{"id":6661,"date":"2022-07-25T17:14:21","date_gmt":"2022-07-25T15:14:21","guid":{"rendered":"https:\/\/www.estiv.org\/?page_id=6661"},"modified":"2022-11-18T10:50:11","modified_gmt":"2022-11-18T09:50:11","slug":"accepted-posters","status":"publish","type":"page","link":"https:\/\/www.estiv.org\/congress2022\/accepted-posters\/","title":{"rendered":"Accepted Posters"},"content":{"rendered":"\n

Instructions for Poster Presenters<\/h2>\n\n\n\n
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Poster presentations<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n
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Poster print service:<\/strong><\/p>\n\n\n\n

If you would like to use the poster printing service, please find below the correct procedure.
1. Send an email to Lidia Anta via bcncongress@bcncongress.com<\/a> with a PDF attachment of the poster.
2. Make sure that the date of the congress and the name of the congress are clearly mentioned in the e-mail.
3. Clearly state in the e-mail the name that should be on the poster tube. This is the person who will collect the poster.
3. The poster can be picked up at the registration desk during the congress days.<\/p>\n\n\n\n

The cost is \u20ac 74,25<\/strong> and should be paid after ordering the poster print.
The poster will be printed on A0<\/strong> size and weigh 150 grams.<\/strong><\/p>\n\n\n\n

The deadline for this service is 11th November 2022<\/strong>.<\/p>\n\n\n\n

SESSION<\/h2>\n\n\n\n

1. Bio-engineering, stem cells and disease models<\/a><\/span>
2a. Models, biomarkers and assays for endocrine disruption and developmental toxicity<\/a> <\/span>
2b. Challenges in cosmetics safety <\/a><\/span>
3a. Models, biomarkers and assays for systemic and immune toxicity <\/a><\/span>
3b. Microphysiological Systems<\/a> <\/span>  <\/span>
4a. Computational toxicology \u2013 in silico modelling, read-across, artificial intelligence and machine learning<\/a><\/span> <\/a>
5a. Toxicokinetics and in vitro \u2013 in vivo extrapolation<\/a><\/span>
5b. In vitro systems to assess respiratory toxicity<\/span><\/a>
6a. In vitro methods for safety testing of biopharmaceuticals\/biotherapies\/vaccines<\/a><\/span>
6b. Knowledge sharing and education<\/a><\/span>
7a. Developmental Neurotoxicity (DNT)<\/a><\/span>
7b. Implementation of NAMs into regulatory frameworks<\/a> <\/span>
8a. In vitro methods for safety assessment of medical devices<\/a><\/span>
8b. In vitro COVID-19 research \/ Lung and cardiovascular models<\/a><\/span>
9. Models and methods<\/a>
10. Nanoparticles research in vitro<\/a>   <\/span> <\/p>\n\n\n\n

<\/p>\n\n\n\n

Go back<\/span><\/a> <\/strong><\/h2>\n\n\n\n

1. Bio-engineering, stem cells and disease models<\/span><\/a> <\/span><\/h2>\n\n\n\n

P-1-1<\/a><\/h2>\n\n\n\n

The effect of methylmercury chloride on three germ layer formation during hiPSC-derived Embryoid Bodies development<\/a><\/h3>\n\n\n\n

Justyna Augustyniak1<\/sup>, Hanna Kozlowska2<\/sup>, Agnieszka Stasinska1<\/sup>, Leonora Buzanska<\/span>P1<\/sup>
1<\/sup> Department of Stem Cells Bioengineering, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
2<\/sup> Laboratory of Advanced Microscopy Techniques, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-2<\/a><\/h2>\n\n\n\n

Preliminary evaluation of extracted collagen from food fish-processing side streams as an active ingredient for cosmetic application.<\/a><\/h3>\n\n\n\n

Lorenzo Dondero<\/span>P1<\/sup>, Giulia De Negri Atanasio1<\/sup>, Federica Robino2<\/sup>, Anastasiia Kharina2<\/sup>, Micaela Tiso3<\/sup>, Francesca Rispo1<\/sup>, Giorgia Allaria1<\/sup>, Francesca Tardanico1<\/sup>, Federica Turrini4<\/sup>, Federica Grasso4<\/sup>, Valentina Orlandi4<\/sup>, Matteo Zanotti Russo2<\/sup>, Raffaella Boggia4<\/sup>, Elena Grasselli1<\/sup>
1<\/sup>  Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy
2<\/sup> ANGEL CONSULTING S.a.s. , Italy
3<\/sup> MICAMO Spin-Off Department of Earth Sciences, University of Genoa, Genova, Italy
4<\/sup> Department of Pharmacy, University of Genoa, Genova, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-3<\/a><\/h2>\n\n\n\n

An innovative and robust strategy to generate hepatocyte-like cells from individual patients to investigate idiosyncratic hepatotoxicity of drugs<\/a><\/h3>\n\n\n\n

GUILLEM GARCIA LLORENS<\/span>P1,2<\/sup>, TERESA MART\u00cdNEZ SENA1<\/sup>, JOSE VICENTE CASTELL RIPOLL1,2,3<\/sup>, ROQUE BORT MARTI1,3<\/sup>
1<\/sup> Experimental Hepatology Research Unit, Instituto de Investigaci\u00f3n Sanitaria La Fe
2<\/sup>  Biochemistry and Molecular Biology Department, Universidad de Valencia, Valencia, Spain.
3<\/sup> CIBEREHD
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-4<\/a><\/h2>\n\n\n\n

Human peripheral neurons with enhanced nociceptor features for the study of pain-related dysfunctions<\/a><\/h3>\n\n\n\n

Anna-Katharina Holzer<\/span>P1<\/sup>, Christiaan Karreman1<\/sup>, Ilinca Suciu1<\/sup>, Harald Wohlfarth1<\/sup>, Marcel Leist1<\/sup>
1<\/sup> In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation at the University of Konstanz, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-5<\/a><\/h2>\n\n\n\n

Development of in vitro cardiotoxicity assessment using human iPS cell technology<\/a><\/h3>\n\n\n\n

Yasunari Kanda<\/span>P1<\/sup>, Sae Hayashi1<\/sup>, Ayano Satsuka1<\/sup>
1<\/sup> National Institute of Health Sciences (NIHS) Japan
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-6<\/a><\/h2>\n\n\n\n

Stem cell toxicity is detected by cell internal indicator, SERPINB2<\/a><\/h3>\n\n\n\n

Seong-Kwan Kim<\/span>P1,2<\/sup>, Se-Ra Park1,2<\/sup>, Soo-Rim Kim1,2<\/sup>, In-Sun Hong1,2<\/sup>
1<\/sup> Laboratory of stem cell research, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 406-840, Republic of Korea.
2<\/sup> Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 406-840, Republic of Korea.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-7<\/a><\/h2>\n\n\n\n

Establishment of an in vitro rabbit neurosphere model  to evaluate neurodevelopmental adverse effects induced by Intra-uterine growth restriction (IUGR) and to test future therapies<\/a><\/h3>\n\n\n\n

Britta Anna K\u00fchne<\/span>P1,2<\/sup>, Paula V\u00e1zquez1,2<\/sup>, Carla Loreiro2<\/sup>, Fatima Crispi2<\/sup>, Eduard Gratac\u00f3s2<\/sup>, Jes\u00fas G\u00f3mez-Catal\u00e1n1<\/sup>, Ellen  Fritsche3<\/sup>, Miriam Illa2<\/sup>, Marta Barenys1,2<\/sup>
1<\/sup> GRET, INSA\u2010UB and Toxicology Unit, Pharmacology and Therapeutical Chemistry Department, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.
2<\/sup> BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), Fetal i+D Fetal Medicine Research Center, IDIBAPS, Barcelona, Spain.
3<\/sup> IUF \u2013 Leibniz Research Institute for Environmental Medicine. Auf’m Hennekamp 50, 40225 D\u00fcsseldorf, Germany.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-8<\/a><\/h2>\n\n\n\n

Generation of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes using the Aurora Kinase Inhibitor ZM447439<\/a><\/h3>\n\n\n\n

Su-Jin LeeP1<\/sup>, Hyang-Ae Lee1<\/sup>
1<\/sup> Korea Institute of Toxicology
P<\/sup> Presenting author<\/p>\n\n\n\n

<\/p>\n\n\n\n

P-1-9<\/a><\/h2>\n\n\n\n

Mechanism of the Cyclic Stretch Induced Maturation of the Human Induced Pluripotent Stem Cell-derived Cardiomyocytes<\/a><\/h3>\n\n\n\n

Hyang-Ae Lee<\/span>P1<\/sup>, Su-Jin Lee1<\/sup>, Hyeon-A Kim1<\/sup>
1<\/sup> Korea Institute of Toxicology
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-10<\/a><\/h2>\n\n\n\n

Cellular Model of Parkinson`s Disease for Safety Testing of Selenium-Based Nanodelivery System<\/a><\/h3>\n\n\n\n

Ivan Mami\u0107P1<\/sup>, Maja Beus2<\/sup>, Nikolina Kal\u010dec2<\/sup>, Nikolina Perani\u01072<\/sup>, Petra Tur\u010di\u01071<\/sup>, Ivana Vinkovi\u0107 Vr\u010dek2<\/sup>
1<\/sup> Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kova\u010di\u0107a 1, Zagreb, Croatia
2<\/sup> Institute for Medical Research and Occupational Health, Ksaverska cesta 2, Zagreb, Croatia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-11<\/a><\/h2>\n\n\n\n

Study the toxicity effect of Cycloporin A on angiogenesis progress of endothelial cells derived from induced pluripotent stem cells<\/a><\/h3>\n\n\n\n

Zahra Mazidi<\/span>P1<\/sup>, Matthias  Wieser1<\/sup>, Regina  Grillari2<\/sup>, Johannes Grillari3<\/sup>
1<\/sup> Evercyte GmbH
2<\/sup> Evercyte GmbH, Correspondence author
3<\/sup> Ludwig Boltzmann Institiute, Evecyte GbmH, Correspondence Author
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-12<\/a><\/h2>\n\n\n\n

Discovery of a novel function, immune-modulatory factor CSF-2, improves the therapeutic effect of stem cells from cell damage<\/a><\/h3>\n\n\n\n

Se-Ra Park<\/span>P1,2<\/sup>, Seong-Kwan  Kim1,2<\/sup>, Soo-Rim Kim1,2<\/sup>, In-Sun  Hong1,2<\/sup>
1<\/sup> Laboratory of stem cell research, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 406-840, Republic of Korea.
2<\/sup> Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 406-840, Republic of Korea.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-13<\/a><\/h2>\n\n\n\n

Studying melanoma progression on a commensal 3D-skin model<\/a><\/h3>\n\n\n\n

Aline Rosin<\/span>P1<\/sup>, Maya Kissner1<\/sup>, Tewes Tralau2<\/sup>, Lisa  Lemoine1<\/sup>
1<\/sup> German Federal Institute for Risk Assessment Department Pesticides Safety, Junior Research Group Skin Microbiome
2<\/sup> German Federal Institute for Risk Assessment Department Pesticides Safety
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-14<\/a><\/h2>\n\n\n\n

A novel in vitro 3D model of chronic kidney disease (CKD) in the proximal tubule for drug development and safety.<\/a><\/h3>\n\n\n\n

Elena Tasinato<\/span>P1,2<\/sup>, Kathryn Garner2<\/sup>, Lyle Armstrong1,2<\/sup>, Colin D A Brown2<\/sup>
1<\/sup> Newcastle University
2<\/sup> Newcells Biotech
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-15<\/a><\/h2>\n\n\n\n

ACCURATE EVALUATION OF DRUG METABOLISM BY ENHANCED HEPATOCYTE FUNCTIONS IN A NEW OXYGEN-PERMEABLE PLATE WITH LOW DRUG ADSORPTION<\/a><\/h3>\n\n\n\n

Yasuyuki Sakai<\/span><\/span>P1<\/sup>, Masaki Nishikawa1<\/sup>, Hiroyasu Itoh1<\/sup>, Fumiya Tokito1<\/sup>, Mathieu Danoy1<\/sup>, Takumi Kawanishi2<\/sup>, Hiroshi Arakawa2<\/sup>, Yukio Kato2<\/sup>, Tomoaki Matsugi3<\/sup>, Jingjing Yang3<\/sup>, Katsuhiro Esashika3<\/sup>, Toru Sumita3<\/sup>
1<\/sup> University of Tokyo
2<\/sup> Kanazawa University
3<\/sup> Mitsui Chemicals, Inc.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-16<\/a><\/h2>\n\n\n\n

3D multi cell-type liver organoids as an alternative NAFLD model for drug safety assessment<\/a><\/h3>\n\n\n\n

Ferron Pierre-Jean<\/span><\/span>P1<\/sup>
1<\/sup> INSERM – U1241
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-17<\/a><\/h2>\n\n\n\n

A novel in vitro iPSC-based cardiac organoid model for personalized medicine.<\/a><\/h3>\n\n\n\n

Rosaria Santoro<\/span><\/span>P1<\/sup>, Luca Piacentini1<\/sup>, Chiara Vavassori1<\/sup>, Maura Brioschi1<\/sup>, Cristina Banfi1<\/sup>, Elena  Donetti2<\/sup>, Patrizia Benzoni2<\/sup>, Andrea Barbuti2<\/sup>, Giulio Pompilio1<\/sup>
1<\/sup> Centro Cardiologico Monzino IRCCS
2<\/sup> University of Milan
P<\/sup> Presenting author<\/p>\n\n\n\n

P-1-18<\/a><\/h2>\n\n\n\n

Advanced in vitro model for drug induced kidney injury assessment – generation of kidney organoid for safety assessment purposes<\/a><\/h3>\n\n\n\n

Lukas Wijaya<\/span><\/span>1<\/sup>, Sylvia le D\u00e9v\u00e9dec1<\/sup>, Bob van de Water1<\/sup>

1<\/sup>Leiden Academic Centre for Drug Research<\/p>\n\n\n\n

P-1-19<\/a><\/h2>\n\n\n\n

NEXT GENERATION TARGET ORGAN TOXICITY RISK ASSESSMENT: ENDOGENOUSLY TAGGED HUMAN STEM CELL REPORTERS FOR HIGH-CONTENT SCREENING OF OXIDATIVE STRESS RESPONSE<\/a><\/h3>\n\n\n\n

Tamara Danilyuk<\/span><\/span>1<\/sup>

1<\/sup>Leiden University<\/p>\n\n\n\n

Go back<\/a> <\/h2>\n\n\n\n

2a. Models, biomarkers and assays for endocrine disruption and developmental toxicity <\/span><\/h2>\n\n\n\n
<\/div>\n\n\n\n

P-2a-1<\/a><\/h2>\n\n\n\n

Chlorpyrifos impairs immortalized hypothalamic murine GnRH neurons at human relevant exposure levels<\/a><\/h3>\n\n\n\n

Gabriele Lori1,2<\/sup>, Maria Luisa Casella3<\/sup>, Antonella Tinari1<\/sup>, Sabrina Tait<\/span>P1<\/sup>
1<\/sup> Center for Gender-Specific medicine, Istituto Superiore di Sanit\u00e0
2<\/sup> Science Department, Universit\u00e0 Degli Studi di Roma Tre
3<\/sup> Core Facilities, Istituto Superiore di Sanit\u00e0
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-2<\/a><\/h2>\n\n\n\n

Evaluation of the local tolerance of flagellin aerosol therapy (FLAMOD) on primary human cell-based 3D in vitro nasal, bronchial, small-airway and alveolar models<\/a><\/h3>\n\n\n\n

Jean-Claude Sirard1<\/sup>, Itziar Sanjuan1<\/sup>, Charlotte Green-Jensen2<\/sup>, Nathalie Heuze Vourc’h3<\/sup>, Edouard Sage 4<\/sup>, Cindia Ferreira<\/span>P5<\/sup>, Samuel Constant5<\/sup>
1<\/sup> Institut Pasteur de Lille – Inserm, France
2<\/sup> Statens Serum Institut
3<\/sup> Universit\u00e9 de Tours, France
4<\/sup> Hopital Foch, France
5<\/sup> Epithelix
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-3<\/a><\/h2>\n\n\n\n

Investigation on the reproducibility of the DIO1 inhibition in vitro method based on human liver microsomes<\/a><\/h3>\n\n\n\n

Andreas-Georg Weber1<\/sup>, Barbara Birk1<\/sup>, Hans-Albrecht Huener1<\/sup>, Kostja Renko2<\/sup>, Sandra Coecke<\/span>P3<\/sup>, Steffen Schneider1<\/sup>, Bennard Van Ravenzwaay1<\/sup>, Robert Landsiedel3<\/sup>
1<\/sup> BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany
2<\/sup> 2Institut f\u00fcr Experimentelle Endokrinologie, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany
3<\/sup> European Commission, Joint Research Centre (JRC), Ispra, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-4<\/a><\/h2>\n\n\n\n

A closer look at the evaluation criteria of the H295R In vitro Steroidogenesis Assay test guideline<\/a><\/h3>\n\n\n\n

Caroline Gomes1<\/sup>, Claudia Ruelker1<\/sup>, Nina Hambruch<\/span>P1<\/sup>, Tilmann Walk2<\/sup>, Michael Herold2<\/sup>, Naveed  Honarvar1<\/sup>, Hennicke Kamp2<\/sup>, Dorothee Funk-Weyer1<\/sup>, Robert Landsiedel1<\/sup>
1<\/sup> BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany
2<\/sup> BASF Metabolome Solutions GmbH, Berlin, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-5<\/a><\/h2>\n\n\n\n

LC-MS based analysis of substance-induced displacement of thyroid hormone from its serum binding protein<\/a><\/h3>\n\n\n\n

Andreas Weber1<\/sup>, Lars-Henrik Koeppl1<\/sup>, Melanie Wei\u00dfenfeld1<\/sup>, Nina Hambruch<\/span>P1<\/sup>, Barbara Birk1<\/sup>, Eric Fabian1<\/sup>, Steffen Schneider1<\/sup>, Stephanie Melching-Kollmuss2<\/sup>, Dorothee Funk-Weyer1<\/sup>, Robert Landsiedel1<\/sup>
1<\/sup> BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany
2<\/sup> BASF SE, Agriculture Solutions, Global Toxicology, Limburgerhof, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-6<\/a><\/h2>\n\n\n\n

Impact of interference with retinoid signaling on in vitro differentiation in human neural stem cell-based model<\/a><\/h3>\n\n\n\n

Barbara  Kubickova 1<\/sup>, Sarka Martinkova1<\/sup>, Ondrej Brozman1<\/sup>, Klara Hilscherova<\/span>P1<\/sup>
1<\/sup> RECETOX, Faculty of Science, Masaryk University
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-7<\/a><\/h2>\n\n\n\n

In Vitro pharmacologic profiling For Cosmetic Chemical Systemic Toxicity Safety Testing: A case study on Homosalate<\/a><\/h3>\n\n\n\n

Matthew Burbank<\/span>P1<\/sup>, Nicola Jane Hewitt2<\/sup>, Gerry Kenna2<\/sup>, Mareike Boettcher3<\/sup>, Catherine Mahony4<\/sup>, Johanna Ebmeyer3<\/sup>, Duncan Armstrong5<\/sup>, Audrey Noel-Voisin6<\/sup>, Anne Riu7<\/sup>, Gladys Ouedraogo7<\/sup>
1<\/sup> L\u2019Or\u00e9al Research and Innovation, , Aulnay-sous-Bois, France
2<\/sup> Cosmetics Europe, Brussels, Belgium
3<\/sup> Beiersdorf AG Hamburg, Germany
4<\/sup> Procter & Gamble Technical Centres LTD, Reading, UK
5<\/sup> Duncan Armstrong, Armstrong Pharmacology Ltd., Macclesfield, UK
6<\/sup> L\u2019Or\u00e9al Research and Innovation, Clichy, France
7<\/sup> L\u2019Or\u00e9al Research and Innovation, Aulnay-sous-Bois, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-8<\/a><\/h2>\n\n\n\n

Test Guideline No. 248 (XETA): a new OCDE approved alternative method for the identification of thyroid active chemicals<\/a><\/h3>\n\n\n\n

David Du Pasquier<\/span>P1<\/sup>, Gregory Lemkine1<\/sup>
1<\/sup> Laboratoire Watchfrog
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-9<\/a><\/h2>\n\n\n\n

Relevant impact on the endocrine activity potential by modification of classical in vitro transactivation assays \u2013 exemplary case studies with two UV filters<\/a><\/h3>\n\n\n\n

Sylvie  Emery<\/span>P1<\/sup>, Guillaume Lereaux1<\/sup>, S\u00e9bastien  Gr\u00e9goire1<\/sup>, Matthew Burbank1<\/sup>, Nicola Jane Hewitt2<\/sup>, Audrey Noel-Voisin3<\/sup>, Dagmar Bury3<\/sup>, Gladys Ouedraogo1<\/sup>, Anne Riu1<\/sup>
1<\/sup> L’Or\u00e9al, Research and Innovation, Aulnay-sous-Bois, France
2<\/sup> Cosmetics Europe, Brussels, Belgium
3<\/sup> L\u2019Or\u00e9al Research and Innovation, Clichy, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-10<\/a><\/h2>\n\n\n\n

INCORPORATING A METABOLIZING SYSTEM AND TOPICAL APPLICATION TO IMPROVE THE VALUE OF IN VITRO ENDOCRINE DISRUPTION ASSAYS<\/a><\/h3>\n\n\n\n

Sylvie EMERY<\/span>P1<\/sup>, Guilaume  LEREAUX1<\/sup>, Matthew Burbank1<\/sup>, S\u00e9bastien GREGOIRE1<\/sup>, Dagmar  BURY2<\/sup>, V\u00e9ronique  POULSEN2<\/sup>, Anne RIU3<\/sup>
1<\/sup> L’Or\u00e9al, Research & Innovation, Aulnay-sous-Bois, France
2<\/sup> L\u2019Or\u00e9al Research and Innovation, Clichy, France.
3<\/sup> L\u2019Or\u00e9al Research and Innovation, Aulnay-sous-Bois, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-11<\/a><\/h2>\n\n\n\n

The agonistic bioanalytical equivalent concentration: A novel tool for assessing the endocrine activity of environmental mixtures<\/a><\/h3>\n\n\n\n

Martin Ezechi\u00e1\u0161<\/span>P1<\/sup>
1<\/sup> Institute of Microbiology of the Czech Academy of Sciences
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-12<\/a><\/h2>\n\n\n\n

ENDOCRINE DISRUPTION \u2013 BREAKING FREE FROM IN VIVO TESTING ORTHODOXY<\/a><\/h3>\n\n\n\n

Erik ProchazkaP1<\/sup><\/span><\/span>, Emma Grange1<\/sup>
1<\/sup> Cruelty Free Europe
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-13<\/a><\/h2>\n\n\n\n

PERFORMANCE LIMITATION OF OECD TEST NO. 455 ESTROGEN RECEPTOR TRANSACTIVATION ASSAY CLASSIFICATION CRITERIA USING VM7LUC4E2 CELL LINE.<\/a><\/h3>\n\n\n\n

Theo Le Godec<\/span>P1<\/sup>, Poornima Paramasivan1<\/sup>, Michael McMahon2<\/sup>, Matilda  Bingham1<\/sup>
1<\/sup> Concept Life Sciences
2<\/sup> Penman Consulting
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-14<\/a><\/h2>\n\n\n\n

A metabolomics approach to investigate in vitro the hepatotoxicity of drugs and the mechanisms so far involved<\/a><\/h3>\n\n\n\n

Teresa Martinez-Sena1,2<\/sup>, Erika Moro1<\/sup>, Marta Moreno<\/span>P1<\/sup>, Jose V. Castell1,3<\/sup>
1<\/sup> Experimental Hepatology, IISLAFE
2<\/sup> Analytical Chemistry, University of Valencia
3<\/sup> Departament of Biochemistry and Molecular Biology
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-15<\/a><\/h2>\n\n\n\n

Validation of Endocrine Disrupter Assays at EURL ECVAM<\/a><\/h3>\n\n\n\n

Anne  Milcamps<\/span>P1<\/sup>, Elise  Grignard1<\/sup>, Ingrid Langezaal1<\/sup>, Roman Liska1<\/sup>, Camilla Bernasconi1<\/sup>, Gerard Bowe1<\/sup>, Tom Cole1<\/sup>, Sandra Coecke1<\/sup>, Francesca Pistollato1<\/sup>, Valerie Zuang1<\/sup>, Sharon Munn1<\/sup>
1<\/sup> European Commission
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-16<\/a><\/h2>\n\n\n\n

THE ADIPOGENESIS MODEL OF HUMAN MESENCHYMAL STEM CELLS FOR THE DETERMINATION OF OBESOGENIC POTENTIALS OF SUNSCREENS<\/a><\/h3>\n\n\n\n

Minsoo Noh<\/span>P1<\/sup>, Sungjin Ahn1<\/sup>, Seungchan An1<\/sup>, In Guk Park1<\/sup>, Seok Young Hwang1<\/sup>, Junpyo Gong1<\/sup>
1<\/sup> College of Pharmacy, Seoul National University
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-17<\/a><\/h2>\n\n\n\n

INCREASING THE NUMBER OF AVAILABLE METHODS FOR THE DETECTION OF ENDOCRINE DISRUPTORS BEYOND EATS<\/a><\/h3>\n\n\n\n

Andrea RIVERO-ARZE<\/span>P1<\/sup>, Elise GRIGNARD1<\/sup>, Philippe HUBERT1<\/sup>
1<\/sup> PEPPER – Paris (FR)
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-18<\/a><\/h2>\n\n\n\n

EVALUATION OF THE CYTOTOXICITY OF TETRAHYDROCANNABINOL,CANNABINOL AND CANNABIDIOL IN PRECURSOR CELLS OF THE GLIA<\/a><\/h3>\n\n\n\n

Rene  Rocha<\/span>P1<\/sup>, Javier  Figueroa1<\/sup>, Diego Diaz1<\/sup>, Boris Duffau1<\/sup>, Ivan  Trivi\u00f1o1<\/sup>
1<\/sup> Instituto de Salud Publica de Chile
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-19<\/a><\/h2>\n\n\n\n

Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test<\/a><\/h3>\n\n\n\n

Elisabet Teixido<\/span>P1<\/sup>, Odile Kerkhof2,3<\/sup>, Nils Kl\u00fcver2<\/sup>, Tobias R Kiessling4<\/sup>, Stefan Scholz2<\/sup>
1<\/sup> GRET-Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain.
2<\/sup> Department of Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstra\u03b2e 15, 04318, Leipzig, Germany.
3<\/sup> French agency for food, environmental and occupational health and safety, Anses, France.
4<\/sup> Scientific Software Solutions, 04275, Leipzig, Germany.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-20<\/a><\/h2>\n\n\n\n

Study of Endocrine disruptors-related lipid and carbohydrate metabolism disorders in human hepatocytes<\/a><\/h3>\n\n\n\n

Charbel Touma<\/span>P1<\/sup>, Kevin BERNAL2<\/sup>, Frederic  EZAN 1<\/sup>, Sophie  ROSE 1<\/sup>, Antoine LEGRAND1<\/sup>, Valentine BROURAD1<\/sup>, B\u00e9atrice LE-GRAND2<\/sup>, Corinne CHOULY1<\/sup>, Dominique LAGADIC1<\/sup>, Etienne BLANC2<\/sup>, Sophie LANGOU\u00cbT1<\/sup>
1<\/sup> Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) – UMR_S 1085, 35000 Rennes, France
2<\/sup> Inserm UMR-S 1124, T3S, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-21<\/a><\/h2>\n\n\n\n

OXYSTEROLS PROFILE IN ZEBRAFISH EMBRYOS UPON EXPOSURE TO BISPHENOL A (BPA) AT 8 AND 24 HOURS POST-FERTILISATION<\/a><\/h3>\n\n\n\n

Anton Vremere<\/span>P1<\/sup>, Carmine Merola2<\/sup>, Federico Fanti2<\/sup>, Manuel Sergi2<\/sup>, Monia Perugini2<\/sup>, Dario Compagnone2<\/sup>, Michele Amorena2<\/sup>, Milena Mikhail1<\/sup>, Stefano Lorenzetti1<\/sup>
1<\/sup> ISS – Istituto Superiore di Sanit\u00e0, Department of Food Safety, Nutritionn and Veterinary Public Health
2<\/sup> University of Teramo, Faculty of Bioscience and Technology for Food, Agriculture and Environment
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-2<\/a>2<\/a><\/h2>\n\n\n\n

HIGH CONTENT SCREENING OF BISPHENOLS AND THEIR MIXTURES UNDER CONDITIONS OF LOW-INTENSITY ADIPOGENESIS OF HUMAN MESENCHYMAL STEM CELLS (hMSCs)<\/a><\/h3>\n\n\n\n

Kalle Norgren1<\/sup>, Astrud Tuck1<\/sup>, Antero Vieira Silva1<\/sup>, Paula Burkhardt1<\/sup>, Mattias \u00d6berg1<\/sup>, Vesna Munic Kos<\/span>P1<\/sup>
1<\/sup> Karolinska Institutet
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-23<\/a><\/h2>\n\n\n\n

Reproductive and developmental adverse effects of complex real-life mixtures in human-relevant cell-based assays<\/a><\/h3>\n\n\n\n

Andreas Frederik Treschow<\/span><\/span>P1<\/sup>, Yanying Ma1<\/sup>, Maria Jo\u00e3o Valente1<\/sup>, Maria Margalef2<\/sup>, Maria K\u00f6nig3<\/sup>, Sol\u00e8ne Motteau4<\/sup>, Gaud Dervilly4<\/sup>, Ronan Cariou4<\/sup>, Beate I. Escher3<\/sup>, Marja Lamoree2<\/sup>, Jean-Philippe  Antignac4<\/sup>, Anne Marie Vinggaard1<\/sup>
1<\/sup> National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
2<\/sup> Vrije Universiteit, Department Environment & Health, Amsterdam, the Netherlands
3<\/sup> Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany
4<\/sup> Oniris, INRAE, LABERCA, Nantes, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-24<\/a><\/h2>\n\n\n\n

Teratogenic potential of Cosmetics: Building and Optimize a toolbox to develop an ITS<\/a><\/h3>\n\n\n\n

Matthew Burbank<\/span><\/span>P1<\/sup>, Florian Gautier1<\/sup>, Audrey Noel-Voisin1<\/sup>, Tanja Wildemann1<\/sup>, Anne Riu1<\/sup>, Ann Detroyer1<\/sup>, Typhaine Bringel1<\/sup>, Laurent Guillet-Revol1<\/sup>, Leopold Carron1<\/sup>, No\u00e9mie De Croze1<\/sup>, Gladys Ou\u00e9draogo1<\/sup>
1<\/sup> L’Oreal Research & Innovation, Aulnay-sous-Bois, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2a-25<\/a><\/h2>\n\n\n\n

The role of retinoids in disturbing neural rosette formation<\/a><\/h3>\n\n\n\n

Nadine Dreser<\/span><\/span>P1<\/sup>, Marion Kapitza1<\/sup>, Christiaan  Karreman1<\/sup>, Ilinca Suciu1<\/sup>, Marcel Leist1<\/sup>
1<\/sup> In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp Zbinden Foundation, University of Konstanz
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

2b. Challenges in cosmetics safety <\/span><\/h2>\n\n\n\n

P-2b-1<\/a><\/h2>\n\n\n\n

An OECD 439 Adaptive In Vitro Skin Irritation Test Model<\/a><\/h3>\n\n\n\n

Sevde  Altuntas<\/span>P1,2,3<\/sup>, Ahmet Kat\u01311,4,3<\/sup>, Ashwani  Sharma5<\/sup>
1<\/sup> Experimental Medicine Research and Application Center, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey
2<\/sup> Department of Tissue Engineering, Institution of Health Sciences, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey
3<\/sup> Omic-A Research and Innovation Ltd Company, Pendik, 34668, Istanbul, Turkey
4<\/sup> Department of Tissue Biotechnology, Institution of Health Sciences, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey
5<\/sup> Insight Biosolutions, 35000, Rennes, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2b-2<\/a><\/h2>\n\n\n\n

ToxTool: an innovative database for the cosmetic regulatory affair<\/a><\/h3>\n\n\n\n

Giulia De Negri Atanasio<\/span>P1<\/sup>, Federica Robino2<\/sup>, Lorenzo Dondero1<\/sup>, Elisabetta Perata2<\/sup>, Francesca  Rispo1<\/sup>, Giorgia Allaria1<\/sup>, Francesca  Tardanico1<\/sup>, Francesca Bruzzone2<\/sup>, Matteo Zanotti-Russo2<\/sup>, Elena Grasselli1<\/sup>
1<\/sup> Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy
2<\/sup> ANGEL CONSULTING S.a.s., Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2b-3<\/a><\/h2>\n\n\n\n

Too many Animal Tests on Cosmetic Ingredients for REACH in the EU: actual situation and future prospects<\/a><\/h3>\n\n\n\n

Costanza Rovida<\/span>P1<\/sup>, Francois Busquet2<\/sup>
1<\/sup> CAAT-Europe, Konstanz University, Germany
2<\/sup> Altertox, Belgium
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2b-4<\/a><\/h2>\n\n\n\n

The study on EDs and the application of the NGRA according to the guidelines SCCS NoG XI Ed: two overlapping challenges.<\/a><\/h3>\n\n\n\n

Matteo Zanotti Russo<\/span>P1<\/sup>, Giorgia Allaria2<\/sup>, Lorenzo Dondero2<\/sup>, Giulia De Negri Atanasio2<\/sup>, Francesca Rispo2<\/sup>, Francesca Tardanico2<\/sup>, Federica Robino1<\/sup>, Elisabetta Perata1<\/sup>, Francesca Bruzzone1<\/sup>, Elena Grasselli2<\/sup>
1<\/sup> Angel Consulting S.a.s. 20122 Milano Italy
2<\/sup> Dipartimento Scienze della Terra dell\u2019Ambiente e della Vita-DISTAV, Universit\u00e0 degli Studi di Genova\u201416132 Genova, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-2b-5<\/a><\/h2>\n\n\n\n

Zebrafish: Alternative Model For Cosmetic Testing<\/a><\/h3>\n\n\n\n

Arantza Muriana<\/span><\/span>P1<\/sup>, Andrea Weiner1<\/sup>, Celia Rodriguez 1<\/sup>
1<\/sup> BBD BioPhenix-BIOBIDE
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

3a. Models, biomarkers and assays for systemic and immune toxicity  <\/span><\/h2>\n\n\n\n

P-3a-1<\/a><\/h2>\n\n\n\n

Analysis of the predictive capacity of the SENS-IS assay to define the skin sensitization potency on 186 chemicals<\/a><\/h3>\n\n\n\n

Fran\u00e7oise Cottrez1<\/sup>, Elodie Boite1<\/sup>
1<\/sup> ImmunoSearch, Grasse, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-2<\/a><\/h2>\n\n\n\n

Potential beneficial effects of selenium nanoparticles in the adjuvant anticancer therapy<\/a><\/h3>\n\n\n\n

Elena Ines Adam-Dima<\/span>P1<\/sup>, Mihaela Bala\u02192<\/sup>, Anca Dinischiotu2<\/sup>, Carmen Nicoleta Purdel1<\/sup>, Denisa  Margin\u01031<\/sup>
1<\/sup> “Carol Davila” University of Medicine and Pharmacy Bucharest, Faculty of Pharmacy
2<\/sup> University of Bucharest, Faculty of Biology
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-3<\/a><\/h2>\n\n\n\n

Extending the boundaries of OECD DPRA test N\u00b0442C towards complex substances and mixtures: an innovative feat in HPLC-MS\/MS and skin sensitization testing<\/a><\/h3>\n\n\n\n

Eric  Andres <\/span>P1<\/sup>, Sergio Gonzalez Duque1<\/sup>, Axelle Huyard1<\/sup>, Rola Barcham1<\/sup>, Christophe Dini1<\/sup>
1<\/sup> Oroxcell
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-4<\/a><\/h2>\n\n\n\n

Target organs in cosmetics: which in vitro and in silico models to move towards to increase expertise in systemic toxicity?<\/a><\/h3>\n\n\n\n

Matthew Burbank<\/span>P1<\/sup>, Emilie Barbeau1<\/sup>, Romain Grall1<\/sup>, Ann Detroyer1<\/sup>, Audrey Noel-Voisin2<\/sup>, Gladys Ouedraogo1<\/sup>, Anne Riu3<\/sup>
1<\/sup> L\u2019Or\u00e9al Research and Innovation, , Aulnay-sous-Bois, France
2<\/sup> L\u2019Or\u00e9al Research and Innovation, , Clichy, France
3<\/sup> L\u2019Or\u00e9al Research and Innovation,, Aulnay-sous-Bois, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-5<\/a><\/h2>\n\n\n\n

Safety of cosmetic perfumes screened in chemico and in vitro in combination with targeted chemical analysis<\/a><\/h3>\n\n\n\n

Marketa  Dvorakova<\/span>P1,2<\/sup>, Kristina Kejlova1<\/sup>, Hana Bendova1<\/sup>, Lada Svobodova1,3<\/sup>, Marian Rucki1<\/sup>, Vaclav Sevcik1,4<\/sup>, Barbora Hosikova3<\/sup>, Jan Chrz3<\/sup>, Danuse Ocadlikova1<\/sup>, Hana Kolarova3<\/sup>, Marek Maly1<\/sup>, Dagmar Jirova1<\/sup>, Helena Kandarova5<\/sup>
1<\/sup> National Institute of Public Health, Prague, Czech Republic
2<\/sup> Third Faculty of Medicine, Charles University in Prague, Czech Republic
3<\/sup> Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
4<\/sup> Department of Analytical Chemistry, Faculty of Science, Charles University in Prague, Czech Republic
5<\/sup> Slovak Academy of Sciences, Bratislava, Slovak Republic
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-6<\/a><\/h2>\n\n\n\n

Use of Assay Ready KertainoSens\u00ae Cells to test for Skin Sensitization<\/a><\/h3>\n\n\n\n

Lukas Focke<\/span>P1<\/sup>, Valerie de Boor1<\/sup>, Oliver Wehmeier1<\/sup>
1<\/sup> acCELLerate GmbH
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-7<\/a><\/h2>\n\n\n\n

A predictive 3D liver spheroid model for the assessment of liver repeated dose toxicity<\/a><\/h3>\n\n\n\n

Romain Grall<\/span>P1<\/sup>, Veronique Neiveyans1<\/sup>, Sylvie Emery1<\/sup>, Fran\u00e7oise Gautier2<\/sup>, Gladys Ouedraogo1<\/sup>, Anne Riu1<\/sup>
1<\/sup> L\u2019Or\u00e9al Research and Innovation, Aulnay-sous-Bois, France
2<\/sup> L\u2019Or\u00e9al Research and Innovation, Clichy, France.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-8<\/a><\/h2>\n\n\n\n

Developing an innervated skin model for predicting neuroinflammatory and neurosensory effect of cosmetic compounds<\/a><\/h3>\n\n\n\n

Md Zobaer Hasan<\/span>P1<\/sup>, Amy Leigh Harding2<\/sup>, Hirofumi Nakanishi1<\/sup>, Tetsuo Furuno1<\/sup>, Craig  Murdoch2<\/sup>, Helen E Colley2<\/sup>
1<\/sup> Rohto Pharmaceutical CO.,ltd
2<\/sup> University of Sheffield
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-9<\/a><\/h2>\n\n\n\n

EFFECTS OF PER- AND POLYFLUOROALKYL SUBSTANCES IN HUMAN B AND T CELL LINES<\/a><\/h3>\n\n\n\n

Aafke Janssen<\/span>P1<\/sup>, Karsten Beekmann1<\/sup>, Nicole Pinckaers1<\/sup>, Joke  Hoekstra1<\/sup>, Sanne  Schild1<\/sup>, Ron Hoogenboom1<\/sup>, Ad Peijnenburg1<\/sup>, Jochem Louisse1<\/sup>
1<\/sup> Wageningen Food Safety Research
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-10<\/a><\/h2>\n\n\n\n

IN VITRO 3D KIDNEY MODEL CO-CULTURED WITH HUMAN IMMUNE CELLS INVESTIGATING IMMUNE HYPERACTIVITY ASSOCIATED RENAL INJURY<\/a><\/h3>\n\n\n\n

Yu Bin Lee<\/span>P1<\/sup>, Mi-lang Kyun1<\/sup>, Tamina Park1<\/sup>, Min-Heui Yoo1<\/sup>, Inhye Kim1<\/sup>, Hyewon Jung1<\/sup>, Myeongjin Choi1<\/sup>, Seo Yule Jeong1<\/sup>, Jihye Son1<\/sup>, Dong Ho Woo1<\/sup>, Chang Hoon Choi1<\/sup>, Hyun-A Oh1<\/sup>, Ye-Ji Kim1<\/sup>, Gong Yeon Kim1<\/sup>, Yu Yeong Jeong1<\/sup>, Daeui Park1<\/sup>, Kyoung-Sik Moon1<\/sup>
1<\/sup> Korea Institute of Toxicology
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-11<\/a><\/h2>\n\n\n\n

Establishment of a complex commensal 3-D skin model for toxicity testing<\/a><\/h3>\n\n\n\n

Lisa Lemoine<\/span>P1<\/sup>, Maya Kissner, Aline Rosin, Tewes Tralau
1<\/sup> German Federal Institute for Risk Assessment (BfR)
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-12<\/a><\/h2>\n\n\n\n

EXPLORING CAUSAL RELATIONSHIPS BETWEEN PFAS EXPOSURE AND LIPID HOMEOSTASIS BY THE USE OF A HUMAN LIVER SPHEROID MODEL<\/a><\/h3>\n\n\n\n

Birgitte Lindeman<\/span>P1<\/sup>, Marit L\u00e5g1<\/sup>, Line Sm\u00e5stuen Haug1<\/sup>, Azemira Sabaredzovic 1<\/sup>, Kristine Bjerve G\u00fctzkow1<\/sup>
1<\/sup> Norwegian Institute of Public Health; Division of Climate and Environmental Health
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-13<\/a><\/h2>\n\n\n\n

In vitro study of biosafety of ZnO nanoparticles: coagulation assay and protein corona.<\/a><\/h3>\n\n\n\n

Montserrat Mitjans<\/span>P1<\/sup>, Marc Bilbao1<\/sup>, Laura Marics1<\/sup>, M. Pilar Vinardell1<\/sup>
1<\/sup> Fisiologia, Dep. de Bioqu\u00edmica i Fisiologia, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l’Alimentaci\u00f3, Universitat de Barcelona
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-14<\/a><\/h2>\n\n\n\n

Evaluation of the use of in vitro methods to study the general toxic effect of cosmetic products<\/a><\/h3>\n\n\n\n

Ulyana Protasevich<\/span>P1<\/sup>, Maryna Anisovich1<\/sup>, Tatsiana  Hamolka1<\/sup>, Iryna Ilyukova1<\/sup>
1<\/sup> Republican unitary enterprise \u00abScientific practical centre of hygiene\u00bb
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-15<\/a><\/h2>\n\n\n\n

LIVER METABOLOMICS IN VITRO\u2013 A MINIATURIZED SCREENING APPROACH TO PREDICT THE MODE OF ACTION OF LIVER TOXICANTS IN HEPG2 CELLS<\/a><\/h3>\n\n\n\n

Sabina Ramirez Hincapie<\/span>P1<\/sup>, Barbara  Birk1<\/sup>, Michael  Herold2<\/sup>, Philipp  Ternes2<\/sup>, Volker  Haake2<\/sup>, Varun  Giri1<\/sup>, Franziska Maria  Zickgraf 1<\/sup>, Hans-Albrecht  Huener1<\/sup>, Andreas  Verlohner1<\/sup>, Hennicke  Kamp1<\/sup>, Robert  Landsiedel1<\/sup>, Elke  Richling3<\/sup>, Dorothee  Funk-Weyer1<\/sup>, Bennard  van Ravenzwaay1<\/sup>
1<\/sup> BASF SE
2<\/sup> BASF Metabolome Solution GmbH
3<\/sup> University of Kaiserslautern
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-16<\/a><\/h2>\n\n\n\n

IMPLEMENTING AN IN VITRO METABOLOMICS SCREENING METHOD TO STUDY LIVER TOXICANTS IN HEPG2 CELLS- A CASE STUDY WITH NITROFURANTOIN<\/a><\/h3>\n\n\n\n

Sabina Ramirez Hincapie<\/span>P1<\/sup>, Barbara  Birk1<\/sup>, Franziska Maria Zickgraf1<\/sup>, Michael  Herold2<\/sup>, Philipp Ternes2<\/sup>, Volker  Haake2<\/sup>, Varun  Giri1<\/sup>, Hans-Albrecht  Huener1<\/sup>, Andreas  Verlohner1<\/sup>, Hennicke  Kamp1<\/sup>, Robert  Landsiedel1<\/sup>, Elke  Richling3<\/sup>, Dorothee  Funk-Weyer1<\/sup>, Bennard  van Ravenzwaay1<\/sup>
1<\/sup> BASF SE
2<\/sup> BASF Metabolome Solutions GmbH
3<\/sup> University of Kaiserslautern
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-17<\/a><\/h2>\n\n\n\n

IMPACT OF BENZO[A]PYRENE ON MICRORNAS PROFILES IN HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS AND THEIR DISCHARGED EXTRACELLULAR VESICLES<\/a><\/h3>\n\n\n\n

Rima Souki<\/span>P1<\/sup>, Jeremy  Amosse1<\/sup>, Maguy  Basbous2<\/sup>, Eric  Le Ferrec1<\/sup>, Dominique Lagadic-Gossmann1<\/sup>, Christine Demeilliers2<\/sup>, Anne Maitre2<\/sup>, Lydie Sparfel1<\/sup>
1<\/sup> Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail),  UMR_S 1085, F-35000 Rennes, France
2<\/sup> Univ. Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, TIMC Laboratory (UMR CNRS 5525), EPSP Team, 38000, Grenoble, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-18<\/a><\/h2>\n\n\n\n

Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis<\/a><\/h3>\n\n\n\n

Jonas van Ertvelde<\/span>P1<\/sup>, Anouk Verhoeven1<\/sup>, Tamara Vanhaecke1<\/sup>, Ramiro Jover2<\/sup>, Jian  Jiang1<\/sup>, Mathieu  Vinken1<\/sup>
1<\/sup> Entity of In Vitro Toxicology and Dermato Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
2<\/sup> Joint Research Unit in Experimental Hepatology, University of Valencia; IIS Hosp. La Fe; CIBERehd; Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-19<\/a><\/h2>\n\n\n\n

An adverse outcome pathway network for liver steatosis induced by chemicals<\/a><\/h3>\n\n\n\n

Anouk Verhoeven<\/span>P1<\/sup>, Jonas  van Ertvelde 1<\/sup>, Mathieu Vinken1<\/sup>, Robim Marcelino Rodrigues1<\/sup>, Joost Boeckmans1<\/sup>, Alexandra  Gatzios1<\/sup>, Sara  Sepehri1<\/sup>, Marth  Stinckens1<\/sup>, Ramiro  Jover2<\/sup>, Anna  Rapisarda2<\/sup>, Birgitte  Lindeman3<\/sup>, Graciela Lopez Soop3<\/sup>, Camilla  Svendsen3<\/sup>, Jian  Jiang1<\/sup>, Tamara  Vanhaecke1<\/sup>
1<\/sup> Entity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
2<\/sup> Joint Research Unit in Experimental Hepatology, University of Valencia; IIS Hosp. La Fe; CIBERehd; Spain
3<\/sup> Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3a-20<\/a><\/h2>\n\n\n\n

Advanced biological models for hazard assessment of nanomaterials on human health<\/a><\/h3>\n\n\n\n

Laura Maria Azzurra Camassa<\/span>P1<\/sup>, Hamed Sadeghiankaffash1<\/sup>, Zheng Congying2<\/sup>, Kristine Haugen Ammarkrud1<\/sup>, Sergey Shaposhnikov2<\/sup>, Shan Zienolddiny-Narui11<\/sup>
1<\/sup> National Institute of Occupational Health in Norway, 0033 Oslo, Norway
2<\/sup> Norgenotech AS, 0379 Oslo, Norway
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

3b. Organ-on-a-chip & Microphysiological Systems   <\/span><\/h2>\n\n\n\n

P-3b-1<\/a><\/h2>\n\n\n\n

On the Real-Time Oxygen Consumption of Hepatocytes in a Microphysiological System<\/a><\/h3>\n\n\n\n

Marie Flechner<\/span>1<\/sup>, Jan Martin Gebler1<\/sup>, Christian Gehre1<\/sup>, Sarah Kammerer2<\/sup>, Dennis Kaden3<\/sup>, Jan-Heiner K\u00fcpper2<\/sup>, Claus Duschl1<\/sup>, Lars Daehne3<\/sup>, Katja UhligP1<\/sup>
1<\/sup> Fraunhofer Institute for Cell Therapy and Immunology (IZI-BB), 14476 Potsdam, Germany
2<\/sup> Brandenburg University of Technology, 01968 Senftenberg, Germany
3<\/sup> Surflay Nanotec GmbH, 12489 Berlin, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-2<\/a><\/h2>\n\n\n\n

PROPOSAL FOR A HUMAN FOETO-PLACENTAL ORGAN-A-CHIP FOR TESTING DEVELOPMENTAL TOXICITY<\/a><\/h3>\n\n\n\n

Emilio Benfenati1<\/sup>, Michaela Luconi2<\/sup>, Udo R. Markert3<\/sup>, Tobias May4<\/sup>, Alessandra Roncaglioni1<\/sup>, Astrid Schmidt5<\/sup>, Miguel A. Sogorb<\/span>P6<\/sup>, Marco Straccia7<\/sup>, Sabrina Tait8<\/sup>, Susanne Wolbankh9<\/sup>
1<\/sup> Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy
2<\/sup> Dept. Clinical & Experimental Biomedical Sciences, University of Florence, Italy
3<\/sup> Placenta Lab, Department of Obstetrics, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany.
4<\/sup> InSCREENeX GmbH, Braunschweig, Germany
5<\/sup> Placenta Lab, Department of Obstetrics, University Hospital Jena, Am Klinikum 1, 07747, Jena, Germany
6<\/sup> Bioengineering Institute, Miguel Hern\u00e1ndez de Elche University, 03202-Elche, Spain
7<\/sup> FRESCI by SCIENCE&STRATEGY SL, Barcelona, Spain
8<\/sup> Center for Gender-Specific Medicine, Istituto Superiore di Sanit\u00e0, Rome, Italy
9<\/sup> Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Donaueschingenstrasse 13, A-1200, Vienna, Austria
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-3<\/a><\/h2>\n\n\n\n

ALL-IN-ONE MICROFLUIDIC-BASED ROBOTIC PLATFORM FOR AUTOMATED TOX SCREENINGS IN C. ELEGANS.<\/a><\/h3>\n\n\n\n

Elena  Katsyuba1<\/sup>, Lazar Stojkovic1<\/sup>, Fabien T\u00e2che1<\/sup>, Matteo Cornaglia1<\/sup>, Laurent Mouchiroud<\/span>P1<\/sup>
1<\/sup> Nagi Bioscience SA, EPFL Innovation Park, Chemin de la Dent d\u2019Oche 1B, CH-1024 Ecublens, Switzerland
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-4<\/a><\/h2>\n\n\n\n

Mutagenicity and genotoxicity assessment of a new biopreservative product rich in Enterocin AS-48<\/a><\/h3>\n\n\n\n

Antonio Cascajosa-Lira<\/span>P1<\/sup>, Ana Isabel Prieto1<\/sup>, Mar\u00eda Puerto1<\/sup>, Enrique  Guillamon2<\/sup>, Alberto Ba\u00f1os2,3<\/sup>, Eva  Valdivia3<\/sup>, \u00c1ngeles  Jos1<\/sup>, Ana Mar\u00eda Came\u00e1n1<\/sup>
1<\/sup> Area of Toxicology. Faculty of Pharmacy.Universidad de Sevilla, Profesor Garc\u00eda Gonz\u00e1lez n\u00b02, 41012 Sevilla, Espa\u00f1a
2<\/sup> DMC Research Center. Camino de Jayena, 82, 18620 Alhend\u00edn, Granada, Espa\u00f1a
3<\/sup> Department of Microbiology. Universidad de Granada. Campus de Fuente Nueva.Dr. Severo Ochoa, 18071 Granada, Espa\u00f1a
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-5<\/a><\/h2>\n\n\n\n

A multiorgan-on chip platform for the in vitro investigation of off-target cardiotoxicity of liver-metabolized anticancer drugs<\/a><\/h3>\n\n\n\n

Erika Ferrari<\/span>P1<\/sup>, Roberta Visone1,2<\/sup>, Paola Occhetta1,2<\/sup>, Marco  Rasponi1,2<\/sup>
1<\/sup> Department of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy
2<\/sup> BiomimX Srl, Milano, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-6<\/a><\/h2>\n\n\n\n

3D human vasculature-on-a-chip: the biological effect of combustible cigarette smoke and vapor from three heated tobacco products on monocyte adhesion to vessels comprising coronary artery endothelial cells<\/a><\/h3>\n\n\n\n

Ayaka Hayashida<\/span>P1<\/sup>, Atsuko  Nozawa1<\/sup>, Kazuhiro  Ohashi1<\/sup>, Shigeaki Ito1<\/sup>
1<\/sup> Scientific Product Assessment Center, Japan Tobacco Inc.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-7<\/a><\/h2>\n\n\n\n

What are the barriers to adoption of new approach methodologies for gastrointestinal toxicity testing? A systematic review of in vitro models of  gastrointestinal toxicity<\/a><\/h3>\n\n\n\n

Alasdair  Irvine<\/span>P1<\/sup>, Paul Jochems1<\/sup>, Roos Masereeuw1<\/sup>
1<\/sup> Utrecht University
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-8<\/a><\/h2>\n\n\n\n

A systematic review of in vitro models of drug-induced liver injury<\/a><\/h3>\n\n\n\n

Alasdair  Irvine<\/span>P1<\/sup>, Vivian  Lehman2,3<\/sup>, Bart  Spee4<\/sup>, Sabine  Fuchs2<\/sup>, Ross Masereeuw 5<\/sup>, Mathieu  Vinken6<\/sup>
1<\/sup> Utrecht Institute for Pharmaceutical Sciences (UIPS), Division of Pharmacology, Utrecht University
2<\/sup> Department of Metabolic Diseases, University Medical Center Utrecht
3<\/sup> Department of Veterinary Medicine, Utrecht University
4<\/sup> Department of Veterinary Medicine, Utrecht University,
5<\/sup> Utrecht Institute for Pharmaceutical Sciences (UIPS), Division of Pharmacology, Utrecht University
6<\/sup> Department of In Vitro Toxicology, Vrije Universiteit Brussel
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-9<\/a><\/h2>\n\n\n\n

USE OF MICROFLUIDIC CHAMBERS IN ENVIRONMENTAL TOXICITY STUDIES USING FISH CELLS AS A MODEL<\/a><\/h3>\n\n\n\n

Gemma Lopez <\/span>P1<\/sup>, Cinta  Porte1<\/sup>, Xavier  Mu\u00f1oz2<\/sup>, Carlos  Barata1<\/sup>
1<\/sup> IDAEA-CSIC
2<\/sup> IMB-CNM-CSIC
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-10<\/a><\/h2>\n\n\n\n

SOLUBLE FACTORS ARE INVOLVED IN THE PROPAGATION OF LIVER FIBROSIS IN VITRO<\/a><\/h3>\n\n\n\n

Saskia Schmidt<\/span>P1,2<\/sup>, Catherine Messner1,3<\/sup>, Carine Gaiser1<\/sup>, Bradley Petkus4<\/sup>, Lo\u00efc  Burr4<\/sup>, Joy Roth5<\/sup>, Alexandra Homsy5<\/sup>, Felix Kurth4<\/sup>, Silvia Generelli4<\/sup>, Laura Suter-Dick1,3<\/sup>
1<\/sup> School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Muttenz, 4132, Switzerland
2<\/sup> Department of Pharmaceutical Sciences, University of Basel, Basel, 4056, Switzerland
3<\/sup> SCAHT: Swiss Centre of Applied Human Toxicology, Basel, 4055, Switzerland
4<\/sup> Centre Suisse d\u2019Electronique et de Microtechnique SA (CSEM), Landquart, 7302, and Muttenz, 4132, Switzerland
5<\/sup> Haute Ecole Arc ing\u00e9nierie (HES-SO), La Chaux-de-Fonds, 2300, Switzerland
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-11<\/a><\/h2>\n\n\n\n

A microfluidic-based in vitro reconstruction of synaptic circuits as an alternative model for pharmacologic research<\/a><\/h3>\n\n\n\n

Clelia  Introna<\/span><\/span>P1,2<\/sup>, In\u00eas  Pereira3<\/sup>, Guochang Lyu4<\/sup>, Maria Jos\u00e8 Lopez Martinez3,5,6<\/sup>, Josep Samitier3,5,6<\/sup>, Berta  Coll7<\/sup>, Jordi Soriano8,9<\/sup>, Ernest Arenas4<\/sup>, Daniel Tornero Prieto7,2<\/sup>, Josep M. Canals Coll1,2<\/sup>
1<\/sup> Laboratory of Stem Cells and Regenerative Medicine, Department of Biomedical Sciences and Creatio – Production and Validation Center of Advanced Therapies, Faculty of Medicine and Health Sciences; Institute of Neurosciences, University of Barcelona; Barcelona, Spain;
2<\/sup> August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
3<\/sup> Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC) Barcelona Institute of Science and Technology BIST, Barcelona, Spain);
4<\/sup> Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
5<\/sup> Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain;
6<\/sup> Department of Electronic and Biomedical Engineering, University of Barcelona, Barcelona, Spain.
7<\/sup> Laboratory of Neuronal Stem Cells and Cerebral Damage, Department of Biomedical Sciences and Creatio – Production and Validation Center of Advanced Therapies, Faculty of Medicine and Health Sciences; Institute of Neurosciences, University of Barcelona; Barcelona, Spain.
8<\/sup> Departament de F\u00edsica de la Mat\u00e8ria Condensada, Universitat de Barcelona, Barcelona, Spain.
9<\/sup> Universitat de Barcelona Institute of Complex Systems (UBICS), Barcelona, Spain.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-3b-12<\/a><\/h2>\n\n\n\n

A microfluidic, patient-derived tumor-on chip platform for therapeutic efficacy and safety evaluation of CAR-T cell products<\/a><\/h3>\n\n\n\n

Julia Roosz<\/span><\/span>1,2<\/sup>
1<\/sup> NMI Natural and Medical Sciences Institute at the University of T\u00fcbingen
2<\/sup> Department of Microphysiological Systems, University of T\u00fcbingen, T\u00fcbingen, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

4a. Computational toxicology \u2013 in silico modelling, read-across, artificial intelligence and machine learning   <\/span><\/h2>\n\n\n\n

P-4a-1<\/a><\/h2>\n\n\n\n

Adverse Outcome Network For Obesity Initiated By Endocrine Disruptors developed using the AOP-helpFinder tool<\/a><\/h3>\n\n\n\n

Kevin Bernal1<\/sup>, Florence Jornod1<\/sup>, Xavier Coumoul1<\/sup>, Etienne Blanc1<\/sup>, MinJi Kim2<\/sup>, Karine AudouzeP<\/sup><\/span>1<\/sup>
1<\/sup> Universit\u00e9 Paris Cit\u00e9, Inserm U1124, 75006 Paris, France
2<\/sup> Universit\u00e9 Sorbonne Paris Nord, Inserm U1124, 75006 Paris, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-2<\/a><\/h2>\n\n\n\n

Development of a easy-to-use, semantic technology-based knowledgebase containing toxicological information of cosmetic ingredients to assist animal-free risk assessment<\/a><\/h3>\n\n\n\n

Sara SepehriP<\/sup><\/span>1<\/sup> <\/sup>, Robim M. Rodrigues1<\/sup> , Mona Delagrange1<\/sup> , Joery De Kock1<\/sup> , Audrey Sanctorum 2<\/sup> , Jan Maushagen 2<\/sup> , Christophe Debruyne 3<\/sup>, Olga De Troyer 2<\/sup> , Tamara Vanhaecke1<\/sup>
1<\/sup> Department of In Vitro Toxicology and Dermato-Cosmetology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
2<\/sup> WISE lab, Vrije Universiteit Brussel, Brussels, Belgium
3<\/sup> Montefiore Institute of Li\u00e8ge University, Quartier Polytech 1, All\u00e9e de la D\u00e9couverte 10, 4000 Li\u00e8ge, Belgium<\/p>\n\n\n\n

P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-3<\/a><\/h2>\n\n\n\n

Three steps to select analogues for skin sensitization prediction using read-across: an exemplary case study with vanillin<\/a><\/h3>\n\n\n\n

Fran\u00e7oise Gauthier1<\/sup>, Fleur Tourneix1<\/sup>, Hind Assaf-Vandecasteele1<\/sup>, Dagmar Bury1<\/sup>, Nathalie Al\u00e9p\u00e9e<\/span>P1<\/sup>
1<\/sup> L’Oreal R&I
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-4<\/a><\/h2>\n\n\n\n

Elucidating the Inhibition Mechanism of six FDA-Approved Drugs on P-glycoprotein (P-gp) Transporter by Molecular Docking Simulation<\/a><\/h3>\n\n\n\n

Abira Dey1<\/sup>, Ruoya Li2<\/sup>, Nathalie Larzat2<\/sup>, Jean Bernard  Idoipe2<\/sup>, Ahmet Kati3<\/sup>, Ashwani SHARMA<\/span>P2<\/sup>
1<\/sup> Indian Science and Technology Foundation, Delhi-110053, India
2<\/sup> Insight Biosolutions, 35000, Rennes, France
3<\/sup> Experimental Medicine Research and Application Center, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey, Department of Biotechnology, Institution of Health Sciences, University of Health Sciences Turkey, Uskudar, Istanbul, Turkey,
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-5<\/a><\/h2>\n\n\n\n

ORBITOX \u2013 A COMPUTATIONAL TRANSLATIONAL DISCOVERY PLATFORM FOR DATA MINING AND READ-ACROSS<\/a><\/h3>\n\n\n\n

Alexander  Sedykh1<\/sup>, Austin  Ross1<\/sup>, Vijay  Gombar1<\/sup>, Nicole  Kleinstreuer2<\/sup>, Alex  Merick3<\/sup>, Ruchir  Shah1<\/sup>, Warren  Casey3<\/sup>
1<\/sup> Sciome LLC
2<\/sup> NICEATM, NIEHS
3<\/sup> NTP, NIEHS
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-6<\/a><\/h2>\n\n\n\n

Use of text-mining and chemoinformatics as additional decision-making tools for the chemical selection process of the EU-NETVAL thyroid validation study<\/a><\/h3>\n\n\n\n

David  Asturiol<\/span>P1<\/sup>, Alessandro  Antonelli2<\/sup>, Anna  Beronius3<\/sup>, Patience Browne4<\/sup>, Thomas  Cole1<\/sup>, Raffaella Corvi1<\/sup>, Barbara  Demeneix5<\/sup>, Alexius  Freyberger6<\/sup>, Mary Gilbert Gilbert7<\/sup>, Elise  Grignard1<\/sup>, Kl\u00e1ra Hilscherov\u00e18<\/sup>, Aude Kienzler1<\/sup>, Dries Knapen9<\/sup>, Josef  K\u04e7hrle10<\/sup>, Ingrid Langezaal1<\/sup>, Sharon  Munn1<\/sup>, Amalia  Munoz Pineiro1<\/sup>, Gea  Oliveri Conti11<\/sup>, Alicia  Paini1<\/sup>, Alex  Patak1<\/sup>, Mauro Petrillo1<\/sup>, Daniel  Pickford12<\/sup>, Francesca  Pistollato1<\/sup>, Anna  Price1<\/sup>, Antonio  Puertas Gallardo1<\/sup>, Maddalena  Querci1<\/sup>, Barbara Raffael1<\/sup>, Kostja  Renko10<\/sup>, Tammy  Stoker7<\/sup>, Jukka  Sund1<\/sup>, Guy  Van den Eede13<\/sup>, Michael  Wade14<\/sup>, Maurice Whelan1<\/sup>, Sandra Coecke1<\/sup>
1<\/sup> European Commission, Joint Research Centre, Italy
2<\/sup> University of Pisa, Italy
3<\/sup> Karolinska Institutet, Sweden 
4<\/sup> OECD, France
5<\/sup> National Museum of  Natural History
6<\/sup> Bayer AG
7<\/sup> US Environmental Protection Agency, USA
8<\/sup> Masaryk University, Czechia
9<\/sup> University of Antwerp, Belgium
10<\/sup> Charit\u00e9-Universit\u04d3tsmedizin, Germany
11<\/sup> University of Catania, Italy
12<\/sup> Syngenta, UK
13<\/sup> European Commission, Joint Research Centre
14<\/sup> Health Canada, Canada
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-7<\/a><\/h2>\n\n\n\n

IMPLEMENTATION OF IN SILICO-BASED READ-ACROSS ASSESSMENT FOR GENOTOXICITY FOR PESTICIDE RESIDUES UNDER EU LEGISLATION AND KEY CHALLENGES<\/a><\/h3>\n\n\n\n

Minako  Allen<\/span>P1<\/sup>, Maria  Pellizzaro 1<\/sup>, Rebecca Silcock1<\/sup>
1<\/sup> Exponent International Ltd
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-8<\/a><\/h2>\n\n\n\n

Development and validation of machine learning based QSAR models to predict the TPO inhibitors<\/a><\/h3>\n\n\n\n

Bharath BR<\/span>P1<\/sup>, Vaibhav Barot1<\/sup>, Rahul Date1<\/sup>, Abhay Deshpande1<\/sup>
1<\/sup> Jai Research Foundation
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-9<\/a><\/h2>\n\n\n\n

High throughput in vitro genotoxicity methods for hazard identification and characterization of \u201cdata poor\u201d compounds<\/a><\/h3>\n\n\n\n

Steve Bryce<\/span>P1<\/sup>, Jeff Bemis1<\/sup>, Stephen  Dertinger1<\/sup>, Stephanie Smith-Roe2<\/sup>, Kristine Witt2<\/sup>
1<\/sup> Litron Laboratories, Rochester NY
2<\/sup> Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-10<\/a><\/h2>\n\n\n\n

Combining gene expressions and imaged-based morphological features for chemical-phenotype profiles<\/a><\/h3>\n\n\n\n

Natacha Cerisier<\/span>P1<\/sup>, Bryan Dafniet1<\/sup>, Olivier Taboureau1<\/sup>
1<\/sup> Universit\u00e9 Paris Cit\u00e9, INSERM U1133, CNRS UMR8251, 75006, Paris, France.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-11<\/a><\/h2>\n\n\n\n

Development and Translation of Quantitative Neuronal Adverse Outcome Pathway (qNAOP) model for Neurotoxicity Risk Assessment<\/a><\/h3>\n\n\n\n

Deepika Deepika<\/span>P1<\/sup>, Raju Prasad Sharma1<\/sup>, Marta Schuhmacher1<\/sup>, Vikas Kumar1<\/sup>
1<\/sup> Environmental Engineering Laboratory, Departament d’Enginyeria Quimica, Universitat Rovira i Virgili, Av. Pa\u00efsos Catalans 26, 43007 Tarragona, Catalonia, Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-12<\/a><\/h2>\n\n\n\n

CONTRIBUTION MAPPING: USING STRUCTURE\u2013TOXICITY RELATIONSHIPS (STR) AND MECHANISTIC INTERPRETABILITY OF IN SILICO MODELS TO ASSESS DEVELOPMENTAL TOXICITY AND ENDOCRINE-DISRUPTING POTENTIAL OF TWELVE UV FILTERS<\/a><\/h3>\n\n\n\n

Andrezza Di Pietro Micali Canavez<\/span>P1<\/sup>, Carlos  Eduardo Matos dos Santos 2<\/sup>, Desiree Cigaran Schuck1<\/sup>, Marcio  Lorencini1<\/sup>
1<\/sup> Grupo Botic\u00e1rio
2<\/sup> Altox Ltd
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-13<\/a><\/h2>\n\n\n\n

Physiological map to study kidney toxicity in the ONTOX project<\/a><\/h3>\n\n\n\n

Alessio Gamba<\/span>P1<\/sup>, Luiz Carlos Maia Ladeira1<\/sup>, Rapha\u00eblle Lesage2<\/sup>, Dani\u00ebl Roodzant3<\/sup>, Devon Barnes4<\/sup>, Manoe Janssen4<\/sup>, Marc Teunis3<\/sup>, Rosalinde Masereeuw4<\/sup>, Liesbet Geris1,2,5<\/sup>, Bernard Staumont1<\/sup>
1<\/sup> Biomechanics Research Unit, GIGA In Silico Medicine, University of Li\u00e8ge, Belgium.
2<\/sup> Skeletal Biology and Engineering Research Center, KU Leuven, Belgium.
3<\/sup> Innovative testing in Life Sciences & Chemistry, Utrecht University of Applied Sciences, The Netherlands.
4<\/sup> Div. Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.
5<\/sup> Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Belgium.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-14<\/a><\/h2>\n\n\n\n

QUANTITATIVE ADVERSE OUTCOME PATHWAY MODELING FOR CHRONIC TOXICITY<\/a><\/h3>\n\n\n\n

Shigeaki Ito<\/span>P1<\/sup>, Sayak Mukherjee2<\/sup>, Kazuo Erami1<\/sup>, Shugo Muratani1<\/sup>, Akina Mori1<\/sup>, Sakuya Ichikawa1<\/sup>, Kei Yoshino1<\/sup>, Dawn Fallacara2<\/sup>
1<\/sup> Scientific Product Assessment Center, Japan Tobacco Inc., 6-2, Aoba-ku, Yokohama, Japan
2<\/sup> Battelle, 505 King Ave., Columbus, OH 43201
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-15<\/a><\/h2>\n\n\n\n

Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis<\/a><\/h3>\n\n\n\n

Jian jiang<\/span>P1<\/sup>, Jonas van Ertvelde1<\/sup>, G\u00f6khan Ertaylan2<\/sup>, Ralf Peeters3,4<\/sup>, Danyel Jennen5<\/sup>, Theo de Kok3,5<\/sup>, Mathieu Vinken1<\/sup>
1<\/sup> Entity of In Vitro Toxicology and Dermato\u2011Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
2<\/sup> Vlaamse Instelling voor Technologisch Onderzoek (VITO) NV, Health, Boeretang 200, 2400 Mol, Belgium
3<\/sup> Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands
4<\/sup> Department of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands
5<\/sup> Department of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-16<\/a><\/h2>\n\n\n\n

Virtual Human Platform for Safety Assessment (VHP4Safety): Assessing the safety of chemicals and pharmaceuticals based on human data<\/a><\/h3>\n\n\n\n

Anne Kienhuis<\/span>P1<\/sup>, Cyrille Krul2<\/sup>, Juliette Legler3<\/sup>
1<\/sup> National Institute for Public Health and the Environment (RIVM)
2<\/sup> University of Applied Sciences Utrecht (HU)
3<\/sup> Utrecht University
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-17<\/a><\/h2>\n\n\n\n

A COMPARATIVE COMPUTATIONAL PREDICTION OF THE BINDING OF ANDROGEN- AND ESTROGEN-LIKE FLAVONOIDS TO THEIR COGNATE (NON)NUCLEAR RECEPTORS<\/a><\/h3>\n\n\n\n

Stefano Lorenzetti<\/span>P1<\/sup>, Giulia D’Arrigo2<\/sup>, Eleonora Gianquinto2<\/sup>, Giulia Rossetti3<\/sup>, Gabriele Cruciani4<\/sup>, Francesca Spyrakis2<\/sup>
1<\/sup> ISS – Istituto Superiore di Sanit\u00e0, Department of Food Safety, Nutritionn and Veterinary Public Health
2<\/sup> University of Turin, Department of Drug Science and Technology
3<\/sup> Aachen University, Department of Neurology
4<\/sup> University of Perugia, Department of Chemistry, Biology and Biotechnology
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-18<\/a><\/h2>\n\n\n\n

Designing physiological maps as a tool to study liver toxicology<\/a><\/h3>\n\n\n\n

Luiz Carlos Maia Ladeira<\/span>P1<\/sup>, Alessio Gamba1<\/sup>, Rapha\u00eblle Lesage2<\/sup>, Anouk Verhoeven3<\/sup>, Jonas  van Ertvelde3<\/sup>, Jian Jiang3<\/sup>, Dani\u00ebl Roodzant4<\/sup>, Marc Teunis4<\/sup>, Ramiro Jover5<\/sup>, Tamara Vanhaecke3<\/sup>, Mathieu Vinken3<\/sup>, Harm  Heusinkveld6<\/sup>, Liesbet Geris1,2,7<\/sup>, Bernard Staumont1<\/sup>
1<\/sup> Biomechanics Research Unit, GIGA In Silico Medicine, University of Li\u00e8ge, Belgium
2<\/sup> Skeletal Biology and Engineering Research Center, KU Leuven, Belgium
3<\/sup> Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Belgium
4<\/sup> Innovative Testing in Life Sciences & Chemistry, University of Applied Sciences Utrecht, The Netherlands
5<\/sup> Dept. Biochemistry, University of Valencia, IIS Hosp. La Fe, CIBERehd, Spain
6<\/sup> Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
7<\/sup> Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Belgium
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-19<\/a><\/h2>\n\n\n\n

Toxicity prediction of mycotoxins by in silico modeling<\/a><\/h3>\n\n\n\n

Martina Palomino-Sch\u00e4tzlein<\/span>P1<\/sup>, Josefa Tolosa2<\/sup>, Eva Serrano-Candelas1<\/sup>, Jose Luis Vall\u00e9s-Pardo1<\/sup>, Salvador  Moncho1<\/sup>, Rafael Gozalbes1<\/sup>
1<\/sup> ProtoQSAR SL, CEEI, Parque Tecnol\u00f3gico de Valencia (Av. Benjamin Franklin 12, 46980, Paterna, Valencia, Spain)
2<\/sup> Laboratory of Toxicology. Faculty of Pharmacy. University of Valencia (Av. Vicent Andr\u00e9s Estell\u00e9s s\/n. 46100. Burjasot, Valencia, Spain)
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-20<\/a><\/h2>\n\n\n\n

Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and toxicokinetic data gaps within the ONTOX project<\/a><\/h3>\n\n\n\n

Alessandra Roncaglioni<\/span>P1<\/sup>, Domenico Gadaleta1<\/sup>, Erika Colombo1<\/sup>, Eva Serrano-Candelas2<\/sup>, Pablo Aparicio2<\/sup>, Rafael Gozalbes2<\/sup>, Emilio Benfenati1<\/sup>
1<\/sup> Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
2<\/sup> ProtoQSAR SL, Valencia, Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-21<\/a><\/h2>\n\n\n\n

Development new web-tool for phototoxicity prediction on the base of machine learning approach<\/a><\/h3>\n\n\n\n

Marta \u0160olt\u00e9sov\u00e1 Prnov\u00e1<\/span>P1,2<\/sup>, Matej Halinkovi\u010d2<\/sup>, Tibor Sloboda2<\/sup>, Kate\u0159ina Mu\u0161kov\u00e12<\/sup>, Patrik Pavla\u010dka2<\/sup>, Jakub Kn\u00e1nik2<\/sup>, Helena Kan\u010f\u00e1rov\u00e11<\/sup>
1<\/sup> Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Bratislava, Slovakia
2<\/sup> Faculty of Informatics and Information Technologies Slovak University of Technologies in Bratislava, Slovakia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-22<\/a><\/h2>\n\n\n\n

QSAR MODEL FOR PREDICTING MYCOTOXIN MUTAGENICITY<\/a><\/h3>\n\n\n\n

Josefa Tolosa<\/span>P1<\/sup>, Martina Palomino-Sch\u00e4tzlein2<\/sup>, Eva Serrano-Candelas2<\/sup>, Jos\u00e9 Luis Vall\u00e9s-Pardo2<\/sup>, Salvador Moncho2<\/sup>, Rafael Gozalbes2<\/sup>
1<\/sup> University of Valencia
2<\/sup> ProtoQSAR
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-23<\/a><\/h2>\n\n\n\n

Computational modelling of neural tube closure defects<\/a><\/h3>\n\n\n\n

Job Berkhout<\/span><\/span>P1,2<\/sup>, Aldert Piersma1,2<\/sup>, Juliette Legler2<\/sup>, Alessio Gamba3<\/sup>, Luiz Carlos Maia Ladeira3<\/sup>, Bernard Staumont3<\/sup>, Rapha\u00eblle Lesage4<\/sup>, Liesbet Geris3,4,5<\/sup>, Harm Heusinkveld1<\/sup>
1<\/sup> RIVM, the Netherlands
2<\/sup> IRAS, Utrecht University, The Netherlands
3<\/sup> GIGA In Silico Medicine, University of Li\u00e8ge, Belgium
4<\/sup> Skeletal Biology and Engineering Research Center, KU Leuven, Belgium
5<\/sup> Biomechanics Section, KU Leuven, Belgium
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-24<\/a><\/h2>\n\n\n\n

ASSESSING A BATTERY OF IN SILICO MODELS AS PREDICTION TOOL FOR COMPOUNDS EXERTING REPRODUCTIVE HEALTH EFFECTS<\/a><\/h3>\n\n\n\n

Serhii Kolesnyk<\/span><\/span>1,2<\/sup>, Mykola Prodanchuk2<\/sup>, Yana Kolianchuk2<\/sup>, Nataliia Bubalo3<\/sup>, Alex Odermatt1<\/sup>, Martin Smiesko1<\/sup>
1<\/sup> Department of Pharmaceutical Sciences, University of Basel, Switzerland
2<\/sup> L.I.Medved\u2019s Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Kyiv, Ukraine
3<\/sup> Jaksch Lifescience Consulting GmbH
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-25<\/a><\/h2>\n\n\n\n

Facilitating modern toxicology with Natural Language Processing<\/a><\/h3>\n\n\n\n

Marie Corradi<\/span><\/span>P1<\/sup>, Alyanne de Haan1<\/sup>, Thomas Luechtefeld2,3<\/sup>, Marc Teunis1<\/sup>
1<\/sup> Hogeschool Utrecht
2<\/sup> ToxTrack
3<\/sup> CAAT
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4a-26<\/a><\/h2>\n\n\n\n

Using molecular docking simulations to elucidate molecular initiating event (MIE) interactions of neonicotinoid pesticides and human nicotinic acetylcholine receptors (nAChRs)<\/a><\/h3>\n\n\n\n

Karin Grillberger<\/span><\/span>P1<\/sup>, Gerhard F. Ecker1<\/sup>
1<\/sup> University of Vienna
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

4b. Local toxicity testing (safety and efficacy)<\/span><\/h2>\n\n\n\n

P-4b-1<\/a><\/h2>\n\n\n\n

Concentration, typology of surfactants, in vitro and clinical ocular tolerance studies: a multi-parameterized approach for foaming cosmetics intended to claim \u201cdo not sting the eyes\u201d<\/a><\/h3>\n\n\n\n

Rakotomalala Sandrine1<\/sup>, Berrada-Gomez Marie-Pierre<\/span>P1<\/sup>, Baco David2<\/sup>, Ferret Pierre-Jacques1<\/sup>
1<\/sup> Safety Assessment Department, Pierre Fabre Dermo-Cosm\u00e9tique, Toulouse, France
2<\/sup> Global Innovation Center Department, Pierre Fabre Dermo-Cosm\u00e9tique, Toulouse, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-2<\/a><\/h2>\n\n\n\n

Effect of a modulator on the skin sensitization potency of cosmetic fragrance formulations<\/a><\/h3>\n\n\n\n

Carine LINOSSIER1<\/sup>, Marine CUSCUSA1<\/sup>, Marisa MELONI2<\/sup>, Andy FORRERYD3<\/sup>, Myl\u00e8ne LANVIN1<\/sup>
1<\/sup> COTY
2<\/sup> VITROSCREEN
3<\/sup> SENZAGEN
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-3<\/a><\/h2>\n\n\n\n

Comparison between HET-CAM protocols and a product use clinical study for eye irritation evaluation of personal care products according to their surfactant composition<\/a><\/h3>\n\n\n\n

Mart\u00edn Nicol\u00e1s Rivero1<\/sup>, Mariela Lenze1<\/sup>, Mercedes Izaguirre1,2<\/sup>, Martina Benedetti1,2<\/sup>, Silvia P\u00e9rez Damonte3<\/sup>, Silvia Wikinski1,2<\/sup>, Mar\u00eda Laura Guti\u00e9rrez<\/span>P1,2<\/sup>
1<\/sup> Institute of Pharmacology – University of Buenos Aires
2<\/sup> CONICET
3<\/sup> CLAIM CRO
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-4<\/a><\/h2>\n\n\n\n

DECISION TREE FOR OCULAR SAFETY ASSESSMENT OF AGROCHEMICAL FORMULATIONS<\/a><\/h3>\n\n\n\n

Mart\u00edn Nicol\u00e1s Rivero1<\/sup>, Mariela Lenze1,2<\/sup>, Agustina Reschini1<\/sup>, Juan Ignacio Pina3<\/sup>, Romina Martinez4<\/sup>, Silvia Wikinski1,2<\/sup>, Mar\u00eda Laura Guti\u00e9rrez<\/span>P1,2<\/sup>
1<\/sup> Institute of Pharmacology – University of Buenos Aires
2<\/sup> CONICET
3<\/sup> ATANOR SCA
4<\/sup> Dr Julio Mendez Hospital
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-5<\/a><\/h2>\n\n\n\n

THE RECONSTRUCTED HUMAN EPIDERMIS (RHE) EFFICIENCY IN THE CLASSIFICATION OF BIOLOGICAL PRODUCT BY THE IN VITRO IRRITATION AND CORROSION TESTS (OECD 439 AND 431).<\/a><\/h3>\n\n\n\n

Bruna Assun\u00e7\u00e3o Bechtold1<\/sup>, Julio C\u00e9sar Cianci2<\/sup>, Maria \u00b4Paula Mancini Coelho3<\/sup>, Leandro Fernando Felix4<\/sup>, Thatiane Nunes Santana5<\/sup>, Vanja Dakic6<\/sup>, Rodrigo De Vecchi6<\/sup>, Luis Paulo Fava7<\/sup>, Priscilla Muniz Ribeiro da Silva8<\/sup>, Juliana Falcato Vecina<\/span>P8<\/sup>
1<\/sup> Specialist, M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil
2<\/sup> Laboratory Assistant, M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil
3<\/sup> Laboratory Analyst; Merieux NutriSciences (Bioagri Laborat\u00f3rios Ltda)
4<\/sup> Trainee, M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil
5<\/sup> Laboratory technique, M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil
6<\/sup> Researcher, Episkin Academy, Rio de Janeiro-RJ, Brazil
7<\/sup> Coordinator; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.
8<\/sup> Researcher; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-6<\/a><\/h2>\n\n\n\n

PROFICIENCY DEMONSTRATION OF MERIEUX NUTRISCIENCE (BIOAGRI LABORAT\u00d3RIOS LTDA) ON IN VITRO EYE IRRITATION AND SERIOUS EYE DAMAGE IMPLEMENTATION<\/a><\/h3>\n\n\n\n

Maria Paula Mancini Coelho1<\/sup>, Bruna Assun\u00e7\u00e3o Bechtold2<\/sup>, Julio C\u00e9sar Cianci3<\/sup>, Larissa Gabriele Costa3<\/sup>, Leandro Fernando Felix4<\/sup>, Thatiane Nunes Santana5<\/sup>, Vanja Dakic6<\/sup>, Rodrigo De Vecchi6<\/sup>, Luis Paulo Fava7<\/sup>, Priscilla Muniz Ribeiro da Silva8<\/sup>, Juliana Falcato Vecina<\/span>P8<\/sup>
1<\/sup> Laboratory Analist; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.
2<\/sup> Specialist, M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.
3<\/sup> Laboratory Assistant, M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.
4<\/sup> Trainee, M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.
5<\/sup> Laboratory Technique, M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.
6<\/sup> Researcher, Episkin Academy, Rio de Janeiro-RJ, Brazil
7<\/sup> Coordinator, M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.
8<\/sup> Researcher; M\u00e9rieux NutriScience \/ Bioagri Laborat\u00f3rios Ltda, Piracicaba-SP, Brazil.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-7<\/a><\/h2>\n\n\n\n

SkinEthic\u2122 HCE Time-to-Toxicity : World\u2019s first adopted new approach methodology on its own for eye hazard identification adopted by OECD<\/a><\/h3>\n\n\n\n

Nathalie Al\u00e9p\u00e9e1<\/sup>, Fr\u00e9d\u00e9ric Amaral<\/span>P1<\/sup>, Virginie Leblanc1<\/sup>, Laurent Nardelli1<\/sup>, Val\u00e9rie Tagliati2<\/sup>, S\u00e9verine Teluob2<\/sup>, Anaelle Viricel2<\/sup>, Val\u00e9rie Michaut1<\/sup>
1<\/sup> L’Oreal R&I
2<\/sup> Episkin SA
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-8<\/a><\/h2>\n\n\n\n

COMPOUND A-111 \u2013 A NOVEL SMALL MOLECULE CANDIDATE FOR THE TOPICAL TREATMENT OF HYPERPIGMENTATION<\/a><\/h3>\n\n\n\n

Agnieszka Gunia-Krzy\u017cak1<\/sup>, Justyna Popi\u00f3\u01422<\/sup>, Magda Borczuch-Kosta\u0144ska1<\/sup>, Katarzyna W\u00f3jcik-Pszczo\u0142a2<\/sup>, Paulina Koczurkiewicz-Adamczyk2<\/sup>, Patryk Kasza3<\/sup>, Przemys\u0142aw Szafra\u0144ski3<\/sup>, Dorota  \u017belaszczyk1<\/sup>, El\u017cbieta P\u0119kala2<\/sup>
1<\/sup> Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland
2<\/sup> Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland
3<\/sup> Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-9<\/a><\/h2>\n\n\n\n

Corneal-derived biomolecular solution: application as an in chemico method for ocular toxicity assessment<\/a><\/h3>\n\n\n\n

Jordana Andrade Santos1<\/sup>, Wanessa Amorim Dias1<\/sup>, Artur Christian  Garcia da Silva<\/span>P1<\/sup>, Marize  Campos Valadares1<\/sup>
1<\/sup> Laboratory of Research and Education in In Vitro Toxicology, Federal University of Goi\u00e1s, Goi\u00e2nia, Goi\u00e1s, Brazil
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-10<\/a><\/h2>\n\n\n\n

A new approach for Eye Hazard Assessment of surfactants based on in vitro Test Methods<\/a><\/h3>\n\n\n\n

Els Adriaens<\/span>P1<\/sup>, Nathalie Al\u00e9p\u00e9e2<\/sup>, Takayuki Abo3<\/sup>, Dan Bagley4<\/sup>, Jason Magby4<\/sup>, Arianna Giusti5<\/sup>, Karsten Mewes6<\/sup>
1<\/sup> Adriaens Consulting, Belgium
2<\/sup> L\u2019Or\u00e9al R&I, France
3<\/sup> Kao Corporation, Japan
4<\/sup> Colgate Palmolive, United States
5<\/sup> Cosmetics Europe, Belgium
6<\/sup> Henkel AG & Co. KGaA, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-11<\/a><\/h2>\n\n\n\n

DEVELOPMENT OF AN IN VITRO WOUND HEALING MODEL USING LIVE-CELL IMAGING: APPLICATION IN DERMATOLOGY AND COMSETIC FIELDS<\/a><\/h3>\n\n\n\n

Manon BartheP1<\/sup>, Jean-Paul Th\u00e9not2<\/sup>, Hanan Osman-Ponchet2<\/sup>
1<\/sup> PKDERM Laboratories
2<\/sup> PKDERM SAS
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-12<\/a><\/h2>\n\n\n\n

A NEW HUMAN IN VITRO SKIN MODEL OF EPIDERMAL BARRIER DAMAGE<\/a><\/h3>\n\n\n\n

Manon Barthe<\/span>P1,2<\/sup>, V\u00e9ronique M. Braud2<\/sup>, Jean-Paul Th\u00e9not3<\/sup>, Hanan Osman-Ponchet3<\/sup>
1<\/sup> PKDERM Laboratories
2<\/sup> Universit\u00e9 C\u00f4te d\u2019Azur, CNRS UMR7275, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire – France
3<\/sup> PKDERM SAS
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-13<\/a><\/h2>\n\n\n\n

Study of the efficacy and safety on in vitro human skin models of a Curcumin emulsion for skin pathologies treatment<\/a><\/h3>\n\n\n\n

M\u00f3nica Betanzos<\/span>P1<\/sup>, Adrian  Garc\u00eda1<\/sup>, Senda Basasoro2<\/sup>, Paloma G\u00f3mez1<\/sup>, Garazi Berra2<\/sup>, Gartze Mentxaka1<\/sup>, Amaia  Garc\u00eda1<\/sup>, Nagore Gabilondo2<\/sup>, Felipe Go\u00f1i de Cerio1<\/sup>
1<\/sup> GAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, Spain
2<\/sup> Materials & Technologies\u2019 Research Group (GMT), Department of Chemical and Environmental Engineering, Faculty of Engineering of Gipuzkoa, University of the Basque Country, Donostia-San Sebastian, Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-14<\/a><\/h2>\n\n\n\n

Cutaneous tolerance of personal care products dedicated to babies and adults with sensitive skin:  in vitro\/in vivo correlation<\/a><\/h3>\n\n\n\n

Marie-Pierre Gomez-Berrada<\/span>P1<\/sup>, H\u00e9l\u00e8ne Recoules1<\/sup>, Sophie Catoire2<\/sup>, Laetitia Beaudequin2<\/sup>, Adeline Josseaume2<\/sup>, Pierre-Jacques Ferret1<\/sup>
1<\/sup> Safety Products Department, Pierre Fabre Dermo Cosmetique, Toulouse, France
2<\/sup> Cell Alternativ, Trosly Breuil, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-15<\/a><\/h2>\n\n\n\n

Retrospective review on in vitro phototoxicity data generated in 3D skin models to support development of new OECD test guideline<\/a><\/h3>\n\n\n\n

Helena Kandarova<\/span>P1<\/sup>, Hans  Raabe2<\/sup>, Allison  Hilberer2<\/sup>, Neepa Choksi3<\/sup>, Dave  Allen3<\/sup>
1<\/sup> Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, D\u00fabravsk\u00e1 cesta 9, 841 04 Bratislava, Slovak republic
2<\/sup> Institute for In Vitro Sciences, Inc., 30 W. Watkins Mill Road, Suite 100, Gaithersburg, Maryland 20878, United States
3<\/sup> Integrated Laboratory Systems, Inc., 601 Keystone Park Drive, Suite 800, Morrisville, NC, 27560, United States
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-16<\/a><\/h2>\n\n\n\n

ESTABLISHMENT OF A COMMENSAL 3D SKIN MODEL FOR STUDYING MICROBIAL MODULATION OF PESTICIDE TOXICITY<\/a><\/h3>\n\n\n\n

Maya Kissner<\/span>P1<\/sup>, Aline Rosin1<\/sup>, Tewes Tralau2<\/sup>, Lisa Lemoine1<\/sup>
1<\/sup> German Federal Institute for Risk Assessment, Department Pesticides Safety, Junior Research Group Skin Microbiome
2<\/sup> German Federal Institute for Risk Assessment, Department Pesticides Safety
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-17<\/a><\/h2>\n\n\n\n

Determination and Sub-categorization of Ocular Irritants Using the EpiOcular Tissue Model – Prediction Models for Liquids and Solids<\/a><\/h3>\n\n\n\n

Silvia Letasiova<\/span>P1<\/sup>, Lenka Hudecova1<\/sup>, Jan Markus1<\/sup>, Yulia  Kaluzhny2<\/sup>, Mitch Klausner2<\/sup>
1<\/sup> MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
2<\/sup> MatTek Corporation, Ashlad, MA, USA
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-18<\/a><\/h2>\n\n\n\n

SAFETY AND EFFICACY TESTING OF COSMETIC PRODUCTS: OVERVIEW OF ESTABLISHED METHODS AND NEW MODELS.<\/a><\/h3>\n\n\n\n

Hanan Osman-Ponchet<\/span>P1<\/sup>, Manon Barthe2<\/sup>, Jean-Paul Th\u00e9not1<\/sup>
1<\/sup> PKDERM SAS
2<\/sup> PKDERM Laboratories
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-19<\/a><\/h2>\n\n\n\n

In vitro evaluation of safety profile of a cosmetic ingredient – 4-methoxychalcone<\/a><\/h3>\n\n\n\n

Justyna Popi\u00f3\u0142<\/span>P1<\/sup>, Karolina S\u0142oczy\u0144ska1<\/sup>, Paulina Koczurkiewicz-Adamczyk1<\/sup>, Dorota \u017belaszczyk2<\/sup>, Katarzyna Orze\u01422<\/sup>, Katarzyna W\u00f3jcik-Pszczo\u0142a1<\/sup>, Przemys\u0142aw  Szafra\u0144ski3<\/sup>, Patryk Kasza3<\/sup>, El\u017cbieta P\u0119kala1<\/sup>, Agnieszka Gunia-Krzy\u017cak2<\/sup>
1<\/sup> Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University \u2013 Medical College
2<\/sup> Department of Bioorganic Chemistry, Faculty of Pharmacy, Jagiellonian University \u2013 Medical College
3<\/sup> Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University \u2013 Medical College
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-20<\/a><\/h2>\n\n\n\n

Pre-Clinical in vitro assessment of tobacco-free nicotine pouch products<\/a><\/h3>\n\n\n\n

Sarah Jean Pour<\/span>P1<\/sup>, Roman  Wieczorek1<\/sup>, Edgar Trelles Sticken1<\/sup>, Ole  Dethloff1<\/sup>, Liam Simms2<\/sup>, Matthew Stevenson2<\/sup>
1<\/sup> Reemtsma Cigarettenfabriken GmbH
2<\/sup> Imperial Brands PLC
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-21<\/a><\/h2>\n\n\n\n

Skin sensitization of \u201cchallenging\u201d compounds: in vitro strategy applied to bio-based ingredients<\/a><\/h3>\n\n\n\n

Micka\u00ebl PUGINIER<\/span>P1<\/sup>, Alicia Roso1<\/sup>
1<\/sup> Seppic, 50 boulevard National, CS 90020, 92257 La Garenne Colombes Cedex, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-22<\/a><\/h2>\n\n\n\n

Measurement and culture method of organoid for toxicity assessment of nanomaterials<\/a><\/h3>\n\n\n\n

Ahruem Baek<\/span><\/span>P1<\/sup>, Tae Geol Lee1<\/sup>, Min Beom Heo1<\/sup>
1<\/sup> Safety Measurement Institute, Korea Research Institute of Standards and Science (KRISS)
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-23<\/a><\/h2>\n\n\n\n

New based on cell assay to evaluate eye stinging potential of chemicals and cosmetic formulations<\/a><\/h3>\n\n\n\n

Marize Valadares<\/span><\/span>P1<\/sup>, Lara  Brito 1<\/sup>, Carolina Motter  Catarino2<\/sup>, Artur C Garcia Silva 1<\/sup>, Desiree Cigaran  Schuck2<\/sup>, Andrezza Di Pietro Micali  Canavez2<\/sup>
1<\/sup> Federal Univeristy of Goi\u00e1s
2<\/sup> Grupo Boticario
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-24<\/a><\/h2>\n\n\n\n

Cytotoxicity Profile and Prooxidant Effects of the New Ruthenium Complex HE-10 in Human Skin Fibroblast Cells<\/a><\/h3>\n\n\n\n

Hande \u00d6zba\u015fak<\/span><\/span>P1<\/sup>, Hani  Elbeheiry2<\/sup>, Martin  Schulz2<\/sup>, Mojm\u00edr  Mach1<\/sup>, Lucia  Ra\u010dkov\u00e11<\/sup>
1<\/sup> Centre of Experimental Medicine Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava, Slovakia
2<\/sup> Friedrich Schiller University Jena, Institute of Physical Chemistry, Jena, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-4b-25<\/a><\/h2>\n\n\n\n

Application of fluorescence-based methods for in chemico and in vitro detection of photoreactive chemicals<\/a><\/h3>\n\n\n\n

Hande \u00d6zba\u015fak<\/span><\/span>P1<\/sup>, Hani  Elbeheiry2<\/sup>, Martin  Schulz2<\/sup>, Mojm\u00edr  Mach1<\/sup>, Lucia  Ra\u010dkov\u00e11<\/sup>
<\/p>\n\n\n\n

K\u00e1ren do Carmo Gon\u00e7alves1<\/sup>, Artur Christian Garcia da Silva<\/span><\/span>P1<\/sup>, Jordana Andrade Santos1<\/sup>, Marize Campos Valadares1<\/sup>
1<\/sup> Laboratory of Research and Education in In vitro Toxicology (Tox In) \u2013 Faculty of Pharmacy \u2013 Federal University of Goi\u00e1s (UFG)
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

5a. Toxicokinetics and in vitro \u2013 in vivo extrapolation<\/span><\/h2>\n\n\n\n

P-5a-1<\/a><\/h2>\n\n\n\n

In vitro biotransformation of propyl-propane-thiosulfonate (PTSO): Identification and characterization of metabolites<\/a><\/h3>\n\n\n\n

Antonio Cascajosa-Lira<\/span>P1<\/sup>, Concepci\u00f3n  Medrano-Padial1<\/sup>, Silvia Pichardo1<\/sup>, Alberto Ba\u00f1os2<\/sup>, Enrique Guillam\u00f3n2<\/sup>, \u00c1ngeles  Jos1<\/sup>, Ana M. Came\u00e1n1<\/sup>
1<\/sup> Area of Toxicology. Faculty of Pharmacy. University of de Seville, Profesor Garc\u00eda Gonz\u00e1lez n\u00b02, 41012 Seville, Spain.
2<\/sup> DMC Research Center. Camino de Jayena, 82, 18620 Alhend\u00edn, Granada, Spain.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5a-2<\/a><\/h2>\n\n\n\n

Preliminary results to the determination of dermal toxicological reference  values for a neurotoxic organophosphorus agent<\/a><\/h3>\n\n\n\n

Marie-Laure CointotP1<\/sup>, Lysiane Champion2<\/sup>, Alan Hubert2<\/sup>, Jennifer Millerioux2<\/sup>, Anne Boss\u00e9e2<\/sup>
1<\/sup> French Ministry for Armed Forces
2<\/sup> French Ministry for Armed Forces
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5a-3<\/a><\/h2>\n\n\n\n

Preliminary results to the determination of dermal toxicological reference  values for a neurotoxic organophosphorus agent<\/a><\/h3>\n\n\n\n

Marie-Laure COINTOT<\/span>P1<\/sup>, Lysiane CHAMPION1<\/sup>, Alan HUBERT1<\/sup>, Jennifer MILLERIOUX1<\/sup>, Anne BOSSE1<\/sup>
1<\/sup> French Ministry of Armed Forces
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5a-4<\/a><\/h2>\n\n\n\n

PBK Modelling Of In Vivo Distribution Kinetics In The ONTOX Project<\/a><\/h3>\n\n\n\n

Ren\u00e9 Geci<\/span>P1,2<\/sup>, Alicia Paini2<\/sup>, Stephan Schaller2<\/sup>, Huan Yang2<\/sup>, Lars K\u00fcpfer1<\/sup>
1<\/sup> University Hospital RWTH Aachen, 52074 Aachen, Germany
2<\/sup> esqLABS GmbH, Hambierich 34, 26683 Saterland, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5a-5<\/a><\/h2>\n\n\n\n

Developing toxicokinetic models for chemical risk assessment of Homosalate using MOIE – a Cosmetics Europe Case Study<\/a><\/h3>\n\n\n\n

Anne Mousti\u00e9<\/span><\/span>P1<\/sup>, Nazanin Golbamaki1<\/sup>, Matthew Burbank1<\/sup>, Laur\u00e8ne Roussel-Berlier1<\/sup>, Guillaume Lereaux1<\/sup>, Fran\u00e7oise Gautier2<\/sup>, Audrey  Noel-Voisin2<\/sup>, Nicky Hewitt3<\/sup>, Gladys Ou\u00e9draogo1<\/sup>, S\u00e9bastien Gr\u00e9goire1<\/sup>
1<\/sup> L’Or\u00e9al R&I Advanced research, Aulnay-sous-Bois, France
2<\/sup> L’Or\u00e9al R&I-Saint-Ouen France
3<\/sup> Cosmetic Europe, Brussels, Belgium
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

5b. In vitro systems to assess respiratory toxicity  <\/span><\/h2>\n\n\n\n

P-5b-1<\/a><\/h2>\n\n\n\n

INHALATION TOXICITY ASSESSMENT OF AN AEROSOLIZED SUNSCREEN PRODUCT WITH AN IN VITRO PULMONARY MODEL<\/a><\/h3>\n\n\n\n

B\u00e9atrice BUI1<\/sup>, Marie-Pierre GOMEZ-BERRADA<\/span>P1<\/sup>, Pierre-Jacques FERRET1<\/sup>
1<\/sup> Safety Products Department, Pierre Fabre Dermo Cosmetique, Toulouse, FRANCE
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-2<\/a><\/h2>\n\n\n\n

Novel fully primary human airway epithelium-alveolar macrophages in vitro co-cultures models to study host pathogen interactions<\/a><\/h3>\n\n\n\n

Bernadett  Boda1<\/sup>, Samuel Constant<\/span> P1<\/sup>
1<\/sup> Epithelix
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-3<\/a><\/h2>\n\n\n\n

Utilisation of human 3D bronchial tissues for e-cigarette assessment<\/a><\/h3>\n\n\n\n

Matthew  Stevenson1<\/sup>, Lukasz  Czekala<\/span>P1<\/sup>, Roman Wieczorek1<\/sup>, Edgar Trelles Sticken1<\/sup>, Sarah  Jean Pour 1<\/sup>, Fiona  Chapman1<\/sup>, Liam Simms1<\/sup>
1<\/sup> Imperial Brands PLC
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-4<\/a><\/h2>\n\n\n\n

Electronic Nicotine Delivery Systems exhibit lower toxicity compared to cigarettes: The Replica Study experience<\/a><\/h3>\n\n\n\n

Massimo Caruso<\/span>P1,2<\/sup>, Alfio Distefano1<\/sup>, Rosalia Emma1<\/sup>, Sonja Rust3<\/sup>, Konstantinos Poulas4,5<\/sup>, Fahad Zadjali6<\/sup>, Silvia Boffo7<\/sup>, Antonio Giordano7<\/sup>, Vladislav Volarevic8<\/sup>, Konstantinos Mesiakaris4,5<\/sup>, Georgios Karanasios5<\/sup>, Mohammed  Al Tobi6<\/sup>, Najwa Albalushi6<\/sup>, Angelo Canciello7<\/sup>, Aleksandar Arsenijevic8<\/sup>, Aleksandar Ilic8<\/sup>, Tancredi Caruso1<\/sup>, Giuseppe Carota1<\/sup>, Mariarita Spampinato1<\/sup>, Roberta Pulvirenti1<\/sup>, Pietro Zuccarello9<\/sup>, Margherita Ferrante9<\/sup>, Riccardo Polosa10,2<\/sup>, Giovanni Li Volti1,2<\/sup>
1<\/sup> Department of Biomedical and Biotechnological Sciences, University of Catania, (Italy)
2<\/sup> Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, (Italy)
3<\/sup> ECLAT Srl, spin-off of the University of Catania, (Italy)
4<\/sup> Institute for Research and Innovation, IRIS, Patras Science Park, Patras (Greece)
5<\/sup> Laboratory of Molecular Biology and Immunology, Department of Pharmacy, University of Patras, Patras (Greece)
6<\/sup> College of Medicine and Health Sciences, Department of Clinical Biochemistry, Sultan Qaboos University (Oman)
7<\/sup> Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, College of Science and Technology, Temple University (USA)
8<\/sup> Center for Molecular Medicine and Stem Cell Research, Department of Microbiology and Immunology, Faculty of Medical Sciences University of Kragujevac (Serbia)
9<\/sup> Department of Medical, Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia\u201d, University of Catania (Italy)
10<\/sup> Department of Clinical and Experimental Medicine, University of Catania (Italy)
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-5<\/a><\/h2>\n\n\n\n

IN VITRO AIR-LIQUID INTERFACE EXPOSURE OF LUNG CELLS TO THERAPEUTIC AEROSOLS FOR PRECLINCAL DRUG DEVELOPMENT<\/a><\/h3>\n\n\n\n

Evelien Frijns<\/span>P1<\/sup>, An Jacobs1<\/sup>, Jo Van Laer1<\/sup>, Karen Hollanders1<\/sup>, Sylvie Remy1<\/sup>, Dirk Jochmans2<\/sup>, Sandra Verstraelen1<\/sup>
1<\/sup> VITO NV, Unit HEALTH, Boeretang 200, 2400 Mol, Belgium
2<\/sup> REGA Institute KU Leuven, Herestraat 49, 3000 Leuven, Belgium
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-6<\/a><\/h2>\n\n\n\n

New concepts in inhalation toxicology: The in vitro approach<\/a><\/h3>\n\n\n\n

Tanja Hansen<\/span>P1<\/sup>, Detlef Ritter1<\/sup>, Jan Knebel1<\/sup>, Nico Sonnenschein1<\/sup>, Norman Nowak1<\/sup>, Sylvia Escher1<\/sup>, Katharina  Bl\u00fcmlein1<\/sup>, Katharina Schwarz1<\/sup>
1<\/sup> Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-7<\/a><\/h2>\n\n\n\n

UNDERSTANDING THE TOXICITY OF A BTEX MIXTURE: AIR\/LIQUID INTERFACE EXPOSURE OF ORGANOTYPIC LUNG CULTURES<\/a><\/h3>\n\n\n\n

Nour Jaber<\/span>P1<\/sup>, Claude  Emond2<\/sup>, Fabrice  Bray3<\/sup>, Paul  Genevray4<\/sup>, Christian  Rolando3<\/sup>, Fabrice  Cazier4<\/sup>, Sylvain  Billet1<\/sup>
1<\/sup> UR4492, Unit\u00e9 de Chimie Environnementale et Interactions sur le Vivant, SFR Condorcet FR CNRS 3417, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France.
2<\/sup> PKSH Inc, D\u00e9partement de Sant\u00e9 Environnementale et Sant\u00e9 au Travail de l\u2019Ecole de sant\u00e9 publique, Universit\u00e9 de Montr\u00e9al, Canada.
3<\/sup> Univ. Lille, CNRS, UAR 3290, MSAP, Miniaturisation pour la Synth\u00e8se l’Analyse et la Prot\u00e9omique, F-59 000, Lille, France.
4<\/sup> CCM, Centre Commun de mesure, Universit\u00e9 du Littoral C\u00f4te d\u2019Opale, Dunkerque, France.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-8<\/a><\/h2>\n\n\n\n

Fine dust toxicity evaluation on uterus using endometrial stem cells<\/a><\/h3>\n\n\n\n

Soo-Rim Kim<\/span>P1,2<\/sup>, Se-Ra Park1,2<\/sup>, Seong-Kwan Kim1,2<\/sup>, In-Sun Hong1,2<\/sup>
1<\/sup> Laboratory of stem cell research, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 406-840, Republic of Korea.
2<\/sup> Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 406-840, Republic of Korea.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-9<\/a><\/h2>\n\n\n\n

Flavors in e-cigarettes – a tasty hazard?<\/a><\/h3>\n\n\n\n

Selina Rinaldi<\/span>P1<\/sup>, Elke  Pieper1<\/sup>, Nadja Mallock1<\/sup>, Peter Laux1<\/sup>, Andreas Luch1<\/sup>
1<\/sup> German Federal Institute for Risk Assessment – Department for Chemical and Product Safety
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-10<\/a><\/h2>\n\n\n\n

Dosimetry in inhalation: an in vitro inhalation model to study the relevance of dose parameters related to particle mass and particle number<\/a><\/h3>\n\n\n\n

Detlef Ritter<\/span>P1<\/sup>, Katharina Schwarz1<\/sup>, Wolfgang Koch1<\/sup>
1<\/sup> Fraunhofer ITEM
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-11<\/a><\/h2>\n\n\n\n

Development of alternative in vitro and ex vivo models for testing of inhalable antibiotics<\/a><\/h3>\n\n\n\n

Katharina Schwarz<\/span>P1<\/sup>, Sabine  Wronski1<\/sup>, Detlef Ritter1<\/sup>, Jan Knebel1<\/sup>, Katharina Bluemlein1<\/sup>, Sven Cleeves1<\/sup>, Nico Sonnenschein1<\/sup>, Laura Mueller1<\/sup>, Monika Niehof1<\/sup>, Katherina Sewald1<\/sup>, Tanja Hansen1<\/sup>, Norman Nowak1<\/sup>, Armin Braun1<\/sup>
1<\/sup> Fraunhofer Institute for Toxicology and Experimental Medicine
P<\/sup> Presenting author<\/p>\n\n\n\n

P-5b-12<\/a><\/h2>\n\n\n\n

Ex vivo porcine precision cut lung slices (PCLS) for pulmonary toxicity assessment<\/a><\/h3>\n\n\n\n

Katharina Schwarz<\/span>P1<\/sup>, Sabine  Wronski1<\/sup>, Detlef Ritter1<\/sup>, Jan Knebel1<\/sup>, Katharina Bluemlein1<\/sup>, Sven Cleeves1<\/sup>, Nico Sonnenschein1<\/sup>, Laura Mueller1<\/sup>, Monika Niehof1<\/sup>, Katherina <\/p>\n\n\n\n

Marcella Miranda Siqueira  Furtuoso1<\/sup>, Bruna Cristiane Oliveira  Pedralli1<\/sup>, Marize Valadares<\/span><\/span>P2<\/sup>
1<\/sup> Federal Univeristy of Goi\u00e1s
2<\/sup> Federal University of Goi\u00e1s
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

6a. In vitro methods for safety testing of biopharmaceuticals\/biotherapies\/vaccines  <\/span><\/h2>\n\n\n\n

P-6a-1<\/a><\/h2>\n\n\n\n

Liver spheroid co-cultures with fresh or cryopreserved hepatocytes and endothelial cells as tool to investigate metabolism and hepatotoxicity<\/a><\/h3>\n\n\n\n

Jana Moer1<\/sup>, David Kwapiszewski1<\/sup>, Anett Ullrich<\/span>P1<\/sup>, Simon Beuck2<\/sup>, Madlen Matz-Soja3<\/sup>, Andrea Zimmermann4<\/sup>
1<\/sup> Primacyt Cell Culture Technology GmbH
2<\/sup> A&M Labor Service GmbH
3<\/sup> Lehrstuhl f\u00fcr Allgemeine Biochemie, Universit\u00e4t Leipzig
4<\/sup> Hepatobili\u00e4re Chirurgie und viszerale Transplantation, S\u00e4chsischer Inkubator f\u00fcr klinische Translation
P<\/sup> Presenting author<\/p>\n\n\n\n

<\/p>\n\n\n\n

P-6a-2<\/a><\/h2>\n\n\n\n

A novel polymer generates cell repellent surfaces and allows 3D cell culture<\/a><\/h3>\n\n\n\n

Anett Ullrich1<\/sup>, Veronique Schwartz2<\/sup>, Dieter Runge<\/span>P1<\/sup>
1<\/sup> Primacyt Cell Culture Technology GmbH, Schwerin, Germany
2<\/sup> Chemovator GmbH, Mannheim, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-3<\/a><\/h2>\n\n\n\n

Use of Assay Ready THP-1 derived macrophages to test for pyrogen contamination<\/a><\/h3>\n\n\n\n

Adrian Dittberner1<\/sup>, Lukas Focke<\/span>P1<\/sup>, Mirta Jacobs1<\/sup>, Karen Hinsch1<\/sup>
1<\/sup> acCELLerate GmbH
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-4<\/a><\/h2>\n\n\n\n

Validation of the ToxProfiler reporter assay and its application in mechanistic toxicity testing<\/a><\/h3>\n\n\n\n

Bas ter Braak1<\/sup>, Liesanne Wolters1<\/sup>, Giel Hendriks1<\/sup>, Torben Osterlund<\/span>P1<\/sup>
1<\/sup> Toxys B.V.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-5<\/a><\/h2>\n\n\n\n

Genotoxicity assessment of potentially mutagenic nucleoside analogues using ToxTracker<\/a><\/h3>\n\n\n\n

Inger Brandsma1<\/sup>, Remco Derr1<\/sup>, Gaonan  Zhang1<\/sup>, Nynke Moelijker1<\/sup>, Giel Hendriks1<\/sup>, Torben Osterlund1<\/sup>
1<\/sup> Toxys B.V.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-6<\/a><\/h2>\n\n\n\n

Exploring the use of spheroid cultures of human liver cells for the mechanistic testing of carcinogenic compounds<\/a><\/h3>\n\n\n\n

Bruna dos Santos Rodrigues1<\/sup>, Prashant Kadam<\/span>P1<\/sup>, Kaat  Leroy1<\/sup>, Sarah  Vanbellingen2<\/sup>, Joeri L.  Aerts2<\/sup>, Mathieu Vinken1<\/sup>
1<\/sup> Entity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
2<\/sup> Entity of Neuro-Aging and Viro-Immunotherapy, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-7<\/a><\/h2>\n\n\n\n

In vitro study of the potential of new liposomal delivery systems for future medical applications in inhalation therapies<\/a><\/h3>\n\n\n\n

Juliana Carrillo Romero1,2<\/sup>, Amaia Garcia Bilbao<\/span>P1<\/sup>, Laura Fern\u00e1ndez M\u00e9ndez2<\/sup>, Adrian Garcia1<\/sup>, Alberto Katsumiti1<\/sup>, Pedro  Ramos Cabrer2,3<\/sup>, Susana  Carregal Romero2,3,4<\/sup>, Felipe Go\u00f1i de Cerio1<\/sup>
1<\/sup> GAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, 48170 Spain
2<\/sup> Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebasti\u00e1n, 20014 Spain
3<\/sup> Ikerbasque, Basque Foundation for Science, Bilbao, 48013 Spain
4<\/sup> CIBER de Enfermedades Respiratorias (CIBERES), Madrid, 28029 Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-8<\/a><\/h2>\n\n\n\n

In vitro microenvironment modifies the neurotoxic response of SH-SY5Y cells<\/a><\/h3>\n\n\n\n

V\u00e9ronique De Conto1<\/sup>, Vaihere Cheung1<\/sup>, Gregory Maubon1<\/sup>, Zied Souguir1<\/sup>, Nathalie Maubon1<\/sup>, Elodie Vandenhaute1<\/sup>, Vincent Berezowski2<\/sup>
1<\/sup> HCS Pharma
2<\/sup> Lille Neuroscience and Cognition, U1172
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-9<\/a><\/h2>\n\n\n\n

THE POTENTIAL OF 3D CELL-BASED PLATFORMS FOR THE SCREENING OF NOVEL DRUG CANDIDATES TARGETING THE HEPATIC PLASMODIUM INFECTION<\/a><\/h3>\n\n\n\n

Francisca Arez<\/span>P1,2<\/sup>, Diana Fontinha3<\/sup>, Sofia P. Rebelo4,2<\/sup>, Christoph Fischli5,6<\/sup>, Claude Oeuvray7<\/sup>, Manuel  Carrondo4,2<\/sup>, Matthias Rottmann5,6<\/sup>, Thomas Spangenberg7<\/sup>, Catarina Brito4,2<\/sup>, Beatrice Greco7<\/sup>, Miguel  Prud\u00eancio3<\/sup>, Paula M Alves4,2<\/sup>
1<\/sup> iBET, Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, 2780-901 Oeiras, Portugal
2<\/sup> Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal
3<\/sup> Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal
4<\/sup> iBET,  Instituto de Biologia Experimental e Tecnol\u00f3gica, Apartado 12, 2780-901 Oeiras, Portugal
5<\/sup> Swiss TPH, Basel 4051, Switzerland
6<\/sup> University of Basel, Basel 4003, Switzerland
7<\/sup> Merck Global Health Institute, Ares Trading S.A., Route de La Verrerie 6, CH-1267, Coinsins, Switzerland, a subsidiary of Merck KGaA, Darmstadt Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-10<\/a><\/h2>\n\n\n\n

The potential of 3D reconstructed Human intestinal models for biowaiver studies and finished products testing<\/a><\/h3>\n\n\n\n

Rola BARCHAM<\/span>P1<\/sup>, Eric ANDRES1<\/sup>, Axel HUYARD1<\/sup>, Christophe DINI1<\/sup>
1<\/sup> Oroxcell, 102 avenue Gaston Roussel, 93230 Romainville, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-11<\/a><\/h2>\n\n\n\n

Mechanistic Investigation of Drug-Induced Liver Toxicity using Human 3D InSight Liver Model<\/a><\/h3>\n\n\n\n

Anna Borgstr\u00f6m<\/span>P1<\/sup>, Katarzyna Sanchez1<\/sup>, Friederike Wenz1<\/sup>, Natalia  Zapi\u00f3rkowska-Blumer1<\/sup>, Armin  Wolf 1<\/sup>, Bruno Filippi1<\/sup>
1<\/sup> InSphero AG, Wagistrasse 27a, 8952 Schlieren, Switzerland
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-12<\/a><\/h2>\n\n\n\n

Use of 3D human liver microtissues to assess hepatotoxicity of biologics<\/a><\/h3>\n\n\n\n

Reiner Class<\/span>P1<\/sup>, Andrea Kiessling1<\/sup>, Breda Twomey1<\/sup>, Milena Mennecozzi1<\/sup>, Monika Kijanska2<\/sup>, Agata Gorecka2<\/sup>
1<\/sup> UCB Biopharma
2<\/sup> InSphero AG
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-13<\/a><\/h2>\n\n\n\n

MTS application as alternative in vitro method to assess the toxicity of veterinary autogenous vaccines produced at Istituto Zooprofilattico Sperimentale dell\u2019Umbria e delle Marche \u201cTogo Rosati\u201d: preliminary data.<\/a><\/h3>\n\n\n\n

Claudia Colabella<\/span>P1<\/sup>, Lucia Anzalone1<\/sup>, Martina Pellegrini1<\/sup>, Giulio Saveri1<\/sup>, Monica Cagiola1<\/sup>, Antonella Di Paolo1<\/sup>
1<\/sup> Istituto Zooprofilattico Sperimentale dell\u2019Umbria e delle Marche \u201cTogo Rosati\u201d, via G. Salvemini 1, 06126 Perugia, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-14<\/a><\/h2>\n\n\n\n

In vitro microenvironment modifies the neurotoxic response of SH-SY5Y cells<\/a><\/h3>\n\n\n\n

V\u00e9ronique DE CONTO<\/span>P1<\/sup>, Vaihere Cheung1<\/sup>, Gregory  MAUBON1<\/sup>, Zied Souguir1<\/sup>, Nathalie Maubon1<\/sup>, Elodie Vandenhaute1<\/sup>, Vincent Berezowski2<\/sup>
1<\/sup> HCS Pharma
2<\/sup> Lille Neuroscience and Cognition, U1172
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-15<\/a><\/h2>\n\n\n\n

Interplay between in vitro off-target pharmacological promiscuity, cytotoxicity, and in vivo tolerability in rodents to improve the safety profile of anti-malarial drug discovery<\/a><\/h3>\n\n\n\n

Helga Gerets<\/span>P1<\/sup>, Annie Delaunois1<\/sup>, Alicia Sibony1<\/sup>, Reiner Class1<\/sup>, Teresa De Haro Garcia1<\/sup>, Benoit Laleu2<\/sup>, Martin  Lowe3<\/sup>, Renaud Fleurance1<\/sup>, Marie-Luce Rosseels1<\/sup>, Jean-Pierre Valentin1<\/sup>
1<\/sup> UCB BioPharma SRL
2<\/sup> MMV
3<\/sup> exscientia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-16<\/a><\/h2>\n\n\n\n

USEFULNESS OF THE ZEBRAFISH EMBRYO MODEL TO EVALUATE NEW THERAPIES AGAINST MULTIDRUG-RESISTANT BACTERIA<\/a><\/h3>\n\n\n\n

Laura Guzman<\/span>P1<\/sup>, Cristina  Marqu\u00e9s1<\/sup>, Elena  S\u00e1nchez-L\u00f3pez2,3,4<\/sup>, Amanda  Cano2,3,4<\/sup>, Antoni  Camins4,5,6<\/sup>, Yolanda  Cajal2<\/sup>, Miren  Ettcheto4,5,6<\/sup>, Francesc  Rabanal7<\/sup>, Marta  Barenys1,8<\/sup>
1<\/sup> GRET i Unitat de Toxicologia, Departament de Farmacologia, Toxicologia i Qu\u00edmica Terap\u00e8utica, Facultat de Farm\u00e0cia i  Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona (UB), Av. de Joan XXIII, 27-31, 08028 Barcelona, Spain
2<\/sup> Unitat de Fisicoqu\u00edmica, Departament de Farm\u00e0cia, Tecnologia farmac\u00e8utica i fisicoqu\u00edmica, Facultat de Farm\u00e0cia i  Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona (UB), Av. de Joan XXIII, 27-31,08028 Barcelona, Spain
3<\/sup> Institut de Nanoci\u00e8ncia i Nanotecnologia (IN2UB), Universitat de Barcelona (UB), Av. Diagonal, 64, 08028 Barcelona, Spain.
4<\/sup> Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Neurodegenerativas (CIBERNED), Instituto de Carlos III, Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.
5<\/sup> Unitat de Farmacologia, Departament de Farmacologia, Toxicologia i Qu\u00edmica Terap\u00e8utica, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona (UB), Av. de Joan XXIII, 27-31,08028 Barcelona, Spain
6<\/sup> Institut de Neuroci\u00e8ncies, Universitat de Barcelona (UB), Passeig de la Vall d\u2019Hebron, 171, 08035 Barcelona, Spain
7<\/sup> Unitat de Qu\u00edmica Org\u00e0nica, Departament de qu\u00edmica inorg\u00e0nica i org\u00e0nica, Facultat de Qu\u00edmica, Universitat de Barcelona (UB), C\/Mart\u00ed i Franqu\u00e8s, 1-11, 08028 Barcelona, Spain
8<\/sup> Institut de Recerca en Nutrici\u00f3 i Seguretat Aliment\u00e0ria (INSA), Universitat de Barcelona (UB), Av. Prat de la Riba, 171, 08921 Barcelona, Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-17<\/a><\/h2>\n\n\n\n

Induction and evaluation of an oxidative stress response in the EpiDermFT in vitro human skin model<\/a><\/h3>\n\n\n\n

Jan Markus<\/span>P1<\/sup>, Silvia Letasiova1<\/sup>, Kaitlyn Marengo2<\/sup>, Jon Oldach2<\/sup>, Alex Armento2<\/sup>, Anna Langerveld3<\/sup>, Elisabeth Lehigh3<\/sup>
1<\/sup> MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
2<\/sup> MatTek Corporation, Ashland, MA, USA
3<\/sup> Genemarkers LLC, Kalamazoo, MI
P<\/sup> Presenting author<\/p>\n\n\n\n

<\/p>\n\n\n\n

P-6a-18<\/a><\/h2>\n\n\n\n

hiPSCs and hiPSCs-derived renal proximal tubular cells showed different response to nephrotoxic compounds<\/a><\/h3>\n\n\n\n

Isaac Musong Mboni Johnston<\/span>P1<\/sup>, Nicole Schupp1<\/sup>
1<\/sup> Heinrich Heine University hospital, Institute of Toxicology
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-19<\/a><\/h2>\n\n\n\n

Low Endotoxin Recovery (LER) effect in pharmaceutical products analyzed with the Monocyte Activation Test (MAT).<\/a><\/h3>\n\n\n\n

Marco Mingolla<\/span>P1,2<\/sup>, Chiara Celli2<\/sup>, Fabrizio Lecce2<\/sup>
1<\/sup> Universit\u00e0 degli Studi di Torino, Molecular Medicine, Torino, Italy
2<\/sup> Merck KGaA, Istituto di Ricerche Biomediche \u201cA. Marxer\u201d RBM S.p.A., Ivrea, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-20<\/a><\/h2>\n\n\n\n

An epidermal model containing melanocytes for skin pigmentation and lightening studies<\/a><\/h3>\n\n\n\n

Marek Puskar<\/span>P1<\/sup>, Bridget Breyfogle2<\/sup>, Seyoum Ayehunie2<\/sup>, Silvia Letasiova1<\/sup>, Jon Oldach2<\/sup>, Alex Armento2<\/sup>, Mitchell Klausner2<\/sup>
1<\/sup> MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
2<\/sup> MatTek Corporation, Ashland, MA, USA
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-21<\/a><\/h2>\n\n\n\n

PITFALLS OF THE MTT ASSAY AND CYTOTOXICITY EVALUATION OF TRADITIONAL ANTIMALARIALS<\/a><\/h3>\n\n\n\n

Lucia Rackova<\/span>P1<\/sup>
1<\/sup> Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Dubravska cesta 9, 841 04 Bratislava, Slovakia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-22<\/a><\/h2>\n\n\n\n

Long-term upregulation in drug metabolization and hepatic gene expression in primary human hepatocytes (PHH) after exogenous exposure to human intestinal microbiome secretome peptides<\/a><\/h3>\n\n\n\n

Natalia S\u00e1nchez-Romero<\/span>P1,2<\/sup>, Pilar  Sainz de la Maza Arnal1,2<\/sup>, Maria Jes\u00fas Lozano Limones1,2<\/sup>, Mario  Fern\u00e1ndez Sanz2<\/sup>, \u00c1lvaro  Blanes Rodr\u00edguez2<\/sup>, Sandra  Meliton Barbancho2<\/sup>, Pedro Baptista2,3,4,5<\/sup>
1<\/sup> Cytes Biotechnologies
2<\/sup> Health Research Institute of Arag\u00f3n (IIS Arag\u00f3n)
3<\/sup> Department of Biomedical and Aerospace Engineering, Carlos III University of Madrid
4<\/sup> ARAID Foundation
5<\/sup> CIBERehd
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-23<\/a><\/h2>\n\n\n\n

Novel in vitro approaches in safety evaluation of cemtirestat<\/a><\/h3>\n\n\n\n

Marta \u0160olt\u00e9sov\u00e1 Prnov\u00e1<\/span>P1,2<\/sup>, Peter P\u00f4bi\u01611<\/sup>, Marek Lep\u00e1\u010dek1<\/sup>, Lucia Ra\u010dkov\u00e11<\/sup>, Jana Viskupi\u010dov\u00e11<\/sup>, Tea Lani\u0161nik Ri\u017ener3<\/sup>, Sreeparna Banerjee4<\/sup>, Helena Kan\u010f\u00e1rov\u00e15<\/sup>, Milan \u0160tefek5<\/sup>
1<\/sup> Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Bratislava, Slovakia
2<\/sup> Faculty of informatics and information technologies Slovak University of Technologies in Bratislava, Slovakia
3<\/sup> Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia
4<\/sup> Department of Biological Sciences, Middle East Technical University, Ankara, Turkey
5<\/sup> nstitute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Bratislava, Slovakia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-24<\/a><\/h2>\n\n\n\n

Drug-induced QTc prolongation and Torsades de Pointes: evolving ICH S7B in light of emerging in silico, in vitro and in vivo data and implication for drug development<\/a><\/h3>\n\n\n\n

Jean-Pierre VALENTIN<\/span>P1<\/sup>, Derek LEISHMAN2<\/sup>, Hugo VARGAS3<\/sup>
1<\/sup> UCB Biopharma, Braine l’Alleud, Belgique
2<\/sup> Eli-Lilly, Indianapolis, USA.
3<\/sup> Amgen, California, USA
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-25<\/a><\/h2>\n\n\n\n

Novel Human-Relevant Preclinical Safety Testing Strategy for Recombinant Human Monoclonal Antibodies Directed Against Foreign Targets<\/a><\/h3>\n\n\n\n

April Naab1<\/sup>, Jeffrey Brown<\/span><\/span>P1<\/sup>, Esther Wenzel2<\/sup>, Stefan D\u00fcbel2<\/sup>, Paul Stickings3<\/sup>, Michael Hust2<\/sup>
1<\/sup> PETA Science Consortium International e.V.
2<\/sup> Technische Universit\u00e4t Braunschweig
3<\/sup> National Institute for Biological Standards and Control
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-26<\/a><\/h2>\n\n\n\n

Hepatic 3D cell models as a cell-based biosensor-like system for the in vitro (geno)toxicity testings<\/a><\/h3>\n\n\n\n

Martina  \u0160tampar<\/span><\/span>P1,2<\/sup>, Barbara  Breznik1<\/sup>, Sonja \u017dabkar1<\/sup>, Metka  Filipi\u010d1<\/sup>, Bojana \u017degura1<\/sup>
1<\/sup> National Institute of Biology, Department for Genetic Toxicology and Cancer Biology
2<\/sup> Jozef Stefan International Postgraduate School, Slovenia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-27<\/a><\/h2>\n\n\n\n

Development of a primary culture system to investigate compound toxicity in steatotic hepatocytes<\/a><\/h3>\n\n\n\n

Anett Ullrich<\/span><\/span>P1<\/sup>, Tim Brecklinghaus2<\/sup>, Jan G. Hengstler2<\/sup>, Dieter Runge1<\/sup>
1<\/sup> PRIMACYT Cell Culture Technology GmbH
2<\/sup> Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6a-28<\/a><\/h2>\n\n\n\n

LONG-TERM RECORDING OF CARDIAC ACTION POTENTIALS FOR CHRONIC CARDIOTOXICITY ASSESSMENT<\/a><\/h3>\n\n\n\n

Giuseppina Iachetta1<\/sup>, Giovanni Melle2<\/sup>, Nicol\u00f2  Colistra2<\/sup>, Francesco De Angelis1<\/sup>, Michele Dipalo<\/span><\/span>P1<\/sup>
1<\/sup> Istituto Italiano di Tecnologia
2<\/sup> Foresee Biosystems srl
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

6b. Knowledge sharing and education  <\/span><\/h2>\n\n\n\n

P-6b-2<\/a><\/h2>\n\n\n\n

Ukrainian National 3Rs Center. An effective tool to advance the 3Rs principles by focusing on their scientific impacts and benefits<\/a><\/h3>\n\n\n\n

Nataliia Bubalo<\/span>P1<\/sup>, Serhii Kolesnyk1<\/sup>, Petro Zhminko1<\/sup>, Marina Zinovieva1<\/sup>, Yana  Kolianchuk1<\/sup>, Inna Rashkivska1<\/sup>
1<\/sup> L.I.Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety Ministry of Health, Ukraine
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6b-3<\/a><\/h2>\n\n\n\n

Reproducibility in Cell Culture: Replacing Fetal Bovine Serum<\/a><\/h3>\n\n\n\n

Tilo Weber<\/span>P1<\/sup>, Kristina Wagner 1<\/sup>, Jessica Rosolowski1<\/sup>, Joachim Wiest2<\/sup>
1<\/sup> Animal Welfare Academy of the German Animal Welfare Federation, Neubiberg, Germany
2<\/sup> cellasys GmbH, Kronburg, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-6b-4<\/a><\/h2>\n\n\n\n

FUN with NAMs<\/span><\/span><\/a><\/h3>\n\n\n\n

francois busquetP1<\/sup>
1<\/sup> altertox
P<\/sup> Presenting author<\/p>\n\n\n\n

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7a. Developmental Neurotoxicity (DNT)  <\/span><\/h2>\n\n\n\n

P-7a-1<\/a><\/h2>\n\n\n\n

Developmental toxicity assessment of nanoparticles: The importance of indirect placenta-mediated toxicity mechanisms<\/a><\/h3>\n\n\n\n

Battuja Dugershaw-Kurzer1,2<\/sup>, Patrycja  Nowak-Sliwinska3,4<\/sup>, Ren\u00e9 Hornung5<\/sup>, Arjan Griffioen6<\/sup>, Judy R. van Beijnum6<\/sup>, Stefan Masjosthusmann7<\/sup>, Ellen Fritsche7<\/sup>, Tina Buerki-Thurnherr<\/span>P1<\/sup>
1<\/sup> Laboratory for Particles Biology Interactions, Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen, Switzerland
2<\/sup> Laboratory of Toxicology, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
3<\/sup> Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland
4<\/sup> Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
5<\/sup> Department of Gynaecology and Obstetrics, Kantonsspital St.Gallen, St. Gallen, Switzerland
6<\/sup> Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands
7<\/sup>  IUF – Leibniz Research Institute for Environmental Medicine, Duesseldorf, German
P<\/sup> Presenting author<\/p>\n\n\n\n

P-7a-2<\/a><\/h2>\n\n\n\n

DEVELOPMENTAL NEUROTOXICITY OF ACRYLAMIDE AND ITS METABOLITE GLYCIDAMIDE IN A HUMAN MIXED CULTURE OF NEURONS AND ASTROCYTES UNDERGOING DIFFEFRENTIATION<\/a><\/h3>\n\n\n\n

Oddvar Myhre<\/span>P1<\/sup>, Malene Lislien1<\/sup>, J\u00f8rn A Holme2<\/sup>, Hubert Dirven1<\/sup>, Ragnhild E Paulsen3<\/sup>, Inger Margit Alm1<\/sup>, Ellen Skarpen4<\/sup>, Vigdis S\u00f8rensen4<\/sup>, Peter Macko5<\/sup>, Francesca Pistollato5<\/sup>, Nur Duale1<\/sup>, Anna J Lauv\u00e5s1<\/sup>
1<\/sup> Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway.
2<\/sup> Department of Air Pollution and Noise, Norwegian Institute of Public Health, Oslo, Norway.
3<\/sup> Department of Pharmacy, University of Oslo, Norway
4<\/sup> Core Facility for Advanced Light Microscopy, Institute for Cancer Research, Oslo University Hospital, Norway
5<\/sup> European Commission, Joint Research Centre (JRC), Ispra, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-7a-3<\/a><\/h2>\n\n\n\n

In vitro study of fumonisin B1 and ochratoxin A on undifferentiated SH-SY5Y cells and contribution of beetroot in alleviating toxic effects<\/a><\/h3>\n\n\n\n

Raquel Penalva-Olcina<\/span>P1<\/sup>, M\u00f3nica  Fern\u00e1ndez-Franz\u00f3n1<\/sup>, Ana Juan-Garc\u00eda1<\/sup>
1<\/sup> Universitat de Val\u00e8ncia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-7a-4<\/a><\/h2>\n\n\n\n

APPLIYING NAMS TO SAFETY EVALUATION OF HERBAL PRODUCTS CONSUMED BY CATALAN PREGNANT AND LACTATING WOMEN: INTERVIEW-BASED CONSUMPTION SURVEY AND DEVELOPMENTAL NEURO\/TOXICITY EVALUATION IN ZEBRAFISH EMBRYOS<\/a><\/h3>\n\n\n\n

Noelia G Romero<\/span>P1<\/sup>, Elisabet  Teixid\u00f31,2<\/sup>, Nicole  Feliu1<\/sup>, Salvador  Ca\u00f1igueral3<\/sup>, Jes\u00fas  G\u00f3mez-Catal\u00e1n1,2<\/sup>, Marta  Barenys1,2<\/sup>
1<\/sup> GRET and Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII 27 31, Barcelona, Spain.
2<\/sup> Institute of Nutrition Research and Food Safety (INSA UB), University of Barcelona, Barcelona, Spain.
3<\/sup> Unitat de Farmacologia, Farmacogn\u00f2sia, i Terap\u00e8utica, Facultat de Farm\u00e0cia, i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona, Av. Joan XXIII  27-31, 08028 Barcelona, Spain.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-7a-5<\/a><\/h2>\n\n\n\n

Application of a human in vitro testing battery for endocrine disruptor (ED)-induced developmental neurotoxicity (DNT) to refine EDC hazard assessment<\/a><\/h3>\n\n\n\n

Katharina Koch<\/span><\/span>P1<\/sup>, Kevin Schl\u00fcppmann1<\/sup>, Saskia H\u00fcsken1<\/sup>, Louisa Stark1<\/sup>, Arif D\u00f6nmez1<\/sup>, Nils F\u00f6rster2,3<\/sup>, Ellen Fritsche1,4<\/sup>
1<\/sup> Leibniz Research Institute for Environmental Medicine (IUF), D\u00fcsseldorf, Germany
2<\/sup> Bioinformatics Group, Department of Biology and Biotechnology, Ruhr-University Bochum, Bochum, Germany
3<\/sup> Bioinformatics, Center for Protein Diagnostics (ProDi), Ruhr-University Bochum, Bochum, Germany
4<\/sup> Medical Faculty, Heinrich-Heine-University, D\u00fcsseldorf, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

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7b. Implementation of NAMs into regulatory frameworks \u2013 establishing scientific confidence, development of standards and good practices  <\/span><\/h2>\n\n\n\n

P-7<\/a>b<\/a>-1<\/a><\/h2>\n\n\n\n

INCREASING PREDICTIVITY OF COMPOUND MULTI-ORGAN TOXICITY THROUGH HIGH-THROUGHPUT ZEBRAFISH ASSAYS<\/a><\/h3>\n\n\n\n

Carles Cornet<\/span><\/span>P1<\/sup>, Valentina Schiavone1<\/sup>, Sergio Jarque1<\/sup>, Maria Rubio-Brotons1<\/sup>, V\u00edctor Ordo\u00f1ez 1<\/sup>,  UPC data science  cours participants 2<\/sup>, Jessica Garc\u00eda-Fern\u00e1ndez1<\/sup>, Ferran Arqu\u00e91<\/sup>, Rafael  Mi\u00f1ana-Prieto1<\/sup>, Javier Terriente1<\/sup>, Sylvia Dyballa1<\/sup>, Vincenzo Di Donato1<\/sup>
1<\/sup> ZeClinics – IGTP research centre, Barcelona (SPAIN)
2<\/sup> Universitat Polit\u00e8cnica de Catalunya \u00b7 Barcelona Tech – UPC 
P<\/sup> Presenting author<\/p>\n\n\n\n

P-7b-2<\/a><\/h2>\n\n\n\n

LARGE SCALE MANUFACTURING OF NAMS<\/a><\/h3>\n\n\n\n

Karina Cuanalo-Contreras<\/span><\/span>P1<\/sup>, Dennis Benkmann1<\/sup>
1<\/sup> SABEU GmbH & Co. KG
P<\/sup> Presenting author<\/p>\n\n\n\n

P-7b-3<\/a><\/h2>\n\n\n\n

Development of a new methodology to quantify the activation of the Nrf2 (key event 2) by allergens<\/a><\/h3>\n\n\n\n

Bruna  Pedralli1<\/sup>, Maria de F\u00e1tima Barbosa  Costa2<\/sup>, Marize Valadares<\/span><\/span>P2<\/sup>
1<\/sup> Laboratory of Education and Research in Toxicology In Vitro – Tox In – Pharmacy Faculty, Federal University of Goi\u00e1s
2<\/sup> Laboratory of Education and Research in Toxicology In Vitro – Tox In –  Pharmacy Faculty, Federal University of Goi\u00e1s
P<\/sup> Presenting author<\/p>\n\n\n\n

P-7b-4<\/a><\/h2>\n\n\n\n

Reduction of animal use in reproductive and developmental toxicity studies – new methodology approach<\/a><\/h3>\n\n\n\n

Yana Kolianchuk<\/span><\/span>1<\/sup>, Arne Jaksch1<\/sup>, Jenny Keicher1<\/sup>, Nataliia Bubalo1<\/sup>

1<\/sup>JAKSCH LIFESCIENCE CONSULTING GmbH<\/p>\n\n\n\n

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8a. In vitro methods for safety assessment of medical devices<\/span><\/h2>\n\n\n\n

P-8a-1<\/a><\/h2>\n\n\n\n

Optimization of skin sensitization testing strategy in vitro for medical device extracts<\/a><\/h3>\n\n\n\n

Lada Svobodova1,2<\/sup>, Kristina Kejlova<\/span>P1<\/sup>, Alena Vlkova1<\/sup>, Marian Rucki1<\/sup>, Dagmar Jirova1<\/sup>, Hana Kolarova2<\/sup>
1<\/sup> National Institute of Public Health Prague
2<\/sup> Faculty of Medicine and Dentistry, Department of Medical Biophysics, Palack\u00fd University
P<\/sup> Presenting author<\/p>\n\n\n\n

P-8a-2<\/a><\/h2>\n\n\n\n

In vitro method for quantitative potency assessment of skin sensitizers during development of novel materials for intended use in medical devices<\/a><\/h3>\n\n\n\n

Ulrika Mattson1<\/sup>, Karla Lienau2<\/sup>, David Waeckerlin2<\/sup>, Robin Gradin1<\/sup>, Rose-Marie Jenvert<\/span><\/span> P1<\/sup>
1<\/sup> SenzaGen AB
2<\/sup> Sonova AG
P<\/sup> Presenting author<\/p>\n\n\n\n

P-8a-3<\/a><\/h2>\n\n\n\n

Development, pre-validation and validation of the EpiDerm in vitro skin irritation protocol for the medical devices extracts<\/a><\/h3>\n\n\n\n

Silvia Letasiova<\/span>P1<\/sup>, Jan  Markus1<\/sup>, Bridget  Breyfogle2<\/sup>, Michael A.  Bachelor2<\/sup>, Helena  Kandarova3<\/sup>
1<\/sup> MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia
2<\/sup> MatTek Corporation, Ashland, MA, USA
3<\/sup> Centre of Experimental Medicine SAS, Slovak Academy of Sciences, Bratislava, Slovakia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-8a-4<\/a><\/h2>\n\n\n\n

Bio-compatibility assessment of medical devices using reconstructed in vitro 3D human cornea-like tissue model<\/a><\/h3>\n\n\n\n

Peter  P\u00f4bi\u0161<\/span>P1<\/sup>, Lucia Milec1<\/sup>, Zuzana Strakov\u00e11<\/sup>, Helena Kandarova1<\/sup>
1<\/sup> Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia
P<\/sup> Presenting author<\/p>\n\n\n\n

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8b. In vitro COVID-19 research \/ Lung and cardiovascular models<\/span><\/h2>\n\n\n\n

P-8b-1<\/a><\/h2>\n\n\n\n

COMPARISON OF EXPRESSION PROFILE OF SARS-COV-2 KEY RECEPTORS IN SKIN AND LUNG IN VITRO MODELS<\/a><\/h3>\n\n\n\n

Manon Barthe<\/span>P1,2<\/sup>, V\u00e9ronique M. Braud2<\/sup>, Jean-Paul Th\u00e9not3<\/sup>, Hanan Osman-Ponchet3<\/sup>
1<\/sup> PKDERM Laboratories
2<\/sup> Universit\u00e9 C\u00f4te d\u2019Azur, CNRS UMR7275, Institut de Pharmacologie Mol\u00e9culaire et Cellulaire – France
3<\/sup> PKDERM SAS
P<\/sup> Presenting author<\/p>\n\n\n\n

P-8b-2<\/a><\/h2>\n\n\n\n

INTESTINAL ADVERSE OUTCOMES IN COVID-19: CURRENT EVIDENCE AND UNCERTAINTIES USING THE ADVERSE OUTCOME PATHWAY FRAMEWORK.<\/a><\/h3>\n\n\n\n

Laure-Alix Clerbaux<\/span>P1<\/sup>, Julija Fillipovska2<\/sup>, Amalia Mu\u00f1oz3<\/sup>, Mauro Petrillo4<\/sup>, Helena Soares5<\/sup>, Sally Mayasich6<\/sup>, Maria-Joao Amorim7<\/sup>, Lucia Grenga8<\/sup>
1<\/sup> European Commission, Joint Research Centre (JRC), Ispra, Italy
2<\/sup> Independent scientist, Ohrid, North Macedonia
3<\/sup> European Commission, Joint Research Centre (JRC), Geel, Belgium
4<\/sup> Past affiliation: European Commission, Joint Research Centre (JRC), Ispra, Italy. Current affiliation: Seidor Italy srl, Milano, Italy
5<\/sup> Human Immunobiology and Pathogenesis Group, CEDOC, NOVA Medical School | Faculdade de Ci\u00eancias M\u00e9dicas, NOVA University of Lisbon, Lisbon, Portugal
6<\/sup> University of Wisconsin-Madison Aquatic Sciences Center at US EPA, Duluth, MN, USA
7<\/sup> Instituto Gulbenkian de Ci\u00eancia, Lisbon, Portugal
8<\/sup> Universit\u00e9 Paris-Saclay, CEA, INRAE, D\u00e9partement M\u00e9dicaments et Technologies pour la Sant\u00e9, Paris, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-8b-3<\/a><\/h2>\n\n\n\n

COVID-19 through the lens of the Adverse Outcome Pathways: What can we learn from the view on the relationship between ACE2 dysfunction and its interaction with SARS-COV2<\/a><\/h3>\n\n\n\n

Julija Filipovska<\/span>P1,2<\/sup>
1<\/sup> Independent Scientist, Ohrid, North Macedonia
2<\/sup> The work was inspired and performed as part of the CIAO project (https:\/\/www.ciao-covid.net\/)
P<\/sup> Presenting author<\/p>\n\n\n\n

P-8b-4<\/a><\/h2>\n\n\n\n

Potential role of quercetin in modulating SARS-CoV-2-induced cytokine storm<\/a><\/h3>\n\n\n\n

Elodie OLIVIER<\/span>P1<\/sup>, M\u00e9lody DUTOT1,2<\/sup>, Patrice RAT1<\/sup>
1<\/sup> Laboratoire de Chimie Analytique et Toxicologie Exp\u00e9rimentale Toxicologie Cellulaire (UMR CNRS 8038), Facult\u00e9 de Pharmacie de Paris \u2013 Universit\u00e9 de Paris
2<\/sup> Yslab, 2 rue F\u00e9lix Le Dantec, 29000 Quimper, France
P<\/sup> Presenting author<\/p>\n\n\n\n

P-8b-5<\/a><\/h2>\n\n\n\n

ESTROGENIC ACTIVITY RELATED TO THE PRESENCE OF SARS-COV-2 IN WASTEWATER<\/a><\/h3>\n\n\n\n

Francesca Rispo<\/span>P1<\/sup>, Lorenzo  Dondero1<\/sup>, Giulia  De Negri Atanasio1<\/sup>, Giorgia  Allaria1<\/sup>, Francesca Tardanico 1<\/sup>, Stefano Rosatto2<\/sup>, Marta Bellisomi2<\/sup>, Giulia Palumbi2<\/sup>, Irene Tomesani2<\/sup>, Alberto Izzotti3<\/sup>, Elena Nicosia2<\/sup>, Elena Grasselli1<\/sup>
1<\/sup> Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy
2<\/sup> ARPAL Liguria, Italy
3<\/sup> Department of Experimental Medicine, University of Genoa, Genova, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

9. Models and methods  <\/span><\/h2>\n\n\n\n

P-MODELS-1<\/a><\/h2>\n\n\n\n

APPLICATION OF BENCHMARK DOSE APPROACH FOR ASSESSMENT OF EFFECTS ON RED BLOOD CELLS REVEALED DURING NON-CLINICAL TOXICITY STUDY OF DRUG CANDIDATE<\/a><\/h3>\n\n\n\n

Mykola Prodanchuk1<\/sup>, Zhminko Peter1<\/sup>, Maryna Zinovieva<\/span>P1<\/sup>, Serhii Kolesnyk1<\/sup>
1<\/sup> L.I.Medved\u2019s Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine, Kyiv
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-2<\/a><\/h2>\n\n\n\n

IN VITRO TRANSCRIPTIONAL BIOMARKERS INVOLVED IN LIVER STEATOSIS AND MIXTURE EFFECTS OF HEPATOTOXIC PESTICIDES THROUGH AN ADVERSE OUTCOME PATHWAY-BASED APPROACH<\/a><\/h3>\n\n\n\n

Efrosini Katsanou1<\/sup>, Anastasia  Spyropoulou<\/span>P1<\/sup>, Petros Batakis1<\/sup>, Dajana Lichtenstein2<\/sup>, Claudia Luckert2<\/sup>, Albert Braeuning2<\/sup>, Alfonso Lampen2<\/sup>, Kyriaki Machera1<\/sup>
1<\/sup> Laboratory of Pesticides\u2019 Toxicology, Department of Pesticides Control and Phytopharmacy, Benaki Phytopathological Institute, Athens, Greece
2<\/sup> German Federal Institute for Risk Assessment, Dept. Food Safety, Berlin, Germany
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-3<\/a><\/h2>\n\n\n\n

Thermodynamic study on efficient removal of Cr(III), Cu(II) and Cd(II) heavy metal ions by SnO2\/MWCNT nanocomposite.<\/a><\/h3>\n\n\n\n

Shima Mohamad Khani1<\/sup>, Mahdieh Bazargani2<\/sup>, Nikoo Hosseini1<\/sup>
1<\/sup> Islamic Azad University, Science and Research Branch ,Tehran ,Iran.
2<\/sup> Sharif University of Technology,Tehran,Iran.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-4<\/a><\/h2>\n\n\n\n

PANORAMIX: Providing risk assessments of complex real-life mixtures for the protection of Europe\u2019s citizens and the environment<\/a><\/h3>\n\n\n\n

Anne Marie Vinggaard1<\/sup>, Marja  Lamoree2<\/sup>, Beate  I. Escher3<\/sup>, Jean-Philippe Antignac4<\/sup>, Martin  Scholze5<\/sup>, Tina Kold Jensen6<\/sup>, Matthias Herzler7<\/sup>, Marc Audebert8<\/sup>, Timo Hamers2<\/sup>, Andreas  Kortenkamp5<\/sup>, Fran\u00e7ois  Busquet9<\/sup>, Matteo Piumatti<\/span>P9<\/sup>, Gaud  Dervilly4<\/sup>, Maria  Jo\u00e3o Valente1<\/sup>, Ronan  Cariou4<\/sup>, Sol\u00e8ne  Moteau4<\/sup>, Michael  Oelgeschl\u00e4ger7<\/sup>, Kostja  Renko7<\/sup>, Sebastian  Schmeisser7<\/sup>, Dieter  Maier10<\/sup>, Lone  Ladegaard Laursen11<\/sup>
1<\/sup> National Food Institute, Technical University of Denmark, Kemitorvet Building 202, 2800 Kgs. Lyngby, Denmark
2<\/sup> Vrije Universiteit, Department Environment & Health, De Boelelaan 1108, 1081 HZ Amsterdam, the Netherlands
3<\/sup> Department of Cell Toxicology, Helmholtz Centre for Environmental Research – UFZ, Permoserstr. 15, DE-04318 Leipzig, Germany; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University T\u00fcbingen, Schnarrenbergstr. 94-96, DE-72076 T\u00fcbingen, Germany.
4<\/sup> Oniris, INRAE, LABERCA, Nantes, France
5<\/sup> Brunel University London, Institute of Environment, Health and Societies, Kingston Lane, Uxbridge, Middlesex UB8 3PH, United Kingdom
6<\/sup> Dep of Environmental Medicine, University of Southern Denmark, Denmark
7<\/sup> German Federal Institute for Risk Assessment (BfR), Department Chemicals and Product Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany
8<\/sup> PrediTox, Toulouse, France
9<\/sup> Altertox Academy, Brussels, Belgium
10<\/sup> Biomax Informatics, Planegg, Germany
11<\/sup> Faculty of Health Science, University of Southern Denmark, Denmark
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-5<\/a><\/h2>\n\n\n\n

IN VITRO MUTAGENICITY AND GENOTOXICITY OF PURE ANATOXIN-A<\/a><\/h3>\n\n\n\n

Cristina Plata-Calzado1<\/sup>, Concepcion Medrano-Padial1<\/sup>, Leticia Diez-Quijada1<\/sup>, Ana I Prieto1<\/sup>, Ana M Camean1<\/sup>, Angeles Jos<\/span>P1<\/sup>
1<\/sup> Area of Toxicology. Faculty of Pharmacy. Universidad de Sevilla. Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-6<\/a><\/h2>\n\n\n\n

Mutagenenicity and genotoxicity evaluation of reduced graphene oxide by the mouse lymphoma assay and standard and enzyme- modified comet assays<\/a><\/h3>\n\n\n\n

Oscar Cebadero-Dominguez1<\/sup>, Concepcion Medrano-Padial1<\/sup>, Maria Puerto1<\/sup>, Ana M Camean1<\/sup>, Angeles Jos<\/span>P1<\/sup>
1<\/sup> Area of Toxicology. Faculty of Pharmacy. Universidad de Sevilla. Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-7<\/a><\/h2>\n\n\n\n

GLIMPSES INTO IN VITRO TESTING OF MYCOTOXIN MIXTURES: INTERACTION BETWEEN TOXINS AND THEIR METABOLIC ACTIVATION<\/a><\/h3>\n\n\n\n

Mohammad Abdulkader Akbarsha<\/span>P1<\/sup>, Loganathan Gayathri2<\/sup>, Dharumadurai Dhanasekaran2<\/sup>, Albert P Li3<\/sup>
1<\/sup> Mahatma Gandhi-Doerenkamp Centre (MGDC), Bharathidasan University, Tiruchirappalli 620024, India. Present address: National College (Autonomous), Tiruchirappalli 620001, India
2<\/sup> Department of Microbiology, Bharathidasan University, Tiruchirappalli 620024, India
3<\/sup> In Vitro ADMET Laboratories LLC, 9221 Rumsey Road, Columbia, MD 21045, USA
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-8<\/a><\/h2>\n\n\n\n

Regulation of cholesterol transport and metabolism by tumor necrosis factor alpha in a human in vitro blood-brain barrier model<\/a><\/h3>\n\n\n\n

Rodrigo Azevedo Loiola<\/span>P1<\/sup>, Shiraz Dib1<\/sup>, Lucie Dehouck1<\/sup>, Emmanuel Sevin1<\/sup>, Jens Pahnke2<\/sup>, Fabien Gosselet1<\/sup>
1<\/sup> Universit\u00e9 d’Artois – France
2<\/sup> University of Oslo, Norway
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-9<\/a><\/h2>\n\n\n\n

Development of an adverse outcome pathway for kidney tubular necrosis<\/a><\/h3>\n\n\n\n

Devon Barnes<\/span>P1<\/sup>, Alasdair Irvine1<\/sup>, Alessio Gamba2<\/sup>, Luiz Carlos Maia Ladeira2<\/sup>, Bernard Staumont2<\/sup>, Huan Yang3<\/sup>, Inger-Lise Steffensen4<\/sup>, Liesbet Geris2,5,6<\/sup>, Manoe Janssen1<\/sup>, Rosalinde Masereeuw1<\/sup>
1<\/sup> Utrecht Institute for Pharmaceutical Sciences, Utrecht University
2<\/sup> Biomechanics Research Unit, GIGA In Silico Medicine, University of Li\u00e8ge
3<\/sup> esqLABS
4<\/sup> Department of Food Safety, Norwegian Institute of Public Health
5<\/sup> Skeletal Biology and Engineering Research Center
6<\/sup> Biomechanics Section, Department of Mechanical Engineering
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-10<\/a><\/h2>\n\n\n\n

Neurotoxic effect of potential countermeasures in case of nerve agent poisoning<\/a><\/h3>\n\n\n\n

Tena \u010cade\u017e<\/span>P1<\/sup>, Zrinka Kovarik1<\/sup>
1<\/sup> Institute for Medical Research and Occupational Health, Zagreb, Croatia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-11<\/a><\/h2>\n\n\n\n

New Salmonella strains resistant to sulfonylurea and  triazole-pyrimidine herbicides and their use in the Ames test<\/a><\/h3>\n\n\n\n

Olga Egorova<\/span>P1<\/sup>, Nataliya Suzina2,3<\/sup>, Nataliya Ilyushina1<\/sup>
1<\/sup> The Federal Budgetary Establishment of Science \u00abFederal Scientific Center of Hygiene named after F.F. Erisman\u00bb of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2<\/sup> G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms
3<\/sup> Federal Research Center \u00abPushchino Center for Biological Research of the Russian Academy of Sciences\u00bb
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-12<\/a><\/h2>\n\n\n\n

BPS DISPLAYS SIMILAR PHENOTYPIC AND METABOLIC RESPONSES TO BPA IN HEPG2 AND INS-1E CELLS<\/a><\/h3>\n\n\n\n

Lara Ferreira Azevedo<\/span>P1,2<\/sup>, Mauro Miguel Masiero2<\/sup>, Sarah Cherkaoui2<\/sup>, Maria Fernanda Hornos Carneiro 1,3<\/sup>, Fernando  Barbosa J\u00fanior1<\/sup>, Nicola Zamboni2<\/sup>
1<\/sup> Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo-USP, Ribeir\u00e3o Preto, Brazil
2<\/sup> Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
3<\/sup> Facultad de Qu\u00edmica y de Farmacia, Campus San Joaqu\u00edn Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-13<\/a><\/h2>\n\n\n\n

Comparison of a heated tobacco stick product and a combustible cigarette: chemical analysis and in vitro toxicological evaluation<\/a><\/h3>\n\n\n\n

Tsuneo Hashizume<\/span>P1<\/sup>, Shinkichi Ishikawa1<\/sup>, Shigeaki Ito1<\/sup>, Toshiro Fukushima1<\/sup>
1<\/sup> Japan Tobacco Inc.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-14<\/a><\/h2>\n\n\n\n

A High Content Analysis approach for a better detection of bacterial factors involved in the virulence of Bacillus cereus and Clostridium perfringens Strains<\/a><\/h3>\n\n\n\n

Kevin Hogeveen<\/span>P1<\/sup>, Rachelle Lanceleur1<\/sup>, Abdelrahim Abakabir-Mahamat1<\/sup>, Olivier Firmesse1<\/sup>, Val\u00e9rie  Fessard1<\/sup>
1<\/sup> French Agency for Food, Environmental and Occupational Health and Safety
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-15<\/a><\/h2>\n\n\n\n

Investigation of toxicokinetic and toxikodynamic mixture effects within plant protection products using new approach methodologies: a case study of two products containing tebuconazole + prothioconazole and cypermethrin + piperonylbutoxide<\/a><\/h3>\n\n\n\n

Mawien Karaca<\/span>P1,2<\/sup>, Christian Tobias Willenbockel1<\/sup>, Tewes Tralau1<\/sup>, Denise Bloch1<\/sup>, Philip Marx-Stoelting1,2<\/sup>
1<\/sup> German Federal Institute for Risk Assessment
2<\/sup> Technical University of Berlin
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-16<\/a><\/h2>\n\n\n\n

CHRONIC LOW-DOSE EXPOSURE TO DIBUTYL PHTHALATE AFFECTS NO PRODUCTION, CELL MIGRATION, AND ANGIOGENESIS IN HUMAN ENDOTHELIAL CELL LINE EA.HY926<\/a><\/h3>\n\n\n\n

Dunja Kokai<\/span>P1<\/sup>, Bojana Stanic1<\/sup>, Biljana Tesic1<\/sup>, Dragana Samardzija Nenadov1<\/sup>, Kristina Pogrmic-Majkic1<\/sup>, Svetlana Fa Nedeljkovic1<\/sup>, Nebojsa Andric1<\/sup>
1<\/sup> University of Novi Sad, Faculty of Sciences, Department of Biology and Ecology, Serbia
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-17<\/a><\/h2>\n\n\n\n

Mixture effects of extracts from environment, food and blood on neurite outgrowth compared to cytotoxicity in SH-SY5Y cells<\/a><\/h3>\n\n\n\n

Jungeun Lee<\/span>P1<\/sup>, Marc Audebert2<\/sup>, Jean-Philippe Antignac3<\/sup>, Laure Khoury4<\/sup>, Maria K\u00f6nig1<\/sup>, Marja Lamoree5<\/sup>, Maria Margalef Jorne5<\/sup>, Solene Motteau3<\/sup>, Chrstina R\u00f8rbye6<\/sup>, Rita Schlichting1<\/sup>, Anne-marie Vinggaard7<\/sup>, Maria Jo\u00e3o Valente7<\/sup>, Beate Escher1<\/sup>
1<\/sup> Department of Cell Toxicology, UFZ\u2013Helmholtz Centre for Environmental Research, Leipzig, Germany
2<\/sup> INRAE UMR1331 TOXALIM, France
3<\/sup> Oniris, INRAE, Laboratoire d\u2019Etude des R\u00e9sidus et Contaminants dans les Aliments, 44300 Nantes, France
4<\/sup> Preditox, Toulouse, France
5<\/sup> Department Environment & Health, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands
6<\/sup> Hvidovre Hospital, Denmark
7<\/sup> National Food Institute, Technical University of Denmark, Lyngby, Denmark
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-18<\/a><\/h2>\n\n\n\n

Connexin-based channel activity is not specifically altered by hepatocarcinogenic chemicals<\/a><\/h3>\n\n\n\n

Kaat Leroy<\/span>P1<\/sup>, Axelle Cooreman1<\/sup>, Raf Van Campenhout1<\/sup>, Bruno  Cogliati2<\/sup>, Mathieu Vinken1<\/sup>
1<\/sup> Entity of In vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel
2<\/sup> Department of Pathology, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-19<\/a><\/h2>\n\n\n\n

STUDY OF CITRININ TOXIC EFFECTS ON A 3D NEUROBLASTOMA MODEL: CYTOTOXICITY, OXIDATIVE STRESS AND CELL DEATH<\/a><\/h3>\n\n\n\n

Francisco J.  Mart\u00ed-Quijal<\/span>P1<\/sup>, Noemi Torriero2,3<\/sup>, Francisco J.  Barba1<\/sup>, Mar\u00eda Jos\u00e9  Ruiz1<\/sup>, Maria Rosaria  Esposito2,3<\/sup>, Elisa Cimetta2,3<\/sup>
1<\/sup> Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andr\u00e9s Estell\u00e9s s\/n, 46100, Valencia, Spain
2<\/sup> Department of Industrial Engineering (DII), University of Padua, Via Marzolo 9, 35131, Padova, Italy
3<\/sup> Fondazione Istituto di Ricerca Pediatrica Citt\u00e0 Della Speranza (IRP) \u2013 Lab BIAMET, Corso Stati Uniti 4, 35127, Padova, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-20<\/a><\/h2>\n\n\n\n

THE ROLE OF ENVIRONMENTAL CONTAMINANTS DETECTABLE IN WASTE OF ELECTRICAL AND ELECTRONIC EQUIPMENT (WEEE) PLANTS IN A549 AND HEPG2 CELL LINES \u2013 THE VAISAL PROJECT<\/a><\/h3>\n\n\n\n

Milena Mikhail<\/span>P1<\/sup>, Alessandra Di Veroli2<\/sup>, Anton  Vremere1<\/sup>, Stefano Di Bona2<\/sup>, Francesca Buiarelli3<\/sup>, Giulia Simonetti3<\/sup>, Patrizia Di Filippo4<\/sup>, Donatella Pomata4<\/sup>, Carmela Riccardi4<\/sup>, Franco Lucarelli5<\/sup>, Giulia Pazzi5<\/sup>, Roberta Galarini6<\/sup>, Carolina Barola6<\/sup>, Simone Moretti6<\/sup>, Fabiola Paoletti6<\/sup>, Laura Goracci2<\/sup>, Gabriele Cruciani2<\/sup>, Stefano Lorenzetti7<\/sup>
1<\/sup> ISS – Istituto Superiore di Sanit\u00e0, Department of Food Safety, Nutritionn and Veterinary Public Health
2<\/sup> University of Perugia, Department of Chemistry, Biology and Biotechnology
3<\/sup> University Sapienza of Rome, Department of Chemistry
4<\/sup> INAIL-DIT
5<\/sup> University of Florence, Department of Physics
6<\/sup> Istituto Zooprofilattico Sperimentale dell\u2019Umbria e delle Marche \u201dTogo Rosati\u201d
7<\/sup> ISS – Department Food Safety, Nutrition and Veterinary Public Health
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-21<\/a><\/h2>\n\n\n\n

PK-driven drug test for the evaluation of the efficacy of anti-cancer treatment regimens<\/a><\/h3>\n\n\n\n

Andrey Poloznikov<\/span>P1<\/sup>, Martin Schumacher1<\/sup>, Sergey Nikulin1<\/sup>
1<\/sup> MimiQ GmbH
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-22<\/a><\/h2>\n\n\n\n

INTEGRATED ENVIRONMENTAL AND HUMAN IN VITRO TOXICITY APPROACH FOR DINOFLAGELLATES<\/a><\/h3>\n\n\n\n

Cristina Scarone<\/span>P1<\/sup>, Susanna Alloisio2<\/sup>, Francesco Misurale1<\/sup>, Valentina  Giussani3<\/sup>, Laura Pezzolesi4<\/sup>, Rossella Pistocchi4<\/sup>, Antonio Novellino2<\/sup>, Aldo Pagano1<\/sup>, Anna Maria Bassi1<\/sup>
1<\/sup> Department of Experimental Medicine- University of Genoa, Italy
2<\/sup> ETT Spa, Italy
3<\/sup> ARPAL Liguria, Italy
4<\/sup> University of Bologna, Italy
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-23<\/a><\/h2>\n\n\n\n

INTEGRATEIDENTIFICATION OF A NOVEL MODE OF ACTION OF VANILLIN DERIVATIVE COMPOUND VERATRALDEHYDE<\/a><\/h3>\n\n\n\n

Taku Watanabe<\/span><\/span>P1<\/sup>, Satoru Munakata1<\/sup>, Tomohiro Takahashi1<\/sup>, Shiori Kimuro1<\/sup>, Tsuneo Hashizume1<\/sup>
1<\/sup> Japan Tobacco Inc.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-24<\/a><\/h2>\n\n\n\n

Using an in vitro inflamed intestinal model to study the effect of deoxynivalenol on primary bile acid malabsorption in human<\/a><\/h3>\n\n\n\n

Jingxuan Wang<\/span><\/span>P1<\/sup>, Wouter Bakker1<\/sup>, Laura de Haan1<\/sup>, Hans Bouwmeester1<\/sup>
1<\/sup> Division of Toxicology, Wageningen University and Research
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-25<\/a><\/h2>\n\n\n\n

Use of RNA seq-based gene expression signatures of pesticide active substances in human kidney cells to support definition of cumulative assessment groups (CAGs) for risk assessment<\/a><\/h3>\n\n\n\n

Aafke Janssen1<\/sup>, Karsten Beekmann1<\/sup>, Deborah Rijkers1<\/sup>, Valerie van der Vorst1<\/sup>, Hans Mol1<\/sup>, Ad Peijnenburg1<\/sup>, Jochem Louisse<\/span><\/span>P1<\/sup>
1<\/sup> Wageningen Food Safety Research
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-26<\/a><\/h2>\n\n\n\n

Receptor-mediated activities of 4- and 5-ring unsubstituted and methylated polycyclic aromatic hydrocarbons (PAHs) in relation to their developmental toxicity potency<\/a><\/h3>\n\n\n\n

Jing Fang<\/span><\/span>P1<\/sup>, Danlei Wang1<\/sup>, Ivonne Rietjens1<\/sup>, Peter Boogaard1<\/sup>, Lenny Kamelia2<\/sup>
1<\/sup> Division of Toxicology, Wageningen University and Research
2<\/sup> Shell Global Solutions International B.V.
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-27<\/a><\/h2>\n\n\n\n

Validation of skin and ocular irritation and severe damage (corrosion) tests as non-animal alternatives using OECD guideline evaluation substances<\/a><\/h3>\n\n\n\n

Paul Rawlinson1<\/sup>, Matthew  Tate1<\/sup>, Callum Stagg1<\/sup>, Gary  Henzell1<\/sup>, Elias Halkes-Wellstead<\/span><\/span>P1<\/sup>
1<\/sup> Gentronix Ltd
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-28<\/a><\/h2>\n\n\n\n

Vital human material as an innovative approach to move towards human-based science without animal research – What are the challenges ?<\/a><\/h3>\n\n\n\n

Cyrille Krul1<\/sup>, Erin Hill<\/span><\/span>P2<\/sup>
1<\/sup> University of applied sciences Utrecht
2<\/sup> Institute for In Vitro Sciences
P<\/sup> Presenting author<\/p>\n\n\n\n

P-MODELS-29<\/a><\/h2>\n\n\n\n

Perspective multi-modal acting compounds against SARS-COV-2 virus<\/a><\/h3>\n\n\n\n

J. Viskupicova 1<\/sup>, P. Rezbarikova 1<\/sup>, M. Soltesova Prnova 1<\/sup>, H. Kandarova<\/span><\/span>P1<\/sup>, M. Majekova 1<\/sup>
1<\/sup> Centre of Experimental Medicine SAS, Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, Dubravska cesta 9, SK-841 04 Bratislava, Slovak Republic
P<\/sup> Presenting author<\/p>\n\n\n\n

Go back<\/a> <\/p>\n\n\n\n

10. Nanoparticles research in vitro<\/h2>\n\n\n\n

P-NANO-1<\/a><\/h2>\n\n\n\n

ASSOCIATION OF DOXORUBICIN AND pH-SENSITIVE NANOPARTICLES CONTAINING AN ORGANOSELENIUM COMPOUND AS AN INNOVATIVE APPROACH TO SENSITIZE MDR CELLS: AN IN VITRO STUDY<\/a><\/h3>\n\n\n\n

Leticia B Macedo1<\/sup>, Daniele R Nogueira-Librelotto1<\/sup>, Daniela Mathes1<\/sup>, Raquel Mello da Rosa2<\/sup>, Oscar E Dorneles Rodrigues2<\/sup>, Clarice M Bueno Rolim1<\/sup>, M Pilar Vinardell<\/span>P3<\/sup>
1<\/sup> Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Departamento de Farm\u00e1cia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil
2<\/sup> Programa de P\u00f3s-Gradua\u00e7\u00e3o em Qu\u00edmica, Departamento de Qu\u00edmica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
3<\/sup> Departament de Bioquimica i Fisiologia, Facultat de Farmacia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Barcelona, Barcelona, Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-NANO-2<\/a><\/h2>\n\n\n\n

Toxicity of polystyrene micro- and nano-plastics in human A549 lung cells<\/a><\/h3>\n\n\n\n

Marta Pennati1<\/sup>, Judith Desmet1<\/sup>, Tiantian Wang1<\/sup>, Mahboubeh Hosseinzadeh1<\/sup>, Cinta Porte<\/span>P1<\/sup>
1<\/sup> IDAEA-CSIC
P<\/sup> Presenting author<\/p>\n\n\n\n

P-NANO-3<\/a><\/h2>\n\n\n\n

NEUROTOXICITY ASSESSMENT OF Cd\/Se QUANTUM DOTS NANOPARTICLES IN T98G HUMAN GLIOBLASTOMA CELLS THROUGH A TRANSCRIPTOMIC APPROACH<\/a><\/h3>\n\n\n\n

Encarnaci\u00f3n Fuster1<\/sup>, H\u00e9ctor Candela1<\/sup>, Jorge Est\u00e9vez1<\/sup>, Eugenio Vilanova1<\/sup>, Miguel A. Sogorb<\/span>P1<\/sup>
1<\/sup> Instituto de Bioingenier\u00eda, Universidad Miguel Hern\u00e1ndez de Elche, Avenida de la Universidad s\/n, 03202 Elche, Spain
P<\/sup> Presenting author<\/p>\n\n\n\n

P-NANO-4<\/a><\/h2>\n\n\n\n

New development for studying the genotoxicity of nanomaterials in liver cell models<\/a><\/h3>\n\n\n\n

Julia VARET1<\/sup>, Audrey BARRANGER1<\/sup>, Camille CROCHET1<\/sup>, Sylvie HUET1<\/sup>, Ludovic LE HEGARAT1<\/sup>, Val\u00e9rie FESSARD<\/span>P1<\/sup>
1<\/sup> Anses, Foug\u00e8res laboratory, Toxicology of contaminants unit
P<\/sup> Presenting author<\/p>\n\n\n\n

P-NANO-5<\/a><\/h2>\n\n\n\n

INVOLVEMENT OF OXIDATIVE STRESS AND CALCIUM SIGNALING IN NICKEL OXIDE NANOPARTICLES – INDUCED ALTERATIONS IN HUMAN PULMONARY ARTERY ENDOTHELIAL CELLS<\/a><\/h3>\n\n\n\n

Oph\u00e9lie Germande<\/span>P1,2<\/sup>, Sabrina Lacomme3,2<\/sup>, Etienne Gontier3,2<\/sup>, Jean – Fran\u00e7ois Quignard1,2<\/sup>, Roger Marthan1,2,4<\/sup>, Magalie Baudrimont5,2<\/sup>, Christelle Guibert1,2<\/sup>, Juliette Deweirdt *1,2<\/sup>, Isabelle Baudrimont *    *equal contribution6,7<\/sup>
1<\/sup> INSERM U 1045, CRCTB
2<\/sup> Universit\u00e9 de Bordeaux
3<\/sup> BIC, UMS 3420 CNRS \u2013 US4 INSERM
4<\/sup> CHU de Bordeaux
5<\/sup> UMR EPOC 5805
6<\/sup> INSERM U 1045, CRCTB 
7<\/sup> Universit\u00e9 de Bordeaux 
P<\/sup> Presenting author<\/p>\n\n\n\n

P-NANO-6<\/a><\/h2>\n\n\n\n

Cytotoxicity of nanomixtures: effects of silver and polystyrene nanoparticles on human macrophages<\/a><\/h3>\n\n\n\n

Krunoslav Ilic<\/span>P1<\/sup>, Nikolina Kalcec1<\/sup>, Lucija  Krce2<\/sup>, Ivica  Aviani2<\/sup>, Petra Tur\u010di\u01073<\/sup>, Ivan Pavi\u010di\u01071<\/sup>, Ivana Vinkovic Vrcek1<\/sup>
1<\/sup> Institute for Medical Research and Occupational Health
2<\/sup> Faculty of Science, University of Split
3<\/sup> Faculty of Pharmacy and Biochemistry, University of Zagreb
P<\/sup> Presenting author<\/p>\n\n\n\n

P-NANO-7<\/a><\/h2>\n\n\n\n

Erythrocyte photoassay as a preliminary tool to evaluate potential photoprotective activity of guarana-loaded nanosomes<\/a><\/h3>\n\n\n\n

Adriana Solange Maddaleno<\/span>P1<\/sup>, Isabel Roggia2<\/sup>, Patr\u00edcia Gomes2<\/sup>, Maria Pilar Vinardell1<\/sup>, Montserrat Mitjans1<\/sup>
1<\/sup> Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona, Spain
2<\/sup> Post Graduate Program in Nanosciences, Centro Universit\u00e1rio Franciscano, Santa Maria, Brazil
P<\/sup> Presenting author<\/p>\n\n\n\n

P-NANO-8<\/a><\/h2>\n\n\n\n

Exposure to polystyrene micro- and nano-plastics modifies the lipidome of zebrafish liver cells.<\/a><\/h3>\n\n\n\n

Tiantian Wang<\/span>P1<\/sup>, Cinta Porte1<\/sup>
1<\/sup> IDAEA-CSIC
P<\/sup> Presenting author<\/p>\n\n\n\n

P-NANO-9<\/a><\/h2>\n\n\n\n

In vitro phototoxicity assessment of nanoparticles<\/a><\/h3>\n\n\n\n

Min Beom Heo<\/span><\/span>P1<\/sup>, In Young Kim1<\/sup>, Tae Geol Lee1<\/sup>
1<\/sup> Korea Research Institute of Standards and Science
P<\/sup> Presenting author<\/p>\n\n\n\n

P-NANO-10<\/a><\/h2>\n\n\n\n

Effects of gold nanoparticles with protein corona on immune cell heterogeneity and cellular differentiation : A single cell based, high-dimensional mass cytometry study<\/a><\/h3>\n\n\n\n

Sehee Park<\/span><\/span>P1<\/sup>, My Ha2<\/sup>, Sook Jin Kwon3<\/sup>, Yangsoon Lee1<\/sup>, Jaewoo Song4<\/sup>, Tae Hyun Yoon1,3<\/sup>
1<\/sup> Hanyang University, Seoul, Republic of Korea
2<\/sup> Vaccine & Infectious Disease Institute, University of Antwerp, Belgium
3<\/sup> Yoon Idea Lab. Co. Ltd, Seoul, Republic of Korea
4<\/sup> Yonsei University, Seoul, Republic of Korea
P<\/sup> Presenting author<\/p>\n\n\n\n\n