>, Thomas&nbsp; Loret<sup>3<\/sup>, Walter&nbsp; Westerink<sup>5<\/sup>, Sebastian&nbsp; Hoffmann<sup>6<\/sup><br><sup>1<\/sup> Institute for Evidence-Based Toxicology<br><sup>2<\/sup> aQuaTox Solutions<br><sup>3<\/sup> French National Institute for Industrial Environment and Risks (INERIS),<br><sup>4<\/sup> Instituto de Salud Carlos III (ISCIII)<br><sup>5<\/sup> Charles River Laboratories<br><sup>6<\/sup> Institute for Evidence-Based Toxicology (IEBT),<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a><\/a><a href=\"http:\/\/0\" class=\"ek-link\">P<\/a><mark style=\"background-color:rgba(0, 0, 0, 0);color:#1e73be\" class=\"has-inline-color\"><a href=\"http:\/\/0\" class=\"ek-link\">21<\/a><\/mark><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">\u0392-carotene nanocarriers as a tool to sustain hyaluronic acid and counteract skin ageing: A case study<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Zinaida Shakel<\/span><sup>P1<\/sup>, Salette Reis<sup>1<\/sup>, Maria Cavinato-Nascimento<sup>2<\/sup>, Sofia Lima<sup>1<\/sup><br><sup>1<\/sup> University of Porto<br><sup>2<\/sup> Leopold Franzens Universit\u00e4t Innsbruck<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P22<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Blocking complement as a preventative measure for kidney ischemia reperfusion injury: insights from a human kidney-on-a-chip study<\/a><\/h3>\n\n\n\n<p>Linda Gijzen<sup>1<\/sup>, Laura Tool<sup>1<\/sup>, Eline Haspeslagh<sup>2<\/sup>, Rumaisha Annida<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Tina Thakkar<\/span><sup>P1<\/sup>, Jolien Delaere<sup>2<\/sup>, Kevin Budding<sup>2<\/sup>, Erik Hack<sup>2<\/sup>, Inge van de Walle<sup>2<\/sup><br><sup>1<\/sup> MIMETAS B.V, Oegstgeest, The Netherlands<br><sup>2<\/sup> Argenx B.V, Zwijnaarde, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P23<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Adapting RNA-seq as an alternative acquisition platform for gene expression quantification in the GARDskin assay<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Andy Forreryd<\/span><sup>P1<\/sup>, Tim Lindberg<sup>1<\/sup>, Robin Gradin<sup>1<\/sup>, Henrik Johansson<sup>1<\/sup><br><sup>1<\/sup> SenzaGen AB<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P24<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Addressing the role of maternal inflammation in autism spectrum disorder using immune-competent iPSC derived brain microphysiological systems<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alex Rittenhouse<\/span><sup>P1<\/sup>, Jingyi Zhang<sup>1<\/sup>, Jason Laird<sup>1<\/sup>, Lena Smirnova<sup>1<\/sup><br><sup>1<\/sup> Johns Hopkins Bloomberg School of Public Health<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P25<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Novel 3D-printed cell culture inserts for advanced in vitro skin regeneration<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Magdalena Metzger<\/span><sup>P1<\/sup>, Magdalena Bauer<sup>1<\/sup>, Marvin Corea<sup>1<\/sup>, Barbara Sch\u00e4dl<sup>1<\/sup>, Johannes Grillari<sup>1<\/sup>, Peter Dungel<sup>1<\/sup><br><sup>1<\/sup> Ludwig Boltzmann Institute for Traumatology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P26<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Continuous in vitro cultivation of a defined human gut microbiota: assessing media-driven shifts using the peristaltic mixed tubular bioreactor (PETR)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Anwar Walid<\/span><sup>P1,2<\/sup>, Katrin Dohnt<sup>1,2<\/sup><br><sup>1<\/sup> Institute of biochemical engineering, TU Braunschweig, Germany<br><sup>2<\/sup> Braunschweig Integrated Centre of Systems Biology (BRICS), TU Braunschweig, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P27<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development and application of an immunocompetent in vitro stem cell-based intestinal model for hazard assessment; testing the effects of faba bean, cricket and yellow chlorella proteins<\/a><\/h3>\n\n\n\n<p>Loes Duivenvoorde<sup>1<\/sup>, Yara&nbsp; Awad<sup>2<\/sup>, Benedetta Fabrizi<sup>1<\/sup>, St\u00e9phane Hazebrouck<sup>2<\/sup>, Aafke Janssen<sup>1<\/sup>, Mustafa Usta<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Meike van der Zande<\/span><sup>P1<\/sup><br><sup>1<\/sup> Wageningen Food Safety Research, Akkermaalsbos 2, 6708 WB Wageningen, The Netherlands<br><sup>2<\/sup> D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9 (DMTS), Universit\u00e9 Paris-Saclay, CEA, INRAe, Service de Pharmacologie et d\u2019Immunoanalyse, 91190 Gif-sur-Yvette, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P28<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">A targeted in vitro approach to fill hazard data gaps in the context of safe and sustainable by design (SSBD): a flame retardants case study<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nienke Ruijter<\/span><sup>P1<\/sup>, Mario&nbsp; Wenger<sup>2<\/sup>, David Beal<sup>1<\/sup>, Margaux Papin<sup>1<\/sup>, Jos\u00e9phine Steck<sup>3<\/sup>, Martin Himly<sup>2<\/sup>, Marie Carri\u00e8re<sup>1<\/sup><br><sup>1<\/sup> Univ. Grenoble-Alpes, CEA, CNRS, Grenoble INP, IRIG, SyMMES, CIBEST, 38000 Grenoble, France<br><sup>2<\/sup> Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Salzburg, 5020, Austria<br><sup>3<\/sup> Univ. Grenoble Alpes, CEA, Liten, DTNM, 38000 Grenoble, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P29<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Epivaginal\u2122 in Europe: cross-site reproducibility and discriminatory performance using ET-50 and multi-endpoint readouts<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Emily Reis<\/span><sup>P1<\/sup>, Jam Markus<sup>1<\/sup>, Karol&nbsp; Forro<sup>2<\/sup>, Mitchell&nbsp; Klausner<sup>3<\/sup>, Timothy&nbsp; Landry <sup>3<\/sup>, Kaitlyn&nbsp; Coen <sup>3<\/sup>, Silvia&nbsp; Letasiova <sup>1<\/sup>, Kristina&nbsp; Kejlov\u00e1 <sup>4<\/sup>, Mark\u00e9ta&nbsp; Dvo\u0159\u00e1kov\u00e1 <sup>4<\/sup>, Eli\u0161ka&nbsp; P\u00e1calov\u00e1 <sup>4<\/sup><br><sup>1<\/sup> MatTek IVLSL, Bratislava, Slovakia<br><sup>2<\/sup> Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia<br><sup>3<\/sup> MatTek Corporation, Ashland, MA, USA<br><sup>4<\/sup> Centre of Toxicology and Health Safety, National Institute of Public Health, Prague, Czech Republic<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P30<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Enhanced oxygen supply enables sustained function of primary human hepatocyte spheroids<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">YOSUKE MATSUMOTO<\/span><sup>P1<\/sup>, YUICHI SHIRASAKI<sup>1<\/sup>, KOJI NAKAZAWA<sup>2<\/sup><br><sup>1<\/sup> Taica Corporation<br><sup>2<\/sup> University of Kitakyushu<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"challenges\"><span style=\"background-color:#fff\" class=\"has-inline-background\"><a href=\"#challengescosmeticssafety\" class=\"ek-link\">Challenges in cosmetics safety&nbsp;<\/a><a class=\"ek-link\">&nbsp;<\/a><\/span><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P31<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Safety assessment of botanicals and natural complex substances<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ashwin Shah<\/span><sup>P1<\/sup>, Iris M\u00fcller<sup>1<\/sup>, Paul Benndorf<sup>1<\/sup>, Carmon Kee<sup>1<\/sup>, \u00d6zge Osmanoglu<sup>1<\/sup>, Nadia Heramvand<sup>1<\/sup>, Simone Hoffmann-D\u00f6rr<sup>1<\/sup><br><sup>1<\/sup> Henkel AG &amp; Co. KGaA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P32<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Reciprocal interaction between PPAR\u03b3 and CEBP\u03b1 in lipid metabolism regulation: hypothesis of a self-sustaining regulatory loop in HaCaT cells<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lorenzo Dondero<\/span><sup>P1,2<\/sup>, Giulia De Negri Atanasio<sup>1,3<\/sup>, Francesca&nbsp; Tardanico<sup>1,3<\/sup>, Matteo Sergiampietri<sup>1<\/sup>, Erica Lertora<sup>1,3,4<\/sup>, Bruno Burlando<sup>5<\/sup>, Ilaria&nbsp; Demori<sup>5<\/sup><br><sup>1<\/sup> Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy<br><sup>2<\/sup>&nbsp; Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy<br><sup>3<\/sup> Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy<br><sup>4<\/sup> Angel Consulting S.a.s<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P33<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development of a senior canine skin model for NAM-based safety assessment and efficacy of novel pet cosmetic ingredients<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Minji Kim<\/span><sup>P1<\/sup>, Heeyeon&nbsp; Cho<sup>1<\/sup>, Eun-jin Park<sup>1<\/sup>, Kyung-Eun Lee<sup>1<\/sup>, Chunho Park<sup>1<\/sup><br><sup>1<\/sup> COSMAXBTI<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P34<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Permeability of hazardous agents in cooling lubricants after application of occupational skin protection products<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Vanessa Geyik<\/span><sup>P1<\/sup>, Magdalena Metzger<sup>1<\/sup>, Anna Szorger<sup>1<\/sup>, Clemens Dobusch<sup>2<\/sup>, Parisa Ansari<sup>2<\/sup>, Peter Dungel<sup>1<\/sup><br><sup>1<\/sup> Ludwig Boltzmann Institute for Traumatology<br><sup>2<\/sup> Austrian Workers&#8217; Compensation Board AUVA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P35<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Addressing toxicological data gaps in cosmetic safety assessment: A case study on the regulatory challenges related to the use of read across and NAMs<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sanghamitra Mishra<\/span><sup>P1<\/sup>, Avneet Kaur Suri<sup>2<\/sup>, Celine&nbsp; De Roy<sup>1<\/sup>, Ankushreddy Patil<sup>2<\/sup>, Monica Autiero<sup>1<\/sup>, Thomas Petry<sup>1<\/sup><br><sup>1<\/sup> ToxMinds BV<br><sup>2<\/sup> ToxMinds India Consulting Pvt. Ltd.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P36<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Optical coherence tomography enhances mecanistic evaluation of ocular irritation in an ex vivo bovine eye model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Wiam NEDJAR<\/span><sup>P1<\/sup>, Soumia CHAOUCHE<sup>1<\/sup>, Cha\u00eema TOUILEB<sup>1<\/sup>, Imadeddine ZEBBICHE<sup>2<\/sup>, Younes ZEBBICHE<sup>1<\/sup><br><sup>1<\/sup> Department of Industrial Pharmacy \u2013 Faculty of Pharmacy \u2013 University of Health Sciences, Algiers<br><sup>2<\/sup> FOCUS CENTER<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"computational\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Computational%20toxicology\" class=\"ek-link\">Computational toxicology \u2013 in silico modelling, read-across, artificial intelligence and machine learning<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P37<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development of an in silico approach for predicting human internal exposure to topically applied cosmetic ingredients in NGRA<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Shimpei Terasaka<\/span><sup>P1<\/sup>, Kazutoshi Saitou<sup>1<\/sup>, Yuuichi Itou<sup>1<\/sup><br><sup>1<\/sup> Safety Science Research Laboratory, Kao Corporation, Japan<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P38<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Computational prediction of the kinetic and toxicological parameters of cylindrospermopsin<\/a><\/h3>\n\n\n\n<p>Antonio Cascajosa-Lira<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Remedios Guzm\u00e1n-Guill\u00e9n<\/span> <sup>P1<\/sup>, Silvia Pichardo<sup>1<\/sup>, Ana Mar\u00eda Came\u00e1n<sup>1<\/sup>, Angeles Jos<sup>1<\/sup>, Ana I. Prieto<sup>1<\/sup><br><sup>1<\/sup> Toxicology Area, Faculty of Pharmacy, University of Seville, Spain.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P39<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Preliminary machine learning approach to the immunotoxicity of cosmetic related PFAS<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lici Damar Cristina Diaz Bambague<\/span><sup>P1<\/sup>, William Giovanni Quevedo Buitrago<sup>1<\/sup>, Luis Fernando Nino Vasquez<sup>1<\/sup><br><sup>1<\/sup> Universidad Nacional de Colombia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P40<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Evolution of AI-based toxicity prediction and the emerging role of third-generation architectures<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Kohtaro Yuta<sup>P1<\/sup><\/span><br><sup>1<\/sup> In Silico Data, Ltd.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P41<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"http:\/\/0\" class=\"ek-link\">EndocrineAI: an AI-driven platform for endocrine disruption screening<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Bharath BR<\/span><sup>P1<\/sup>, Jahnavi S<sup>1<\/sup>, Nadeem Khan<sup>1<\/sup><br><sup>1<\/sup> Jai Research Foundation<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P42<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Establishment of readiness criteria for AI-models for risk assessment: ReadyAI<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Joyce de Paula Souza<\/span><sup>P1,2<\/sup>, Jonathan&nbsp; Blum<sup>1,2<\/sup>, Uko&nbsp; Maran <sup>3<\/sup>, Sulev&nbsp; Sild <sup>3<\/sup>, Louis Dawson<sup>4<\/sup>, Laura&nbsp; Holden <sup>4<\/sup>, Robert&nbsp; Lee <sup>4<\/sup>, Aleksandra&nbsp; \u010cavo\u0161ki <sup>4<\/sup>, Veronika&nbsp; Karnel <sup>5<\/sup>, Lukas Meusburger<sup>5<\/sup>, Sandrine&nbsp; Fraize-Frontier<sup>6<\/sup>, Alexander Walsh<sup>6<\/sup>, Gilles Rivi\u00e8re<sup>6<\/sup>, Giuseppa Raitano<sup>7<\/sup>, Alessandra&nbsp; Roncaglioni <sup>7<\/sup>, Emma&nbsp;&nbsp; Di Consiglio <sup>8<\/sup>, Olga&nbsp; Tcheremenskaia <sup>8<\/sup>, Cecilia Bossa<sup>8<\/sup>, Lina&nbsp; Wendt-Rasch<sup>9<\/sup>, Michal Kalapus<sup>10<\/sup>, Tomasz&nbsp; Puzyn <sup>10<\/sup>, Ellen&nbsp; Fritsche <sup>1,2<\/sup><br><sup>1<\/sup> Swiss Centre for Applied Human Toxicology, Switzerland<br><sup>2<\/sup> Department of Pharmaceutical Sciences, University of Basel, Switzerland<br><sup>3<\/sup> Institute of Chemistry, University of Tartu, Estonia<br><sup>4<\/sup> Birmingham Law School, University of Birmingham, United Kingdom<br><sup>5<\/sup> Austrian Agency for Health and Food Safety (AGES), Department Risk Assessment, Austria<br><sup>6<\/sup> French Agency for Food, Environmental and Occupational Health &amp; Safety (ANSES), France<br><sup>7<\/sup> Department of Environmental Health Sciences, Mario Negri Institute for Pharmacological Research, Italy<br><sup>8<\/sup> Environment &amp; Health Department, Italian National Institute of Health (ISS), Italy<br><sup>9<\/sup> Swedish Chemicals Agency (KemI), Sweden<br><sup>10<\/sup> Faculty of Chemistry, University of Gdansk, Poland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P43<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Cheminformatics interaction profiles implicate the UV filter benzophenone-4 as a potential obesogen via PPARY activation<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Junpyo Gong<\/span><sup>P1<\/sup>, Minsoo Noh<sup>1<\/sup><br><sup>1<\/sup> College of Pharmacy &amp; Natural Products Research Institute, Seoul National University, Seoul, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P44<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Building a quantitative adverse outcome pathway for AOP #38 \u2013 protein alkylation leads to liver fibrosis<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Levi Winkelman<\/span><sup>P1<\/sup>, Joost Beltman<sup>1<\/sup>, James Stevens<sup>1<\/sup><br><sup>1<\/sup> Division of Cell-systems and Drug Safety, LACDR, Leiden University, the Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P45<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Uncovering compound mode of action via hierarchical clustering of structural and morphological profiles<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Floriane Odje<\/span><sup>P1<\/sup>, Elena&nbsp; von Coburg<sup>2<\/sup>, Sebastian Dunst<sup>2<\/sup>, Andrea Volkamer<sup>1<\/sup><br><sup>1<\/sup> Universit\u00e4t des Saarlandes<br><sup>2<\/sup> German Centre for the Protection of Laboratory Animals (Bf3R)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P46<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Enhancing in silico prediction of Ames mutagenicity for organosilicon compounds and exploring chemical space boundaries<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Barbara G.&nbsp; Schmitt<\/span><sup>P1<\/sup>, Emilio Benfenati<sup>2<\/sup>, Robert S.&nbsp; Foster<sup>3<\/sup>, Grace Kocks<sup>3<\/sup>, Guiseppa Raitano<sup>2<\/sup>, Rachael E.&nbsp; Tennant<sup>3<\/sup>, Carole Forlini<sup>4<\/sup>, Eckart Gura<sup>5<\/sup>, Shawn Seidel<sup>6<\/sup>, Farah Koraichi-Emeriau<sup>7<\/sup><br><sup>1<\/sup> Evonik Operations GmbH<br><sup>2<\/sup> Istituto di Ricerche Farmacologiche Mario Negri<br><sup>3<\/sup> Lhasa Ltd.<br><sup>4<\/sup> Elkem Silicones France SAS<br><sup>5<\/sup> Wacker Chemie AG<br><sup>6<\/sup> The Dow Chemical Company<br><sup>7<\/sup> Equitox<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P47<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Systematic linkage of transcriptomics data to adverse outcome pathways for toxicity prediction<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sidra&nbsp;Adil<\/span><sup>P1<\/sup>, Theo de Kok<sup>1<\/sup>, Egon Willighagen<sup>1<\/sup>, Tooba Abbassi-Daloii<sup>1<\/sup>, Marvin Martens<sup>1<\/sup><br><sup>1<\/sup> Department of Translational Genomics (TGX), NUTRIM, Maastricht University, Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P48<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"http:\/\/0\" class=\"ek-link\">AI4AOPOMICS: artificial intelligence for integrating omics data into adverse outcome pathways<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Donghyeon Kim<\/span><sup>P1,2<\/sup>, Th\u00e9o Jamay<sup>2<\/sup>, Florence Jornod<sup>2<\/sup>, Jinhee Choi<sup>1<\/sup>, Karine Audouze<sup>2<\/sup><br><sup>1<\/sup> School of Environmental Engineering, University of Seoul, 163 Seoulsiripdae-ro, Dongdaemun-gu, Seoul 02504, Republic of Korea<br><sup>2<\/sup> Universit\u00e9 Paris-Cit\u00e9, Inserm, HealthFex, SysTox team, 45 rue des Saints-P\u00e8res, 75006 Paris, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P49<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Validation of AI-based toxicity prediction models with reference chemicals for regulatory applications<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Donghyeon Kim<\/span><sup>P1<\/sup>, Siyeol Ahn<sup>1<\/sup>, Jiyong Jeong<sup>1<\/sup>, Jinhee Choi<sup>1<\/sup><br><sup>1<\/sup> School of Environmental Engineering, University of Seoul, 163 Seoulsiripdae-ro, Dongdaemun-gu, Seoul 02504, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P50<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Decoding biological processes through multi-omic network diffusion<\/a><\/h3>\n\n\n\n<p>Antoine Bodein<sup>1<\/sup>, Marie-Pier Scott-Boyer<sup>1<\/sup>, Kahina Abed<sup>2<\/sup>, Gladys Ouedraogo<sup>2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Romain Grall<\/span><sup>P2<\/sup>, Anne Riu<sup>2<\/sup>, Olivier Perin<sup>2<\/sup>, Arnaud Droit<sup>1<\/sup><br><sup>1<\/sup> 1Molecular Medicine Department, CHU de Qu\u00e9bec Research Center, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada<br><sup>2<\/sup> L\u2019Or\u00e9al Research &amp; Innovation, Aulnay-sous-Bois, France\u202f<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P51<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Chemical clustering of natural complex substance (NCS) materials: A hierarchical clustering approach for use in non-animal safety assessments<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Holger Moustakas<\/span><sup>P1<\/sup>, Jake Muldoon<sup>1<\/sup>, Trevor Penning<sup>2<\/sup>, Amanda Bryant-Friedrich<sup>3<\/sup>, Mark Cronin<sup>4<\/sup>, Daniel Liebler<sup>5<\/sup>, Danielle Botelho<sup>1<\/sup>, Anne Marie Api<sup>1<\/sup><br><sup>1<\/sup> Research Institute of Fragrance Materials, Inc., 1200 MacArthur Boulevard, Mahwah, NJ 07430, USA<br><sup>2<\/sup> Center of Excellence in Environmental Toxicology, The University of Pennsylvania, Perelman School of Medicine, 1315 Biomedical Research Building (BRB) II\/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA<br><sup>3<\/sup> Wayne State University Graduate School Professor of Pharmaceutical Sciences, 5057 Woodward Avenue, Suite 11208, Detroit, MI, 48202, USA<br><sup>4<\/sup> School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK<br><sup>5<\/sup> Department of Biochemistry, Vanderbilt University, B3301A Medical Center North 465 21st Avenue South, Nashville, TN, 37232-6350, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P52<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Advancing chemical grouping: development and application of signature-based structure-activity groups for non-animal safety assessments<\/a><\/h3>\n\n\n\n<p>Jake Muldoon<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Holger Moustakas<\/span><sup>P1<\/sup>, Terry Schultz<sup>2<\/sup>, Trevor Penning<sup>3<\/sup>, Amanda Bryant-Friedrich<sup>4<\/sup>, Danielle Botelho<sup>1<\/sup>, Anne Marie Api<sup>1<\/sup><br><sup>1<\/sup> Research Institute of Fragrance Materials, Inc., 1200 MacArthur Boulevard, Mahwah, NJ 07430, USA<br><sup>2<\/sup> The University of Tennessee, College of Veterinary Medicine, 2407 River Drive, Knoxville, TN 37996-4500, USA<br><sup>3<\/sup> Center of Excellence in Environmental Toxicology, The University of Pennsylvania, Perelman School of Medicine, 1315 Biomedical Research Building (BRB) II\/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA<br><sup>4<\/sup> Wayne State University Graduate School Professor of Pharmaceutical Sciences, 5057 Woodward Avenue, Suite 11208, Detroit, MI, 48202, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P53<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">An approach to characterise and define tolerable uncertainty in read-across for toxicity prediction<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mark Cronin<\/span><sup>P1<\/sup>, Terry Schultz<sup>2<\/sup><br><sup>1<\/sup> Liverpool John Moores University, Liverpool, UK<br><sup>2<\/sup> University of Tennessee, Knoxville TN, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P54<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Heme metabolism and mycotoxins: lessons learned from Atlantic salmon &#8211; a computational multi-target investigation<\/a><\/h3>\n\n\n\n<p>Lorenzo Pedroni<sup>1<\/sup>, Ole J. N\u00f8stbakken <sup>2<\/sup>, Kai K. Lie<sup>2<\/sup>, Chiara Dall&#8217;Asta<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Luca Dellafiora<\/span><sup>P1<\/sup><br><sup>1<\/sup> Department of Food and Drug, University of Parma, Parma, Italy<br><sup>2<\/sup> Institute of Marine Research, Bergen, Norway<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P55<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Guardrailed, auditable agentic workflows for computational toxicology via the model context protocol (MCP)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ivo Djidrovski<\/span><sup>P1<\/sup><br><sup>1<\/sup> Institute for Risk Assessment Sciences (IRAS), Utrecht University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P56<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\".\" class=\"ek-link\">O-QT: auditable AI-assisted QSAR toolbox read-across workflows for VHP4Safety implementation<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ivo Djidrovski<\/span><sup>P1<\/sup>, Juliette Legler<sup>1<\/sup>, Raymond Pieters<sup>1,2<\/sup>, Marc Teunis<sup>2<\/sup><br><sup>1<\/sup> Institute for Risk Assessment Sciences (IRAS), Utrecht University<br><sup>2<\/sup> HU-University of Applied Sciences, Innovative Testing, Utrecht, the Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P57<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Macrophage-explicit PBPK model predicts long-term human organ accumulation of ingested microplastics<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Shohei Kaneko<\/span><sup>P1<\/sup>, Gaku Shimodaira<sup>1<\/sup>, Takeshi Katsuda<sup>1<\/sup>, Masaki Nishikawa<sup>1<\/sup>, Yasuyuki Sakai<sup>1<\/sup><br><sup>1<\/sup> Dept. of Chemical System Engineering, School of Engineering, The University of Tokyo<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P58<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Automated quantification of collagen gel contraction using a fine-tuned foundation model for in vitro toxicity assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sandeul Ryu<\/span><sup>P1<\/sup>, Minju Kim<sup>2<\/sup>, Heesung Hwang<sup>1<\/sup>, Yejin Park<sup>1<\/sup>, Jiwon Yoo<sup>1<\/sup>, Juhee Lee<sup>3,1<\/sup>, Seung Min Oh<sup>2,1,4<\/sup><br><sup>1<\/sup> Department of Bio-application Toxicity, Hoseo University, Asan, Republic of Korea.<br><sup>2<\/sup> Animal Welfare &amp; Alternative Testing Research Center, Hoseo University, Asan, Republic of Korea.<br><sup>3<\/sup> Department of ICT Automotive Engineering, Hoseo University, Asan, Republic of Korea.<br><sup>4<\/sup> Department of Animal Health and Welfare, Hoseo University, Asan, Republic of Korea.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P59<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Case study on the use of AOP-based AI model for prioritization of endocrine disrupting chemicals from consumer products<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Donghyeon Kim<\/span><sup>P1,2<\/sup>, Jaeseong Jeong<sup>1<\/sup>, Ajaya Kumar Sahoo<sup>1<\/sup>, Sangha Ahn<sup>1<\/sup>, Gaeul Yang<sup>1<\/sup>, Chaein Chong<sup>1<\/sup>, Jinhee Choi<sup>1<\/sup><br><sup>1<\/sup> School of Environmental Engineering, University of Seoul, 163 Seoulsiripdae-ro, Dongdaemun-gu, Seoul 02504, Republic of Korea<br><sup>2<\/sup> Universit\u00e9 Paris-Cit\u00e9, Inserm, HealthFex, SysTox team, 45 rue des Saints-P\u00e8res, 75006 Paris, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P60<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">A hybrid in silico\/in vitro approach to address applicability-domain limitations in chemical carcinogenicity prediction<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ani Tevosyan<\/span><sup>P1<\/sup>, Hayk Daghunts<sup>1<\/sup>, Lusine Khondkaryan<sup>1<\/sup>, Gohar Tadevosyan<sup>1<\/sup>, Lilit Apresyan<sup>1<\/sup>, Anna Misakyan<sup>1<\/sup>, Zaven Navoyan<sup>2<\/sup>, Nelly Babayan<sup>1,2<\/sup><br><sup>1<\/sup> Institute of Molecular Biology, NAS RA<br><sup>2<\/sup> Toxometris.ai Inc.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P61<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Co-regulated gene network analysis to uncover mechanisms of liver toxicity liabilities in vitro<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sibel Bahtiri<\/span><sup>P1<\/sup>, Steven Kunnen<sup>1<\/sup>, Lukas Wijaya<sup>1<\/sup>, Tessa Hagens<sup>1<\/sup>, Giulia Callegaro<sup>1<\/sup>, Marije Niemeijer<sup>1<\/sup>, Bob van de Water<sup>1<\/sup><br><sup>1<\/sup> Leiden Academic Centre for Drug Research<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P62<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Using AI tools for systematic literature search, appraisal, and data extraction for the development of adverse outcome pathways<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Roseline Awoga<\/span><sup>P1<\/sup>, Vajagathali Mohammed<sup>1<\/sup>, Nefeli C Vytinioti<sup>1,2<\/sup>, Anna Forsby<sup>1<\/sup><br><sup>1<\/sup> Stockholm University<br><sup>2<\/sup> Karolinska Institute<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P63<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Integrated analysis of cellular pathways of respiratory nanotoxicity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jiating Deng<\/span><sup>P1<\/sup>, Lianyong Han<sup>1<\/sup>, Carola&nbsp; Voss<sup>2<\/sup>, Tobias&nbsp; St\u00f6ger<sup>1<\/sup><br><sup>1<\/sup> Institute of Lung Health and Immunity (LHI), Helmholtz Center Munich<br><sup>2<\/sup> Hannover Medical School, Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery, Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO); Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German&nbsp; Center for Lung Research (DZL), Hannover, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"echa\"><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#medical-devices\" class=\"ek-link\">ECHA, EMA and EFSA perspectives on the use of NAMs<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P64<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">EFSA\u2019s proposed assessment strategy for waiving of dog studies in pesticide approval<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Adriana&nbsp;Scattareggia Marchese<\/span><sup>P1<\/sup>, Martina Panzarea<sup>1<\/sup>, Judy Choi<sup>2<\/sup>, Andrea Terron<sup>1<\/sup>, Jochem Louisse<sup>1<\/sup>, Tamara Coja<sup>3<\/sup>, Antonio Hern\u00e0ndez-Jerez<sup>4<\/sup>, Olavi Pelkonen<sup>5<\/sup><br><sup>1<\/sup> European Food Safety Authority (EFSA)<br><sup>2<\/sup> German Federal Institute for Risk Assessment (BfR)<br><sup>3<\/sup> Austrian Agency for Health and Food Safety (AGES)<br><sup>4<\/sup> University of Granada<br><sup>5<\/sup> University of Oulu<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P65<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Integration of new approach methodologies in the toxicological and allergenicity assessment of novel foods: EFSA\u2019s tiered approach<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Maria Glymenaki<\/span><sup>P1,2<\/sup>, Marcello&nbsp; Laganaro<sup>1<\/sup>, Irene&nbsp; Nuin Garciarena<sup>1<\/sup>, Annamaria&nbsp; Rossi<sup>1<\/sup>, Maura&nbsp; Magani<sup>1<\/sup>, Ermolaos&nbsp; Ververis<sup>1<\/sup>, Andrea&nbsp; Germini<sup>1<\/sup>, Oc\u00e9ane&nbsp; Albert<sup>1<\/sup><br><sup>1<\/sup> European Food Safety Authority, Nutrition and Food Innovation Unit, Parma, Italy<br><sup>2<\/sup> Department of Metabolism Digestion and Reproduction, Imperial College London, United Kingdom<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P66<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Integrating new approach methodologies in the risk assessment of decontaminating substances for foods of animal origin<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">CRISTINA CROERA<\/span><sup>P1<\/sup>, BLANKA HALAMODA<sup>1<\/sup><br><sup>1<\/sup> European Food Safety Authority (EFSA), Food Ingredients and Packaging (FIP) Unit, Parma, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"funding\"><a href=\"#funding\" class=\"ek-link\">Funding the development, validation and implementation of NAMs<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P67<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">What have we achieved? A retrospective assessment of 3Rs projects funded by the set foundation<\/a><\/h3>\n\n\n\n<p>Katja Sommer<sup>1<\/sup>, Claus-Michael Lehr<sup>1,2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Kristina Wagner<\/span><sup>P1,3<\/sup>, Joachim Coenen<sup>1,4<\/sup><br><sup>1<\/sup> Foundation for the Promotion of Alternatives to Animal Testing (set Foundation), Frankfurt am Main, Germany<br><sup>2<\/sup> Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbr\u00fccken, Germany<br><sup>3<\/sup> German Animal Welfare Federation &#8211; Animal Welfare Academy, Neubiberg, Germany<br><sup>4<\/sup> Merck KGaA, Darmstadt, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P68<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Human residual tissue becomes a valuable source in scientific research<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Gerry Wagenaar<\/span><sup>P1<\/sup>, Ilse Duivenvoorden<sup>1<\/sup>, Sjors van Kats<sup>1<\/sup><br><sup>1<\/sup> Department of VitalTissue, ETB-BISLIFE, Jan van Krimpenweg 17, 2031 CG Haarlem, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P69<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Landscape of challenges for in vitro testing of complex mixtures.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Benjamin KOPP<\/span><sup>P1<\/sup>, Marion Alriquet<sup>2<\/sup>, Maricel Marin-Kuan<sup>2<\/sup>, Marie-Christine Chagnon<sup>3<\/sup><br><sup>1<\/sup> Gnosis by Lesaffre, Marcq-en-Baroeul, France<br><sup>2<\/sup> Soci\u00e9t\u00e9 des Produits Nestl\u00e9 S.A., Nestl\u00e9 Research, Lausanne, Switzerland<br><sup>3<\/sup> Institut Agro Dijon, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P70<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Comparative RNA-seq profiling of 2D, static 3D and dynamic 3D cultures and their concordance with human tissue expression<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">LAURA GOMEZ CUADRADO<\/span><sup>P1<\/sup>, DAVID PALACIOS<sup>2<\/sup>, MARTA SENDRA<sup>1,2<\/sup>, DALIA DE LA FUENTE-VIVAS<sup>1<\/sup>, ROC\u00cdO BARROS<sup>1<\/sup>, SONIA MARTEL-MART\u00cdN<sup>1<\/sup>, PILAR MU\u00d1IZ<sup>2<\/sup><br><sup>1<\/sup> International Research Center in Critical Raw Materials for Advanced Industrial Technologies (ICCRAM), R&amp;D Center, Universidad de Burgos, Plaza de Misael Ba\u00f1uelos s\/n, 09001, Burgos, Spain<br><sup>2<\/sup> Department of Biotechnology and Food Science, Faculty of Sciences, University of Burgos, Plaza Misael Ba\u00f1uelos, 09001, Burgos, Spain<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"silico\"><a href=\"#silico\" class=\"ek-link\">In vitro and in silico methods for safety assessment of medical devices<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P71<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">In vitro sensitization assessment of medical device extracts: prevalidation results of GARDskin medical device for potential inclusion in ISO 10993-10<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Andy Forreryd<\/span><sup>P1<\/sup>, Per Alftr\u00e9n<sup>1<\/sup>, Robin Gradin<sup>1<\/sup>, Henrik Johansson<sup>1<\/sup>, Tim Lindberg<sup>1<\/sup><br><sup>1<\/sup> SenzaGen AB<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P73<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Replace animal tests (RAT) list \u2013 medical devices<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Emma Grange<\/span><sup>P1<\/sup>, Kate Shipton<sup>1<\/sup>, Laura Alvarez<sup>1<\/sup><br><sup>1<\/sup> Cruelty Free International<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"respiratory\"><a href=\"#respiratory\" class=\"ek-link\">In vitro systems to assess respiratory toxicity<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P74<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">A comprehensive model for predicting the toxicology of mineral fibres by connecting the fibre parameters to the key characteristics of carcinogens<\/a><\/h3>\n\n\n\n<p>Alessandro Gualtieri<sup>1<\/sup>, Serena Mirata<sup>2,3<\/sup>, Vanessa Almonti<sup>4<\/sup>, Mario Passalacqua<sup>5,3<\/sup>, Stefania Vernazza<sup>5,3<\/sup>, Anna Maria Bassi<sup>5,3<\/sup>, Armanda Pugnaloni<sup>6<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Sonia Scarf\u00ec<\/span><sup>P2,3<\/sup><br><sup>1<\/sup> Dept. of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Modena, Italy<br><sup>2<\/sup> Dept. Earth, Environment and Life Sciences, University of Genova, Itay<br><sup>3<\/sup> Inter-University Centre for the Promotion of the 3Rs Principles in Teaching &amp; Research, Turin, Italy<br><sup>4<\/sup> Center for Advanced Technologies, Poznan, Poland<br><sup>5<\/sup> Dept. Experimental Medicine, University of Genova, Italy<br><sup>6<\/sup> Dept. Clinical and Molecular Sciences, Polytechnic University of Marche, Torrette di Ancona, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P75<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Acellular in vitro dissolution of man-made vitreous fibers in synthetic lung fluids using single fiber and USP-4 (united states pharmacopeia apparatus 4) setups<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Denis V. Okhrimenko<\/span><sup>P1<\/sup>, Saetlai Z. Khai<sup>2,1<\/sup>, Alexandra Beltrami<sup>3<\/sup>, Pia Nielsen<sup>1<\/sup>, Susan L.S. Stipp<sup>3<\/sup>, Yuanzheng Yue<sup>2<\/sup>, Mette Solvang<sup>1<\/sup><br><sup>1<\/sup> ROCKWOOL A\/S<br><sup>2<\/sup> Aalborg University<br><sup>3<\/sup> Technical University of Denmark<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P76<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Cytotoxicity assessment of solid fuel particulate matter using a \u201ccells-on-particles\u201d platform<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Gail\u0117 Pocevi\u010di\u016bt\u0117<\/span><sup>P1<\/sup>,&nbsp; Violeta Kaunelien\u0117<sup>1<\/sup>, Edvardas Bagdonas<sup>2<\/sup>, Jurgita Ovadnevait\u0117<sup>3<\/sup>, Darius \u010ciu\u017eas<sup>1<\/sup>, Dainius Martuzevi\u010dius<sup>1<\/sup><br><sup>1<\/sup> Department of Environmental Technology, Faculty of Chemical Technology, Kaunas University of Technology, Lithuania<br><sup>2<\/sup> Department of Regenerative Medicine, Centre for Innovative Medicine, Vilnius, Lithuania<br><sup>3<\/sup> School of Natural Sciences, Physics, University of Galway, Galway, Ireland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P77<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Assessing the toxicity of traffic-derived air pollution using a primary human air-liquid interface airway in vitro model<\/a><\/h3>\n\n\n\n<p>Gerrit Bredeck<sup>1,2<\/sup>, Tina Wahle<sup>1<\/sup>, Angela K\u00e4mpfer<sup>1<\/sup>, Jochen Dobner<sup>1<\/sup>, John Boere<sup>3<\/sup>, Paul Fokkens<sup>3<\/sup>, Evert Duistermaat<sup>3<\/sup>, Tim Spannbrucker<sup>1<\/sup>, Andrea Rossi<sup>1<\/sup>, Flemming Cassee<sup>3,4<\/sup>, Roel Schins<sup>1,5<\/sup><br><sup>1<\/sup> IUF &#8211; Leibniz Research Institute for Environmental Medicine, D\u00fcsseldorf, Germany<br><sup>2<\/sup> Centro de Investigaciones Biol\u00f3gicas Margarita Salas (CIB-CSIC), Madrid, Spain<br><sup>3<\/sup> Centre for Sustainability, Environment and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands<br><sup>4<\/sup> Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands<br><sup>5<\/sup> Department of Pharmacology and Toxicology, Maastricht University, Maastricht, the Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P78<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Respiratory uptake of inhaled dinoseb and rotenone using primary bronchial epithelial cells<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Yvonne Staal<\/span><sup>P1<\/sup>, V\u00e9ronique de Bruijn<sup>1<\/sup>, Jolanda Vermeulen<sup>1<\/sup>, Theo Sinnige<sup>2<\/sup>, Edwin Zwart<sup>1<\/sup>, Eline Groeneveld<sup>1<\/sup>, Anne Kienhuis<sup>1,2<\/sup><br><sup>1<\/sup> RIVM<br><sup>2<\/sup> Utrecht University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P79<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Advancing non-animal respiratory toxicology: a TRPA1-based in vitro model for airway irritant detection<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Robert Bedford<\/span><sup>P1<\/sup><br><sup>1<\/sup> Labcorp Early Development Laboratories Ltd.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P80<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Assessing inhalation toxicity of cosmetic compounds on upper airway and alveolar air-liquid interface models after liquid or nebulized exposure<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Carolin G\u00f6bel<\/span><sup>P1<\/sup>, Gerlinde Pappa<sup>1<\/sup>, Andreas&nbsp; Schepky<sup>1<\/sup>, Daniela Lange<sup>1<\/sup><br><sup>1<\/sup> Beiersdorf AG, Hamburg, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P81<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Breathing small airways lung-on-chip to model COPD pathophysiology and assess lung toxicity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marco Mondini<\/span><sup>P1<\/sup>, Valeria Fragozo Mesa<sup>2<\/sup>, Gessica Marchini<sup>3<\/sup>, Roberta Visone<sup>1<\/sup><br><sup>1<\/sup> BiomimX Srl<br><sup>2<\/sup> Politecnico di Milano<br><sup>3<\/sup> Chiesi Farmaceutici Spa<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P82<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">In silico evaluation of inhalation exposure to essential oils<\/a><\/h3>\n\n\n\n<p>Adeline NALIN<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Manon FOURNIER<\/span><sup>P1<\/sup>, S\u00e9bastien GREGOIRE<sup>2<\/sup><br><sup>1<\/sup> AROMA-ZONE<br><sup>2<\/sup> S\u00e9bastien Gr\u00e9goire Consulting<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P83<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Towards prospective identification of respiratory sensitizers: setting up a co-culture of bronchial epithelial and dendritic-like cells<\/a><\/h3>\n\n\n\n<p>Eline Groeneveld<sup>1<\/sup>, Evert Duistermaat<sup>2<\/sup>, Ren\u00e9e de Boeck<sup>2<\/sup>, Jolanda Vermeulen<sup>1<\/sup>, Eric Gremmer<sup>1<\/sup>, Rob vandebriel<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">V\u00e9ronique de Bruijn<\/span><sup>P1<\/sup><br><sup>1<\/sup> Centre for Health Protection, National Institute of Public Health &amp; the Environment<br><sup>2<\/sup> Centre for Sustainability, Environment and Health, National Institute of Public Health &amp; the Environment<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P84<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">The exposure to inhalable substances and their impact on the safety assessment of cosmetic products and their ingredients<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Erica Lertora<\/span><sup>P1,2,3<\/sup>, Giulia&nbsp; De Negri Atanasio<sup>1,3<\/sup>, Lorenzo Dondero<sup>1,3<\/sup>, Francesca Tardanico<sup>1,3<\/sup>, Matteo&nbsp; Sergiampietri<sup>1<\/sup>, Serena&nbsp; Mirata<sup>1<\/sup>, Matteo&nbsp; Zanotti Russo<sup>2<\/sup>, Sonia&nbsp; Scarf\u00ec<sup>1,3<\/sup>, Elena Grasselli<sup>1,3,4<\/sup><br><sup>1<\/sup> Department of Earth, Environment and Life Science, University of Genoa, Corso Europa 26, Genoa, Italy<br><sup>2<\/sup> Angel Consulting, Via San Senatore 14, 20122, Milan, Italy<br><sup>3<\/sup> Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy<br><sup>4<\/sup> National Center for the Development of New Technologies in Agriculture (Agritech), 80121, Naples, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P85<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Effects of ozone on lung cells exposed at the air-liquid interface under controlled conditions.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Louise VERHAEGHE<\/span><sup>P1,2<\/sup>, Suen BOULE<sup>1,2<\/sup>, Dominique COURCOT<sup>1,2<\/sup>, Yann LANDKOCZ<sup>1,2<\/sup><br><sup>1<\/sup> UCEiV UR4492 &#8211; Dunkerque &#8211; France<br><sup>2<\/sup> Universit\u00e9 du Littoral C\u00f4te d&#8217;Opale &#8211; Dunkerque &#8211; France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P86<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Phthalates alone or in a mixture induce mitochondrial dysfunction and phenotypic modification in bronchial cells<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lyse Szymanski<\/span><sup>P1<\/sup>, Margueritta&nbsp; Al Zallouha<sup>1<\/sup>, Cl\u00e9mence Bouzar<sup>1<\/sup>, Edwige&nbsp; Votier<sup>1<\/sup>, Christelle&nbsp; Monteil <sup>1<\/sup>, Tiphaine Rogez-Florent <sup>1<\/sup><br><sup>1<\/sup> Univ Rouen Normandie, Universit\u00e9 Caen Normandie, Normandie Univ, ABTE UR 4651, F-76000 Rouen<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P87<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Mixture toxicity of benzene, toluene, ethylbenzene, and xylene (BTEX) in a human organotypic model of the respiratory tract exposed acutely or repeatedly at the air\/liquid interface<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Hugo Bes<\/span><sup>P1<\/sup>, Fabrice Bray<sup>2<\/sup>, Nour Jaber<sup>1<\/sup>, Doroth\u00e9e Dewa\u00eble<sup>3<\/sup>, St\u00e9phanie Devassine<sup>2<\/sup>, Christian Rolando<sup>2<\/sup>, Fabrice Cazier<sup>3<\/sup>, Claude Emond<sup>4<\/sup>, Sylvain Billet<sup>1<\/sup><br><sup>1<\/sup> UR4492 Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant, Universit\u00e9 du Littoral C\u00f4te d&#8217;Opale<br><sup>2<\/sup> Univ. Lille, CNRS, USR 3290 &#8211; MSAP<br><sup>3<\/sup> CCM, Centre Commun de Mesures, Universit\u00e9 du Littoral C\u00f4te d&#8217;Opale<br><sup>4<\/sup> PKSH Inc, Crabtree, Qu\u00e9bec, Canada<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P88<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Study of the toxicity of prenol, a second generation biofuel, by coupling an atmospheric simulation chamber to an air-liquid interface exposure device<\/a><\/h3>\n\n\n\n<p>Reem Al Mawla<sup>1,2<\/sup>, C\u00e9cile Coeur<sup>2<\/sup>, Nicolas Houzel<sup>2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Sylvain Billet<\/span><sup>P1<\/sup><br><sup>1<\/sup> UR4492 Unit\u00e9 de chimie environnementale et interactions sur le vivant (UCEIV), Universit\u00e9 du Littoral C\u00f4te d&#8217;Opale, Dunkerque, France<br><sup>2<\/sup> UR4493 Laboratoire de Physico-Chimie de l\u2019Atmosph\u00e8re (LPCA), Universit\u00e9 Littoral C\u00f4te d\u2019Opale, Dunkerque, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P89<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">In vitro immune off-target toxicity assessment using morph_ONE for antibody drug conjugates (ADCs)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ewelina&nbsp;Hoffman<\/span><sup>P1<\/sup>, Josephine Joel<sup>1<\/sup>, Elinda Zequiri<sup>1<\/sup>, Rhamiya Mahendran<sup>1<\/sup>, Victoria Hutter<sup>1,2<\/sup><br><sup>1<\/sup> ImmuONE Limited, Sycamore House, Stevenage, Herts, UK, SG1 2BP<br><sup>2<\/sup> Centre for Topical Drug Delivery and Toxicology, University of Hertfordshire, Hatfield, Herts, UK, AL10 9AB<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P90<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">An advanced airway-on-a-chip model with unidirectional flow and perfusable microvascular network for studying fibrosis<\/a><\/h3>\n\n\n\n<p>Artur&nbsp; Rodrigues<sup>1<\/sup>, Iris Schilt<sup>1<\/sup>, Alexis&nbsp; Dalaud<sup>1<\/sup>, Camilla Clavijo<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Tina hakkar<\/span><sup>P1<\/sup>, Job Komen<sup>1<\/sup>, Todd&nbsp; Burton<sup>1<\/sup>, Lenie van den Broek<sup>1<\/sup><br><sup>1<\/sup> MIMETAS B.V, Oegstgeest, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P91<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">A novel adverse outcome pathway for respiratory sensitisation: challenges and opportunities for in vitro safety assessment using new approach methodologies (NAMs)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mark\u00e9ta Dvo\u0159\u00e1kov\u00e1<\/span><sup>P1<\/sup><br><sup>1<\/sup> National Institute of Public Health<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P92<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Establishment of a human pulmonary in vitro co-culture model for nanoplastic toxicological assessment: calu-3 and THP-1 macrophages<\/a><\/h3>\n\n\n\n<p>Claudia Anguita Sol\u00e9<sup>1<\/sup>, Javier Guti\u00e9rrez Garc\u00eda<sup>1<\/sup>, Alba Garc\u00eda-Rodr\u00edguez<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Laura&nbsp;Rubio Lorente<\/span><sup>P1<\/sup>, Alba Hern\u00e1ndez Bonilla<sup>1<\/sup><br><sup>1<\/sup> Group of Mutagenesis, Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Aut\u00f2noma de Barcelona, 08193 Cerdanyola del Vall\u00e8s, Barcelona, Spain<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P94<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Cooling agents in e-cigarettes: toxicological evaluation of WS-3, WS-5 and WS-23 in bronchial epithelial models<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Aleksandra Khomutetckaia<\/span><sup>P1<\/sup><br><sup>1<\/sup> German Federal Institute for Risk Assessment<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P95<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Transcriptomic and cytokine responses of reconstructed human bronchial epithelium to respiratory versus skin sensitizers<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Honoka Aoshima<\/span><sup>P1<\/sup>, Kanae Ishimori<sup>1<\/sup>, Shinkichi Ishikawa<sup>1<\/sup>, Izuru Mizoguchi<sup>2<\/sup>, Takayuki Yoshimoto<sup>2<\/sup>, Takao Ashikaga<sup>3<\/sup><br><sup>1<\/sup> Scientific Product Assessment Center, R&amp;D Group, Japan Tobacco Inc., Kanagawa, Japan<br><sup>2<\/sup> Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan<br><sup>3<\/sup> Division of Genome Safety Science, National Institute of Health Sciences Center for Biological Safety and Research, Kanagawa, Japan<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P96<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">The USP-4 as a tool to assess the dissolution of man-made vitreous fibres<\/a><\/h3>\n\n\n\n<p>L\u00e9a Hi\u00e9ronimus<sup>P1<\/sup>, Julien de Cruz<sup>1<\/sup>, Denis Okrimenko<sup>2<\/sup>, John Hoffman<sup>3<\/sup>, Heather Kessler<sup>3<\/sup>, Dan Edson<sup>3<\/sup>, Maxime Jacquemin<sup>4<\/sup>, Quentin H\u00e9rault<sup>4<\/sup>, Natasa Drnovsek<sup>5<\/sup>, Ur\u0161ka&nbsp; Kova\u010di\u010d <sup>5<\/sup>, Jordi Aixart<sup>6<\/sup>, Nerea Mascaraque<sup>6<\/sup>, Keith Rickabaugh<sup>7<\/sup>, Brandon Wiggins<sup>7<\/sup>, Amy Madl<sup>8<\/sup>, Mette Solvang<sup>2<\/sup><br><sup>1<\/sup> EURIMA, Rue de Deux Eglises 29, 1000 Brussels, Belgium<br><sup>2<\/sup> ROCKWOOL A\/S, Hovedgaden 584, 2640 Hedehusene, Denmark<br><sup>3<\/sup> Owens Corning S&amp;T, 2790 Columbus Road, Granville, OH 43023, USA<br><sup>4<\/sup> Saint-Gobain Research Paris, 41 quai Lucien Lefranc, 93300 Aubervilliers, France<br><sup>5<\/sup> Knauf Insulation, Rue de Maestricht 95, 4600 Vise, Belgium<br><sup>6<\/sup> URSA Insulation S.A., Paseo de Recoletos 3, Madrid 28004, Spain<br><sup>7<\/sup> RJ Lee Group, Inc., 800 Presque Isle Drive, Pittsburgh, PA 15239, USA<br><sup>8<\/sup> Valeo Sciences LLC, 333 Corporate Drive, Suite 130, Ladera Ranch, CA 92694, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P97<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Estimation of respiratory irritation potency of industrial chemicals by using the TRPV1 expressing SH-SY5Y cell model and machine learning<\/a><\/h3>\n\n\n\n<p>Mar\u00eda Hinojosa<sup>1,2<\/sup>, Gunnar Johanson<sup>3<\/sup>, Ulf Norinder<sup>4,5<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Anna Forsby<\/span><sup>P1<\/sup><br><sup>1<\/sup> Department of Biochemistry and Biophysics, Stockholm University, Sweden<br><sup>2<\/sup> Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden<br><sup>3<\/sup> Institute of Environmental Medicine, Karolinska Institutet, Stockholm Sweden<br><sup>4<\/sup> MTM research Centre, School of Science and Technology, \u00d6rebro University, Sweden<br><sup>5<\/sup> Department of Pharmaceutical Biosciences, Uppsala University, Sweden<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P98<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Single-cell mass cytometry reveals multicellular context\u2013dependent reshaping of oxidative stress\u2013related key events following Ceria nanoparticle exposure<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Eunseo Lee<\/span><sup>P1<\/sup>, Hyojoo Bang<sup>1<\/sup>, Seung-Geun Park<sup>1<\/sup>, Tae Hyun Yoon<sup>1<\/sup><br><sup>1<\/sup> Department of Chemistry, College of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P99<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">An AOP-based in vitro evaluation of humidifier disinfectant\u2013induced pulmonary fibrosis using a 3D human epithelial\u2013fibroblast co-culture model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Minju Kim<\/span><sup>P1<\/sup>, Heesung Hwang<sup>2<\/sup>, Yejin Park<sup>2<\/sup>, Sandeul&nbsp; Ryu<sup>2<\/sup>, Jiwon Yoo<sup>2<\/sup>, Juhee Lee<sup>2,3<\/sup>, Seung Min Oh<sup>1,2,4<\/sup><br><sup>1<\/sup> Animal Welfare &amp; Alternative Testing Research Center, Hoseo University, Asan, Republic of Korea<br><sup>2<\/sup> Department of Bio-application Toxicity, Hoseo University, Asan, Republic of Korea<br><sup>3<\/sup> Department of ICT Automotive Engineering, Hoseo University, Asan, Republic of Korea<br><sup>4<\/sup> Department of Animal Health and Welfare, Hoseo University, Asan, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P100<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Short-term exposure to titanium dioxide nanoparticles induces transformation-associated phenotypes in human bronchial epithelial cells<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Yejin Park<\/span><sup>P1<\/sup>, Ei Ju Heo<sup>1<\/sup>, Minju Kim<sup>2<\/sup>, Heesung Hwang<sup>1<\/sup>, Sandeul Ryu<sup>1<\/sup>, Jiwon Yoo<sup>1<\/sup>, Juhee Lee<sup>1,3<\/sup>, Seung Min Oh<sup>2,1,4<\/sup><br><sup>1<\/sup> Department of Bio-application Toxicity, Hoseo University, Asan, Republic of Korea.<br><sup>2<\/sup> Animal Welfare &amp; Alternative Testing Research Center, Hoseo University, Asan, Republic of Korea.<br><sup>3<\/sup> Department of ICT Automotive Engineering, Hoseo University, Asan, Republic of Korea.<br><sup>4<\/sup> Department of Animal Health and Welfare, Hoseo University, Asan, Republic of Korea.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P101<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">From primary NHBE cells to functional 3D inverted bronchial tissue: high-content imaging\u2011based monitoring of differentiation<\/a><\/h3>\n\n\n\n<p>Eline Berghmans<sup>1<\/sup>, An Jacobs<sup>1<\/sup>, Inge Nelissen<sup>1<\/sup>, Sandra Verstraelen<sup>1<\/sup><br><sup>1<\/sup> Flemish Institute for Technological Research (VITO), Environmental Intelligence (EI) Unit, Mol, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P102<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Applicability of the soluairway\u2122 human airway model as a NAMs platform for in vitro acute respiratory toxicity testing<\/a><\/h3>\n\n\n\n<p>Ji-Woo&nbsp; Choe <sup>1,2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Eun-Ji Gwak<\/span><sup>P3<\/sup>, Geon-Hee&nbsp; Lee<sup>3<\/sup>, Su-Hyun Lee<sup>3<\/sup>, Ga-Eun Kim<sup>4<\/sup>, Ha-Ryong Kim<sup>4<\/sup>, Kyung-Min&nbsp; Lim <sup>1,2<\/sup><br><sup>1<\/sup> College of Pharmacy and Graduate School of Pharmaceurical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea<br><sup>2<\/sup> Graduated Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Republic of Korea<br><sup>3<\/sup> R&amp;D Institute, Biosolution Co., Ltd., Seoul, Republic of Korea<br><sup>4<\/sup> College of Pharmacy, Korea University, Sejong 30019, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P103<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">A human systemic model for simultaneously evaluating antibody-drug conjugates efficacy and the risk of interstitial lung disease<\/a><\/h3>\n\n\n\n<p>Jimmy&nbsp; Vernaz<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Xiao-Yann Huang<\/span><sup>P1<\/sup>, Samuel&nbsp; Constant<sup>1<\/sup>, Clelia Bourgoint<sup>2<\/sup>, Gregory Segala<sup>2<\/sup>, Aurelien Roux<sup>3<\/sup>, Simon Latour<sup>3<\/sup><br><sup>1<\/sup> Epithelix<br><sup>2<\/sup> FluoSphera SA<br><sup>3<\/sup> University of Geneva<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P104<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Impact of berry-flavoured nicotine-free e-liquids on an in vitro model of the alveolar-capillary barrier: in vitro toxicity evaluation and chemical analysis<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Emma Filaudeau<\/span><sup>P1,2<\/sup>, Amelia-Naomi Sabo<sup>1,3<\/sup>, Anita Lebert<sup>1<\/sup>, V\u00e9ronique Kemmel<sup>1,3<\/sup><br><sup>1<\/sup> Laboratoire de Pharmacologie et Toxicologie Neurocardiovasculaire \u2013 UR7296, Universit\u00e9 de Strasbourg, Strasbourg, France<br><sup>2<\/sup> GAIATREND, Rohrbach-l\u00e8s-Bitche, FRANCE<br><sup>3<\/sup> Laboratoire de Biochimie et Biologie Mol\u00e9culaire, H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P105<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Lung surfactant inhibition assay &#8211; a method to predict early signs of acute inhalation toxicity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jorid S\u00f8rli<\/span><sup>P1<\/sup><br><sup>1<\/sup> The National Research Centre for the Working Environment<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P106<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Mechanistic assessment of methyl methacrylate using human relevant new approach methodologies<\/a><\/h3>\n\n\n\n<p>Sabina Burla<sup>1<\/sup>, Kai Blumbach<sup>2<\/sup>, Frank Faulhammer<sup>3<\/sup>, Tina M. Sommer<sup>2<\/sup>, Helena Obernolte<sup>4<\/sup>, Katherina Sewald<sup>4<\/sup>, Servane Contal<sup>5<\/sup>, Sebastien Cambier<sup>5<\/sup>, Karin Wiench<sup>3<\/sup><br><sup>1<\/sup> INVITROLIZE<br><sup>2<\/sup> Evonik Operations GmbH<br><sup>3<\/sup> BASF SE<br><sup>4<\/sup> Fraunhofer ITEM<br><sup>5<\/sup> LIST<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P107<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Searching minimal coculture conditions to reproduce the initial inflammatory response to inhaled carbon nanoparticles<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Osama Huzain<\/span><sup>P1<\/sup>, Lianyong Han<sup>1<\/sup>, Carola Voss<sup>2<\/sup>, Tobias St\u00f6ger<sup>1<\/sup><br><sup>1<\/sup> Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Germany;&nbsp; German Center for Lung Research (DZL), Munich , Germany<br><sup>2<\/sup> Hannover Medical School, Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery, Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Hannover, Germany;&nbsp; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P108<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Impact of nicotine on calcium flux and markers of endoplasmic reticulum stress in vitro<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Anita LEBERT<\/span><sup>P1<\/sup>, Amelia-Naomi SABO<sup>1,2<\/sup>, Emma Filaudeau<sup>1,3<\/sup>, Manon DIFFOR<sup>1<\/sup>, V\u00e9ronique&nbsp; KEMMEL<sup>1,2<\/sup><br><sup>1<\/sup> Laboratoire de Pharmacologie et Toxicologie Neurocardiovasculaire \u2013 UR7296, Centre de Recherche en Biom\u00e9decine, Universit\u00e9 de Strasbourg, Strasbourg, France&nbsp;<br><sup>2<\/sup> Laboratoire de Biochimie et Biologie Mol\u00e9culaire, H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France<br><sup>3<\/sup> GAIATREND, Rohrbach-l\u00e8s-Bitche, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"knowledge\"><a href=\"#knowledge\" class=\"ek-link\">Knowledge sharing and education<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P109<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">The convener: A trade association\u2019s role in advancing animal-free science for chemicals safety assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Francesca&nbsp;Rapolla<\/span><sup>P1<\/sup>, Caroline Rainsford<sup>1<\/sup><br><sup>1<\/sup> Cosmetic, Toiletry and Perfumery Association<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P110<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Inova hub: illuminating the full landscape of NAMs<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jennifer Venhorst<\/span><sup>P1<\/sup>, Pedro Sim\u00f5es Ruas<sup>1<\/sup>, Tanja Rouhani Rankouhi<sup>1<\/sup>, Jochem de Vries<sup>1<\/sup>, Erik Lemcke<sup>1<\/sup><br><sup>1<\/sup> TNO<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P111<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Science communication: bridging the gap between animal research and new approach methodologies (NAMs): a knowledge sharing campaign<\/a><\/h3>\n\n\n\n<p>Monicah Kirathi<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Francois Busquet<\/span><sup>P1<\/sup>, Leonie&nbsp; Mueller<sup>1<\/sup><br><sup>1<\/sup> Altertox<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P112<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">The potential protection of Tamarix extracts against toxicity induced by selected beauty products in Hs27 human skin fibroblasts.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">ABDULLAH&nbsp; ALNUQAYDAN<\/span><sup>P1<\/sup>, Faten M.&nbsp; Ali Zainy,<sup>2<\/sup><br><sup>1<\/sup> Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University<br><sup>2<\/sup> Chemistry Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P113<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#fake link\" class=\"ek-link\">Re-place: a national platform to strengthen dissemination and uptake of new approach methodologies in Belgium<\/a><\/h3>\n\n\n\n<p>Maude Everaert<sup>1<\/sup>, Mieke Van Mulders<sup>2<\/sup>, Vera Rogiers<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Birgit Mertens<\/span><sup>P2<\/sup><br><sup>1<\/sup> In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Brussels, Belgium<br><sup>2<\/sup> Department of Chemical and Physical Health Risks, Sciensano, Brussels, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P114<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">ICCS best practice guidance document for serious eye damage and eye irritation assessment using new approach methodologies for substances in cosmetics and personal care products<\/a><\/h3>\n\n\n\n<p>Takayuki Abo<sup>1<\/sup>, Els Adriaens<sup>2<\/sup>, Nathalie Al\u00e9p\u00e9e<sup>3<\/sup>, Lauren Brown<sup>4<\/sup>, Alessandra Cavarzan<sup>5<\/sup>, Neepa Choksi<sup>4<\/sup>, Renato Ivan de \u00c1vila<sup>6<\/sup>, Carolin Goebel<sup>7<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Donna S. Macmillan<\/span><sup>P8<\/sup>, Karsten R. Mewes<sup>9<\/sup>, Chelsea O&#8217;Driscoll<sup>10<\/sup><br><sup>1<\/sup> Kao Corporation, Japan<br><sup>2<\/sup> Adriaens Consulting, Belgium<br><sup>3<\/sup> L&#8217;Or\u00e9al Research &amp; Innovation, France<br><sup>4<\/sup> ToxStrategies LLC, USA<br><sup>5<\/sup> Reckitt Benckiser Italia S.P.A., Italy<br><sup>6<\/sup> Safety, Environmental and Regulatory Science (SERS), Unilever, UK<br><sup>7<\/sup> Beiersdorf AG, Germany<br><sup>8<\/sup> International Collaboration on Cosmetics Safety, USA<br><sup>9<\/sup> Henkel, AG &amp; Co. KGaA, Germany<br><sup>10<\/sup> Procter &amp; Gamble, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P115<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Structured research, adequate reproducibility: a digital approach to managing the complexity of in vitro studies<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Iasmina Marcovici<\/span><sup>P1<\/sup><br><sup>1<\/sup> INVITRIO SCIENTIFIC SRL, Romania<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"testing\"><a href=\"#testing\" class=\"ek-link\">Local toxicity testing (safety and efficacy)<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P116<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Optimizing keratinocyte spheroid formation: efficiency and morphological outcomes<\/a><\/h3>\n\n\n\n<p>J\u00e9ssica Nascimento da Silva&nbsp; Pinto<sup>1<\/sup>, Patr\u00edcia Prado&nbsp; Augusto<sup>1<\/sup>, Matheus de Souza&nbsp; Alves<sup>1<\/sup>, J\u00falia Lu\u00edza Andr\u00e9&nbsp; Santana<sup>1<\/sup>, Wilson Dias&nbsp; Segura<sup>1<\/sup>, Meg Cristina de Castilho&nbsp; Costa<sup>2<\/sup>, Carolina Motter&nbsp; Catarino<sup>2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Patricia Santos Lopes<\/span><sup>P1<\/sup><br><sup>1<\/sup> Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas, Universidade Federal de S\u00e3o Paulo, Diadema, SP, Brazil<br><sup>2<\/sup> Pre-Clinical &amp; Product Safety &#8211; Grupo Botic\u00e1rio, Brazil<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P117<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Fruits from Brazilian Cerrado as a potential source for application in cosmetics: in silico and in vitro analysis<\/a><\/h3>\n\n\n\n<p>Bruna Stephany Fernandes&nbsp; Lopes<sup>1<\/sup>, Larissa Silva Costa<sup>1<\/sup>, Marcelo Dutra Duque<sup>1<\/sup>, V\u00e2nia Rodrigues Leite-Silva<sup>1,2<\/sup>, Newton Andreo-Filho<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Patricia Santos Lopes<\/span><sup>P1<\/sup><br><sup>1<\/sup> Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas, Universidade Federal de S\u00e3o Paulo, Rua S\u00e3o Nicolau 210, Diadema 09913-030, Brazil<br><sup>2<\/sup> Therapeutics Research Centre, The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P118<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Nanocellulose as a food additive: assessing the toxicological implications of nanocellulose in the gastrointestinal tract.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jia Yi Poh<\/span><sup>P1<\/sup>, Magdiel Inggrid Setyawati<sup>1<\/sup>, Kee Woei Ng<sup>1,2<\/sup><br><sup>1<\/sup> School of Materials Science and Engineering, Nanyang Technological University<br><sup>2<\/sup> Nanyang Environment and Water Research Institute (NEWRI), Nanyang Technological University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P119<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Comparison of in vitro skin sensitization strategy using a data set of cosmetic raw materials<\/a><\/h3>\n\n\n\n<p>Elise Roux<sup>1<\/sup>, Fr\u00e9d\u00e9ric Alby<sup>1<\/sup>, Elodie Clouet<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Emilie Floch<\/span><sup>P1<\/sup>, Marie Pierre Gomez Berrada<sup>1<\/sup>, Pierre Jacques Ferret<sup>1<\/sup><br><sup>1<\/sup> Safety Products Department, Pierre Fabre Dermo-Cosm\u00e9tique, Toulouse, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P120<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">An in vitro strategy using RhE to assess the tolerance and efficacy of personal care products based on a concrete example: a repair balm<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Agathe DENIAU<\/span><sup>P1<\/sup>, Manon FOURNIER<sup>1<\/sup>, Adeline JOSSEAUME<sup>2<\/sup>, Sophie CATOIRE<sup>2<\/sup>, Adeline NALIN<sup>1<\/sup><br><sup>1<\/sup> Aroma-Zone<br><sup>2<\/sup> CELL ALTERNATIV<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P121<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Epidermal repair after superficial burn: in vitro evaluation of reparative effects and soothing products<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Adeline JOSSEAUME<\/span><sup>P1<\/sup>, Sophie GOLDBLUM<sup>2<\/sup>, Sophie CATOIRE<sup>1<\/sup><br><sup>1<\/sup> CELL ALTERNATIV<br><sup>2<\/sup> PURESSENTIEL<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P122<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Evaluation of human blood as a sustainable alternative to bovine blood in the red blood cell (RBC) test for eye irritation assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Daniela Lange<\/span><sup>P1<\/sup>, Andreas Schepky<sup>1<\/sup>, Nadine M\u00fcller<sup>1<\/sup><br><sup>1<\/sup> Beiersdorf AG<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P123<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Investigation of the intestinal effects of dietary advanced glycation endproducts in an vitro model of the inflamed intestine<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Angela A.M. K\u00e4mpfer<\/span><sup>P1<\/sup>, Heleen A. van der Hout<sup>2<\/sup>, Roel P.F. Schins<sup>1,2<\/sup>, Misha F. Vrolijk<sup>2<\/sup><br><sup>1<\/sup> IUF &#8211; Leibniz Research Institute for Environmental Health<br><sup>2<\/sup> Department of Pharmacology and Toxicology, Maastricht University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P124<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Integrated transcriptomics as a new approach methodology (NAM) for predictive chemical safety and efficacy assessment in skin models<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Thomas Darde<\/span><sup>P1<\/sup>, Pamela El Azzi<sup>2<\/sup>, Fr\u00e9d\u00e9ric Chalmel<sup>3<\/sup><br><sup>1<\/sup> SciLicium<br><sup>2<\/sup> Wepredic<br><sup>3<\/sup> INSERM U1085 \u2013 IRSET<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P125<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Further development of the in vitro photoassay using THP-1 cells to identify phototoxic chemicals<\/a><\/h3>\n\n\n\n<p>Adriana S Maddaleno<sup>1<\/sup>, Laia Guardia-Escot\u00e9<sup>2<\/sup>, M. Pilar Vinardell<sup>1<\/sup>, Elisabet Teixid\u00f3<sup>2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Montse Mitjans<\/span><sup>P1<\/sup><br><sup>1<\/sup> Dpt. Bioqu\u00edmica i Fisiologia, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l&#8217;alimentaci\u00f3, Universitat de Barcelona<br><sup>2<\/sup> Departament de Farmacologia, Toxicologia i Qu\u00edmica Terap\u00e8utica,&nbsp; Facultat de Farm\u00e0cia i Ci\u00e8ncies de l&#8217;alimentaci\u00f3, Universitat de Barcelona<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P126<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Empowering discovery of safe and effective drugs targeting cystic fibrosis infections by using new Candida albicans-CF zebrafish model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Aleksandar Pavic<\/span><sup>P1,2<\/sup>, Natasa&nbsp; Radakovic<sup>1<\/sup>, Nikola&nbsp; Plackic<sup>1<\/sup>, Aleksandar Sovtic<sup>3<\/sup>, Fabio&nbsp; Zobi<sup>4<\/sup>, Joachim&nbsp; Morschh\u00e4user<sup>5<\/sup><br><sup>1<\/sup> Institute of Molecular Genetics and Genetic Engineering University of Belgrade<br><sup>2<\/sup> L. S. Skaggs Pharmacy Institute Pharmacology &amp; Toxicology College of Pharmacy &#8211; University of Utah<br><sup>3<\/sup> Institute of Mother and Child Healthcare of Serbia &#8220;Dr Vukan \u010cupi\u0107&#8221;<br><sup>4<\/sup> Universit\u00e9 de Fribourg&nbsp; Facult\u00e9 des Sciences et de M\u00e9decine<br><sup>5<\/sup> Institut f\u00fcr Molekulare Infektionsbiologie Universit\u00e4t W\u00fcrzburg<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P127<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Multimodal neurotoxicity profiling of pesticides using a human iPSC-based organ-on-chip platform<\/a><\/h3>\n\n\n\n<p>Rapha\u00eblle Baumier<sup>1<\/sup>, Jessica Rontard<sup>2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Beno\u00eet Maisonneuve<\/span><sup>P2<\/sup>, Guillaume Becker<sup>1<\/sup>, Thibault Honegger<sup>2<\/sup><br><sup>1<\/sup> ANSES<br><sup>2<\/sup> NETRI<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P128<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development and optimization of an MCTT HCE\u2122-based eye hazard identification assay<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nam-Hee Kang<\/span><sup>P1<\/sup>, Soo In Lee<sup>1<\/sup>, Joohwan Kim<sup>1<\/sup>, Sun Wook Woo<sup>1<\/sup><br><sup>1<\/sup> Korean Center for the Validation of Alternative Methods (KoCVAM), Nonclinical Resource Research Division, National Institute of Food and Drug Safety Evaluation,&nbsp; Ministry of Food and Drug Safety<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P129<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Establishment of a KeraSkin\u2122 RhE-based skin sensitization test method<\/a><\/h3>\n\n\n\n<p>Sun Wook Woo<sup>1<\/sup>, Nam-Hee Kang<sup>1<\/sup>, HanBit Bong<sup>1<\/sup>, Joohwan Kim<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Rheeda Lee<\/span><sup>P<\/sup><br><sup>1<\/sup> Korean Center for the Validation of Alternative Methods (KoCVAM), Nonclinical Resource Research Division, National Institute of Food and Drug Safety Evaluation,&nbsp; Ministry of Food and Drug Safety<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P130<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">A reconstructed canine epidermis model as an alternative approach for local tolerance assessment in veterinary pharmacology and pet care<\/a><\/h3>\n\n\n\n<p>J\u00e9r\u00f4me <span style=\"text-decoration: underline;\" class=\"ek-underline\">Dellacasagrande<\/span><sup>P1<\/sup><br><sup>1<\/sup> QIMA Life Sciences<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P131<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Tissue-specific effect of antiparasitic substances. An in vitro approach.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">David Hern\u00e1ndez-Moreno<\/span><sup>P1<\/sup>, Elsa Rodr\u00edguez-Somoza <sup>2<\/sup>, Marcos Perez-Lopez<sup>2<\/sup>, M.Luisa Fernandez-Cruz<sup>1<\/sup><br><sup>1<\/sup> Department of Environment and Agronomy, National Institute for Agriculture and Food Research and Technology (INIA, CSIC). Madrid. Spain<br><sup>2<\/sup> Toxicology Area, Veterinary School, University of Extremadura. Caceres. Spain<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P132<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development of a 3D atopic dermatitis model using keraskin\u2122 and its application in preclinical efficacy evaluation<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Hye-jin Lee<\/span><sup>P1<\/sup>, Eun-Ji Gwak<sup>1<\/sup>, Geon-Hee&nbsp; Lee<sup>1<\/sup>, Su-Hyon&nbsp; Lee<sup>1<\/sup><br><sup>1<\/sup> R&amp;D Institute, Biosolution Co., Ltd., Seoul, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P133<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Toxicological evaluation of pristine MXene, polypyrrole-functionalized MXene, and MXene\u2013graphene hybrids using cellular and computational models<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Dalia de la Fuente-Vivas<\/span><sup>P1<\/sup>, Sergio de la Huerta<sup>1,2<\/sup>, Julia Rodr\u00edguez-Vinagre<sup>1<\/sup>, David Palacios<sup>1,3<\/sup>, Santiago Aparicio<sup>1,2<\/sup>, Laura G\u00f3mez-Cuadrado<sup>1<\/sup><br><sup>1<\/sup> International Research Center in Critical Raw Materials for Advanced Industrial Technologies (ICCRAM), Universidad de Burgos, Centro de I+D+I, Burgos, Spain<br><sup>2<\/sup> Department of Chemistry, Universidad de Burgos, Burgos 09001, Spain<br><sup>3<\/sup> Department of Biotechnology and Food Science, Universidad de Burgos, Burgos 09001, Spain<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P134<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Comparative hepatotoxicity assessment of a magnetic colloidal suspension containing oleic acid-double functionalized iron oxide nanoparticles in 2D and 3D liver models<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Iasmina Marcovici<\/span><sup>P1,2<\/sup>, Elena-Alina Moac\u0103<sup>1,2<\/sup>, Cristina-Adriana Dehelean<sup>1,2<\/sup><br><sup>1<\/sup> Faculty of Pharmacy, &#8220;Victor Babes&#8221; University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.<br><sup>2<\/sup> Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, &#8220;Victor Babes&#8221; University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P135<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Skin corrosion\/irritation: evaluating the readiness of NAMs for regulatory decision-making<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">B. de S\u00e1 Cal\u00e7ada<\/span><sup>P1<\/sup>, M. E. Schutte<sup>2<\/sup>, T. Holmes<sup>1<\/sup>, S. Wright-Williams<sup>3<\/sup>, J. Mehta<sup>3<\/sup><br><sup>1<\/sup> ADAMA Deutschland GmbH, Edmund-Rumppler-Str. 6, 51149 Cologne, Germany<br><sup>2<\/sup> ADAMA Northern Europe BV., Arnhemseweg 87, Leusden, the Netherlands<br><sup>3<\/sup> ADAMA Agricultural Solutions UK, Arlington Business Park, Theale, Reading, United Kingdon<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"developmental\"><a href=\"#assay\" class=\"ek-link\">Models, biomarkers and assays for developmental toxicity<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P136<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Advancing developmental toxicity testing with species-specific in vitro methods<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jing Fang<\/span><sup>P1<\/sup>, Tom&nbsp; Zwetsloot<sup>1<\/sup>, Jos\u00e9 M. Horcas-Nieto<sup>1<\/sup>, Amer Jamalpoor<sup>1<\/sup><br><sup>1<\/sup> Toxys B.V., Leiden BioScience Park, Oegstgeest, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P137<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Developmental neurotoxicity of dibutyl phthalate and its primary metabolite mono-n-butyl phthalate in zebrafish embryo model<\/a><\/h3>\n\n\n\n<p>Suyeon Lee<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Sangwoo Lee<\/span><sup>P1<\/sup>, Woo-Keun Kim<sup>1<\/sup><br><sup>1<\/sup> Korea Institue of Toxicology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P138<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">From DNT to DART: leveraging a NAM success story<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Julia Alicia Boos<\/span><sup>P1<\/sup>, Angela Bearth<sup>1,2<\/sup>, Lucia&nbsp; Selfa Aspiroz<sup>3<\/sup>, Ellen Fritsche<sup>1<\/sup><br><sup>1<\/sup> SCAHT &#8211; Swiss Centre of Applied Human Toxicology<br><sup>2<\/sup> HF Partners GmbH<br><sup>3<\/sup> European Commission, Joint Research Centre (JRC)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P139<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Human stem cell-derived osteoblasts for in vitro assessment of skeletal malformation<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Connor Philippo<\/span><sup>P1<\/sup>, Jos\u00e9 M. Horcas-Nieto<sup>1<\/sup>, Giel&nbsp; Hendriks<sup>1<\/sup>, Amer Jamalpoor<sup>1<\/sup><br><sup>1<\/sup> Toxys B.V.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P140<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Qualification and quantification of a novel human in vitro syncytiotrophoblastic barrier: A predictive tool for maternal exposure.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Romain Grall<\/span><sup>P1<\/sup>, Mickael Le Balch<sup>1<\/sup>, Theo Sizorn-Gueguen<sup>1<\/sup>, Sylvie Emery<sup>1<\/sup>, Anne Riu<sup>1<\/sup>, Kevin Cache<sup>1<\/sup>, Gladys Ouedraogo<sup>1<\/sup>, Matthew Burbank<sup>1<\/sup><br><sup>1<\/sup> L\u2019Or\u00e9al Research &amp; Innovation, Aulnay-sous-Bois, France\u202f<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P141<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Integrating hPSC-derived monolayer and brain-on-chip models as new approach methodologies for developmental neurotoxicity testing.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marta Cervera-Sospedra<\/span><sup>P1,2<\/sup>, Clelia Introna<sup>1,2<\/sup>, Georgina Bombau<sup>1,2<\/sup>, Cinta Gomis<sup>1,2<\/sup>, Marc Estarellas<sup>1,2<\/sup>, Josep Samitier<sup>3<\/sup>, Josep M. Canals<sup>1,2<\/sup><br><sup>1<\/sup> Laboratory of Stem Cells and Regenerative Medicine, Department of Biomedical Sciences; and Creatio, production and validation center of advanced therapies, Faculty of Medicine and Health Sciences; and Institute of Neurosciences, University of Barcelona, Barcelona, Spain.<br><sup>2<\/sup> Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona-Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.<br><sup>3<\/sup> Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P142<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development of an in vitro placental barrier model to assess the teratogenicity potential of chemical compounds.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Giovana Bento<\/span><sup>P1<\/sup>, Nathalia&nbsp; Indolfo <sup>1<\/sup>, Melissa&nbsp; Ganzerla<sup>1<\/sup>, Juliana Costa<sup>1<\/sup>, Graziele&nbsp; Sousa<sup>1<\/sup>, Ana Clara Stival<sup>2<\/sup>, Marize&nbsp; Valadares<sup>2<\/sup><br><sup>1<\/sup> Natura<br><sup>2<\/sup> ToxIn Lab- Federal University of Goi\u00e1s<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P143<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Metabolomics and lipidomics for neurotoxicity assessment in human 3D brain spheres: an example with glycol ether solvents<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Isabel Meister<\/span><sup>P1,2<\/sup>, Mathieu Galmiche<sup>1,2<\/sup>, David Lopez Rodriguez<sup>3,4,2<\/sup>, Julien Boccard<sup>1,2<\/sup>, David Pamies<sup>3,2<\/sup>, Tatjana Saric<sup>5,6<\/sup>, Estelle Maret<sup>6<\/sup>, No\u00e9line H\u00e9ritier<sup>3,2<\/sup>, Massimo Frangiamone<sup>3,2<\/sup>, Aur\u00e9lien Thomas<sup>5,6<\/sup>, Nancy Hopf<sup>7<\/sup>, Marie-Gabrielle Zurich<sup>3,2<\/sup>, Serge Rudaz<sup>1,2<\/sup><br><sup>1<\/sup> School of Pharmaceutical Sciences, University of Geneva, Switzerland<br><sup>2<\/sup> Swiss Center for Applied Human Toxicology<br><sup>3<\/sup> Department of Biomedical Sciences, University of Lausanne, Switzerland<br><sup>4<\/sup> Institute of Earth Surface Dynamics, University of Lausanne, Switzerland<br><sup>5<\/sup> Unit of Forensic Toxicology and Chemistry, CURML, Lausanne and Geneva University Hospitals, Switzerland<br><sup>6<\/sup> Unit of Toxicology, CURML, Faculty of Biology and Medicine, University of Lausanne, Switzerland<br><sup>7<\/sup> Unisant\u00e9, Center for Primary Care and Public Health and University of Lausanne, Switzerland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P144<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">A regulatory-relevant human placental model to identify early endocrine and molecular disruptions<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Beatrice Anna Brugger<\/span><sup>P1<\/sup>, Caroline Buff<sup>1<\/sup>, Jack Morikka<sup>2<\/sup>, Lorenzo Campini<sup>2<\/sup>, Dario Greco<sup>2<\/sup>, Peter Wick<sup>1<\/sup>, Tina Buerki-Thurnherr<sup>1<\/sup><br><sup>1<\/sup> Nanomaterials in Health Lab, Empa St. Gallen, Switzerland<br><sup>2<\/sup> Faculty of Medicine and Health Technology, Tampere University, Finland<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P145<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Non-exhaust particles from electric vehicles: evaluation in human skin and lung models within the LIFE-NEEVE project.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ver\u00f3nica Ruiz-Torres<\/span><sup>P1<\/sup>, Mar\u00eda Jos\u00e9&nbsp; Peri\u00e1\u00f1ez-Ord\u00f3\u00f1ez<sup>2<\/sup>, Alicia&nbsp; Castillo-Rivas<sup>2<\/sup>, Paloma&nbsp; \u00c1lvarez-Mateos<sup>2<\/sup>, Dominik&nbsp; Soare<sup>3<\/sup>, Kenji&nbsp; Kondo <sup>3<\/sup>, Leonid&nbsp; Japs<sup>3<\/sup>, Marie&nbsp; Lens <sup>3<\/sup>, Matthias&nbsp; Schr\u00f6der<sup>3<\/sup>, Peter&nbsp; Lienerth<sup>3<\/sup>, Mar\u00eda&nbsp; Herranz-L\u00f3pez<sup>1<\/sup>, Vicente&nbsp; Micol<sup>1<\/sup>, Enrique&nbsp; Barraj\u00f3n<sup>1<\/sup><br><sup>1<\/sup> Institute of Biomedical Research of Elche (IDiBE), Miguel Hern\u00e1ndez University (UMH), Elche, Spain.<br><sup>2<\/sup> Department of Chemical Engineering, Faculty of Chemistry, University of Seville, Spain.<br><sup>3<\/sup> HORIBA Europe GmbH, Hans-Mess-Str. 6, 61440 Oberursel, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P146<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Cross-species human and primate iPSC-based NAMs for in vitro developmental toxicity assessment of targeted protein degraders<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Fabian P Suchy<\/span><sup>P1,2<\/sup>, Katie Kotok<sup>1,3<\/sup>, Lena Br\u00fccker<sup>4<\/sup>, Lucia Ramirez<sup>1<\/sup>, Philip Hewitt<sup>4<\/sup>, Morteza Roodgar<sup>1,2<\/sup><br><sup>1<\/sup> Exir Bio, Menlo Park, CA 94025, USA.<br><sup>2<\/sup> Stanford University, School of Medicine, Stanford University, Stanford, CA 94305, USA.<br><sup>3<\/sup> San Jos\u00e9 State University, San Jose, CA 95192, USA.<br><sup>4<\/sup> Merck Healthcare KGaA, Darmstadt, 64293, Germany.&nbsp;<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P147<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Evaluation of neurodevelopmental disruptions induced by emerging Bisphenol analogues using zebrafish embryo<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Suyeon Lee<\/span><sup>P1,2<\/sup>, Sangwoo Lee<sup>1,2<\/sup>, Woo-Keun Kim<sup>1,2<\/sup><br><sup>1<\/sup> Korea Institute of Toxicology<br><sup>2<\/sup> University of Science &amp; Technology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P148<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development of regulatory toxicity indicators for biocides: bridging transgenic zebrafish imaging with AOP-based human health risk assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Donggon Yoo<\/span><sup>P1,2<\/sup>, Sangwoo Lee<sup>1,2<\/sup>, Woo-Keun Kim<sup>1,2<\/sup><br><sup>1<\/sup> Human and Environmental Toxicology, University of Science and Technology, Daejeon 34113, Republic of Korea.<br><sup>2<\/sup> Departmemt of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P149<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">High-throughput quantitative analysis of PLP1-positive oligodendrocytes in a 3D human iPSC-derived brain model for chemical screening<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Federica Lamberto<\/span><sup>P1<\/sup>, Andrea&nbsp; Aranda Prats<sup>1<\/sup>, Lena&nbsp; Smirnova<sup>2<\/sup>, David Pamies<sup>1<\/sup><br><sup>1<\/sup> Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Switzerland<br><sup>2<\/sup> Center for Alternatives to Animal Testing, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P150<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">The devTOX quickPredict\u2122 assay: blinded study demonstrates high inter-laboratory reproducibility for in vitro developmental toxicity NAM<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Darren Kidd<\/span><sup>P1<\/sup>, Daniel Bramham<sup>1<\/sup>, Irina Komjarova<sup>2<\/sup>, Craig Griffiths<sup>2<\/sup>, Paul Bushdid<sup>3<\/sup>, Jessica Palmer<sup>4<\/sup>, Elizabeth Donley<sup>4<\/sup><br><sup>1<\/sup> Labcorp, Harrogate, UK<br><sup>2<\/sup> Labcorp, Huntingdon, UK<br><sup>3<\/sup> Labcorp, Greenfield, IN, USA<br><sup>4<\/sup> Stemina Biomarker Discovery Inc, Madison, WI, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go <\/a><a href=\"#topics\" class=\"ek-link\">b<\/a><a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">ack<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"endocrine\"><a href=\"#endocrine\" class=\"ek-link\">Models, biomarkers and assays for endocrine disruption<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P151<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development and validation of a sodium iodine symporter (NIS) inhibition assay using a hNIS overexpressing cell model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sjoerd Verkaart<\/span><sup>P1<\/sup><br><sup>1<\/sup> PhD<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P152<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Endocrine disrupting properties of water soluble metal working fluids: effects on steroid hormone production and receptor transcriptional activities.<\/a><\/h3>\n\n\n\n<p>Christian Darne<sup>1<\/sup>, Myl\u00e8ne Lorcin<sup>1<\/sup>, Marie Perceau<sup>1<\/sup>, Dieynaba Ndiaye<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Laurent Gat\u00e9<\/span><sup>P1<\/sup><br><sup>1<\/sup> Institut National de Recherche et de S\u00e9curit\u00e9, D\u00e9partement Toxicologie et Biom\u00e9trologie, 1 rue du Morvan, 54519 Vandoeuvre-l\u00e8s-Nancy, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P153<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">C. Elegans as an innovative biosensor for combined toxicity in surface water: exploratory insights from the INNOWACE project<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Amra Milasinovic<\/span><sup>P1<\/sup>, Nienke&nbsp; Stigter<sup>1<\/sup>, Roberta&nbsp; Hofman-Caris<sup>2<\/sup>, Cyrille A.M.&nbsp; Krul<sup>1<\/sup>, Raymond H.H.&nbsp; Pieters<sup>3<\/sup><br><sup>1<\/sup> HU University of Applied Sciences, Research Group Innovative Testing in Life Sciences &amp; Chemistry, Utrecht, The Netherlands<br><sup>2<\/sup> KWR Water Research Institute, Nieuwegein, The Netherlands<br><sup>3<\/sup> Utrecht University, Institute for Risk Assessment Sciences, Utrecht, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P154<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Towards serum-free, hormone-controlled culture conditions for in vitro steroidogenesis assays<\/a><\/h3>\n\n\n\n<p>Eli\u0161ka \u0158eh\u016f\u0159kov\u00e1<sup>1<\/sup>, Lucie&nbsp;B\u00edzov\u00e1<sup>1<\/sup>, Lola&nbsp;Bajard<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Iva Sovadinov\u00e1<\/span><sup>P1<\/sup><br><sup>1<\/sup> RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic&nbsp;<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P155<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Refining predictive transcript markers for liver steatosis in metabolism-disrupting compound screening<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Dajana Lichtenstein<\/span><sup>P1<\/sup>, Heike Sprenger<sup>1<\/sup>, Albert Braeuning<sup>1<\/sup><br><sup>1<\/sup> German Federal Institute for Risk Assessment<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P156<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">NAM-based assay panel for evaluating compound effects on thyroid hormone synthesis<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Cl\u00e9mence Budin<\/span><sup>P1<\/sup>, Harrie Besselink<sup>1<\/sup>, Tjalf de Boer<sup>1<\/sup>, Abraham Brouwer<sup>1<\/sup><br><sup>1<\/sup> BioDetection Systems BV<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P157<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Chlorpyrifos induces dimorphic effects in immortalized hypothalamic murine neurons in presence of physiological concentrations of sexual hormones<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Irene Masciola<\/span><sup>P1<\/sup>, Gabriele Lori<sup>1<\/sup>, Marialuisa Casella<sup>1<\/sup>, Antonella&nbsp;Tinari<sup>1<\/sup>, Sabrina Tait<sup>1<\/sup><br><sup>1<\/sup> Istituto Superiore di Sanit\u00e0<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P158<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Thyroid hormone-disrupting potential of wastewater treatment plant effluents across Europe: insights from an in vitro bioassay battery<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marie Smutn\u00e1<\/span><sup>P1<\/sup>, Puja Kumari<sup>1<\/sup>, Zuzana Tou\u0161ov\u00e1<sup>1<\/sup>, Saskia Finckh<sup>2<\/sup>, Ji\u0159\u00ed Nov\u00e1k<sup>1<\/sup>, Werner Brack<sup>2<\/sup>, Kl\u00e1ra Hilscherov\u00e1<sup>1<\/sup><br><sup>1<\/sup> RECETOX, Masaryk University, Brno, Czech Republic<br><sup>2<\/sup> Department of Effect-Directed Analysis, UFZ \u2013 Helmholtz Centre for Environmental Research, Leipzig, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P159<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Advancing mechanistic investigations of thyroid toxicity through new analytical parameters in a 3D RAT thyroid model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nicolas Orsini<\/span><sup>P1<\/sup>, Julia K\u00fchnlenz<sup>1<\/sup>, Helen Tinwell<sup>1<\/sup><br><sup>1<\/sup> Bayer CropScience, Human Safety, Sophia Antipolis, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P160<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Endocrine-disrupting potential of pollutant mixtures in settled dust samples from households with little children from eight European countries<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jiri Novak<\/span><sup>P1<\/sup>, Marie Smutna<sup>1<\/sup>, Lisa Melymuk<sup>1<\/sup>, Klara Hilscherova<sup>1<\/sup><br><sup>1<\/sup> RECETOX, Masaryk University, Brno, Czech Republic<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P161<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Integrated zebrafish NAMs for endocrine disruption: mechanistic insights into thyroid and estrogen pathways<\/a><\/h3>\n\n\n\n<p>Andrea Weiner<sup>1<\/sup>, Ander Arbelaiz<sup>1<\/sup>, Mikel Queralt<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Arantza Muriana<\/span><sup>P1<\/sup><br><sup>1<\/sup> BBD BioPhenix SL &#8211; Biobide<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P162<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Testicular organoids: a potential model to study the impact of endocrine-disrupting chemicals on steroidogenesis<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Katerina Papageorgiou<\/span><sup>P1,2<\/sup>, Samuel Madureira Silva<sup>1<\/sup>, Andrea Errico<sup>3<\/sup>, Mikael Pedersen<sup>4<\/sup>, Ellen Goossens<sup>1<\/sup>, Tamara Vanhaecke<sup>2<\/sup>, Yoni Baert<sup>2<\/sup><br><sup>1<\/sup> Genetics, Reproduction and Development research group, Biology of the Testis (BITE) laboratory, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.<br><sup>2<\/sup> In Vitro Toxicology and Dermato-cosmetology (IVTD) laboratory, Vrije Universiteit Brussel (VUB), 1090 Brussels, Belgium.<br><sup>3<\/sup> University of Verona; Department of Neurosciences, Biomedicine and Movement Sciences; 37124 Verona, Italy.<br><sup>4<\/sup> National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P163<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Hazard assessment of endocrine disruption potential using new alternative methods[SV1.1]: integration of in vitro thyroid peroxidase inhibition potency and metabolic fate of 3-amino-2,6-dimethylphenol explains its lack of thyroid toxicity in vivo<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sebastian Oskar Jarzina<\/span><sup>P1<\/sup>, Sjoerd&nbsp; Verkaart<sup>2<\/sup>, Joris van den Elzen<sup>2<\/sup>, Nuria Pineiro Costas<sup>2<\/sup>, Manuela Pavan<sup>3<\/sup>, Christian&nbsp; Novello<sup>3<\/sup>, Brunhilde Bl\u00f6meke<sup>4<\/sup>, Mira Wenker<sup>2<\/sup>, Carsten Goebel<sup>1<\/sup>, Karma Claire Fussell <sup>1<\/sup><br><sup>1<\/sup> Wella Company<br><sup>2<\/sup> Charles River Lab.<br><sup>3<\/sup> Innovatune Srl<br><sup>4<\/sup> University Trier<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P164<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Diverging endocrine disruption potential of resorcinol and paracetamol: thyroid peroxidase inhibition potency and metabolic fate differences under pharmaceutical and cosmetic use explain their contrasting endocrine disruption capabilities<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sebastian Oskar Jarzina<\/span><sup>P1<\/sup>, Sjoerd Verkaart<sup>2<\/sup>, Joris van den Elzen<sup>2<\/sup>, Manuela&nbsp; Pavan<sup>3<\/sup>, Christian Novello<sup>3<\/sup>, Brunhilde&nbsp; Bl\u00f6meke<sup>4<\/sup>, Mira Wenker<sup>2<\/sup>, Carsten Goebel<sup>1<\/sup>, Karma Claire Fussell<sup>1<\/sup><br><sup>1<\/sup> Wella Company<br><sup>2<\/sup> Charles River Lab.<br><sup>3<\/sup> Innovatune Srl<br><sup>4<\/sup> University Trier<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P165<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Monitoring PFAS and estrogenic bioactivity in source water using ER\u03b1- and PFAS-CALUX: A NAMs and ecosystem approach<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Giulia De Negri Atanasio<\/span><sup>P1,2<\/sup>, Lorenzo Dondero<sup>1,2<\/sup>, Francesca Tardanico<sup>1,2<\/sup>, Matteo Sergiampietri<sup>1<\/sup>, Erica Lertora<sup>1,2,3<\/sup>, Giacomo Rosa<sup>1<\/sup>, Andrea Costa<sup>1<\/sup>, Sebastiano Salvidio<sup>1<\/sup>, Elena&nbsp; Grasselli<sup>1,2,4<\/sup><br><sup>1<\/sup> Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy<br><sup>2<\/sup> Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro3R), Pisa, Italy<br><sup>3<\/sup> Angel Consulting S.a.s, Milano, Italy<br><sup>4<\/sup> Biostructures and Biosystems National Institute, Roma, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P166<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Generation of a historical control database, and acceptance and interpretation criteria for an in vitro comparative T4-glucuronidation assay using primary human and RAT hepatocyte (TruVivo\u00ae) for determination of human relevance of liver enzyme-mediated thyroid effects<\/a><\/h3>\n\n\n\n<p>Ahtasham Raza<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Lauren Kent<\/span><sup>P2<\/sup>, Marco Corvaro<sup>3<\/sup>, Jinlang Dong<sup>1<\/sup>, Justin Brown<sup>1<\/sup>, Suhair Al Janabi<sup>1<\/sup>, Stephanie Kellum<sup>1<\/sup>, Ed LeCluyse<sup>4<\/sup>, Jessica LaRocca<sup>5<\/sup>, Raja Settivari<sup>1<\/sup>, Shadia Catalano<sup>1<\/sup><br><sup>1<\/sup> Corteva Agriscience, Newark, Delaware, USA<br><sup>2<\/sup> Corteva Agriscience, Milton, United Kingdom<br><sup>3<\/sup> Corteva Agriscience, Rome, Italy<br><sup>4<\/sup> LifeNet Health LifeSciences, Research Triangle Park, North Carolina, USA<br><sup>5<\/sup> Corteva Agriscience, Indianapolis, Indiana, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P167<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Functional and safety assessment of estradiol and phytoestrogens in human epidermal models<\/a><\/h3>\n\n\n\n<p>Francesca Rispo<sup>1<\/sup>, Giulia&nbsp; De Negri Atanasio<sup>1<\/sup>, Ilaria&nbsp; Demori<sup>2<\/sup>, Francesca Tardanico<sup>1<\/sup>, Giosu\u00e8 Costa<sup>3<\/sup>, Emanuela Marchese<sup>3<\/sup>, Sim\u00f3n&nbsp; Perera del Rosario<sup>4,5<\/sup>, Eva&nbsp; Serrano-Candelas<sup>4<\/sup>, Martina&nbsp; Palomino-Sch\u00e4tzlein<sup>6<\/sup>, Lorenzo Dondero<sup>1<\/sup>, Annalisa Salis<sup>7<\/sup>, Gianluca Damonte<sup>7<\/sup>, Erica Lertora<sup>1,8<\/sup>, Matteo&nbsp; Sergiampietri<sup>1,8<\/sup>, Sara Ferrando<sup>1<\/sup>, Silvia Letasiova<sup>9<\/sup>, Jan Markus<sup>9<\/sup>, Matteo&nbsp; Zanotti-Russo<sup>8<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Elena Grasselli<\/span><sup>P1,10,11<\/sup><br><sup>1<\/sup> Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy<br><sup>2<\/sup> Department of Pharmacy, University of Genoa, Genova, Italy<br><sup>3<\/sup> Department of Health Sciences, University &#8220;Magna Graecia&#8221;, Catanzaro, Italy<br><sup>4<\/sup> ProtoQSAR SL, Centro Europeo de Empresas Innovadoras, Parque Tecnol\u00f3gico de Valencia, Valencia, Spain<br><sup>5<\/sup> Departament de Medicina i Ci\u00e8ncies de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain<br><sup>6<\/sup> Moldrug AI Systems S.L, Valencia, Spain<br><sup>7<\/sup> Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy<br><sup>8<\/sup> Angel Consulting Srl, Milano, Italy<br><sup>9<\/sup> MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia<br><sup>10<\/sup> Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Pisa, Italy<br><sup>11<\/sup> Biostructures and Biosystems National Institute, Roma, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P168<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Luteolin promotes steroidogenesis in I-10 mouse leydig cells exposed to atrazine<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Maryam Dawod<\/span><sup>P1<\/sup>, Ali Siddiqi<sup>1<\/sup>, Pengli Bu<sup>1<\/sup><br><sup>1<\/sup> Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John\u2019s University, Queens, 11439, NY, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P169<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Multiple mechanisms of AhR\/CAR\/PXR activators in thyroid (T-) modality: an in vitro perspective on human relevance<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Audrey BAZE<\/span><sup>P1<\/sup>, Betty Ory<sup>1<\/sup>, Lucille Wiss<sup>1<\/sup>, Am\u00e9lie Sch\u00e4fer<sup>1<\/sup>, Cassandra Chanel<sup>1<\/sup>, Corinne Guicheney<sup>2<\/sup>, Klaus Biemel<sup>3<\/sup>, Laure Asselin<sup>1<\/sup><br><sup>1<\/sup> KaLy-Cell SAS (GBA Group)<br><sup>2<\/sup> GBA Pharma<br><sup>3<\/sup> Pharmacelsus GmbH (GBA Group)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P170<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Interlaboratory validation study of a mineralocorticoid receptor transactivation assay (MRTA) to identify endocrine disruptors in an in vitro setting<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Kevin Schl\u00fcppmann<\/span><sup>P1<\/sup>, Andrea Rivero-Arze<sup>1<\/sup>, Pauline Lelandais<sup>1<\/sup>, Patrick Balaguer<sup>2<\/sup>, Torben \u00d6sterlund<sup>1<\/sup><br><sup>1<\/sup> Pepper, Paris, France<br><sup>2<\/sup> Institut de Recherche en Canc\u00e9rologie de Montpellier (IRCM), INSERM U1194, ICM, Univ Montpellier, Montpellier, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P171<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Validation project of a fluorescent FITC-T4 transthyretin competitive binding assay<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nathalie Belot<\/span><sup>P1<\/sup>, Pauline Lelandais<sup>1<\/sup>, Timo Hamers<sup>2<\/sup>, Toine Bovee<sup>3<\/sup>, Torben \u00d6sterlund<sup>1<\/sup><br><sup>1<\/sup> Pepper<br><sup>2<\/sup> Vrije Universiteit Amsterdam (VU), NL<br><sup>3<\/sup> Wageningen Food Safety Research (WFSR), NL<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P172<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Enhancement project of the LC-MS\/MS based steroidogenesis profiling assay (OECD TG456)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nathalie Belot<\/span><sup>P1<\/sup>, Nina Hambruch<sup>2<\/sup>, Torben \u00d6sterlund<sup>1<\/sup><br><sup>1<\/sup> Pepper<br><sup>2<\/sup> BASF<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P173<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Chemical mixture driven androgen receptor disruption<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Nikolina Perani\u0107<\/span><sup>P1<\/sup>, Lucija Bo\u017ei\u010devi\u0107<sup>1<\/sup>, Korinna Altmann<sup>2<\/sup>, Jana Hildebrandt<sup>2<\/sup>, Ivana Vinkovi\u0107 Vr\u010dek<sup>1<\/sup><br><sup>1<\/sup> Institute for Medical Research and Occupational Health<br><sup>2<\/sup> Bundesanstalt f\u00fcr Materialforschung und -pr\u00fcfung<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"systemic\"><a href=\"#systemic\" class=\"ek-link\">Models, biomarkers and assays for systemic and immune toxicity<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a>P174<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">In vitro genotoxicity assessment of chitin intended for use in the food industry<\/a><\/h3>\n\n\n\n<p>Ant\u00eda Lestido-Cardama<sup>1<\/sup>, Leticia Diez-Quijada<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Mar\u00eda Puerto<\/span><sup>P1<\/sup>, \u00c1ngeles Jos<sup>1<\/sup><br><sup>1<\/sup> Area of Toxicology, Faculty of Pharmacy, University of Seville, Seville, Spain.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P175<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Evaluating assay sensitivity in NGRA: A comparative study of cellular stress panels<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Adam Wood<\/span><sup>P1<\/sup>, Eva de Tombe<sup>2<\/sup>, Tamara Meijer<sup>2<\/sup>, Sharon Scott<sup>1<\/sup>, Bensu Tangil<sup>2<\/sup>, Bas ter Braak<sup>2<\/sup>, Amer Jamalpoor<sup>2<\/sup><br><sup>1<\/sup> Unilever<br><sup>2<\/sup> Toxys<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P176<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Integrated in vitro approach for immunotoxicity assessment of synthetic amorphous silica nanomaterials<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Amandine L\u00ea<\/span><sup>P1,2<\/sup>, Emilie&nbsp; Brun <sup>3<\/sup>, Ambre&nbsp; Jacquet<sup>1<\/sup>, C\u00e9dric&nbsp; F\u00e9ral-Martin<sup>2<\/sup>, Jacques-Aur\u00e9lien&nbsp; Sergent<sup>4<\/sup>, Marc&nbsp; Pallardy<sup>1<\/sup>, Armelle&nbsp; Biola-Vidamment<sup>1<\/sup><br><sup>1<\/sup> Universit\u00e9 Paris-Saclay, Inserm, Inflammation, Microbiome and Immunosurveillance, Facult\u00e9 de Pharmacie, 91 400, Orsay, France<br><sup>2<\/sup> Solvay, 93300, Aubervilliers, France.<br><sup>3<\/sup> Universit\u00e9 Paris-Saclay, CNRS, Institut de Chimie Physique, 91405, Orsay, France.<br><sup>4<\/sup> Solvay, Toxicological and Environmental Risk Assessment Unit, 1120 Neder-Over-Heembeek, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P177<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Toxicity and vector role of micro- and nanoplastics with pesticide residues in human cell line models<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Orlagh Gormley<\/span><sup>P1<\/sup>, Ali Can<sup>1<\/sup>, Gary Hardiman<sup>1<\/sup><br><sup>1<\/sup> School of Biological Sciences and Institute for Global Food Security, Queen&#8217;s University Belfast, 19 Chlorine Gardens, Belfast, BT9 5DL, Northern Ireland, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P178<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Investigation of the potential of Bisphenol A substitutes to induce allergic contact sensitization using OECD defined approaches<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Victor J. Johnson<\/span><sup>P1<\/sup>, Travis Gulledge<sup>2<\/sup>, Michael I. Luster<sup>1<\/sup>, Gary R. Burleson<sup>1<\/sup>, Florence G. Burleson<sup>1<\/sup><br><sup>1<\/sup> Burleson Research Technologies, Inc., Morrisville, NC, USA<br><sup>2<\/sup> Torque Bio, Inc., Durham, NC, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a>P179<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Developing a 3D multi component human skin model for vitiligo biomarker identification<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">MD ZOBAER HASAN<\/span><sup>P1,2<\/sup>, David Openshaw<sup>1<\/sup>, Hirofumi Nakanishi<sup>2<\/sup>, Kiichiro Sohara<sup>2<\/sup>, Tetsuo Furuno<sup>2<\/sup>, Craig Murdoch<sup>1<\/sup>, Helen Colley<sup>1<\/sup><br><sup>1<\/sup> University of Sheffield<br><sup>2<\/sup> Rohto Pharmaceutical<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">P<mark style=\"background-color:rgba(0, 0, 0, 0);color:#1e73be\" class=\"has-inline-color\">180<\/mark><\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">Setting up new approach methods to study B cell immunotoxicity using peripheral blood mononuclear cells<\/a><\/h3>\n\n\n\n<p>Wendy Jansen Holleboom<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Aafke WF Janssen<\/span><sup>P1<\/sup><br><sup>1<\/sup> Wageningen Food Safety Research, part of Wageningen University &amp; Research, Wageningen, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P<\/a><a class=\"ek-link\">1<\/a><a class=\"ek-link\">8<\/a><a class=\"ek-link\">1<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Recapitulating immune-driven hepatotoxicity using a liver microphysiological platform<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Justina Then<\/span><sup>P1<\/sup>, Isavella Georgiades<sup>1<\/sup>, Emily Richardson<sup>1<\/sup>, Tomasz Kostrzewski<sup>1<\/sup><br><sup>1<\/sup> CN Bio Innovations Ltd, Science Park, Cambridge, United Kingdom<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">P182<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Development and characterization of an immunocompetent and vascularized skin model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ambre All\u00e9on<\/span><sup>P1,2<\/sup>, Annia Perez-Riveron<sup>1<\/sup>, Pualani Ateni<sup>1<\/sup>, Marina Simon<sup>2<\/sup>, Christian Poinsot<sup>2<\/sup>, Edith Filaire<sup>2<\/sup>, Vincent Flacher<sup>1<\/sup><br><sup>1<\/sup> Laboratory CNRS UPR3572\/I2CT Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Mol\u00e9culaire et Cellulaire, Strasbourg, France.<br><sup>2<\/sup> Groupe Icare, Biop\u00f4le Clermont-Limagne, Saint Beauzire, France.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a class=\"ek-link\">P<\/a><a href=\"#fake\" class=\"ek-link\">183<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Comparative analysis of cellular respones to selected carcinogens in 3D HEPG2 monoculture and HEPG2\/kupffer cell co-culture models<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tim Ravnjak<\/span><sup>P1,2<\/sup>, Gillian&nbsp; Conway<sup>3<\/sup>, Michael&nbsp; Burgum<sup>3<\/sup>, Shareen&nbsp; Doak<sup>3<\/sup>, Bojana \u017degura<sup>1,2<\/sup><br><sup>1<\/sup> National Institute of Biology, Department of Genetic Toxicology and Cancer Biology, Ve\u010dna pot 121, Ljubljana, Slovenia<br><sup>2<\/sup> Jozef Stefan International Postgraduate School, Jamova cesta 39, Ljubljana, Slovenia<br><sup>3<\/sup> In Vitro Toxicology Group, Faculty of Medicine, Health and Life Sciences, Swansea University Medical School, Swansea University, SA2 8PP, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">P184<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Biodegradable plastics: contaminants of emerging concern<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Cigdem Erdogan<\/span><sup>P1<\/sup>, Ali Can<sup>1<\/sup>, Gary&nbsp; Hardiman<sup>1<\/sup><br><sup>1<\/sup> Queen&#8217;s University Belfast<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\".\" class=\"ek-link\">P<\/a><a href=\"#FAke\" class=\"ek-link\">1<\/a><a href=\".\" class=\"ek-link\">85<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a class=\"ek-link\">Linking structural similarity to toxicogenomic profiles: transcriptomic read-across of flavonoids<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Markus Bruell<\/span><sup>P1<\/sup>, Silja Vo\u00df<sup>1<\/sup>, Rita Fernandes<sup>1<\/sup>, Andreas Schepky<sup>1<\/sup>, Johanna Ebmeyer<sup>1<\/sup><br><sup>1<\/sup> Beiersdorf AG<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><span style=\"text-decoration: underline;\" class=\"ek-underline\"><a href=\"#FAke\" class=\"ek-link\">P186<\/a><\/span><\/h2>\n\n\n\n<h3 class=\"block-heading\"><span style=\"text-decoration: underline;\" class=\"ek-underline\"><a href=\"#FAke\" class=\"ek-link\">Assessment of the sensitizing potential of chemicals and proteins, alone and in mixtures, using the bmdc model<\/a><\/span><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Z. Salmon<\/span><sup>P1,2<\/sup>, S. Jacquenet<sup>2<\/sup>, A. Coiscaud<sup>2<\/sup>, J. Mathiot<sup>2<\/sup>, S. Muller<sup>2<\/sup>, M. Mourot-Bousquenaud<sup>2<\/sup>, S. Kerdine-R\u00f6mer<sup>1<\/sup>, F. Battais<sup>2<\/sup><br><sup>1<\/sup> Universit\u00e9 Paris-Saclay, Inserm, Inflammation microbiome immunosurveillance, Team ITALI &#8211; Immunotoxicology, Allergy and Immunogenicity 91400, ORSAY, France<br><sup>2<\/sup> French Research and Safety Institute for the Prevention of Occupational Accidents and Disease (INRS, \u00ab Immunology, sensitization and allergies \u00bb laboratory, Toxicology and Biomonitoring Division, Vandoeuvre-l\u00e8s-Nancy, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\"><span style=\"text-decoration: underline;\" class=\"ek-underline\">P18<\/span>7<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">When safe isn\u2019t safe together: co-exposure to individually non-toxic compounds alters liver HEPG2 spheroid functional integrity<\/a><\/h3>\n\n\n\n<div class=\"block-gutenberghub-block-style-previewer\"><\/div>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">P188<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">Comparative roles of CYP2E1 in isoniazid- and iproniazid-induced hepatotoxicity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Yasuhiro Masubuchi<\/span><sup>P1<\/sup>, Kyohei Miyauchi<sup>1<\/sup><br><sup>1<\/sup> Faculty of Pharmaceutical Sciences, Chiba Institute of Science<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">P189<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">Mechanistic investigation of the immunotoxicity of synthetic amorphous silica nanomaterials using new approach methodologies<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ambre Jacquet<\/span><sup>P1<\/sup>, Amandine L\u00ea <sup>1<\/sup>, Agata Nawrotek Maalouf<sup>2<\/sup>, Marc Pallardy<sup>1<\/sup>, Mahel Zeghouf <sup>2<\/sup>, Armelle&nbsp; Biola-Vidamment<sup>1<\/sup><br><sup>1<\/sup> Universit\u00e9 Paris-Saclay, INSERM, Inflammation, Microbiome and Immunosurveillance, Orsay, France<br><sup>2<\/sup> ENS Paris-Saclay, CNRS, Laboratoire de Biologie et Pharmacologie Appliqu\u00e9e, Gif-Sur-Yvette, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P190<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Development of a large-pore cell-based in vitro intestinal model for size-dependent microplastic transport and safety assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Yicheng Wei<\/span><sup>P1<\/sup>, Shohei Kaneko<sup>1<\/sup>, Hyunjin Choi<sup>2<\/sup>, Takeshi Katsuda<sup>1<\/sup>, Masaki Nishikawa<sup>1<\/sup>, Yasuyuki Sakai<sup>1<\/sup><br><sup>1<\/sup> Graduate School of Engineering, The University of Tokyo<br><sup>2<\/sup> Department of Bio and Brain Engineering, Daejeon, Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P191<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Ex vivo nonclinical system using fresh circulating human whole blood (id.flow\u00ae) for evaluating immunotoxicity<\/a><\/h3>\n\n\n\n<p>Helena Laven<sup>1<\/sup>, Erika Fletcher<sup>1<\/sup>, Gunilla T\u00f6rnqvist<sup>1<\/sup>, Louise Nilsson<sup>1<\/sup>, Alexander Kele<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Sakthi Srinivasan<\/span><sup>P1<\/sup>, Sara Mangsbo<sup>1<\/sup><br><sup>1<\/sup> Immuneed AB, Uppsala, Sweden<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P192<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Predictive and mechanistic immunotoxicology using single-cell metabolomics<\/a><\/h3>\n\n\n\n<p>Jeany Delafiori<sup>1<\/sup>, Mohammed Shahraz<sup>2<\/sup>, Katja Ovchinnikova<sup>1<\/sup>, Shawn Owens<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Theodore Alexandrov<\/span><sup>P1,2<\/sup><br><sup>1<\/sup> DeepCyte, Inc.<br><sup>2<\/sup> Department of Pharmacology, University of California San Diego<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P193<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Integrating complementary in vitro endpoints reveals mitochondrial and oxidative effects of PA\u03b2N beyond standard viability assays<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Elodie OLIVIER<\/span><sup>P1<\/sup>, Hilal WEHBI<sup>2<\/sup>, Gilles PHAN<sup>2<\/sup>, Isabelle BROUTIN<sup>2<\/sup><br><sup>1<\/sup> Universit\u00e9 Paris Cit\u00e9, UMR CNRS 8038 C-TAC, Paris, France<br><sup>2<\/sup> Universit\u00e9 Paris Cit\u00e9, UMR CNRS 8038, Paris, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P194<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Testing immunomodulatory effects (IMOC) of micro-and nanoplastic particles (MNP) and isothiazolinones in human monocytic cells<\/a><\/h3>\n\n\n\n<p>Sebastian&nbsp; Wolf<sup>1,2<\/sup>, Antonia Koerber<sup>1,3<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Hermann-Josef Thierse<\/span><sup>P1,2<\/sup><br><sup>1<\/sup> German Federal Institute for Risk Assessment, Department for Chemicals and Product Safety, Berlin, Germany<br><sup>2<\/sup> Heidelberg University, Medical Faculty Mannheim, Mannheim, Germany<br><sup>3<\/sup> Freie Universit\u00e4t Berlin, Institute of Biochemistry, Berlin, Germany University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P195<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">A combined comet assay and viability strategy for phototoxicity and photogenotoxicity screening in HaCaT cells<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Elisabet Teixid\u00f3<\/span><sup>P1<\/sup>, Laura Pous<sup>1<\/sup>, Adrianna S Maddaleno<sup>2<\/sup>, Laia Guardia-Escot\u00e9<sup>1<\/sup>, Maria Pilar&nbsp; Vinardell<sup>2<\/sup>, Montse&nbsp; Mitjans<sup>2<\/sup><br><sup>1<\/sup> GRET &#8211; Toxicologia, Departament de Farmacologia, Toxicologia i Qu\u00edmica Terap\u00e8utica, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona<br><sup>2<\/sup> CEREX &#8211; Fisiologia, Departament de Bioqu\u00edmica i Fisiologia, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"vaccines\"><a href=\"#vaccines\" class=\"ek-link\">Non-animal methods for safety testing of biopharmaceuticals\/biotherapies\/vaccines<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#fake link\" class=\"ek-link\">P196<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#fake link\" class=\"ek-link\">Development of human iPSC-derived hepatocytes for drug discovery, translational research and toxicity testing<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tom Harris-Brown<\/span><sup>P1<\/sup>, Gianmarco Mastrogiovanni<sup>2<\/sup>, Sabitri Ghimire<sup>2<\/sup>, Roxana Piscupescu<sup>2<\/sup>, Jethro Hundling Hundling<sup>2<\/sup>, Nick&nbsp; James<sup>2<\/sup>, Victoria Cornelius<sup>2<\/sup>, Stefan Milde<sup>2<\/sup>, Andrew Knights<sup>2<\/sup>, Val&nbsp; Yianni<sup>2<\/sup>, Ben Newman Newman<sup>2<\/sup>, Karl Firth<sup>2<\/sup>, Will Bernard<sup>2<\/sup><br><sup>1<\/sup> bit.bio<br><sup>2<\/sup> bit.bio<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P197<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Development and validation of a human reporter cell-based assay for mitochondrial toxicity assessment<\/a><\/h2>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tamara Meijer<\/span><sup>P1<\/sup>, Bensu Tangil<sup>1<\/sup>, Bas ter Braak<sup>1<\/sup>, Eva de Tombe<sup>1<\/sup>, Sharon Scott<sup>2<\/sup>, Adam Wood<sup>2<\/sup>, Amer Jamalpoor<sup>1<\/sup><br><sup>1<\/sup> Toxys B.V., Leiden Bio Science Park, The Netherlands<br><sup>2<\/sup> Unilever R&amp;D, SERS, Sharnbrook, United Kingdom<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P198<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Phenotypic screening platforms for neurotoxicity and neurorepair in CNS drug safety assessment<\/a><\/h3>\n\n\n\n<p>Gurvan&nbsp;&nbsp; Mahe <sup>1<\/sup>, Jeroen&nbsp;&nbsp; Esselink <sup>1<\/sup>, Mathew Hembury <sup>1<\/sup>, David K\u00e1roly Ketskem\u00e9ty<sup>1<\/sup>, Mariana Pliego Caballero<sup>1<\/sup>, Maria Blanca&nbsp;Torroba<sup>1<\/sup>, Jody&nbsp; van Offenbeek<sup>1<\/sup>, Kimberly Lo<sup>1<\/sup>, Cindy&nbsp; J.M. Looman<sup>1<\/sup>, Mark Musters<sup>1<\/sup>, Malika Bsibsi<sup>1<\/sup>, Laila Ritsma<sup>1<\/sup>, Ludovico Buti<sup>1<\/sup>, Andre van Marle<sup>1<\/sup>, Sabrina de Munnik<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Peter Imre Racz<\/span><sup>P1<\/sup>, Marijn&nbsp; Vlaming<sup>1<\/sup><br><sup>1<\/sup> Charles River Laboratories<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P199<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Preclinical de-risking of cell therapy products<\/a><\/h3>\n\n\n\n<p>Sabrina de Munnik<sup>1<\/sup>, Benita Quist<sup>1<\/sup>, Henry&nbsp; Leonard<sup>1<\/sup>, Louise Francois<sup>1<\/sup>, Monique Hazenoot<sup>1<\/sup>, Monika Hiller<sup>1<\/sup>, Rhiannon&nbsp;Shea<sup>1<\/sup>, Lauren Schewitz-Bowers<sup>1<\/sup>, Daniel&nbsp; Rocca<sup>1<\/sup>, Robert&nbsp; Nunan<sup>1<\/sup>, Louise Brackenbury<sup>1<\/sup>, Mark&nbsp;Aspinall O\u2019Dea<sup>1<\/sup>, Roxana&nbsp;Redis<sup>1<\/sup>, Gemma Moiset<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Peter Imre Racz<\/span><sup>P1<\/sup><br><sup>1<\/sup> Charles River Laboratories<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P200<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Skimune\u00ae a powerful human-centric platform for the identification of t cell engager immunotoxicity<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Steven O&#8217;Reilly<\/span><sup>P1<\/sup>, Katie Smith<sup>1<\/sup>, Abbas Ishaq<sup>1<\/sup>, Anne Dickinson<sup>1<\/sup><br><sup>1<\/sup> Alcyomics<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P201<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Non human primate in vitro NAMs: a translational platform to complement human NAMs for efficient drug safety evaluation<\/a><\/h3>\n\n\n\n<p>Lucia Ramirez<sup>1<\/sup>, Fabian P.&nbsp; Suchy <sup>1,2<\/sup>, Laura Rijns<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Morteza Roodgar<\/span><sup>P1,2<\/sup><br><sup>1<\/sup> Exir Bio, Menlo Park, CA 94025, USA.<br><sup>2<\/sup> Stanford University, School of Medicine, Stanford University, Stanford, CA 94305, USA.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P202<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Metabolic and cytotoxic readouts differentiate responses of 2D and 3D in vitro pancreatic ductal adenocarcinoma models to 5-fluorouracyl and paclitaxel<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mateo Celini\u0107<\/span><sup>P1<\/sup>, Nikolina Perani\u0107<sup>1<\/sup>, Lucija Bo\u017ei\u010devi\u0107<sup>1<\/sup>, Nikolina Kal\u010dec<sup>1<\/sup>, Ivana Vinkovi\u0107 Vr\u010dek<sup>1<\/sup><br><sup>1<\/sup> Institute for Medical Research and Occupational Health<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P203<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Multicellular human intestinal new approach methodologies (NAM) with machine learning for diarrhea risk strattification across small molecules and antibody drug conjugates (ADC)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Caridad Rosette<\/span><sup>P1<\/sup>, Vivian Xiao Han<sup>1<\/sup>, Sherwin Gervacio<sup>1<\/sup>, Cole Toohey<sup>1<\/sup>, Haylee Aidnick<sup>1<\/sup>, Amar A. Sethi<sup>1<\/sup><br><sup>1<\/sup> VivoSim Labs, Inc.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P204<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Multicellular human 3D liver new approach methodologies (NAM) for DILI risk assessment across small molecules and antibody drug conjugates<\/a><\/h3>\n\n\n\n<p>Mehrsa Mehrabi<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Caridad Rosette<\/span><sup>P1<\/sup>, Rachel Dudum<sup>1<\/sup>, Payton Olson<sup>1<\/sup>, Cole Toohey<sup>1<\/sup>, Haylee Aidnik<sup>1<\/sup>, Amar A. Sethi<sup>1<\/sup><br><sup>1<\/sup> VivoSim Labs Inc<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P205<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">In vitro safety profiling of ADCs using an iPSC-derived human tissue screen to support FDA roadmap for biologics<\/a><\/h3>\n\n\n\n<p>Leo Smit<sup>1<\/sup>, Katerina&nbsp; Pitsa<sup>1<\/sup>, Carola van Berkel<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Sanne Holt<\/span><sup>P1<\/sup><br><sup>1<\/sup> Ncardia Services B.V.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P206<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">InVEST44\u2122 is a cost-effective in vitro safety panel that identifies off-target effects in early stage drug discovery<\/a><\/h3>\n\n\n\n<p>Julian Wooltorton<sup>1<\/sup>, Afsara Ahona<sup>1<\/sup>, Nicole Barbacane<sup>1<\/sup>, Alex D&#8217;Andrea<sup>1<\/sup>, Justin Lansberry<sup>1<\/sup>, Cindy Lay<sup>1<\/sup>, Paige Miller<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Luisa Duque<\/span><sup>P1<\/sup>, John Ries<sup>1<\/sup>, Jamin Steffen<sup>1<\/sup>, Patricia Valentine<sup>1<\/sup><br><sup>1<\/sup> Reaction Biology Corporation, 1 Great Valley Parkway, Suite 2, Malvern PA 19355<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P207<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">A one health view on global outlook and future strategies for aninal testing replacement for vaccines: a report on the AFSA-IABS international conference<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jan Turner<\/span><sup>P1<\/sup>, Laura Viviani<sup>2<\/sup>, Blaise Descampe<sup>3<\/sup>, Colleen Pike<sup>1<\/sup><br><sup>1<\/sup> Humane World for Animals<br><sup>2<\/sup> SciEthiQ<br><sup>3<\/sup> Blaise Management<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"organ\"><a href=\"#organ\" class=\"ek-link\">Organ-on-a-chip &amp; Microphysiological Systems<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P208<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tim Kaden<\/span><sup>P1,2<\/sup>, Katja Graf<sup>1<\/sup>, Knut&nbsp; Rennert<sup>1<\/sup>, Ruoya Li<sup>3<\/sup>, Alexander S.&nbsp; Mosig<sup>2<\/sup>, Martin Raasch<sup>1<\/sup><br><sup>1<\/sup> Dynamic42 GmbH, Jena, Germany<br><sup>2<\/sup> Institute of Biochemistry II, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany<br><sup>3<\/sup> Biopredic International, St Gregoire, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P209<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Qualification of the PhysioMimix DILI assay in the 3RsC-FDA cross-platform DILI project<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Emily Richardson<\/span><sup>P1<\/sup>, Justina Then<sup>1<\/sup>, Isavella&nbsp; Georgiades<sup>1<\/sup>, Ovidiu&nbsp; Novac<sup>1<\/sup>, Kim Lachani<sup>1<\/sup>, Tomasz Kostrzewski<sup>1<\/sup><br><sup>1<\/sup> CN Bio Innovations<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\".\" class=\"ek-link\">P210<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Scaling without compromise: liver MPS for lead optimization screens to investigative toxicology<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ovidiu Novac<\/span><sup>P1<\/sup>, Emily Richardson<sup>2<\/sup>, Clive&nbsp; Roper<sup>3<\/sup>, Tomasz Kostrzewski<sup>2<\/sup><br><sup>1<\/sup> CN Bio Innovations<br><sup>2<\/sup> CN Bio Innovations<br><sup>3<\/sup> Roper Toxicology Consulting Limited<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P211<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Integration of human hepatocytes and kupffer cells into an immune-competent liver organoids-on-a-chip model<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tha\u00eds Silva Pinto<\/span><sup>P1<\/sup>, Kirsten Pondman<sup>2<\/sup>, Maureen\u202f M.J.\u202fGuichelaar<sup>3<\/sup>, Anja&nbsp; Wilmes<sup>1<\/sup><br><sup>1<\/sup> Vrije Universiteit Amsterdam, Faculty of Science, AIMMS, Department of Chemistry and Pharmaceutical Sciences, Division of Molecular Toxicology. Amsterdam \u2013 The Netherlands<br><sup>2<\/sup> University of Twente, Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), BIOS lab-on-a-chip group. Enschede \u2014 The Netherlands<br><sup>3<\/sup> Medisch Spectrum Twente, Department of Gastroenterology &amp; Hepatology. Enschede \u2014 The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P212<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Advancing NAMs with intestinal organoids: cross-species profiling of targeted protein degraders and hook effect dynamics<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Camilla Ceroni<\/span><sup>P1<\/sup>, Orlane Maloudi<sup>1<\/sup>, Carole Pissot<sup>1<\/sup>, Kuno Wuersch<sup>1<\/sup>, Axel Vicart<sup>1<\/sup>, Markus Linder<sup>1<\/sup>, Katie Kubek-Luck<sup>1<\/sup><br><sup>1<\/sup> Novartis Pharma AG<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P213<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">A human liver-on-chip platform integrating HepaRG cells and LSECs to model hepatic function<\/a><\/h3>\n\n\n\n<p>Ambre&nbsp;Giau<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Hugo Coppens-Exandier<\/span><sup>P1<\/sup>, Ana Mesic<sup>2<\/sup>, Louna Blasco<sup>3<\/sup>, Thomas Darde<sup>4<\/sup>, Pamela Bachour El-Azzi<sup>1<\/sup>, Agn\u00e8s Jamin<sup>1<\/sup>, Eva-Anne&nbsp;Subileau<sup>1<\/sup><br><sup>1<\/sup> Biopredic International<br><sup>2<\/sup> ENS Paris \u2013 Saclay Laboratoire LUMIN (UMR9024)<br><sup>3<\/sup> Institut FEMTO-ST (UMR6174)<br><sup>4<\/sup> SciLicium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P214<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Translational toxicology: adapting liver microphysiological system for cross-species evaluation of hepatotoxicity risk<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Isavella Georgiades<\/span><sup>P1<\/sup>, Dr. Justina Then<sup>1<\/sup>, Dr. Ovidiu Novac<sup>1<\/sup>, Dr. Emily Richardson<sup>1<\/sup>, Dr. Tomasz Kostrzewski<sup>1<\/sup><br><sup>1<\/sup> CN Bio Innovations<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P215<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Impact of intestinal model complexity on deoxynivalenol-induced cytotoxicity: a comparative in vitro study<\/a><\/h3>\n\n\n\n<p>Martina S\u00e1nchez<sup>1,2<\/sup>, Mercedes Taroncher<sup>1,2<\/sup>, Mar\u00eda Jos\u00e9 Ruiz<sup>1,2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Veronica Zingales<\/span><sup>P1,2<\/sup><br><sup>1<\/sup> Toxicology Laboratory, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicent Andr\u00e9s Estell\u00e9s s\/n, 46100 Burjassot, Valencia, Spain<br><sup>2<\/sup> Research group on Alternative Methods for the Determination of Toxic Effects and Risk Assessment of Contaminant and Mixture (RiskTox)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P216<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Modeling CAR-T cell migration and efficacy in a microphysiological system<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Rosanna Stolberg<\/span><sup>P1<\/sup>, Dimitrios L. Wagner<sup>2,3<\/sup>, Petra Reinke<sup>2,3<\/sup>, Eva-Maria Dehne<sup>1<\/sup><br><sup>1<\/sup> TissUse GmbH, Berlin, Germany<br><sup>2<\/sup> Charit\u00e9 &#8211; Universit\u00e4tsmedizin Berlin, Berlin, Germany<br><sup>3<\/sup> Berlin Institute of Health (BIH) at Charit\u00e9, Berlin, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P217<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Opportunities in toxicity testing of new drug modalities with 3D in vitro models<\/a><\/h2>\n\n\n\n<p>Sara Shafiei <sup>1<\/sup>, Xandor&nbsp; Spijkers<sup>1<\/sup>, Nienke Wevers<sup>1<\/sup>, Kinga&nbsp; Kosim<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Indi Joore<\/span><sup>P1<\/sup>, Brian Duggan<sup>1<\/sup>, Vincent van Duinen<sup>1<\/sup>, Flavio Bonanini<sup>1<\/sup>, Henriette&nbsp; Lanz<sup>1<\/sup>, Dorota Kurek<sup>1<\/sup><br><sup>1<\/sup> MIMETAS B.V<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P218<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">3D human intestinal organoids as a platform to assess compound-induced gastrointestinal toxicity<\/a><\/h2>\n\n\n\n<p>Tania&nbsp; Martianez Canales<sup>1<\/sup>, Tomasz&nbsp; Cholewinski<sup>1<\/sup>, Youri&nbsp; van Elswijk <sup>1<\/sup>, Melissa&nbsp; Zuiderwijk<sup>2<\/sup>, Behnam&nbsp; Amiri<sup>3<\/sup>, Christian&nbsp; Maass<sup>3<\/sup>, Tessa&nbsp; de Korte<sup>2<\/sup>, Marijn&nbsp; Vlaming<sup>1<\/sup>, Berend van Meer<sup>2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Ludovico Buti<\/span><sup>P1<\/sup><br><sup>1<\/sup> Charles River Labs<br><sup>2<\/sup> Sync Biosystems &#8211; Demcon<br><sup>3<\/sup> MPSlabs, ESQlabs GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P219<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Predicting gastrointestinal toxicity using the assay-ready, primary-derived OrganoReady\u00ae colon organoid model<\/a><\/h3>\n\n\n\n<p>Sara Shafiei <sup>1<\/sup>, Brian&nbsp;Duggan<sup>1<\/sup>, Melanie&nbsp;Cuijpers<sup>1<\/sup>, Ka Yen Liu<sup>1<\/sup>, Moran&nbsp;Morelli<sup>1<\/sup>, Manon Haarmans<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Indi Joore<\/span><sup>P1<\/sup>, Kinga Kosim<sup>1<\/sup>, Lenie van den Broek<sup>1<\/sup>, Pleun Hombrink<sup>1<\/sup>, Sebastiaan Trietsch<sup>1<\/sup><br><sup>1<\/sup> MIMETAS B.V, Oegstgeest, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P220<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">An air\u2013liquid interface (ALI)-compatible, magnetically actuated platform for programmable cyclic stretch in human alveolar in vitro models<\/a><\/h3>\n\n\n\n<p>YU CHE LIN<sup>1,1<\/sup>, Yasuyuki Sakai<sup>1<\/sup>, Masaki NIshikawa<sup>1<\/sup>, Hiroshi Katsuda<sup>1<\/sup><br><sup>1<\/sup> Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P221<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Elucidating gut-liver interactions in first pass metabolism of drugs using on-chip perfused and direct oxygenated MPS (BioStellar\u2122 plate)<\/a><\/h3>\n\n\n\n<p>Dhimas Kurniawan<sup>1<\/sup>, Shion Kanehara<sup>2<\/sup>, Yuna Osada<sup>2<\/sup>, Aiko Mizuno<sup>3<\/sup>, Hirohito Taniguchi<sup>3<\/sup>, Taichi Aihara<sup>3<\/sup>, Katsuhiro Esashika<sup>4<\/sup>, Jingjing Yang<sup>4<\/sup>, Satoshi Yamasaki<sup>4<\/sup>, Yusuke Masuo<sup>2<\/sup>, Yukio Kato<sup>2<\/sup>, Nobuaki Shiraki<sup>5<\/sup>, Shoen Kume<sup>5<\/sup>, Kenta Shinha<sup>6<\/sup>, Hiroshi Kimura<sup>6<\/sup>, Masaki Nishikawa<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Yasuyuki Sakai<\/span><sup>P1<\/sup><br><sup>1<\/sup> University of Tokyo<br><sup>2<\/sup> Kanazawa University<br><sup>3<\/sup> Sumitomo Bakelite Co. Ltd.<br><sup>4<\/sup> Mitsui Chemicals Inc.<br><sup>5<\/sup> Institute of Science Tokyo<br><sup>6<\/sup> Tokai University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P222<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Merging organoid and organ-on-chip technology to generate physiological models of ocular tissue<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Svenja Wingerter<\/span><sup>P1,2<\/sup>, Kevin Achberger<sup>3<\/sup>, Madalena Cipriano<sup>1<\/sup>, Julia&nbsp; Roosz<sup>4<\/sup>, Seyma Bektas Tercan<sup>1<\/sup>, Johanna Chuchuy<sup>1<\/sup>, Kaushambee Dave<sup>3<\/sup>, Simon J. Clark<sup>2,5,6<\/sup>, Stefan Liebau<sup>3<\/sup>, Peter&nbsp; Loskill<sup>1,4<\/sup><br><sup>1<\/sup> Department for Microphysiological Systems, Institute of Biomedical Engineering, Faculty of Medicine, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany<br><sup>2<\/sup> Institute for Ophthalmic Research, Department for Ophthalmology, University Medical Center, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany<br><sup>3<\/sup> Institute of Neuroanatomy &amp; Developmental Biology (INDB), Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany<br><sup>4<\/sup> NMI Natural and Medical Sciences Institute at the University of T\u00fcbingen, Reutlingen, Germany<br><sup>5<\/sup> Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK<br><sup>6<\/sup> University Eye Clinic, Eberhard Karls University of T\u00fcbingen, T\u00fcbingen, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P223<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Single cell printing enables adaptive tumor immunity interactions<\/a><\/h3>\n\n\n\n<p>Yuan Pang<sup>1<\/sup><br><sup>1<\/sup> Tsinghua University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P224<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Microfluidic tumor-on-chip platforms for modeling tumor-immune cell interactions and patient-specific immunotherapy responses ex vivo<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Julia Roosz<\/span><sup>P1<\/sup>, Tengku Ibrahim Maulana<sup>2<\/sup>, Nicole Anderle<sup>1<\/sup>, Andr\u00e9 Rosa<sup>1<\/sup>, Nathalia Ferreira<sup>3<\/sup>, Frauke Alves<sup>3<\/sup>, Peter Loskill<sup>4,2,5<\/sup><br><sup>1<\/sup> NMI Natural and Medical Sciences Institute at the University of T\u00fcbingen, Reutlingen, Germany<br><sup>2<\/sup> Department for Microphysiological Systems, Institute of Biomedical Engineering, Faculty of Medicine, Eberhard Karls University T\u00fcbingen, T\u00fcbingen, Germany<br><sup>3<\/sup> Translational Molecular Imaging, Max-Planck-Institute For Multidisciplinary Sciences, G\u00f6ttingen, Germany&nbsp;&nbsp;&nbsp;<br><sup>4<\/sup> NMI Natural and Medical Sciences Institute at the University of T\u00fcbingen, Reutlingen, Germany&nbsp;<br><sup>5<\/sup> 3R Center T\u00fcbingen for In Vitro Models and Alternatives to Animal Testing, T\u00fcbingen, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P225<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Amitraz induces cytotoxicity and functional alterations in neuronally differentiated SH-SY5Y spheroids<\/a><\/h3>\n\n\n\n<p>Felipe Franco-Campos<sup>1,2<\/sup>, Raquel Penalva-Olcina<sup>1,2<\/sup>, Mercedes Taroncher<sup>1,2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Veronica Zingales<\/span><sup>P1,2<\/sup>, Yelko Rodr\u00edguez-Carrasco<sup>1,2<\/sup>, Mar\u00eda-Jos\u00e9 Ruiz<sup>1,2<\/sup><br><sup>1<\/sup> Toxicology and Food Chemistry Laboratory, Faculty of Pharmacy. University of Valencia, Burjassot-Valencia, Spain<br><sup>2<\/sup> Research Group in Alternative Methods for Determining Toxic Effects and Risk Assessment of Contaminants and Mixtures (RiskTox), University of Valencia, Burjassot-Valencia, Spain<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P226<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Engineering of cancer microenvironments with embedded interconnected microcapillary networks via in vitro magnetic assembly of endothelial-cell \u2018seeds\u2019.<\/a><\/h3>\n\n\n\n<p>Katarzyna Rojek<sup>1<\/sup>, Paulina&nbsp; Musolf<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Jan Guzowski<\/span><sup>P1<\/sup><br><sup>1<\/sup> Institute of Physical Chemistry Polish Academy of Sciences<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\".\" class=\"ek-link\">P2<\/a><a href=\"#FAke\" class=\"ek-link\">2<\/a><a href=\".\" class=\"ek-link\">7<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Impact of intestinal model complexity on deoxynivalenol-induced cytotoxicity: a comparative in vitro study<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Martina S\u00e1nchez<\/span> <sup>P1,2<\/sup>, Mercedes Taroncher<sup>1,2<\/sup>, Mar\u00eda Jos\u00e9 Ruiz<sup>1,2<\/sup>, Veronica Zingales<sup>1,2<\/sup><br><sup>1<\/sup> Toxicology Laboratory, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicent Andr\u00e9s Estell\u00e9s s\/n, 46100 Burjassot, Valencia, Spain<br><sup>2<\/sup> Research group on Alternative Methods for the Determination of Toxic Effects and Risk Assessment of Contaminant and Mixture (RiskTox)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p>   <a href=\"https:\/\/www.estiv.org\/admin\/post.php?post=11120&amp;action=edit#Goback\" class=\"ek-link\">Go back<\/a>    <\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"other\"><a href=\"#other\" class=\"ek-link\">Other<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P228<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Convergence science: the 3Rs versus the NAMs<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Thierry Decelle<\/span><sup>P1<\/sup><br><sup>1<\/sup> DCL solutions<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P229<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Investigation of the effects of reduced gravity on liver using new approach methodologies<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mathieu Vinken<\/span><sup>P1<\/sup><br><sup>1<\/sup> Vrije Universiteit Brussel<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P230<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Multi-level characterization of liver-based in vitro models and their application to food-derived chemicals<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alexandra-Costina Av\u00eervarei<\/span><sup>P1<\/sup>, Amy&nbsp; Maerten<sup>1<\/sup>, Anouk&nbsp; Verhoeven<sup>1<\/sup>, Mathieu&nbsp; Vinken<sup>1<\/sup>, Julen&nbsp; Sanz-Serrano<sup>1<\/sup><br><sup>1<\/sup> Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P231<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Overcoming systemic barriers toward animal-free research through collaboration and critical reflection<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Katja Ten Cate<\/span><sup>P1<\/sup>, Daniela Salvatori<sup>2<\/sup>, Wim de Leeuw<sup>1<\/sup>, Shalenie den Braver<sup>1<\/sup><br><sup>1<\/sup> Netherlands National Committee for the protection of animals used for scientific purposes (NCad)<br><sup>2<\/sup> Ombion Centre for Animal-Free Biomedical Translation (CPBT)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P232<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Challenges and opportunities in evaluation of in vivo and in vitro irritation<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Klara Hammarstrand<\/span><sup>P1<\/sup>, Crystal D\u2019Silva<sup>1<\/sup>, Paul Valaitis<sup>1<\/sup><br><sup>1<\/sup> Baxter Healthcare<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P233<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Development, characterisation and standardisation of in vitro airway models from the nasal cavity down to the alveoli<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Samuel Constant<\/span><sup>P1<\/sup><br><sup>1<\/sup> Epithelix<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P234<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Development of an in vitro model incorporating adverse outcome pathways to assess aerosol effects on cellular mechanisms related to chronic obstructive pulmonary disease<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">David Smart<\/span><sup>P1<\/sup>, Ian Crooks<sup>1<\/sup>, Michael Hollings<sup>2<\/sup>, Damien Breheny<sup>1<\/sup><br><sup>1<\/sup> British American Tobacco<br><sup>2<\/sup> Labcorp UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P235<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">From one lung to many tests: A NAM-compliant ex vivo lung slice model for inhalation toxicity assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Massimo Caruso<\/span><sup>P1,2<\/sup><br><sup>1<\/sup> University of Catania<br><sup>2<\/sup> Center of Excellence for the acceleration of Harm Reduction (CoEHAR)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P236<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Methods to assess delivered dose in air-liquid interface exposure systems<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tobias Krebs<\/span><sup>P1<\/sup><br><sup>1<\/sup> Vitrocell Systems GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P237<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Methods to assess delivered dose in air-liquid interface exposure systems.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tobias Krebs<\/span><sup>P1<\/sup>, Marco&nbsp; Hebestreit<sup>1<\/sup>, Christoph Schlager<sup>1<\/sup>, Paul&nbsp; Schumacher<sup>1<\/sup><br><sup>1<\/sup> Vitrocell Systems GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P238<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Enniatin B1 risk assessment in a new approach methodologies (NAMs) perspective<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mariam MAHDJOUB<\/span><sup>P1<\/sup>, Charl\u00e8ne GENDRE<sup>1<\/sup>, Estelle DUBREIL<sup>1<\/sup>, J\u00e9r\u00f4me HENRI<sup>1<\/sup>, Ludovic LE HEGARAT<sup>1<\/sup><br><sup>1<\/sup> ANSES French Agency for Food, Environmental and Occupational Health and Safety, Foug\u00e8res Laboratory, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P239<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Mechanistic-based multi-omics approach to investigate the hepatotoxicity of nanomaterials: a case study on synthetic amorphous silica used as food additive<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sarah ALILAT<\/span><sup>P1<\/sup>, Pierre-Jean FERRON<sup>1<\/sup>, Andrea&nbsp; HAASE<sup>2<\/sup>, Nolwenn&nbsp; GAUVREAU <sup>1<\/sup>, Francesco&nbsp; CUBADDA<sup>3<\/sup>, Val\u00e9rie&nbsp; FESSARD<sup>1<\/sup>, Thibaut&nbsp; L\u00c9GER <sup>1,4<\/sup><br><sup>1<\/sup> French Agency for Food, Environmental and Occupational Health &amp; Safety (ANSES), Toxicology of Contaminants Unit, Foug\u00e8res, France<br><sup>2<\/sup> Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany<br><sup>3<\/sup> Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanit\u00e0-National Institute of Health, 00161 Rome, Italy<br><sup>4<\/sup> ProMetHEE proteomics and metabolomics facility, Foug\u00e8res Laboratory, French Agency for Food, Environmental and Occupational Health &amp; Safety (ANSES), 35306 Foug\u00e8res CEDEX, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P240<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Hepatotoxicity of food ingredient synthetic amorphous silica (SAS) using NAMs: a case study from the NAMS4NANO project<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Pierre-Jean Ferron<\/span><sup>P1<\/sup>, Anne-Louise Blier<sup>1<\/sup>, Sarah Alilat<sup>1<\/sup>, Noa Oluyn<sup>2<\/sup>, Eveline Verleysen<sup>2<\/sup>, Jan Mast<sup>2<\/sup>, Andrea Haase<sup>3<\/sup>, Francesco Cubadda<sup>4<\/sup>, Kevin Hogeveen<sup>1<\/sup>, Thibaut L\u00e9ger<sup>1<\/sup>, Val\u00e9rie Fessard<sup>1<\/sup><br><sup>1<\/sup> French Agency for Food, Environmental and Occupational Health &amp; Safety (ANSES), Foug\u00e8res, FRANCE<br><sup>2<\/sup> Sciensano, Groeselenbergstraat 99, 1180 Uccle, Belgium<br><sup>3<\/sup> German Federal Institute for Risk Assessment (BfR), Berlin, Germany<br><sup>4<\/sup> Istituto Superiore di Sanit\u00e0 &#8211; National Institute of Health (ISS), 00161 Rome, Italy<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P241<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">In vitro study on inhibitory evaluation of hydrogen peroxide using infusions made from black and roselle tea<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alireza Ebadollahinatanzi<\/span><sup>P1<\/sup><br><sup>1<\/sup> Department of Medicinal Plants, Imam Khomeini Higher Education Center, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P242<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Is the Ames screening test predictive for the regulatory Ames test?<\/a><\/h3>\n\n\n\n<blockquote class=\"block-quote is-layout-flow block-quote-is-layout-flow\">\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Bas-jan van der Leede<\/span><sup>P1<\/sup>, Walter Westerink<sup>1<\/sup>, Mira Wenker<sup>1<\/sup><br><sup>1<\/sup> Charles River Laboratories Den Bosch Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P243<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Detection of DNA cross-links in TK6 cells using a modified version of the in vitro alkaline comet assay<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Walter Westerink<\/span><sup>P1<\/sup>, Bas-jan van der Leede<sup>1<\/sup>, Mira Wenker<sup>1<\/sup><br><sup>1<\/sup> Charles River Laboratories Den Bosch Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P244<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Investigation of early metabolomic indicators of drug-induced liver injury(DILI) using extracellular untargeted metabolomics<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Tae-Yong Jeong<\/span><sup>P1<\/sup><br><sup>1<\/sup> Hankuk University of Foreign Studies<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P245<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Hazard identification with alternative methodologies: a benzophenone-based photoinitiator disturbed bile acid homeostasis in human liver cells<\/a><\/h3>\n\n\n\n<p>Yu-Chi&nbsp; Ho<sup>1<\/sup>, Hui-Ti Tsai<sup>1<\/sup>, Ming-Hsien Tsai<sup>1<\/sup>, Ju-Hsin Hsu<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Pinpin Lin<\/span><sup>P1<\/sup><br><sup>1<\/sup> National Institute of Environmental Health Sciences, National Health Research Institutes, Taiwan<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P246<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">New approach methodologies (NAMs) as first tier in an integrated approach to testing and assessment for non-genotoxic carcinogens<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Manon Bouwmeester<\/span><sup>P1<\/sup>, Andr\u00e9&nbsp; Muller<sup>2<\/sup>, Barira Islam<sup>3<\/sup>, Tjalf de Boer<sup>4<\/sup>, Cl\u00e9mence&nbsp; Budin<sup>4<\/sup>, Emiel Rorije<sup>2<\/sup>, Mirjam Luijten<sup>1<\/sup><br><sup>1<\/sup> Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands<br><sup>2<\/sup> Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands<br><sup>3<\/sup> Certara Predictive Technologies, Certara UK Limited, Sheffield, S1 2BJ, United Kingdom<br><sup>4<\/sup> BioDetection Systems BV, Science Park 406, 1098 XH, Amsterdam, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P247<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Estimation of intra-specific ranges of genetic susceptibility to toxicity using genetically diverse populations of human lymphoblastoid cell lines.<\/a><\/h3>\n\n\n\n<p>Konrad Patyra<sup>1<\/sup>, Maria Adonay<sup>2,3<\/sup>, Robert Anholt<sup>2,3<\/sup>, Trudy Mackay<sup>2,3<\/sup>, Pekka Kohonen<sup>1,4<\/sup>, John&nbsp; Colbourne<sup>5<\/sup>, Juha Rantala<sup>1<\/sup>, Roland Grafstr\u00f6m<sup>1,4<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Vesa Hongisto<\/span><sup>P1<\/sup><br><sup>1<\/sup> Misvik Biology Oy, Turku, Finland<br><sup>2<\/sup> Center for Human Genetics, Clemson University, Greenwood, SC, USA<br><sup>3<\/sup> Department of Genetics and Biochemistry, Clemson University, Clemson, SC, USA<br><sup>4<\/sup> Institute for Environmental Medicine, Karolinska Institutet, Solna, Sweden<br><sup>5<\/sup> School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, United Kingdom<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P248<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">High-throughput RNA sequencing reveals distinct transcriptomic responses of human jurkat T cells to cyanotoxins and their binary mixture<\/a><\/h3>\n\n\n\n<p>Ronald F&nbsp;Borja<sup>1<\/sup>, Antonio Casas-Rodr\u00edguez<sup>1<\/sup>, M\u00f3nica P\u00e9rez-Alegre<sup>2<\/sup>, Eloisa And\u00fajar<sup>2<\/sup>, Mar\u00eda Puerto<sup>1<\/sup>, Angeles Jos<sup>1<\/sup><br><sup>1<\/sup> Area of Toxicology, Faculty of Pharmacy, University of Seville, Seville, Spain.<br><sup>2<\/sup> Genomics Unit, Andalusian Centre of Molecular Biology and Regenerative Medicine (CABIMER), CSIC, University of Seville,&nbsp; Pablo de Olavide University, Seville, Spain<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P249<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Evaluation of the neurotoxicity of biocide isothiazolinone<\/a><\/h3>\n\n\n\n<p>Ha-Na Oh<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Woo-Keun Kim<\/span><sup>P1<\/sup><br><sup>1<\/sup> Korea Institue of Toxicology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P250<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Human relevance assessment of adverse outcome pathways and associated NAMs<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Annick van den Brand<\/span><sup>P1<\/sup>, Elisavet Renieri<sup>2<\/sup>, Emma Di Consiglio<sup>3<\/sup>, Graciela L\u00f3pez Soop<sup>4<\/sup>, Jeske van Boxel<sup>1<\/sup>, Mirjam Luijten<sup>1<\/sup><br><sup>1<\/sup> Rijksinstituut voor Volksgezondheid en Milieu (RIVM) &#8211; NL<br><sup>2<\/sup> Aristotle University of Thessaloniki (AUTH) &#8211; GR<br><sup>3<\/sup> Istituto Superiore di Sanit\u00e0 (ISS) &#8211; IT<br><sup>4<\/sup> National Institute of Occupational Health (STAMI) &#8211; NO<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P252<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Transcriptomic\u2013based analysis to discriminate non-genotoxic carcinogens from genotoxic carcinogens and non-carcinogens in a human HepaRG spheroid model: mechanistic insights and biomarker identification<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mariam Saleh<\/span><sup>P1<\/sup>, Kevin Hogeveen<sup>1<\/sup>, Thibaut&nbsp; Leger<sup>1<\/sup>, Val\u00e9rie Fessard<sup>1<\/sup>, Ludovic Le H\u00e9garat<sup>1<\/sup><br><sup>1<\/sup> Agence nationale de s\u00e9curit\u00e9 sanitaire de l&#8217;alimentation, de l&#8217;environnement et du travail (ANSES)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P253<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Characterization of the performance and sensitivity of deiodinase 1 inhibition bioassay using different in vitro models<\/a><\/h3>\n\n\n\n<p>Tereza Ne\u0161porov\u00e1<sup>1<\/sup>, Veronika Jane\u010dkov\u00e1<sup>1<\/sup>, Marie Smutn\u00e1<sup>1<\/sup>, Jiri Nov\u00e1k<sup>1<\/sup><br><sup>1<\/sup> Masaryk University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P254<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Establishment and optimization of thawing procedures for murine non-parenchymal liver cells as progress of primary hepatic co-culture systems<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Emina Wagner<\/span><sup>P1<\/sup>, Tanja Krimmling<sup>1<\/sup>, Anett Ullrich<sup>1<\/sup><br><sup>1<\/sup> PRIMACYT Cell Culture Technology GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P255<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Metabolic activities in rainbow trout (oncorhynchus mykiss) S9 fractions liver and extrahepatic organs as an alternative in vitro ecotoxicity assessment approach<\/a><\/h3>\n\n\n\n<p>Marcel Reu<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Tanja Krimmling<\/span><sup>P1<\/sup>, Melissa Thiede<sup>1<\/sup>, Amani Alkufairi<sup>1<\/sup>, Alexander Sattler<sup>1<\/sup>, Jennifer Schuldt<sup>1<\/sup>, Dieter&nbsp; Runge<sup>1<\/sup>, Anett Ullrich<sup>1<\/sup><br><sup>1<\/sup> PRIMACYT Cell Culture Technology GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P256<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Impact of microplastics in ambient air on A549 alveolar cells and RPMI 2650 nasal cells<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Camille BONNEFOUS<\/span><sup>P1,2<\/sup>, Fr\u00e9d\u00e9ric LEDOUX<sup>1,2<\/sup>, Yann LANDKOCZ<sup>1,2<\/sup><br><sup>1<\/sup> UCEiV UR4492 &#8211; Dunkerque &#8211; France<br><sup>2<\/sup> Universit\u00e9 du Littoral C\u00f4te d&#8217;Opale &#8211; Dunkerque &#8211; France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P257<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Perimyelintox: developing a peripheral demyelination assay<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Cody Niedergeses<\/span><sup>P1<\/sup>, Lisa Maria Haiber<sup>1<\/sup>, Britta Anna K\u00fchne<sup>1,2<\/sup>, Julia Sp\u00e4nle<sup>1<\/sup>, Peter Schertl<sup>3<\/sup>, Bettina Seeger<sup>1<\/sup><br><sup>1<\/sup> Institute for Food Quality and Safety, Research Group Food Toxicology and Alternative\/Complementary Methods to Animal Experiments, University of Veterinary Medicine Hannover, Foundation, 30173 Hannover, Germany<br><sup>2<\/sup> German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (BfR), Berlin, Germany<br><sup>3<\/sup> Institute of Cell Biology and Biophysics, Research Group Cell Biology, Leibniz University Hannover, 30419 Hannover, Germany\u202f<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P258<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Potency-response (PR) plots: a new tool for the visualization of complex data sets<\/a><\/h3>\n\n\n\n<p>Yusuf Hussien<sup>1<\/sup>, Mathyn Rijkers<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Giel Hendriks<\/span><sup>P1<\/sup>, Inger Brandsma<sup>1<\/sup><br><sup>1<\/sup> Toxys<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P259<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Determination of the genotoxic and chemopreventive properties of beta-sitosterol on human peripheral lymphocytes using the comet assay<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Elif Akta\u015f<\/span><sup>P1<\/sup>, Deniz&nbsp; Y\u00fczba\u015f\u0131o\u011flu<sup>2<\/sup>, Ebru Beyzi<sup>3<\/sup>, Fatma&nbsp; \u00dcnal<sup>2<\/sup><br><sup>1<\/sup> Gazi University, Graduate School of Natural and Applied Sciences, Ankara, T\u00fcrkiye<br><sup>2<\/sup> Gazi University, Faculty of Science, Biology Department, Ankara, T\u00fcrkiye<br><sup>3<\/sup> Gazi University, Vocational School of Health Services, Department of Medical Services and Techniques, Ankara, T\u00fcrkiye<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P260<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Standardizing and automating high throughput organoid culture and downstream applications with the mo:re lab platform<\/a><\/h3>\n\n\n\n<p>Julia Vallverdu<sup>1<\/sup>, Daniel Ziemianowicz <sup>1<\/sup>, Dana Hellmold<sup>1<\/sup><br><sup>1<\/sup> mo:re GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P261<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Comparative evaluation of in silico and in vitro tools for the prediction of metabolites in livestock studies<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Kristin Diercks<\/span><sup>P1<\/sup>, Marc Lamshoeft<sup>1<\/sup>, Mark-Christoph&nbsp; Ott<sup>1<\/sup><br><sup>1<\/sup> Bayer AG<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P262<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Comparing natural toxins and pesticides: A broad targeted metabolomics analysis in HepaRG cells<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Sahra Kiessig<\/span><sup>P1<\/sup>, Philipp Ternes<sup>2<\/sup>, Nicole Rocker<sup>2<\/sup>, Philip Marx-Stoelting<sup>1<\/sup>, Daniela Morais Leme<sup>3<\/sup>, Hennicke Kamp<sup>2<\/sup><br><sup>1<\/sup> Pesticides Safety, German Federal Institute for Risk Assessment<br><sup>2<\/sup> BASF Metabolome Solutions GmbH<br><sup>3<\/sup> Department of Genetics, Federal University of Paran\u00e1 (UFPR)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P263<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Drosophila melanogaster as a model to investigate the effects of environmental contaminants on the gastrointestinal microbiota.<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alba Garc\u00eda-Rodr\u00edguez<\/span><sup>P1<\/sup>, Arnau Rocabert<sup>1<\/sup>, Raquel Egea<sup>1<\/sup>, Ricard Marcos<sup>1<\/sup>, Alba Hern\u00e1ndez<sup>1<\/sup><br><sup>1<\/sup> Universitat Aut\u00f2noma de Barcelona<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P264<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Optimization of exogenous metabolic activation system for enhanced detection of nitrosamines using MultiFlow and MicroFlow assays<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Steven Bryce<\/span><sup>P1<\/sup>, Svetlana Avlasevich<sup>1<\/sup>, Jeff&nbsp; Bemis<sup>1<\/sup>, Stephen Dertinger<sup>1<\/sup><br><sup>1<\/sup> Litron Labs<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P265<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Refining gold standard in vitro models for the NAMs era<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Maria Karlgren<\/span><sup>P1<\/sup><br><sup>1<\/sup> Department of Pharmacy, Uppsala University, Sweden<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P266<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">In vitro genotoxicity \u2013 investigation of different mechanisms using micronucleus test via flow cytometry<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marla Lindemann<\/span><sup>P1<\/sup>, Elisabeth Muschiol<sup>1<\/sup>, Louisa T\u00f6lke<sup>1<\/sup>, Thorsten Kuczius<sup>2<\/sup>, Melanie Esselen<sup>1<\/sup><br><sup>1<\/sup> Institute of food chemistry, University of M\u00fcnster, Corrensstra\u00dfe 45, 48149 M\u00fcnster, Germany<br><sup>2<\/sup> Institute of Hygiene, University Hospital M\u00fcnster, Robert Koch-Stra\u00dfe 41, 48149 M\u00fcnster, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P267<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">From insights to impact: acceleration of NAM implementation by policymakers<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jeske van Boxel<\/span><sup>P1<\/sup>, Vera Versteegh<sup>2<\/sup>, Tim&nbsp; Verbruggen<sup>1<\/sup>, Eva Streekstra<sup>1<\/sup>, Victoria&nbsp; de Leeuw<sup>1<\/sup>, Jelle&nbsp; Vriend<sup>1<\/sup>, Anne&nbsp; Kienhuis<sup>1,3<\/sup><br><sup>1<\/sup> National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands<br><sup>2<\/sup> Utrecht University, Faculty of Medicine, Utrecht, the Netherlands<br><sup>3<\/sup> Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P268<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">The concise summary of the country reports of the Asian federation of societies for alternatives to animal experiments (AFSAAE)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Atsushi Miyashita<\/span><sup>P1,2<\/sup>, D.P.N. De Silva<sup>3,4<\/sup>, Vijay Pal Singh<sup>5,6<\/sup>, Tae-Eun Park<sup>7,8<\/sup>, Yuan Pang<sup>9,10<\/sup><br><sup>1<\/sup> Institute of Medical Mycology, Teikyo University, Japan<br><sup>2<\/sup> Japanese Society for Alternative to Animal Experiments<br><sup>3<\/sup> Department of Chemistry, University of Colombo, Sri Lanka<br><sup>4<\/sup> Society for Alternatives to Animal Testing in Sri Lanka<br><sup>5<\/sup> CSIR- Institute of Genomics and Integrative Biology, India<br><sup>6<\/sup> Society for Alternatives to Animal Experiments (SAAE-India)<br><sup>7<\/sup> Department of Biomedical Engineering, UNIST, Republic of Korea<br><sup>8<\/sup> Korean Society for Alternatives to Animal Experiments<br><sup>9<\/sup> Department of Mechanical Engineering, Tsinghua University, China<br><sup>10<\/sup> Society of Toxicological Alternatives and Translational Toxicology<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P269<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">In vitro safety assessment of locally produced biosimilars and herbal products in Pakistan using 3D liver and kidney microstructures<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jibran Khan<\/span><sup>P1<\/sup><br><sup>1<\/sup> Jinnah University for Women<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P270<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Evaluation of surface water quality with biochemical assays<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Francois Gagne<\/span><sup>P1<\/sup>, Chantale Andr\u00e9<sup>1<\/sup><br><sup>1<\/sup> Environment and Climate Change Canada<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P271<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Standardizing sample preparation and delivered dose in complex in vitro models<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marina&nbsp; P\u00e9rez Gregorio<\/span><sup>P1<\/sup>, Amira Fern\u00e1ndez<sup>1<\/sup>, Juan Francisco Ferrer<sup>1<\/sup>, Cristina&nbsp; Furi\u00f3 <sup>1<\/sup>, Mar\u00eda&nbsp; Lorenzo<sup>1<\/sup>, Paula Smudde<sup>2<\/sup><br><sup>1<\/sup> AIMPLAS (Plastics Technology Centre), Valencia<br><sup>2<\/sup> Universitat Polit\u00e9cnica de Valencia (UPV)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P272<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">A decision tree framework to restrict animal testing as a last resort: A case example for acute oral toxicity assessment in the European union<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Giorgia Pallocca<\/span><sup>P1<\/sup>, Patricia&nbsp; Bishop<sup>1<\/sup>, Patience&nbsp; Browne<sup>2<\/sup>, Marie&nbsp; Darracq-Ghitalla-Ciock<sup>3<\/sup>, Fabian&nbsp; Grimm<sup>4<\/sup>, Laura&nbsp; Holden<sup>5<\/sup>, Jay&nbsp; Ingram<sup>1<\/sup>, Kamel&nbsp; Mansouri<sup>6<\/sup>, Hans&nbsp; Raabe<sup>7<\/sup>, Clive&nbsp; Roper<sup>8<\/sup>, Katherine&nbsp; Santizo<sup>9<\/sup>, Barbara G.&nbsp; Schmitt<sup>10<\/sup>, Thomas A&nbsp; Ward<sup>11<\/sup>, Catherine&nbsp; Willett<sup>1<\/sup><br><sup>1<\/sup> Humane World for Animals<br><sup>2<\/sup> Organization for Economic Cooperation and Development (OECD)<br><sup>3<\/sup> KREATiS<br><sup>4<\/sup> Clariant Produkte GmbH<br><sup>5<\/sup> University of Birmingham<br><sup>6<\/sup> NICEATM\/NIEHS\/NIH<br><sup>7<\/sup> Institute for In Vitro Sciences<br><sup>8<\/sup> Roper Toxicology Consulting Limited<br><sup>9<\/sup> CEFIC<br><sup>10<\/sup> Evonik Operations GmbH<br><sup>11<\/sup> XCellR8<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P273<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Refining the adverse outcome pathway (AOP) for radon-induced lung cancer: integrating genetic variability and environmental co-exposures to improve risk characterization<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Klea Hondro<\/span><sup>P1<\/sup>, Paul&nbsp; Locke<sup>2<\/sup><br><sup>1<\/sup> myself<br><sup>2<\/sup> Professor\/Mentor<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P274<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Miniaturized Ames test systems for nitrosamine mutagenicity screening: A systematic evaluation of miniaturized Ames test formats as sustainable alternatives to conventional genotoxicity testing<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Csaba Bogl\u00e1ri<\/span><sup>P1<\/sup>, C\u00e9cile&nbsp; Koelbert<sup>1<\/sup><br><sup>1<\/sup> Xenometrix AG<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P275<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">In vitro wound healing model for evaluation of cutaneous re-epithelization<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Marek Puskar<\/span><sup>P1<\/sup>, Michael Bachelor<sup>2<\/sup>, Jonathan Oldach<sup>2<\/sup>, Gina Stolper<sup>2<\/sup>, Max Li<sup>2<\/sup>, Alex Armento<sup>2<\/sup>, Patrick Hayden<sup>2<\/sup>, Silvia Letasiova<sup>1<\/sup><br><sup>1<\/sup> MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia<br><sup>2<\/sup> MatTek Corporation, Ashland, MA, USA<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P276<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Male reproductive toxicity induced by aminated polystyrene microplastics<\/a><\/h3>\n\n\n\n<p>Mahmoud Abudayyak<sup>P1<\/sup>, \u00d6zge Sultan Zengin<sup>2<\/sup>, G\u00fcl \u00d6zhan<sup>1<\/sup>, Mohamed F. Abdallah<sup>3<\/sup><br><sup>1<\/sup> Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, T\u00fcrkiye.<br><sup>2<\/sup> Institute of Graduate Studies in Health Sciences, Istanbul University, T\u00fcrkiye.<br><sup>3<\/sup> Department of Food Science, Aarhus University, Denmark.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"considerations\"><a href=\"#nams\" class=\"ek-link\">Regulatory considerations for complex NAMs<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">P277<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#fake link\" class=\"ek-link\">Roadmap on phasing out animal testing for chemical safety assessments<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Katrin&nbsp;Schutte<\/span><sup>P1<\/sup><br><sup>1<\/sup> European Commission<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#fake\" class=\"ek-link\">P278<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Mechanistically informed in vitro genotoxicity model for complex molecules: NAMs to prevent unnecessary in vivo follow-up tests in regulatory field<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Giulia Martina Sitzia<\/span><sup>P1<\/sup>, Monica Locatelli<sup>1<\/sup><br><sup>1<\/sup> Kahlberg Consulting<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P279<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Distinguishing adult and developmental neurotoxicity using new approach methodologies: NAM4NT<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jonathan Blum<\/span><sup>P1,2<\/sup>, Tamara Tal<sup>3,4<\/sup>, Ellen Fritsche<sup>1,2<\/sup><br><sup>1<\/sup> Swiss Centre for Applied Human Toxicology &#8211; SCAHT, Switzerland<br><sup>2<\/sup> Department of Pharmaceutical Sciences, University of Basel, Switzerland<br><sup>3<\/sup> Department of Ecotoxicology, Helmholtz-Centre for Environmental Research &#8211; UFZ, Leipzig, Germany<br><sup>4<\/sup> Medical Faculty, University of Leipzig, Leipzig, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P280<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">A whole-mixture prioritisation approach of plant protection products for non-dietary risk assessment using NAMs<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alkiviadis Stagkos-Georgiadis<\/span><sup>P1,2<\/sup>, Philip Marx-Stoelting<sup>1<\/sup>, Tewes Tralau<sup>3<\/sup>, Denise Bloch<sup>1<\/sup><br><sup>1<\/sup> Department of Pesticides Safety, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Str. 8-10, 10589 Berlin, Germany<br><sup>2<\/sup> University of Potsdam, Institute of Nutritional Science, Department of Nutritional Toxicology, Karl-Liebknecht-Str. 24-25, 14476 Potsdam, Germany<br><sup>3<\/sup> German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Str. 8-10, 10589 Berlin, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P281<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Establishing an adverse outcome pathway for developmental neurotoxicity: inhibition of voltage-gated sodium channels leading to impaired myelination and cognitive dysfunction<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Lidwina Gerner<\/span><sup>P1,2<\/sup>, Jonathan Blum<sup>1,2<\/sup>, Ellen Fritsche<sup>1,2,3<\/sup><br><sup>1<\/sup> SCAHT &#8211; Swiss Centre for Applied Human Toxicology, Basel, Switzerland<br><sup>2<\/sup> Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland<br><sup>3<\/sup> DNTOX GmbH, D\u00fcsseldorf, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P282<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Standardization of hiPSC-derived intestinal epithelial cell models<\/a><\/h3>\n\n\n\n<p>Loes PM Duivenvoorde<sup>1<\/sup>, Deborah&nbsp; Rijkers <sup>1<\/sup>, Meike van der Zande<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Aafke WF Janssen<\/span><sup>P1<\/sup><br><sup>1<\/sup> Wageningen Food Safety Research, part of Wageningen University &amp; Research, Wageningen, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P283<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Global harmonization and modernization of safety pharmacology to support the adoption of emerging technologies<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jan Turner<\/span><sup>P1<\/sup>, Colleen Pike<sup>1<\/sup>, Jennifer&nbsp; Pierson<sup>2<\/sup>, Claire O&#8217;Brien<sup>2<\/sup>, Alexandra&nbsp; Taraboletti<sup>2<\/sup>, Yasunari Kanda<sup>3<\/sup>, Sonja&nbsp; Beken<sup>4<\/sup>, Derek Leishman<sup>5<\/sup>, Jean-Pierre Valentin<sup>6<\/sup><br><sup>1<\/sup> Humane World for Animals, Brussels, Belgium<br><sup>2<\/sup> Health and Environmental Sciences Institute (HESI), Washington, D.C., United States of America<br><sup>3<\/sup> National Institute of Health Sciences (NIHS), Kawasaki, Kanagawa, Japan<br><sup>4<\/sup> Belgian Federal Agency for Medicines and Health Products (FAMHP), Brussels, Belgium<br><sup>5<\/sup> Eli Lilly and Company, Indianapolis, Indiana, United States of America<br><sup>6<\/sup> UCB Biopharma (UCB S.A.), Brussels, Belgium<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"3r\"><a href=\"#3r\" class=\"ek-link\">Role of 3R centres in the dissemination and implementation of NAMs<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P284<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Advancing toxicology through microphysiological systems: the 3Rs collaborative\u2019s efforts to drive adoption and regulatory confidence<\/a><\/h3>\n\n\n\n<p>Megan LaFollette<sup>1<\/sup>, Emily Richardson<sup>2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Clive Roper<\/span><sup>P3,1<\/sup><br><sup>1<\/sup> The 3Rs Collaborative<br><sup>2<\/sup> CN Bio Innovations<br><sup>3<\/sup> Roper Toxicology Consulting Limited<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"http:\/\/,\" class=\"ek-link\">P<\/a><a href=\"#FAke\" class=\"ek-link\">285<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Centro 3R: advancing 3Rs principles in education, research, and beyond<\/a><\/h3>\n\n\n\n<p>Valeria Chiono<sup>1,2<\/sup><br><sup>1<\/sup> Politecnico di Torino<br><sup>2<\/sup> Centro 3R<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P286<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">A novel approach for constructing adverse outcome pathways using transcriptomics-based dual-evidence key event identification<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Jin Yoo<\/span><sup>P1,2<\/sup>, Yubin Han<sup>3<\/sup>, Ji Yeong Park<sup>1,2<\/sup>, Jung Eun Lim<sup>1<\/sup>, Ga Eun Kim<sup>1<\/sup>, In Jae Bang<sup>3<\/sup>, Haryong Kim<sup>1,2<\/sup><br><sup>1<\/sup> College of Pharmacy, Korea University, Republic of Korea<br><sup>2<\/sup> Interdisciplinary Major Program in Innovative Pharmaceutical Sciences, Korea University, Republic of Korea<br><sup>3<\/sup> Institute of Pharmaceutical Science and Translational Research, Korea University, Republic of Korea<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"serum\"><a href=\"#serum\" class=\"ek-link\">Serum-free approaches<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P287<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Revisiting 3Rs: rethinking replacement and new approach methodologies<\/a><\/h3>\n\n\n\n<p>Jessica&nbsp; Rosolowski <sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Tilo Weber<\/span><sup>P1<\/sup>, Atena Malakpour-Permlid<sup>2<\/sup>, Stina Oredsson<sup>3<\/sup><br><sup>1<\/sup> Animal Welfare Academy of the German Animal Welfare Federation, 85579 Neubiberg, Germany<br><sup>2<\/sup> Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark<br><sup>3<\/sup> Department of Biology, Lund University, 223 62 Lund, Sweden<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P288<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Advancing in vitro cell culture practices: achieving truly animal-free experiments and scientifically reliable and reproducible methods<\/a><\/h3>\n\n\n\n<p>Stina Oredsson<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Tilo Weber<\/span><sup>P2<\/sup>, Atena Malakpour-Permlid<sup>3<\/sup><br><sup>1<\/sup> Department of Biology, Lund University, 223 62 Lund, Sweden<br><sup>2<\/sup> Animal Welfare Academy of the German Animal Welfare Federation, 85579 Neubiberg, Germany<br><sup>3<\/sup> Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P289<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Self-assembling peptide hydrogels as user-defined synthetic matrices for in vitro modelling<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Clive Roper<\/span><sup>P1<\/sup>, John Curd<sup>1<\/sup>, Viola Erdelyi<sup>1<\/sup>, Mikayla Shelton<sup>1<\/sup>, Cathy Merry<sup>1<\/sup><br><sup>1<\/sup> PeptiMatrix Limited<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P290<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">A cost-effective animal-free approach for generating primary human hepatocyte spheroids<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Rowena Sison-Young<\/span><sup>P1,2<\/sup>, Chris&nbsp; Goldring<sup>1,2<\/sup>, Ian Copple<sup>1,2<\/sup><br><sup>1<\/sup> Human Liver Research Facility, Liverpool Shared Research Facilities, Faculty of Health and Life Sciences, University of Liverpool, United Kingdom L69 3GE<br><sup>2<\/sup> Department of Pharmacology and Therapeutics, Faculty of Health and Life Sciences, University of Liverpool, United Kingdom L69 3GE<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<h2 class=\"block-heading\" id=\"toxicokinetics\"><a href=\"#toxicokinetics\" class=\"ek-link\">Toxicokinetics and in vitro \u2013 in vivo extrapolation<\/a><\/h2>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P291<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">In vitro study of the biotransformation of cylindrospermopsin using human and RAT liver microsomes<\/a><\/h3>\n\n\n\n<p>Antonio Cascajosa-Lira<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Remedios Guzm\u00e1n-Guill\u00e9n<\/span><sup>P1<\/sup>, Silvia Pichardo<sup>1<\/sup>, Ana Mar\u00eda Came\u00e1n<sup>1<\/sup>, Angeles Jos<sup>1<\/sup>, Ana I. Prieto<sup>1<\/sup><br><sup>1<\/sup> Toxicology Area, Faculty of Pharmacy, University of Seville, Spain.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P292<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Two-layer percutaneous absorption integrated in a PBK framework improves plasma concentration prediction for NGRA of cosmetic ingredients<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Kazutoshi Saito<\/span><sup>P1<\/sup><br><sup>1<\/sup> Kao corporation<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P293<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Working towards the implementation and acceptance of QIVIVE in NAM-based risk assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Anne Zwartsen<\/span><sup>P1<\/sup>, V\u00e9ronique&nbsp; de Bruijn<sup>1<\/sup>, Joost Westerhout<sup>1<\/sup>, Victoria de Leeuw<sup>1<\/sup>, Jordi Minnema<sup>1<\/sup>, Thijs Benschop<sup>1<\/sup>, Lianne de Wit-Bos<sup>1<\/sup>, Eva&nbsp; Streekstra<sup>1<\/sup>, Suzanne Jeurissen<sup>1<\/sup>, Bas Bokkers<sup>1<\/sup><br><sup>1<\/sup> National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P294<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">In vitro-in vivo response-response relationships for the in vitro based risk assessment of chemical substances<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Thijs Benschop<\/span><sup>P1<\/sup>, Jordi Minnema<sup>1<\/sup>, Emma Kasteel<sup>2<\/sup>, Anne Zwartsen<sup>1<\/sup>, Jelle Vriend<sup>1<\/sup>, Anne Kienhuis<sup>1,2<\/sup>, Remco Westerink<sup>2<\/sup>, Agnes Oomen<sup>1,3<\/sup>, Bas Bokkers<sup>1<\/sup><br><sup>1<\/sup> National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands<br><sup>2<\/sup> Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands<br><sup>3<\/sup> University of Amsterdam (UvA), Amsterdam, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P295<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Evaluating acrylamide developmental neurotoxicty using the adverse outcome pathway strategy<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Roseline Ayowumi Awoga<\/span><sup>P1<\/sup>, Birgitte Lindeman <sup>2<\/sup>, Marcin W.&nbsp; Wojewodzic<sup>2,3<\/sup>, Arup Ghosh<sup>2<\/sup>, Vajagathali Mohammed<sup>1<\/sup>,&nbsp; Ylva&nbsp; Johansson <sup>1<\/sup>, Jan Alexander<sup>2<\/sup>, Oddvar Myhre<sup>2<\/sup>, Anna Forsby<sup>1<\/sup><br><sup>1<\/sup> Department of Biochemistry and Biophysics, Stockholm University, Sweden<br><sup>2<\/sup> Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway<br><sup>3<\/sup> Cancer Registry, Norwegian Institute of Public Health, Oslo, Norway<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P296<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">NAM-based multi-omics workflow in zebrafish embryo toxicology: A pilot study with 3,4-dichloroaniline<\/a><\/h3>\n\n\n\n<p>Andrea Weiner<sup>1<\/sup>, Mark R. Viant<sup>2<\/sup>, Elena Sostare<sup>2<\/sup>, Mari Paz Gallego<sup>1<\/sup>, Idoia Ibarburu<sup>1<\/sup>, Lauren Cruchley-Fuge<sup>3<\/sup>, Ossama Ebdali<sup>3<\/sup>, Andrew Southam<sup>3<\/sup>, Ralf Weber<sup>3<\/sup>, John K Coulbourne<sup>2<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Arantza Muriana<\/span><sup>P1<\/sup><br><sup>1<\/sup> BBD BioPhenix SL &#8211; Biobide<br><sup>2<\/sup> Michabo Health Science Ltd., UK<br><sup>3<\/sup> University of Birmingham<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P297<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\".\" class=\"ek-link\">Insight: an in silico tool to suppor<\/a><a href=\"#FAke\" class=\"ek-link\">t<\/a><a href=\".\" class=\"ek-link\"> chemical fate prediction and NAM-based assay design<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Pierre-Andre Billat<\/span><sup>P1<\/sup>, Daniela&nbsp; Brenner<sup>2<\/sup>, K\u00e9vin Bernal<sup>3<\/sup>, Eli\u0161ka&nbsp; Sychrov\u00e1<sup>2<\/sup>, Ji\u0159\u00ed&nbsp; Kohoutek<sup>2<\/sup>, Sophie&nbsp; Langouet<sup>4<\/sup>, Rayane&nbsp; Boufalaas<sup>1,5<\/sup>, Julien&nbsp; Dairou<sup>6<\/sup>, Arnaud&nbsp; T\u00eate<sup>3<\/sup>, Pavel&nbsp; Babica<sup>2<\/sup>, Etienne&nbsp; Blanc<sup>3<\/sup>, Iva Sovadinov\u00e1<sup>2<\/sup>, Cleo Tebby<sup>7<\/sup>, Remy&nbsp; Beaudouin<sup>8,9<\/sup><br><sup>1<\/sup> INERIS, Experimental toxicology and modeling unit (TEAM), Parc ALATA BP2, Verneuil en Halatte, France<br><sup>2<\/sup> RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic<br><sup>3<\/sup> Universit\u00e9 Paris Cit\u00e9, INSERM, Health &amp; Functional Exposomics &#8211; HealthFex, 75006 Paris, France<br><sup>4<\/sup> Universit\u00e9 Rennes, INSERM, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) &#8211; UMR_S 1085, 35000 Rennes, France.<br><sup>5<\/sup> University of technology of Compiegne, CNRS, Biomechanics and Bioengineering, Centre of recherche Royallieu- CS 60319, 60203 Compiegne Cedex, France.<br><sup>6<\/sup> Universit\u00e9 Paris Cit\u00e9, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, F-75006 Paris, France. 45 rue des Saints P\u00e8res, 75006 Paris, France<br><sup>7<\/sup> INERIS, Experimental toxicology and modeling unit (TEAM), Parc ALATA BP2, Verneuil en Halatte, France<br><sup>8<\/sup>&nbsp; INERIS, Experimental toxicology and modeling unit (TEAM), Parc ALATA BP2, Verneuil en Halatte, France<br><sup>9<\/sup> UMR-I 02 SEBIO, INERIS, Parc ALATA BP2, Verneuil en Halatte, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P298<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Evaluating toxicokinetics in mixture toxicity: identifying potential CYP inhibitors and substrates to establish common kinetic groups (CKG)<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Asya Kadic<\/span><sup>P1,2<\/sup>, Bjoern&nbsp; Liebnau<sup>1,3<\/sup>, Albert Braeuning<sup>1<\/sup>, Denise Bloch<sup>1<\/sup>, Philip Marx-Stoelting<sup>1<\/sup><br><sup>1<\/sup> German Federal Risk Assessment Institute<br><sup>2<\/sup> Technical University of Dortmund<br><sup>3<\/sup> Potsdam University<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P299<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Transport and toxicity of indoxyl sulfate and p-cresyl sulfate across physiological barriers<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Pierre Spicher<\/span><sup>P1,2<\/sup>, Lucie Dehouck<sup>2<\/sup>, Marie-Christine Boucau<sup>2<\/sup>, Maxime Culot<sup>2<\/sup>, Sandra Bodeau<sup>1,3<\/sup><br><sup>1<\/sup> MP3CV Laboratory, UR7517, Jules Verne University of Picardie, F-80000 Amiens, France<br><sup>2<\/sup> Blood-Brain Barrier Laboratory (LBHE), UR 2465, University of Artois, F-62300 Lens, France<br><sup>3<\/sup> Department of Clinical Pharmacology, Amiens University Medical Center, F-80000 Amiens, France<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P300<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Mass balance is not related to pesticide physicochemical properties and in vitro model suitability for absorption studies<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alex KleinJan<\/span><sup>P1<\/sup>, Kitty&nbsp; van Summeren<sup>1<\/sup>, Jean Paul&nbsp; ten Klooster<sup>1<\/sup>, Emily&nbsp; Rayner<sup>2<\/sup>, Evita&nbsp; van de Steeg<sup>2<\/sup>, Yvonne&nbsp; Staal<sup>3<\/sup>, Raymond&nbsp; Pieters<sup>1,4<\/sup>, Cyrille&nbsp; Krul<sup>1<\/sup><br><sup>1<\/sup> Innovative Testing in Life Sciences and Chemistry, Research Centre Healthy and Sustainable Living, University of Applied Sciences Utrecht, Utrecht, the Netherlands<br><sup>2<\/sup> Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), 2333 BE Leiden, The Netherlands<br><sup>3<\/sup> National Institute for Public Health and the Environment, Bilthoven, The Netherlands.<br><sup>4<\/sup> Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P301<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Next generation risk assessment: an integrated phenotypic profiling and IVIVE approach for plant protection product mixture effects<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Yemurai Musengi<\/span><sup>P1<\/sup><br><sup>1<\/sup> German Federal Institute for Risk Assessment (BfR)<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P302<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\".#FAke\" class=\"ek-link\">Physiologically-based kinetic (PBK) modelling dataset: an open resource to increase accessibility of PBK models for safety assessment<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Alessio Gamba<\/span><sup>P1<\/sup>, Peter Penson<sup>1<\/sup>, Philippa McCabe<sup>1<\/sup>, Judith Madden<sup>1<\/sup><br><sup>1<\/sup> School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P303<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">In vivo toxicokinetic mechanisms of new psychoactive substances: A narrative review<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Hala Harifi<\/span><sup>P1<\/sup><br><sup>1<\/sup> Laboratory of Biology and Health, Faculty of Science, Ibn Tofail University, Kenitra, Morocco<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P304<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Cytotoxicity of tea polyphenols and their complex phase II metabolism<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Johannes Gr\u00f6ne<\/span><sup>P1<\/sup>, Julian Alfke<sup>1<\/sup>, Erik Reichel<sup>1<\/sup>, Svenja&nbsp; W\u00e4lscher<sup>1<\/sup>, Melanie Esselen<sup>1<\/sup><br><sup>1<\/sup> Institute of Food Chemistry, University of M\u00fcnster, Corrensstra\u00dfe 45, 48149, M\u00fcnster, Germany<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P305<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Integration of in vitro toxicity and high-throughput PBK modelling enables prospective prediction of drug-induced liver injury<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Ren\u00e9 Geci<\/span><sup>P1<\/sup>, Ahenk Zeynep Sayin<sup>1<\/sup>, Stephan Schaller<sup>2<\/sup>, Lars Kuepfer<sup>1<\/sup><br><sup>1<\/sup> University Hospital RWTH Aachen<br><sup>2<\/sup> ESQlabs GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P306<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">High-throughput PBK modelling for systemic PK predictions after dermal exposure<\/a><\/h3>\n\n\n\n<p>Zeynep Edizcan<sup>1<\/sup>, Stephan Schaller<sup>2<\/sup>, Lars Kuepfer<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Ren\u00e9 Geci<\/span><sup>P1<\/sup><br><sup>1<\/sup> University Hospital RWTH Aachen<br><sup>2<\/sup> ESQlabs GmbH<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P307<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Complex distribution phenomenon of test chemicals in cell culture experiments: exemplification by tebufenpyrad<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Mahshid Alimohammadi<\/span><sup>P1<\/sup>, Hiba&nbsp; Khalid<sup>2<\/sup>, Elias Zgheib<sup>2<\/sup>, Anna-Katharina&nbsp; Holzer<sup>1<\/sup>, Naja&nbsp; B\u00fcrgers<sup>1<\/sup>, Viktoria&nbsp; Magel<sup>1<\/sup>, Marcel&nbsp; Leist<sup>1,3<\/sup>, Baiba&nbsp; Gukalova<sup>4<\/sup>, Edgars&nbsp; Liepinsh<sup>4<\/sup><br><sup>1<\/sup> In vitro Toxicology and Biomedicine, University of Konstanz, 78457 Konstanz, Germany<br><sup>2<\/sup> Certara Predictive Technologies, Level 2-Acero, 1 Concourse Way, Sheffield S1 2BJ, UK<br><sup>3<\/sup> Center for Alternatives to Animal Testing in Europe (CAAT-Europe), University of Konstanz, 78457 Konstanz, Germany<br><sup>4<\/sup> Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P308<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Non-human primate gut organoids: A translational in vitro platform for gastrointestinal drug safety testing<\/a><\/h3>\n\n\n\n<p><span style=\"text-decoration: underline;\" class=\"ek-underline\">Laura Rijns<\/span><sup>P1<\/sup>, Fabian P. Suchy<sup>1,2<\/sup>, Lucia&nbsp; Ramirez<sup>1<\/sup>, Morteza Roodgar<sup>1,2<\/sup><br><sup>1<\/sup> Exir Bio, Menlo Park, CA 94025, USA.<br><sup>2<\/sup> Stanford University, School of Medicine, Stanford University, Stanford, CA 94305, USA.<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P309<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Human\u2011relevant in vitro approaches to assess gastrointestinal toxicity of food\u2011grade titanium dioxide (E171)<\/a><\/h3>\n\n\n\n<p>Simone G. van Breda<sup>P1<\/sup>, Nicolaj S. Bischoff<sup>1<\/sup>, Dick T. Sijm<sup>2<\/sup>, Theo M. de Kok<sup>1<\/sup><br><sup>1<\/sup> Department of Translational Genomics, Maastricht University, Maastricht, The Netherlands<br><sup>2<\/sup> Department of Pharmacology &amp; Toxicology, Maastricht University, Maastricht, The Netherlands<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<h2 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">P310<\/a><\/h2>\n\n\n\n<h3 class=\"block-heading\"><a href=\"#FAke\" class=\"ek-link\">Impact of dose metric selection on transcriptomic point of departure (tPOD) derivation in in vitro toxicology<\/a><\/h3>\n\n\n\n<p>Richard Currie<sup>1<\/sup>, Sevil Payvandi<sup>1<\/sup>, Yeyejide Adeleye<sup>1<\/sup>, Jack Feltham<sup>1<\/sup>, <span style=\"text-decoration: underline;\" class=\"ek-underline\">Kathryn Rudd<\/span><sup>P1<\/sup><br><sup>1<\/sup> Syngenta, Bracknell, Berkshire, United Kingdom<br><sup>P<\/sup> Presenting author<\/p>\n\n\n\n<p><a href=\"#topics\" class=\"ek-link\">Go back<\/a><\/p>\n\n\n\n<!--Start of Tawk.to Script-->\n<script type=\"text\/javascript\">\nvar Tawk_API=Tawk_API||{}, Tawk_LoadStart=new Date();\n(function(){\nvar s1=document.createElement(\"script\"),s0=document.getElementsByTagName(\"script\")[0];\ns1.async=true;\ns1.src='https:\/\/embed.tawk.to\/62e8dd7f54f06e12d88c776d\/1g9eq2f9d';\ns1.charset='UTF-8';\ns1.setAttribute('crossorigin','*');\ns0.parentNode.insertBefore(s1,s0);\n})();\n<\/script>\n<!--End of Tawk.to Script-->\n","protected":false},"excerpt":{"rendered":"<p>Instructions for Poster Presenters Please note that unlike what is written in the instructions for poster presentations, you will not&#8230;<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":11440,"menu_order":27,"ping_status":"closed","template":"","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":47,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","_searchwp_excluded":"","_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[0],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_core_expirator_enabled":"","_core_expirator_date":"","_yoast_wpseo_redirect":"","rank_math_redirect":"","redirect":"","_core_expirator_redirect_url":"","footnotes":""},"class_list":["post-14576","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages\/14576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/users\/5"}],"version-history":[{"count":21,"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages\/14576\/revisions"}],"predecessor-version":[{"id":14654,"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages\/14576\/revisions\/14654"}],"up":[{"embeddable":true,"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/pages\/11440"}],"wp:attachment":[{"href":"https:\/\/www.estiv.org\/api\/wp\/v2\/media?parent=14576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}