in3logo An integrated interdisciplinary approach to animal-free nanomaterial and chemical safety assessment.

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The in3 project is funded by the EU's Marie Sklodowska-Curie Action - Innovative Training Network (MSCA-ITN for short) that aims to drive the synergistic development and utilisation of in vitro and in silico tools for human chemical and nanomaterial (NM) safety assessment. Here are our dedicated, motivated, dynamic, early stage researchers.

Coordinator: Prof. Dr. Paul Jennings
Training coordinator: Dr. Maxime Culot
Project manager: Dr. Ellen Langemeijer


  in3 Publications

1. Spinu, N., Bal-Price, A., Cronin, M. T. D., Enoch, S. J., Madden, J. C., & Worth, A. P. (2019). Development and analysis of an adverse outcome pathway network for human neurotoxicity. Archives of Toxicology. doi:10.1007/s00204-019-02551-1

2. Caballero-Alfonso, A. Y., Cruz-Monteagudo, M., Tejera, E., Benfenati, E., Borges, F., Cordeiro, M. N. D. S., . . . Perez-Castillo, Y. (2019). Ensemble-based modeling of chemical compounds with antimalarial activity. Current Topics in Medicinal Chemistry, 19(11), 957-969. doi:10.2174/1568026619666190510100313

3. Lagares, L. M., Minovski, N., & Novič, M. (2019). Multiclass classifier for P-glycoprotein substrates, inhibitors, and non-active compounds. Molecules, 24(10). doi:10.3390/molecules24102006

4. Rauch, C., Feifel, E., Kern, G., Murphy, C., Meier, F., Parson, W., . . . Wilmes, A. (2018). Differentiation of human iPSCs into functional podocytes. PLoS ONE, 13(9). doi:10.1371/journal.pone.0203869


in3 session EUSAAT Linz 2019

Paul Jennings, Marie-Gabrielle Zurich, Maxime Culot, Zahra Mazidi, Sara Wellens and Carolina Nunes at the in3 session in the EUSAAT meeting in Linz Austria in October 2019.

An integrated interdisciplinary approach to animal-free nanomaterial and chemical safety assessment: Results of the in3 project
Chairs: Paul Jennings, NL-Amsterdam & Maxime Culot, FR-Lens
    An introduction to the in3 project
Maxime Culot, FR-Lens, Paul Jennings, NL-Amsterdam 
  In3 Project: a European initiative to evaluate toxicity of chemicals using iPSCs derived in vitro models: Focus on blood brain barrier models for neurotoxicity assessment
Sara Wellens, FR-Lens
  Study the effect of cyclosporin A on functionality of endothelial cells differentiated from iPS cells as in vitro toxicology model system
Zahra Mazidi, AT-Vienna
  Evaluation of human induced Pluripotent Stem Cell derived podocyte-like cells for toxicity testing
Cormac Murphy, NL-Amsterdam (Jennings presented)
  In vitro distribution kinetics and neurotoxicity of the cardiac drug amiodarone in the iPSC-derived human 3D model BrainSpheres
Carolina Nunes, CH-Lausanne 

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in3 session ESTIV 2018 Berlin

The picture after our  in3 session flash presentation bonanza at the 20th International Congress on In Vitro Toxicology (ESTIV2018) New approach methodologies for in vitro toxicology applications at the Estrel Hotel Berlin Sonnenallee 225, Berlin, Germany, October 2018.  

in3 session Project Meetings and Training

Toxicity Assay hands on training. November 2018, Molecular and Computational Toxicity VU Amsterdam.

ESRs, PIs and SAB April 2018, The Last Supper, Milan. 

Building AOPs and the use of the AOP wiki / OECD Toolbox, hands on training July 2018, Liverpool John Moores University, Liverpool, United Kindgom. 

in3 kick off meeting. ESRs, PIs and SAB October 2017, O2 building  VU, Amsterdam.


in3 is funded by the Marie Sklodowska-Curie Action - Innovative Training Network under grant no. 721975.