Posters

Instructions for Poster Presenters

Please note that unlike what is written in the instructions for poster presentations, you will not be required to stand next to your poster during coffee and lunch breaks. There will be two dedicated poster presentation sessions:

Even poster numbers (not abstract numbers!) will present on Tuesday 4 June during Poster Session II (18:30 to 19:30)

Odd poster numbers will present on Wednesday 5 June during Poster Session III (18:30 to 19:30)

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Poster print service:

We offer a convenient local print service through Exposale for all your poster printing needs.

Pricing:

• The cost for print and onsite delivery is €80.00 excluding VAT if ordered before the deadline of May 17th.
• After May 17^th please ask a confirmation that the poster can be still printed depending on date of receiving the print file. The price for late poster printing is €120.00 excluding VAT.

Payment Information:

Please note that payment must be completed before the poster is printed.

Preparing Print Files for Large Format Prints:

To ensure optimal results, please adhere to the following guidelines when preparing your print files:

• All posters must be designed in portrait orientation.
• Poster format should be A0 (width: 84.1cm / 33.1in; height: 118.9cm / 46.8in).
• Accepted file type: standard print PDF.
• Ensure all print files are ideally 1:1 scale.
• Name your print files descriptively for easy identification.
• Convert all fonts into curves to avoid font compatibility issues.
• Ideal bitmap resolution is 100-150 DPI at final size; additionally, please keep individual file sizes under 100MB if possible.
• Include bleeds and correct crop marks for optimal printing.
• Use/send files in CMYK color space only.

Contact Information:

To order your printed poster or for any inquiries, please contact Josef Švec of Exposale:

• Email: josef.svec@exposale.cz

TOPICS

Bio-engineering, stem cells and disease models
Cardiotoxicity and cardiac efficacy models 
Case studies for successful use and implementation of complex in vitro models
Challenges in cosmetics safety
Computational toxicology – in silico modelling, read-across, artificial intelligence and machine learning
In vitro and in silico methods for safety assessment of medical devices
In vitro systems to assess respiratory toxicity
Knowledge sharing and education
Local toxicity testing (safety and efficacy)
Models and methods
Models, biomarkers and assays for developmental toxicity
Models, biomarkers and assays for endocrine disruption
Models, biomarkers and assays for systemic and immune toxicity
Non-animal methods for safety testing of biopharmaceuticals/biotherapies/vaccines
Organ-on-a-chip & Microphysiological Systems
Other NAMs relevant topics

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Bio-engineering, stem cells and disease models 

P1

Hepatic programming of human skin-derived precursor cells into functional hepatocyte-like cells for in vitro liver research

Marth Stinckens^P1, Matthias  Rombaut², Alexandra Gatzios¹, Robim Marcelino Rodrigues¹, Tamara Vanhaecke¹, Joery De Kock^2
1 In Vitro Liver Disease Modelling Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium
² Liver Therapy & Evolution Team, In Vitro Toxicology and Dermato-Cosmetology (IVTD) Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium
^P Presenting author

P2

3D bioprinting of human skin and squamous cell tumors as advanced models for precision medicine

Stefano Lorenzetti^P1, Milena Mikhail¹, Laura Di Benedetto¹, Valeria Bartolocci², Rosanna Monetta², Sofia Raniolo³, Isabella De Angelis¹, Elena Dellambra², Cristina Maria Failla², Sara Maria Giannitelli^3
1 ISS – Istituto Superiore di Sanità
² IDI-IRCCS
³ University Campus Biomedico
^P Presenting author

P3

3D human stem-cell-derived neurons to complement the in vitro neurotoxicity testing for Methylglyoxal

Uliana De Simone¹, Francesca Caloni^P2, Laura Villani³, Luciana Alessandra Russo³, Teresa Coccini^1
1 Istituti Clinici Scientifici Maugeri IRCCS SpA-SB, Laboratory of Clinical and Experimental Toxicology, Toxicology Unit, Pavia, Italy
² Università degli Studi di Milano (ESP)
³ Istituti Clinici Scientifici Maugeri IRCCS, Pathology Unit, Pavia, Italy
^P Presenting author

P4

IN VITRO 2D AND 3D KIDNEY MODELS TO STUDY THE NEPHROTOXIC RESPONSE OF URANIUM EXPOSURE

Marie frerejacques¹, Victoria Powell¹, Sebastien  Giraud², Annabelle Manoury¹, Clémence Finet¹, Céline Bouvier-Capely¹, Clara  Steichen^2,3, Thierry Hauet^2,3,4, Yann  GUEGUEN^P1
1 Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-SANTE, SESANE, Fontenay-aux-Roses, F-92262 France.
² Inserm U1313 – IRMETIST (Ischémie Reperfusion, Métabolisme et Inflammation Stérile en Transplantation), Poitiers, F-860000, France
³ Université de Poitiers, Faculté de médecine et de pharmacie, Poitiers, F-86000, France
⁴ CHU de Poitiers, service de biochimie, Poitiers, F-86000, France
^P Presenting author

P5

DEVELOPMENT OF A NOVEL RIBOSWITCH-BASED CELLULAR MODEL OF TDP-43 PROTEINOPATHY

Vito D’Alessandro^P1,2, Eleonora De Vitis^1,2, Alessia Foscarini², Velia  La Pesa³, Angelo Quattrini³, Alessandro Romano³, Sarah Mizielinska⁴, Francesca Gervaso², Alessandro Polini², Giuseppe Gigli^1,2
1 Dipartimento di Matematica e Fisica E. De Giorgi, Università del Salento, Lecce, Italy
² Institute of Nanotechnology, CNR Nanotec, Lecce, Italy
³ Division of Neuroscience, Institute of Experimental Neurology, IRCCS San Raffaele, Milan, Italy
⁴ UK Dementia Research Institute at King’s College London, London, UK
^P Presenting author

P6

Next -Generation Full-Thickness Human Skin Models Produced using 3D Electrospun Scaffolds and Animal-Component-Free Culture Media

Patrick Hayden^P1, Rayan Hodroj¹, Jayashree Chakravarty¹, Lisa Fitzgerald¹, Jake Pierson¹, Elizabeth Labbe¹, Jacob Le Do¹, Kyle Golden¹, Nathaniel Long¹, Matthew Phaneuf^1
1 BioSurfaces, Inc.
^P Presenting author

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Cardiotoxicity and cardiac efficacy models

P7

Assessment of the proarrhythmic effects of repurposed antimalarials for COVID-19 treatment using a comprehensive in vitro proarrhythmia assay (CiPA)

Seung Hyun Yoon¹, Ki-Suk Kim^P1
1 Korea Institute of Toxicology
^P Presenting author

P8

INTERPLAY BETWEEN CARDIOMYOCYTES AND CARDIAC FIBROBLASTS IN CARDIOTOXICITY CAUSED BY ANTHRACYCLINES, INVOLVEMENT OF THE ANGIOTENSIN-SIGNALLING PATHWAY

Ray Alsuhaibani^P1,2, Gavin Richardson³, Jason Gill^1
1 Transitional and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom
² Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Kingdom of Saudi Arabia
³ Biosciences Institute, Newcastle University, United Kingdom​
^P Presenting author

P9

Qualification of a 3D beating heart-on-chip platform for drug-induced cardiac contractility alterations analyses

Caterina Pernici^P1, Marco Mondini¹, Eva Vermersch², Ambroise Garry², Roberta Visone¹, Marco Rasponi³, Paola Occhetta^1,3
1 BiomimX Srl
² Global Investigative Toxicology Group Sanofi
³ Politecnico di Milano
^P Presenting author

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Case studies for successful use and implementation of complex in vitro models

P10

Decision making in Next Generation Risk Assessment (NGRA) for Skin Sensitisation: How Useful Read-Across Analogue Data Can Be

Nathalie Alépée^P1, Aynur Aptula², Dagmar Bury¹, Els DeConinck³, Johanna Ebmeyer⁴, Francoise Gautier¹, Nicola Gilmour², Sebastian Hoffmann⁵, Petra Kern³, Jochen Kühnl⁴, Cathy Lester⁶, Masaaki Miyazawa⁷, Kanako Nakayama⁷, Hayato Nishida⁸, Erwin van Vliet⁹, Gang Yan Yan^6
1 L’Oreal R&I, France
² Unilever, United Kingdom
³ Procter & Gamble Services NV/SA, Belgium
⁴ Beiersdorf AG, Germany
⁵ seh consulting + services, Germany
⁶ The Procter & Gamble Company, USA
⁷ Kao, Japan
⁸ Shiseido Global Innovation Center, Japan
⁹ Innovitox Consulting & Services, The Netherlands
^P Presenting author

P11

TOPICAL PROBIOTIC FORMULATION PROMOTES RAPID HEALING IN DOG KERATINOCYTE CELLS: A PROMISING APPROACH FOR WOUND MANAGEMENT

Manon Barthe^P1, Lionel  Gillot², Laurie Perdigon ¹, Aline Jacobs², Gregory Schoonbroodt², Paul Mauhin², Emna Bouhajja², Hanan Osman-Ponchet^1
1 PKDERM Laboratories, 45 Boulevard Marcel Pagnol, 06130 Grasse – France
² Probiotic Group Luxembourg S.A., Research and Development Department, 9944Weiswampach, Luxembourg
^P Presenting author

P12

Beneficial effect of hydrolysed marine collagen on physiology of skin models

Lorenzo Dondero^P1, Giulia De Negri Atanasio¹, Erica Lertora¹, Giorgia  Allaria¹, Francesca Rispo¹, Francesca Tardanico¹, Federica Robino², Elisabetta Perata², Raffaella Boggia³, Federica Turrini³, Damien Dupin⁴, Juliana De Souza Nunes⁴, Natividad Diaz⁴, Matteo Zanotti-Russo², Sara Ferrando¹, Elena Grasselli^1,5
1 Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy 
² ANGEL CONSULTING S.a.s. , Italy
³ Department of Pharmacy (DIFAR), University of Genoa, 16132 Genoa, Italy
⁴ CIDETEC, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Gipuzkoa, Donostia-San Sebastián, Spain
⁵ Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy
^P Presenting author

P13

NEW APPROACH METHODS – WHAT DETERMINES VALIDATED? A CASE STUDY USING THE IN VITRO BHAS42 CELL TRANSFORMATION ASSAY FOR CARCINOGENICITY PREDICTION

Darren KIDD^P1, Daniel BRAMHAM¹, Robel MEDHANE¹, Joanne LARNER^1
1 Labcorp Early Development Laboratories Ltd, In Vitro Toxicology Group, Harrogate, UK
^P Presenting author

P14

A BARRIER-ON-CHIP PLATFORM FOR CLINICALLY RELEVENAT SAFETY AND TOXICITY ASSESSMENT: A CASE STUDY OVERVIEW

Janick Stucki^P1, Giulia  Raggi¹, Lea Lara de Maddalena¹, Laurène Froment¹, Nicole Albrecher¹, Andreas Hugi¹, Léa Todeschini¹, Nina Hobi^1
1 AlveoliX AG, Swiss Organs-on-Chip Innovation, Bern, Switzerland
^P Presenting author

P15

BREAKING BARRIERS: IMPEDANCE-BASED ASSESSMENT OF CELLULAR FUNCTIONALITY IN COPD MIMICS

Thanh Huyen Phan¹, Huaikai Shi^2,3, Christopher E. Denes⁴, Alexander J. Cole^5,6, Eline Geervliet^P7, Yiwei Wang^2,8, Yuen Yee Cheng^3,9, Daniel Hesselson^5,6, Susan H. Roelofs⁷, Graham Gregory Neely^4,5, Jun‑Hyeog Jang¹⁰, Wojciech Chrzanowski^1
1 The University of Sydney, Sydney Nano Institute, Faculty of Medicine and Health, Sydney School of Pharmacy, Pharmacy and Bank Building A15, Camperdown, NSW 2006, Australia.
² Burns Research and Reconstructive Surgery, ANZAC Research Institute, Concord Hospital, University of Sydney, Sydney, Australia.
³ Asbestos Disease Research Institute, Concord Hospital, Sydney, Australia.
⁴ The Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre and School of Life & Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
⁵ Centenary Institute, The University of Sydney, Sydney, NSW 2006, Australia.y Institute, The University of Sydney, Sydney, NSW 2006, Australia.
⁶ Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
⁷ Locsense B.V., Locsense B.V., Enschede, The Netherlands.
⁸ Jiangsu Provincial Engineering Research Centre of TCM External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing, China.
⁹ Institute for Biomedical Materials and Devices (IBMD), School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Broadway, NSW 2007, Australia.
¹⁰ Department of Biochemistry, College of Medicine, Inha University, Incheon 400‑712, South Korea.
^P Presenting author

P16

A MULTIMODEL WORKFLOW TO TACKLE THE TOXICITY OF  FOODBORNE COMPOUNDS AT INTESTINAL LEVEL

Janice Bergen^P1,2,3, Francesco Crudo¹, Doris Marko¹, Franz  Berthiller⁴, Giorgia Del Favero^1,2
1 Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria
² Core Facility Multimodal Imaging, Faculty of Chemistry, University of Vienna, Vienna, Austria
³ Vienna Doctoral School in Chemistry (DoSChem), University of Vienna, Vienna, Austria
⁴ Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences, Vienna (BOKU), Austria
^P Presenting author

P17

TAILORMADE SOLUTIONS FOR CHALLENGES IN TESTING SKIN IRRITATION WITH MEDICAL DEVICES USING IN VITRO 3D SKIN MODELS

Ramona Gillere¹, Ulrike Theisen¹, Constantin Brinkmann^P1, Helge Gehrke^1
1 Eurofins BioPharma Product Testing Munich GmbH
^P Presenting author

P204

EX VIVO EVALUATION OF THE OPHTHALMIC BIODISTRIBUTION OF THE PESTICIDES TEBUCONAZOLE AND PYRACLOSTROBIN

Asley  Thalia Medeiros Souza1¹, Leila  Bastos Leal¹, Davi  Pereira de Santana¹, Laís  Matias da Silva¹, Juliana Falcato Vecina^P2
1 Federal University of Pernambuco, Pharmaceutical and Cosmetics Development Center (NUDFAC)
² Mérieux NutriSciences
^P Presenting author

P210

Hepatic 3D cell models for assessment of genotoxic effects induced by BPA, BPC, BPAP and their complex mixtures

Martina Štampar^P1, Tim Ravnjak^1,2, Alja  Štern¹, Bojana Žegura^1,2
1 Department for genetic toxicology and cancer biology, National Institute of Biology, Slovenia;
² Jozef Stefan International Postgraduate School, Slovenia
^P Presenting author

P214

DEVELOPMENT OF IN-VITRO 3D OSTEOARTHRITIS MODEL FOR DRUG SCREEING

Eun-Ji Gwak¹, Chaeyeon Lee¹, Hyuna Lee¹, Suhhee Yeom¹, Su-Hyon  Lee¹, Jungsun Lee^1
1 R&D Institute, Biosolution Co.,Ltd., Seoul, Republic of Korea
^P Presenting author

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Challenges in cosmetics safety  

P18

Predicting eye irritation for wash-off products using in vitro testing methods

Minseok Choi^P1, Go Un Kim^1
1 Safety and Microbiology Lab, R&I Center, AMOREPACIFIC, Yongin, Republic of Korea
^P Presenting author

P19

Safety Assessments Of Cosmetic Ingredients Exclusively Based On Data From New Approach Methodologies

Thorsten Diedam^P1, Martina Hermann¹, Simone Hoffmann-Doerr¹, Detlef  Keller^1
1 Henkel AG & Co. KGaA, Düsseldorf, Germany
^P Presenting author

P20

Read-across supported by new approach methodologies for assessing repeated-dose systemic toxicity : a case study with octisalate

Ann Detroyer^P1, Gladys Ouedraogo¹, Audrey Noel-Voisin¹, Anne Riu¹, Françoise Gautier¹, Sebastien  Gregoire¹, Nazanin Golbamaki¹, Anne Moustie¹, Romain Grall¹, Matthew Burbank^1
1 L’Oreal R&I, France
^P Presenting author

P21

CHEMICAL CHARACTERIZATION, VIABILITY, AND OXIDATIVE DAMAGE PREVENTION IN MACROPHAGES WITH Ocimum gratissimum OIL NANOEMULSION

Julia Salles Gava^P1, Hildegardo Seibert França^2,3, Iana Soares Pessoa⁴, Tamires  Cruz dos Santos⁴, Marcio  Fronza^1,4
1 Pharmaceutical Sciences Graduate Program, Vila Velha University, Vila Velha, ES, Brazil
² Federal Institute of Espírito Santo, Vila Velha, ES, Brazil
³ Multiuser Biomolecular Analysis Laboratory, Federal University of Espírito Santo Vitória, ES, Brazil
⁴ Postgraduate Program in Plant Biotechnology, Vila Velha University, Vila Velha, ES, Brazil
^P Presenting author

P22

NEXT GENERATION RISK ASSESSMENT (NGRA) FOR SKIN SENSITISATION: A CASE STUDY INCORPORATING READ-ACROSS

Petra Kern¹, Nathalie Alépée², Nora Aptula³, Dagmar Bury⁴, Els DeConinck⁵, Johanna Ebmeyer^P6, Francoise Gautier⁴, Nicola Gilmour³, Sebastian Hoffmann⁷, Jochen  Kühnl⁶, Cathy Lester⁸, Masaaki Miyazawa⁹, Kanako Nakayama⁹, Hayato Nishida¹⁰, Erwin van Vliet¹¹, Gang Yan^8
1 Procter & Gamble Services NV/SA, Strombeek-Bever
² L’Oréal, Aulnaysous-Bois, France
³ Unilever, Bedford, United Kingdom
⁴ L’Oréal, Clichy, France
⁵ Procter & Gamble Services NV/SA
⁶ Beiersdorf AG, Hamburg, Germany
⁷ seh consulting + services, Paderborn, Germany
⁸ The Procter & Gamble Company, Mason, OH
⁹ Kao, Tochigi, Japan
¹⁰ Shiseido Global Innovation Center, Takashima, Japan
¹¹ Innovitox Consulting & Services
^P Presenting author

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Computational toxicology – in silico modelling, read-across, artificial intelligence and machine learning

P23

A STRUCTURE-BASED VIEW ON THYROID HORMONE HOMEOSTASIS

Julia Kandler^P1
1 University of Vienna
^P Presenting author

P24

Enriched Systemic Fingerprints for Predicting Drug-Induced Cholestasis

Palle Helmke^P1, Gerhard Ecker^1
1 Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek Platz 2, 1090 Vienna, Austria
^P Presenting author

P25

Application of induced-fit docking for elucidation of a molecular initiating event at the human cytochrome b-c1 complex

Karin Grillberger^P1, Gerhard F. Ecker^1
1 University of Vienna
^P Presenting author

P26

EVALUATION OF THE HEALING CAPACITY OF AN AMPHIBIAN SKIN PEPTIDE IN TWO-DIMENSIONAL CELLULAR MODELS AND ANALYSIS THROUGH AUTOMATIC SEGMENTATION

Erica Lertora^P1, Lorenzo Dondero¹, Giulia De Negri Atanasio¹, Francesca Tardanico¹, Francesca Rispo¹, Giorgia Allaria¹, Vito Paolo Pastore², Alessandro Catenazzi³, Matteo Zanotti-Russo⁴, Elena Grasselli^1,5
1 Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132, Genoa, Italy
² Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, 16132, Genoa, Italy
³ Department of Biological Sciences, Florida International University, Miami, FL, USA
⁴ Angel Consulting, 20122 Milano, Italy
⁵ Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy
^P Presenting author

P27

Data-driven approaches to elucidate toxicological effects at different scales in zebrafish embryos

Wibke Busch^P1, Paul Michaelis¹, Nils Klüver^1
1 UFZ
^P Presenting author

P28

ProtoPRED: a fast tool to predict physicochemical, (eco)toxicological and pharmacokinetic properties of chemicals with QSAR models

Salvador Moncho¹, Laureano E. Carpio¹, Addel Goya¹, Eva Serrano-Candelas¹, Rafael Gozalbes¹, Simon Perera del Rosario^P1
1 ProtoQSAR
^P Presenting author

P29

Bridging AI/ML Advancements with Risk Assessment Needs: A Journey Towards Effective Use and Regulatory Acceptance

Serhii Kolesnyk^P1,2, Nicolas Roth^1,2, Angela Bearth^1,2, Martin Wilks^1,2
1 Swiss Centre for Applied Human Toxicology, University of Basel, Switzerland
² Department of Pharmaceutical Sciences, University of Basel, Switzerland
^P Presenting author

P30

In silico profile of 14 microcystins (MCs): data regarding hepatoxicity and carcinogenicity to help prioritize MCs of concern

Enzo Moreira Silva^P1,2, Cynthia Bomfim Pestana¹, Marize Marzo Solano², Philip Marx-Stoelting², Daniela Morais Leme^1,2
1 Department of Genetics, Federal University of Parana, Curitiba, PR, Brazil
² German Federal Institute for Risk Assessment
^P Presenting author

P31

GENOITS: A WEB-BASED TOOL IMPLEMENTING A PREDICTIVE GENOTOXICITY INTEGRATED TESTING STRATEGY USING QSAR-BASED TOOLS.

José Luis Vallés Pardo^P1, Donna S. MacMillan², Mar Crespo³, Salvador Moncho¹, Addel A. Goya-Jorge¹, Eva Serrano-Candelas¹, Rafael Gozalbes^1,4
1 ProtoQSAR
² Humane Society International
³ Toxiconsultant S.L.
⁴ MolDrug AI Systems SL
^P Presenting author

P32

Improving understanding of toxicologically relevant molecular and cellular targets: The ICCS Higher Tier Evaluation Working Group

Matthew Burbank^P1, Amaia  Irizar², Predrag  Kukic³, Silja Voß⁴, Torben Koenig⁵, Gladys Ouedraogo¹, Catherine Mahony^6
1 L’Oréal Research & Innovation, Aulnay-sous-Bois, France
² The International Fragrance Association (IFRA), Switzerland.
³ Unilever, Colworth Science Park, Bedford, UK
⁴ Beiersdorf AG, Hamburg, Germany
⁵ International Collaboration on Cosmetics Safety (ICCS), NJ, USA.
⁶ Procter & Gamble Technical Centers LTD, Reading, UK
^P Presenting author

P33

The nephron physiological map and associated disease ontologies: developing NAMs for chemical risk assessment in the kidney

Alessio Gamba^P1, Luiz Ladeira¹, Devon A. Barnes², Manoe J. Janssen², Marc Teunis³, Rosalinde Masereeuw², Liesbet Geris^1,4, Bernard Staumont^1
1 Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Belgium
² Utrecht Institute for Pharmaceutical Sciences, Div. Pharmacology, Utrecht University, The Netherlands
³ Innovative Testing in Life Sciences & Chemistry, Utrecht University of Applied Sciences, The Netherlands
⁴ Skeletal Biology and Engineering Research Center, KU Leuven, Belgium
^P Presenting author

P34

Ecotoxicological Evaluation of Bisphenol A and alternatives: A Comprehensive in silico Modelling Approach

Liadys Mora Lagares^P1, Marjan Vračko^1
1 National Institute of Chemistry
^P Presenting author

P35

Development of a generic physiologically based kinetic model to compare internal exposure to organophosphate pesticides in rats and humans

Thijs Moerenhout^P1, Jiaqi Chen¹, Hans Bouwmeester¹, Ivonne M.C.M. Rietjens¹, Nynke I. Kramer^1
1 Division of Toxicology, Wageningen University and Research
^P Presenting author

P36

Mapping Physiology As A Basis For Building Disease Ontology Maps

Bernard Staumont^P1, Luiz Ladeira¹, Alessio Gamba¹, Anouk Verhoeven², Julen Sanz Serrano², Eliška Kuchovská³, Job Berkhout⁴, Devon A. Barnes⁵, Manoe J. Janssen⁵, Marc Teunis⁶, Thomas H. Luechtefeld⁷, Thomas Hartung⁸, Ramiro Jover⁹, Tamara Vanhaecke², Ellen Fritsche¹⁰, Harm J. Heusinkveld⁴, Aldert Piersma¹¹, Rosalinde Masereeuw⁵, Mathieu Vinken², Liesbet Geris^12
1 Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Liège, Belgium
² Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Brussels, Belgium
³ IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany
⁴ Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
⁵ Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
⁶ Innovative Testing in Life Sciences & Chemistry, University of Applied Sciences Utrecht, The Netherlands
⁷ ToxTrack, Baltimore, MD, USA
⁸ Center for Alternatives to Animal Testing (CAAT) – Europe, University of Konstanz, Germany; CAAT, Johns Hopkins University, Baltimore, MD, USA; Johns Hopkins University, Doerenkamp-Zbinden Chair for Evidence-based Toxicology, Baltimore, MD, USA
⁹ Departamento de Bioquímica y Biología Molecular, Universidad de Valencia, Valencia, Spain; Experimental Hepatology and Liver Transplant Unit, Health Research Institute La Fe, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain
¹⁰ IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany
¹¹ Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
¹² Biomechanics Research Unit, GIGA In Silico Medicine, University of Liège, Liège, Belgium; Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium
^P Presenting author

P37

In silico prediction and real-life exposure to a chemical mixture of pesticides

Yana Kolianchuk^P1, Inna  Rashkivska¹, Mojmir Mach^1
1 Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovakia
^P Presenting author

P38

In Silico Predictions of Toxicological Effects and Real-Life Exposure Risks of Common Food Additives

Inna Rashkivska^P1, Yana Kolianchuk¹, Mojmir Mach^1
1 Centre of Experimental Medicine of the Slovak Academy of Sciences, Bratislava, Slovakia
^P Presenting author

P209

Prediction of bird reproduction study endpoints via toxicokinetic-toxicodynamic modelling of in ovo exposure data

David Heckmann^P1, Thomas Martin², Barbara Bauer², Vanessa Baier³, Alicia Paini³, Stephan Schaller³, Patrick Hubbard⁴, Markus Ebeling¹, André Gergs^1
1 Bayer AG, Crop Science Division, Monheim, Germany
² Rifcon GmbH, Goldbeckstraße 13, 69493 Hirschberg an der Bergstraße, Germany
³ esqLABS GmbH, Am Sportplatz 7, 26683 Saterland, Germany
⁴ Eurofins EAG Agroscience, LLC, Easton, MD, USA
^P Presenting author

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In vitro and in silico methods for safety assessment of medical devices

P39

Exploring the acceptance of non-animal methods within the global regulatory landscape of medical devices

Charlotte Laupheimer¹, Arne Jaksch^P1
1 Department of Biocompatibility and Toxicology, JAKSCH LIFESCIENCE CONSULTING GmbH
^P Presenting author

P40

New Approach Methods for Challenging Toxicological Risk Assessments of Medical Devices: A Case Study of Phenyl Propyl Carbonate

Charlotte Laupheimer¹, Shaheena Parween¹, Yana  Kolianchuk¹, Arne Jaksch^P1
1 Department of Biocompatibility and Toxicology, JAKSCH LIFESCIENCE CONSULTING GmbH
^P Presenting author

P41

IN VITRO EVALUATION OF ABSORPTION PROFILE AND EFFICACY OF LACTOFERRIN CONTAINED IN A NASAL SPRAY FORMULATION

Alessandra Zerboni¹, Sara Stoilova¹, Daniele Colombo¹, Michela Mori^P1
1 1MED SA, Via Campagna 13, CH-6982 Agno Switzerland
^P Presenting author

P42

IN VITRO EVALUATION OF INNOVATIVE BIOMATERIALS FOR TISSUE ENGINEERING: WHEY PROTEIN ISOLATE AND CHITOSAN DERIVATES INTERACTION PRODUCTS

Daiana Ianev^P1, Barbara Vigani¹, Michela Mori², Caterina Valentino¹, Marco Ruggeri¹, Giuseppina Sandri¹, Silvia Rossi^1
1 Department of Drug Science, University of Pavia, Via T. Taramelli 12, 27100, Pavia
² 1MED SA, Via Campagna 13, CH-6982 Agno Switzerland
^P Presenting author

P43

IN VITRO IRRITATION OF MEDICAL DEVICES INTENDED FOR APPLICATION TO THE ORAL, VAGINAL OR RECTAL MUCOSA

Barbara De Servi¹, Christian Pellevoisin^P2, Marisa Meloni^3
1 VitroScreen, Milan, Italy
² Urbilateria, Tours, France
³ VitroScreen
^P Presenting author

P44

USE OF AN IN VITRO-TO-IN VIVO EXTRAPOLATION (IVIVE) APPROACH TO DERIVE COMPOUND-SPECIFIC TOLERABLE iINTAKE (TI) VALUES FOR PHTHALATE ESTERS

Anh Nguyen¹, Ronald Brown^P1
1 Risk Science Consortium, LLC
^P Presenting author

P45

Development of an in vitro test method for irritation of medical devices used in the oral cavity

Marek Puskar^P1, Jennifer Molignano², Christian Pellevoisin², Silvia Letasiova¹, Mitchell Klausner^2
1 MatTek In Vitro Life Science Laboratories, Mlynske nivy 73, 821 05 Bratislava, Slovakia
² MatTek Corporation, 200 Homer Ave, MA 01721  Ashland, Massachusetts, United States of America
^P Presenting author

P46

Identification of compounds with weak skin irritation potential using human 3D reconstructed epidermis model

Jan Markus^P1, Jana Halajova¹, Lenka Hudecova¹, Christian Pellevoisin², Marek Puskar¹, Mitchell Klausner², Silvia Letasiova^1
1 MatTek In Vitro Life Science Laboratories, Mlynske Nivy 73, 82105 Bratislava, Slovakia
² MatTek Corporation, 200 Homer Ave, Ashland, MA, USA
^P Presenting author

P47

Integrated Risk Assessment and Compliance Strategies for Nanomaterials in Medical Devices

Chiara Gazerro^P1, Maria Labianca¹, Carla  Landolfi^1
1 ToxHub Srl
^P Presenting author

Go back

In vitro systems to assess respiratory toxicity

P48

Dosing concepts in air-liquid interface (ALI) in vitro inhalation approaches.

Detlef Ritter^P1, Tanja Hansen^1
1 Fraunhofer ITEM, Hannover, Germany
^P Presenting author

P49

The effects of nicotine base on oxidative stress and autophagy in the alveolar-capillary barrier in vitro show similarities with the pathophysiological features of COPD

Amelia-Naomi SABO^P1, Emma FILAUDEAU¹, Guillaume BECKER¹, Laurent  MONASSIER¹, Véronique KEMMEL^1
1 Laboratoire de Pharmacologie et Toxicologie Neurocardiovasculaire, University of Strasbourg, France
^P Presenting author

P50

ADVANCING AEROSOL NANOPARTICLE CYTOTOXICITY ASSESSMENT THROUGH A NOVEL “CELLS ON PARTICLES” IN VITRO MODEL

Edvinas Krugly^P1, Edvardas Bagdonas², Jovilė Raudoniūtė², Preethi Ravikumar¹, Aistė Pupiūtė¹, Darius Čiužas¹, Tadas Prasauskas¹, Rūta Aldonytė², Dainius Martuzevičius^1
1 Faculty of Chemical Technology, Kaunas University of Technology, Lithuania
² Centre for Innovative Medicine, Vilnius, Lithuania
^P Presenting author

P51

Evaluation of the predictiveness of the acellular inhalation bioaccessibility test of ultrafine combustion particle-bound polycyclic aromatic hydrocarbons for assessing particulate matter lung toxicity

Albana Boutamba Mbina^P1, Tiphaine Rogez-Florent², Christelle Monteil^2
1   Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTE UR 4651, F-76000 Rouen, France
² Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, ABTE UR 4651, F-76000 Rouen, France
^P Presenting author

P52

Chemical analysis and cytotoxicity studies of different berry e-liquid flavors according to two exposure methods on an alveolar-capillary barrier cell model

Emma Filaudeau^P1, Amelia-Naomi  Sabo^1,2, Anita  Lebert ¹, Laurent  Monassier¹, Véronique  Kemmel^1,2
1 Laboratoire de Pharmacologie et Toxicologie Neurocardiovasculaire, UR 7296, Faculté de Médecine  de Maïeutique et des Métiers de la Santé, Centre de Recherche en Biomédecine de Strasbourg (CRBS),  67085, Strasbourg, France
² Laboratoire de Biochimie et Biologie Moléculaire, Hôpitaux Universitaires de Strasbourg, 67200,  Strasbourg, France
^P Presenting author

P53

Assessing lung metabolic competency for in vitro inhalation toxicology applications: a single-cell RNA sequencing strategy

Nuria Roldan^P1, Vivek S Patel², Joseph Hughes², Méry Marimoutou², Jose Alvarez², McKenzie Obermok², Carlos Rodriguez², Thomas Kallarakal², Andreas O Stucki¹, Amy J Clippinger¹, Holger P Behrsing^2
1 PETA Science Consortium International e.V., Stuttgart, DE
² Institute for In Vitro Sciences, Inc., Gaithersburg, MD, USA
^P Presenting author

P54

Advanced immunocompetent in vitro primary human lung models for toxicity assessment and infectious disease research

Samuel Constant^P1
1 Epithelix
^P Presenting author

P55

TOXICITY OF REAL-WORLD SUBWAY EMISSIONS IN A MOBILE ALI EXPOSURE MODEL

Micol Introna^P1, Ana T.  Juárez-Facio¹, Sarah S. Steimer¹, Minghui Tu², Ulf Olofsson ², Hanna L.  Karlsson³, N. V. Srikanth  Vallabani³, Karine Elihn^1
1 Stockholm University
² KTH Royal Institute of Technology
³ Institute of Environmental Medicine, Karolinska Institutet
^P Presenting author

P56

In situ exposure of human lung epithelial cells cultured in air-liquid interface to assess effect of air pollution of different influences

Suen Boulé^P1, Fabrice Cazier², Dominique Courcot¹, Yann Landkocz^1
1 Unité de Chimie Environnementale et Interactions sur le Vivant, UCEiV UR4492, Univ. Littoral Côte d’Opale (ULCO), Dunkerque, France.
² Centre Commun de Mesures, Univ. Littoral Côte d’Opale (ULCO), Dunkerque, France.
^P Presenting author

P57

Impact of airborne particulate matter from port, industrial and urban areas on epithelial-to-mesenchymal transition on lung cells.

Yann Landkocz^P1, Margaux Cochard¹, Fréderic Ledoux^1
1 Unité de Chimie Environnementale et Interactions sur le Vivant, UCEiV UR4492, Univ. Littoral Côte d’Opale (ULCO), Dunkerque, France
^P Presenting author

P58

DEVELOPMENT OF A MOBILE ALI EXPOSURE SYSTEM FOR TOXICITY TESTING OF EMISSIONS FROM DIFFERENT TRANSPORTATION MODES

Ana Teresa Juárez Facio^P1, Micol Introna¹, Sara S. Steimer¹, Karine Elihn^1
1 Stockholm University
^P Presenting author

P59

An integrated human-in vitro approach to explore the role of miRNAs in the allergic asthma

Valentina Galbiati¹, Filippo Liviero², Gloria Melzi¹, Francesca Carlotta Passoni^P1, Emanuela Corsini¹, Marina Marinovich^1
1 Università degli Studi di Milano
² Azienda Ospedale – Università di Padova
^P Presenting author

P60

Effects of repeated exposure of human 3D bronchial tissue to fresh smoke and aerosol from heated tobacco products and electronic vapour products

Sarah Jean Pour^P1, Roman Wieczorek¹, Edgar Trelles Sticken¹, Fiona Chapman², Liam Simms², Matthew Stevenson^2
1 Reemtsma Cigarettenfabriken GmbH, an Imperial Brands PLC Company
² Imperial Brands PLC
^P Presenting author

P61

Assessment of a Heated Tobacco Product in the ToxTracker and ToxProfiler assays reveal marked reductions in biological activity compared to a combustible cigarette

Ourania Komini^P1, Remco  Derr², Inger  Brandsma², Bas  ter Braak², Liesanne  Wolters², Edgar Trelles  Sticken³, Roman  Wieczorek³, Sarah  Jean Pour³, Fiona  Chapman¹, Liam Simms¹, Matthew Stevenson^1
1 Imperial Brands PLC
² Mimetas BV
³ Reemtsma Cigarettenfabriken GmbH
^P Presenting author

P62

MULTIPLEX ENDPOINT FOR LONGITUDINAL CHARACTERIZATION OF OXIDATIVE STRESS USING IN VITRO 3D LUNG EPITHELIAL CULTURES

Jorge Pereira^P1
1 PMI R&D, Philip Morris Products S.A., Switzerland.
^P Presenting author

P63

Contemporary in vitro Toxicology Assessment of a Novel Herbal Heated Product (HHP) Compared to Cigarette Smoke

Emma Bishop¹, Fan Yu¹, Stela Bozhilova¹, Fabio Miazzi¹, Yihe Li¹, Lauren Smith¹, David  Smart¹, Damien Breheny^P1
1 B.A.T. (Investments) Ltd.
^P Presenting author

P64

EXPLORING THE POTENTIAL OF EPIGENOTOXICITY TO ASSESS RESPIRATORY EFFECTS OF NANOMATERIALS TOWARDS THEIR RISK ASSESSMENT AND REGULATION

Célia Ventura^1,2, Luís Vieira^1,2, Catarina  C. Silva^1,2, Henriqueta Louro^1,2, Maria João Silva^P1,2
1 National Institute of Health Doutor Ricardo Jorge (INSA), Department of Human Genetics, Lisbon, Portugal
² Centre for Toxicogenomics and Human Health (ToxOmics), NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal
^P Presenting author

P65

FLAVOURS IN E-LIQUIDS – TOXICOLOGICAL INVESTIGATIONS ON RELEVANT IN VITRO LUNG MODELS

Leonie Gloger^P1, Jan Heide², Sebastian Malke³, Johannes Becker¹, Evelyn Kuhn¹, Anja Huber¹, Sven Ehlert², Selina Rinaldi³, Elke Pieper³, Mathilde N. Delaval¹, Ralf Zimmermann^1,2
1 Munich, Germany
² Rostock, Germany
³ Berlin, Germany
^P Presenting author

P66

Coupling an atmospheric simulation chamber to an air/liquid interface cell exposure device to study the toxicity of prenol, a second-generation biofuel, and its ozonolysis products

Reem Al Mawla^1,2, Cécile Coeur¹, Nicolas Houzel¹, Antoine Truffier², Sylvain Billet^P2
1 Laboratoire de Physico-Chimie de l’Atmosphère (LPCA), Université du Littoral Côté d’Opale, Dunkerque, France
² Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), Université du Littoral Côte d’Opale, Dunkerque, France
^P Presenting author

P201

Use of 3D Airway Tissue Models Cultured from Rat, Primate, or Human Cells for Translational Inhalation Studies

Seyoum Ayehunie¹, Robert Jackson¹, Kaitlyn Coen¹, Timothy Landry¹,  Jan Markus², Silvia Letasiova², Emily Reis^P2, Alex  Armento^1
1 MatTek Corporation, Ashland, MA, USA
² MatTek Europe, Bratislava, Slovakia
^P Presenting author

Go back

Knowledge sharing and education

P67

A new animal product free defined universal cell culture medium: Easy to use, do-it-yourself and beneficial for 2D and 3D culturing of normal and cancer cells

Stina Oredsson¹, Atena  Malakpour-Permlid², Tilo Weber^P3, Jeffrey  Bajramovic^4
1 Department of Biology, Lund University, Lund, Sweden
² Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
³ Animal Welfare Academy of the German Animal Welfare Federation, Neubiberg, Germany
⁴ 3Rs Centre Utrecht, Utrecht University, Utrecht, The Netherlands
^P Presenting author

P68

Fun with NAMs

François Busquet^P1
1 Altertox academy
^P Presenting author

P69

Pioneering a Human-Centric Biology Research Database: The Age of Human Biology-Based Research.

Fabrizio Rossi¹, Wynand Alkema², François Busquet³, Tomas Novotny⁴, Nils  Hijlkema², Giuseppe Castro⁵, Pierre Deceuninck⁶, Marco Straccia^P1
1 FRESCI by SCIENCE&STRATEGY SL
² Tenwise BV
³ AlterTox srl
⁴ EcoMole sro
⁵ Ready2Use srl
⁶ European Commission Joint Research Centre
^P Presenting author

P70

DEVELOPING AND EMBEDDING EDUCATION PROGRAMMES IN CO-CREATION WITH RELEVANT STAKEHOLDERS: THE TRANSITION TO ANIMAL-FREE INNOVATION UTRECHT EXPERIENCE (TPI UTRECHT)

Daniela Salvatori^P1,2, Cyrille Krul³, Anne Kienhuis⁴, Merel  Ritskes-Hoitinga¹, Paul, L. Carmichael ⁵, Janneke Hogervorst^6
1 Veterinary Faculty, Utrecht University. The Netherlands
² on behalf of Transition to Animal-free Innovations Utrecht
³ University of Applied Sciences, Utrecht. The Netherlands
⁴ RIVM (Dutch National Institute for Public Health and Environment)
⁵ Safety and Environmental Assurance Centre, Unilever, United Kingdom
⁶ PETA UK, United Kingdom
^P Presenting author

P202

APPLICATION OF HEPATIC 3D SPHEROID MODEL IN ASSESSMENT OF LONG-TERM REPEAT DOSE HEPATOTOXICITY AND NON-ALCOHOLIC STEATOHEPATITIS

Priyanka Mishra^P1, Kirti  Shitiz¹, Rahul Date¹, Abhay Deshpande^1
1 Jai Research Foundation, India
^P Presenting author

P215

Promoting ethical science through education: Bridging the gap with the 3Rs

Axelle Cooreman^P1, Tamara Vanhaecke¹, Vera Rogiers^1
1 Laboratory of In Vitro Toxicology and Dermato-cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel
^P Presenting author

Go back

Local toxicity testing (safety and efficacy)

P71

NEW APPROACH METHODOLOGY TO SKIN EVALUATION FOR PESTICIDES: ADVANTAGES AND LIMITATIONS

Julio Cesar  Cianci¹, Thatiane  Nunes Santana¹, Leandro Fernando Felix², Letícia Braggion Bacchin Lara³, Carla Carolina  Munari¹, Bruna  Assunção Bechtold⁴, Nádia Aline  Corroqué⁵, Carlos Alberto  Goia⁴, Daniela  Viana¹, Luis Paulo  Fava⁶,  Marcelo  Toledo⁷, Juliana Falcato Vecina^P5
1 Laboratory Analyst – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
² Laboratory Assistant – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
³ Trainee – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁴ Specialist – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁵ Researcher – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁶ Laboratory Coordinator – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁷ Test Facility Manager – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
^P Presenting author

P72

EYE DAMAGE, WHAT IS THE BEST STRATEGY TO REGULATE MY PESTICIDE?

Thatiane  Nunes Santana¹, Julio Cesar  Cianci¹, Letícia  Braggion Bacchin Lara², Leandro  Fernando Felix³, Carla  Carolina Munari¹, Bruna  Assunção Bechtold⁴, Nádia Aline  Corroqué⁵, Daniela  Viana¹, Luis  Paulo Fava⁶, Marcelo Toledo⁷, Juliana Falcato Vecina^P5
1 Laboratory Analyst – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
² Trainee – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
³ Laboratory Assistent – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁴ Specialist – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁵ Researcher – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁶ Coordinator – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
⁷ Test Facility Manager – Mérieux NutriScience / Bioagri Laboratórios Ltda, Piracicaba-SP, Brazil.
^P Presenting author

P73

EPIGENETICS BIOMARKERS TO EVALUATE EARLY TOXICITY EFFECTS:  A DERMAL TOXICITY CASE STUDY OF ALUMINUM DIETHYLPHOSPHINATE

Enzo  Zini Moreira Silva^P1, Irisdoris Rodrigues de Souza¹, Daniela  Fiori Gradia¹, Daniel  Pacheco Bruschi¹, Danielle  Palma de Oliveira^2,3, Cynthia  Bomfim Pestana¹, Daniela  Morais Leme^1,3
1 Department of Genetics, Federal University of Parana (UFPR), Curitiba-PR/Brazil
² School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto-SP/Brazil
³ National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), Institute of Chemistry, Araraquara-SP/Brazil
^P Presenting author

P74

SKIN HYDRATION MEASUREMENT: AN IN VITRO APPROACH WITH TEER MEASUREMENT OF HUMAN EPIDERMIS RECONSTRUCTED COMPARED WITH IN VIVO METHODS

Guillaume LACOSTE¹, Alexandra  DIVET², Justine PENNEL², Charles REINIER², Sophie CATOIRE^P1
1 CELL ALTERNATIV, 60350 Trosly Breuil, FRANCE
² COSMEPAR, 44000 Nantes, FRANCE
^P Presenting author

P75

DEVELOPMENT OF A METHOD FOR ASSESSING THE IRRITANT AND SOOTHING EFFECT OF GINGIVAL PRODUCTS USING RECONSTRUCTED HUMAN GINGIVAL EPITHELIUM

Laëtitia BEAUDEQUIN¹, Adeline JOSSEAUME¹, Fabien GUILLON², Sophie CATOIRE^P1
1 CELL ALTERNATIV, 60350 Trosly Breuil, FRANCE
² STERLAB, 06224 Sophia-Antipolis, France
^P Presenting author

P76

RELEVANT END-POINTS TO DEFINE AN IN VITRO STUDY STRATEGY FOR NASAL APPLICATION PRODUCTS USING HUMAN NASAL EPITHELIUM RECONSTRUCTED

Adeline JOSSEAUME¹, Laëtitia BEAUDEQUIN¹, Johan GARDERES², Sophie CATOIRE^P1
1 CELL ALTERNATIV, 60350 Trosly Breuil, FRANCE
² LABORATOIRES GILBERT, 14200 Herouville Saint clair, France
^P Presenting author

P77

VALORIZING MARINE BYPRODUCTS FOR NUTRACEUTICAL APPLICATION

Giorgia Allaria^P1, Lorenzo Dondero¹, Francesca Tardanico¹, Francesca Rispo¹, Giulia De Negri Atanasio¹, Federica Robino², Elisabetta Perata², Raffaella Boggia³, Federica Turrini³, Rebeca Vázquez Sobrado⁴, Marίa Mercedes Alonso Martίnez⁴, Celina Costas Iglesias⁴, Matteo Zanotti Russo², Elena Grasselli^1
1 Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
² Angel Consulting, 20122 Milano, Italy
³ Department of Pharmacy, University of Genoa, 16148 Genoa, Italy
⁴ ANFACO-CECOPESCA, Colexio Universitario, 36310 Vigo, Spain
^P Presenting author

P78

UPCOMING ADOPTION OF A DEFINED APPROACH FOR EYE HAZARD IDENTIFICATION OF NEAT SOLIDS UNDER OECD TG 467?

NATHALIE ALEPEE^P1, ELS ADRIAENS^2
1 L’Oreal R&I
² Adriaens Consulting bv
^P Presenting author

P79

In vitro Hepatotoxicity Test for the Multiple Exposure to Functional Ingredients using AML-12 cells

Sohee LIM^P1, Minho SHIN¹, Hoonjeong KWON^1,2
1 Department of Food and Nutrition, Seoul National University, Seoul, Republic of Korea
² Research Institute of Human Ecology, Seoul National University, Seoul, Republic of Korea
^P Presenting author

P80

Unraveling the Interplay of chemicals and UVA Light: Inflammatory Cytokines as biomarkers of photosafety assessment

Adriana S Maddaleno^P1, Elisabet Teixidó², M Pilar Vinardell¹, Montserrat Mitjans^1
1 Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, Spain
² Toxicologia, Departament de Farmacologia, Toxicologia i Química Terapèutica, Universitat de Barcelona, Spain
^P Presenting author

P81

In vitro tolerance evaluation of cosmetic products: an overview of cutaneous and ocular irritation potential among different product categories

Charlène LEJAMTEL¹, Nathan STOCKMAN^P1, Coralie PLACENTI¹, Eva-Anne SUBILEAU², Christophe CHESNE^1,2
1 Eurosafe, Parc d’Affaires de la Bretèche, 35760 Saint-Grégoire, France
² Biopredic International, Parc d’Affaires de la Bretèche, 35760 Saint-Grégoire, France
^P Presenting author

P82

IN VITRO TEAR FILM INSTABILITY: A NEW PHYSICO-CHEMICAL APPROACH TO EVALUATE EYE DISCOMFORT

Laurent Guillet-Revol¹, Swati Kaushik¹, Thanh Pham¹, Koji Endo², Masanori Orita², Ingrid Gamba¹, Romain Cornet¹, Yoshimune Nonomura³, Caroline Rouas¹, Frédéric Amaral¹, Noémie de Crozé¹, Nathalie Alépée⁴, Fleur Tourneix^P5
1 L’Oréal Research & Innovation, France
² L’Oréal Research & Innovation, Japan
³ Yamagata University Faculty of Engineering, Japan
⁴ L’Oreal R&I
⁵ L’Oréal Research & Innovation
^P Presenting author

P83

3D toxicology models in animal-free nanofibrillar cellulose hydrogels.

Johanna Lampe^P1, Darren Heywood², Piia Mikkonen^1
1 UPM Biomedicals, Finland
² Promega, UK
^P Presenting author

P84

Skin sensitization assessment of pesticide formulations and their active components using the Integrated Testing Strategy

Mariela Lenze^1,2, Martina Daniela  Benedetti ^1,2, Juan Ignacio  Pina ³, Julieta  Roco^1,2, María Laura Gutiérrez^P1,2
1 National Research and Technological Council of Argentina (CONICET)
² Institute of Pharmacology, Buenos Aires University Medical School
³ Atanor S.C.A
^P Presenting author

P85

Harnessing Fish Side-Streams for Sustainable Cosmetics: The EcoeFISHent Project

Elena Grasselli^P1
1 University of Genoa
^P Presenting author

P86

Unveiling Lung Cell Responses to Nanolignin Particles Contributing to New Insights

Dalia de la Fuente-Vivas^P1, Emanuela  Bellinetto², Eleonora  Ruffini², Sofia P. Makri³, Sara Collado¹, Tanja  Meyer⁴, Gianmarco E. Griffini², Laura  Gómez-Cuadrado¹, Sonia  Martel¹, Rocío  Barros¹, Carlos  Rumbo^1
1 University of Burgos-ICCRAM
² Politecnico di Milano
³ Creative Nano PC
⁴ Bio Base Europe Pilot Plant
^P Presenting author

P87

Inter-species different effect of anticoagulant rodenticides. An in vitro approach.

David Hernández-Moreno^P1, Ana Valdehita¹, Azucena Bermejo-Nogales^1
1 Department of Environment and Agronomy, National Institute for Agriculture and Food Research and Technology (INIA, CSIC)
^P Presenting author

P88

Technical applicability of polymers to in vitro test methods – the skin irritation test (SIT)

Ayse Aktalay Hippchen^P1, Susanne  Kolle¹, Dorothee Funk-Weyer¹, Robert Landsiedel^1,2
1 BASF SE, Experimental Toxicology and Ecology, Ludwigshafen am Rhein, Germany
² Free University of Berlin, Pharmacy, Pharmacology and Toxicology, Berlin, Germany
^P Presenting author

P89

EpiOcular time-to-toxicity – a test method for subcategorization of eye irritants

Silvia Letasiova^P1, Lenka Hudecova¹, Jan Markus¹, Yulia Kaluzhny², Els Adriaens³, Mitch Klausner^2
1 MatTek In Vitro Life Science Laboratories, Mlynske Nivy 73, 82105 Bratislava, Slovakia
² MatTek Corporation, 200 Homer Ave, Ashland, MA, USA
³ Adriaens Consulting BVBA, Bellemdorpweg 95, 9981 Aalter, Belgium
^P Presenting author

P90

BETULINIC ACID GAMMA-CYCLODEXTRIN SUPRAMOLECULAR SYSTEM – AN IN VITRO ASSESSMENT ON 2D LUNG CELLS AND 3D RESPIRATORY TISSUE MODEL

Iasmina Marcovici^1,2, Iulia Pinzaru^P1,2, Cristina Dehelean^1,2
1 Toxicology, Drug Industry, Management and legislation University Clinic, “Victor Babes” University of Medicine and Pharmacy from Timisoara, 2 Sq. E. Murgu, 300041, RO
² Research Center for Pharmaco-toxicological Evaluations, “Victor Babes” University of Medicine and Pharmacy from Timisoara, 2 Sq. E. Murgu, 300041, RO
^P Presenting author

P91

Aerosol Chemistry and in vitro evaluation of a Novel Herbal Heated Product Relative to Cigarette Smoke

Ian Crooks^P1, Elinor Marwick¹, Amy Heath¹, Andrew Baxter¹, Maria Pinto¹, Kelly Pereira¹, Simone Hadley¹, Damien Breheny¹, Carolina Garcia-Canton^1
1 B.A.T (Investments) Ltd.
^P Presenting author

P92

c-SRC phosphorylation predicts skin irritation potential of chemicals using a tissue engineered skin model

Md Zobaer  Hasan^P1, Amy Leigh Harding², Hirofumi Nakanishi¹, Kiichiro Sohara¹, Tetsuo Furuno¹, Craig Murdoch², Helen Colley^2
1 Rohto Pharmaceutical CO., Ltd
² University of Sheffield
^P Presenting author

P207

In vitro Phototoxicity: Reconstructed Human Epidermis Phototoxicity test method – OECD 498 – Blinded Test

Christina Spohr^P1, Markus  Schulz^1
1 ICCR-Roßdorf GmbH
^P Presenting author

P213

EVALUATION OF SKIN CORROSIVITY PREDICTION USING THE 3D RECONSTRUCTED HUMAN EPIDERMIS MODEL, KeraSkin™

Jung-Eun  Park¹, Jiyoung Lee², Sanghee Lee², Su-Hyon  Lee¹, Lim Kyung-Min^3
1 R&D Institute, Biosolution Co., Ltd., Republic of Korea
² Environmental Health Research Department, NIER, Republic of Korea
³ College of Pharmacy, Ewha Womans University, Republic of Korea
^P Presenting author

Go back

Models and methods

P93

Beyond the Ink: Understanding Cellular and Molecular Effects of Iron-Based Tattoo Pigments on Macrophages

Marianne Vitipon^P1, Véronique  Collin-Faure ¹, Bastien  Dalzon¹, Thierry  Rabilloud ^1
1 Chemistry and biology of metals, UMR 5249 CNRS/CEA/UGA
^P Presenting author

P94

TOXICOLOGICAL IMPACT OF DEGRADED ORGANIC TATTOO PIGMENTS ON HUMAN CULTURED KERATINOCYTES

Lise Aubry^P1, Lucie  Breuillé¹, Thierry Douki^1
1 Univ. Grenoble Alpes, CEA, CNRS, IRIG, SyMMES, F-38000 Grenoble
^P Presenting author

P95

Is Schild method and the Gaddum equation still valid for receptor antagonist research?

Martin Ezechiáš^P1
1 Institute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, Prague, 142 20, Czech Republic
^P Presenting author

P96

IMAGE-BASED PHENOTYPIC PROFILING OF FISH GILL CELLS UNDERGOING CHEMICAL EXPOSURE

Barbara Jozef^P1, Sven Mosimann^1,2, Miha Tome³, Anze Zupanic³, Kristin Schirmer^1,2,4
1 Eawag: Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland
² ETH Zurich: Swiss Federal Institute of Technology, Zürich, Switzerland
³ NIB: National Institute of Biology, Ljubljana, Slovenia
⁴ EPFL: Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland
^P Presenting author

P97

Impact of Ellagic Acid and Pomegranate Extract on Oxidative Stress in In Vitro and In Vivo Models

Francesca Tardanico^P1, Giulia  De Negri Atanasio¹, Lorenzo Dondero¹, Francesca Rispo¹, Giorgia  Allaria¹, Guendalina  Olivero², Annamaria Pittaluga², Federica  Turrini², Raffaella Boggia², Erica Lertora¹, Sara Ferrando¹, Gianluca Damonte³, Annalisa Salis³, Katia Cortese³, Elena Grasselli^1,4
1 Department of Earth, Environment and Life Science, University of Genoa, Italy
² Department of Pharmacy, University of Genoa, Genoa, Italy
³ Department of Experimental Medicine, University of Genoa, Italy
⁴ Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy
^P Presenting author

P98

Daphnia magna model in the toxicity assessment of gliotoxin, ochratoxin A and its combination

Raquel Penalva-Olcina^P1,2, Cristina Juan¹, Monica Fernández-Franzón¹, Ana  Juan-García¹, Eeva-Riikka Vehniäinen^2
1 Laboratory of food Chemistry and Toxicology, University of Valencia
² Department of Biological and Environmental Science, University of Jyväskylä
^P Presenting author

P99

Application of miniaturized Ames assays to assess mutagenicity of nitrosamine impurities

Csaba Boglàri^P1, Cécile Koelbert^1
1 Xenometrix AG
^P Presenting author

P100

TOXICITY ASSESSMENT OF HIGH MOLECULAR WEIGHT POLYCYCLIC AROMATIC HYDROCARBONS ISOMERS: A STUDY FROM CYTOTOXICITY TO OXIDATIVE STRESS WITH DNA DAMAGE

Lara Ferreira Azevedo ^P1, Cecilia  Cristina de Souza Rocha ¹, Marília Cristina Oliveira Souza ¹, Ana Rita Thomazela Machado ¹, Paula  Pícoli Devóz ¹, Bruno  Alves Rocha ¹, Lusania Maria Greggi Antunes ¹, Andres  Campiglia ², Fernando  Barbosa Júnior ^1
1 University of Sao Paulo, School of Pharmaceutical Sciences of Ribeirao Preto, Department of Clinical Analyses, Toxicology, and Food Sciences. Av. do Café s/nº, 14040-903, Ribeirao Preto, Sao Paulo, Brazil
² Department of Chemistry, University of Central Florida, Orlando, FL 32816, USA
^P Presenting author

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Models, biomarkers and assays for developmental toxicity

P101

Epidemio-Toxicological profile of Colima. RESAS National Strategies in Government of Mexico.

Oliver Mendoza-Cano^P1,2, Ana Luz Quintanilla-Montoya^1,2, Irma E. González-Curiel³, Mónica Ríos-Silva¹, Octavio Gaspar-Ramirez⁴, Andrea  Camacho-de la Cruz⁵, Maria Fernanda Romo-García^6
1 Universidad de Colima
² CONAHCYT CEIBAAS Colima
³ Universidad Autónoma de Zacatecas
⁴ CIATEJ
⁵ acamacho.tox@gmail.com
⁶ Affmna@gmail.com
^P Presenting author

P102

EVALUATION of EMBRYOTOXICITY of THIRAM with ALTERNATIVE METHODOLOGIES

Yu-Chi  Ho¹, Chun-Wei  Tung², Ming-Hsien  Tsai¹, Chen-Yi  Weng¹, Ju-Hsin  Hsu¹, Hsien-Jen  Cheng¹, B Linju  Yen³, Pinpin  Lin^P1
1 National Institute of Environmental Health Sciences, National Health Research  Institutes, Zhunan, Taiwan, R.O.C.
² Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, Taiwan, R.O.C.
³ Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan, R.O.C
^P Presenting author

P103

APPLICATION OF QUANTITATIVE IN VITRO-TO-IN VIVO EXTRAPOLATION TO REPROTRACKER DATA PROVIDES CONSERVATIVE ESTIMATES OF IN VIVO DEVELOPMENTAL TOXICITY

Amer Jamalpoor^P1, Sabine Hartvelt¹, Marjory Moreau², Jeffrey Fisher², Andy Nong², Giel Hendriks^1
1 Toxys B.V.
² ScitoVation
^P Presenting author

P104

NEW APPROACH METHODOLOGIES FOR THE TERATOGENIC POTENTIAL: WHAT IF THE SOLUTION CAME FROM MECHANISTIC NETWORKS?

Matthew Burbank^P1, Florian Gautier¹, Nicky Hewitt², Audrey Noel-Voisin¹, Nazanin Golbamaki¹, Sébastien Grégoire¹, Anne Riu¹, Ann Detroyer¹, Typhaine Bringel¹, Laurent Guillet-Revol¹, Léopold Carron¹, Emilie Le Mevel¹, Noémie De Croze¹, Gladys Ouédraogo^1
1 L’Oréal Research & Innovation, Aulnay-sous-Bois, France
² Cosmetics Europe, Brussels, Belgium
^P Presenting author

P105

A GLOBAL APPROACH TO EVALUATE TERATOGENICITY, THYROID DISRUPTION, AND DEVELOPMENTAL NEUROTOXICITY PRODUCED BY ORGANIC CHEMICALS IN ZEBRAFISH EMBRYOS

Andrea Weiner¹, Ander Arbelaiz¹, Christoph Rummel¹, Arantza Muriana¹, Celia Rodriguez^P
1 BBD BioPhenix S.L.U (Biobide)
^P Presenting author

P106

Chemical Mixture Calculator 2.0: A Web-Based Tool Combining Predicted Human Exposures with High-Throughput In Vitro Toxicity Data to Support Mixture Risk Assessment

Ehab Mustafa^P1, Veronica von Saint Paul², Hilmar Ilgenfritz², Martin Scholze³, Anne Marie Vinggaard^1
1 National Food Institute, Technical University of Denmark, Denmark
² Labvantage – Biomax GmbH, Germany
³ Centre for Pollution Research and Policy, Environmental Sciences Division, Brunel University London, United Kingdom
^P Presenting author

P107

High throughput platform for the validation and application of zebrafish embryo for ICH S5 (R3)

Claudia  Miguel-Sanz¹, Irina Suárez ¹, Sofia  Barreiro¹, Valentina Schiavone¹, Vincenzo Di Donato¹, Anna Navarro^P1
1 ZeClinics, SL
^P Presenting author

P108

Bisphenol and its analogues induce neuroinflammation in BV2 microglial cells through the ROS-NF-κB signaling pathway

Jeong Doo Heo^P1
1 Korea Institute of Toxicology
^P Presenting author

P109

Developmental neurotoxic effects induced by PHMB exposure via oxidative stress mechanism: Integrated approaches with neuronal cells and zebrafish embryo models

Ha-Na Oh¹, Donggon  Yoo¹, Seungmin  Park¹, Sangwoo Lee^P1, Woo-Keun  Kim^1
1 Korea Institute of Toxicology
^P Presenting author

P110

Cytotoxic and Neurotoxic Effects of Copper Pyrithione and Zinc Pyrithione on Neuronal/Astrocytic Co-Cultured Cells Through Oxidative Stress

Ha-Na Oh¹, Woo-Keun Kim^P1
1 Korea Institute of Toxicology
^P Presenting author

P111

Validation of a human 3D high-throughput vasculogenesis model for developmental toxicity screening

Ashwin Shah^P1, Nicholas Dennison^1,2, Maximilian Fusenig¹, Solveig Klier¹, Tina Marie Hauser¹, Linda Sturm¹, Maria Alejandra Ramirez Martinez¹, Jannik Irmai³, Uwe Freudenberg¹, Carsten Werner^1,3
1 Leibniz Institute of Polymer Research Dresden, 01069 Dresden, Germany
² NeuronD, 01307 Dresden, Germany
³ Technische Unversitaet Dresden
^P Presenting author

P112

New insight into long-term effects of phthalates microplastics in developing zebrafish: Evidence from genomic alteration and organ development

Abdulkhalik Mansuri^P1, Krupa  Kansara², Dixit  Raiyani¹, Dhairya Mazmudar^1
1 Biological and Life Sciences, School of Arts & Sciences, Ahmedabad University, Central Campus, Navrangpura, Ahmedabad 380009, Gujarat, India
² Biological and Engineering Discipline, Indian Institute of Technology – Gandhinagar (IITGN), Palaj 382355, Gujarat, India
^P Presenting author

P211

THE METABOLOME OF CELL CULTURE SUPERNATANT AS A PROMISING COMPREHENSIVE BIOMARKER SOURCE FOR IN VITRO TOXICOLOGY

Christoph Magnes^P1, Elmar Zügner¹, Fernanda Monedeiro¹, Heinz Hammerlindl², Helmut Schaider^2
1 JOANNEUM RESEARCH, Institute for Biomedical Research and Technologies, Graz Austria
² Frazer Institute, The University of Queensland, Brisbane, QLD, Australia
^P Presenting author

P212

Screening of Developmental Toxicity Using IPSCs for Agrochemicals

Kathryn Rudd^P1, Yeyejide  Adeleye¹, Richard Currie¹, Theresa  Placke^2
1 Syngenta, Jealott’s Hill International Research Centre, Bracknell, UK
² Syngenta Crop Protection AG, Basel, Switzerland
^P Presenting author

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Models, biomarkers and assays for endocrine disruption

P113

TIME FRAME COMPARISON IN STEROIDOGENESIS ASSAY

Andrea RIVERO ARZE^P1, Elise  GRIGNARD¹, Pauline LELANDAIS¹, Philippe HUBERT^1
1 PEPPER – Paris (FR)
^P Presenting author

P114

EVALUATION OF CYTOTOXICITY AND METABOLISM OF T-2 TOXIN IN HEPATIC SPHEROIDS CULTURED IN MICROFLUIDIC DEVICES

Mercedes Taroncher^P1, Jose M. de Hoyos-Vega², Alan M. Gonzalez-Suarez², Kihak Gwon², Yelko Rodríguez-Carrasco¹, Maria Jose Ruiz¹, Alexander Revzin^2
1 Research Group in Alternative Methods for Determining Toxics Effects and Risk Assessment of Contaminants and Mixtures (RiskTox). Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100, Valencia, Spain
² Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA
^P Presenting author

P115

BUILDING CONFIDENCE IN IN VITRO BATTERIES FOR ENDOCRINE DISRUPTION TESTING

Vera Engelbrecht^P1
1 PETA Science Consortium International e.V.
^P Presenting author

P116

ASSESSING THE IMPACT OF PHYTOESTROGENS ON SKIN VIA NEXT-GENERATION RISK ASSESSMENT

Francesca Rispo^P1, Lorenzo Dondero¹, Giulia De Negri Atanasio¹, Giorgia Allaria¹, Francesca Tardanico¹, Erica  Lertora¹, Ilaria  Demori², Giosuè  Costa³, Emanuela Marchese³, Simón Perera-del-Rosario^4,5, Eva Serrano-Candelas⁴, Martina Palomino-Schätzlein⁴, Elisabetta  Perata⁶, Federica  Robino⁶, Pier Francesco Ferrari⁷, Sara Ferrando¹, Matteo Zanotti-Russo⁶, Jan Markus⁸, Silvia Letasiova⁸, Elena Grasselli^9,10
1 Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy
² Department of Pharmacy, University of Genoa, Genova, Italy 
³ Department of Health Sciences, University “Magna Graecia”, 88100 Catanzaro, Italy 
⁴ ProtoQSAR SL, Centro Europeo de Empresas Innovadoras (CEEI), Parque Tecnológico de Valencia, 46980 Valencia, Spain
⁵ Departament de Medicina i Ciències de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain 
⁶ Angel Consulting S.a.s. 20122 Milano Italy
⁷ Department of Civil, Chemical and Environmental Engineering, University of Genoa, via Opera Pia, 15, 16145 Genoa, Italy    
⁸ MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia 
⁹ Department of Earth, Environment and Life Science, University of Genoa, Genova, Italy
¹⁰ Interuniversity Center for the Promotion of 3R Principles in Teaching and Research (Centro 3R), Italy 
^P Presenting author

P117

sodium iodide symporter as target for endocrine disruptors – novel in vitro bioassays with optional biotransformation step

Puja Kumari^P1, Sebastian Lungu  Mitea^2,3,4, Jiří  Novák¹, Klára  Hilscherová^1
1 RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic  
² RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic
³ Department of Pharmaceutical Biosciences, Drug Safety and Toxicology, Uppsala University (UU), SE-75124 Uppsala, Sweden
⁴ Department of Biology and Environmental Science, Linnaeus University (LNU), SE-39182 Kalmar, Sweden
^P Presenting author

P118

IDENTIFICATION OF MIXTURE RISK DRIVERS OF ANTIANDROGENICITY IN EUROPEAN BLOOD SAMPLES USING HIGH-THROUGHPUT EFFECT-DIRECTED ANALYSIS

Maria João Valente^P1, Maria Margalef², Christina Rørbye³, Marja Lamoree², Anne Marie Vinggaard^1
1 National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark
² Amsterdam Institute for Life and Environment (A-LIFE), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
³ Hvidovre Hospital, Hvidovre, Denmark
^P Presenting author

P119

CLIMBAZOLE AND BISPHENOL A MIXTURE EFFECT ON STEROIDOGENESIS IN MAMMALIAN CELLS

Dieynaba NDIAYE^P1, Mylène LORCIN¹, Marie PERCEAU¹, Flavien DENIS¹, Laurent GATE^1
1 French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), Toxicology and Biomonitoring Division, 1 rue Morvan, F-54519 Vandoeuvre les Nancy, France
^P Presenting author

P120

Pancreatic beta cell signaling and function disruption by metabolic disrupting chemicals.

Katreece Feiertag^P1, Philip  Marx-Stölting¹, Tewes Tralau^1
1 The German Federal Institute for Risk Assessment (BfR)
^P Presenting author

P121

Battery of in vitro testing of deiodinases inhibition by thyroid hormone disrupting chemicals and environmental pollutant mixtures

Veronika Janečková¹, Tereza Nešporová¹, Ondřej  Brózman¹, Sabina Hřibová¹, Jiří Novák¹, Klára Hilscherová^P1
1 Masaryk University, Faculty of Science, RECETOX
^P Presenting author

P122

Refinement of a classical in vitro endocrine activity assay by integrating skin barrier function and skin metabolism to mimic topical application

Emery Sylvie¹, Sayah Ines², Lereaux Guillaume², Viallard Chloé², Gregoire Sebastien², Burbank Matthew², Bury Dagmar³, Rigaudeau Anne-Sophie⁴, Rouas Caroline³, Grall Romain^P1, Riu Anne^1
1 L’Oréal Research and Innovation, Aulnay-sous-Bois, France
² L’Oréal Research and Innovation, Aulnay-sous-bois, France
³ L’Oréal Research and Innovation, Clichy, France
⁴ EPISKIN, Lyon, France
^P Presenting author

P123

Different metabolizing systems improved the informative value of in vitro endocrine disruption assays: a comparative study

Emery Sylvie¹, Budin Clemence², de Boer Tjalf², Brouwer Abraham², Lereaux Guillaume³, Burbank Matthew³, Gregoire Sebastien³, Bury Dagmar⁴, Grall Romain^P1, Riu Anne^1
1 L’Oréal Research and Innovation, Aulnay-sous-Bois, France
² BioDetection Systems, Amsterdam, The Netherlands
³ L’Oréal Research and Innovation, Aulnay-sous-bois, France
⁴ L’Oréal Research and Innovation, Clichy, France
^P Presenting author

P124

Poly-fluoroalkyl substances (PFASs) detectable in waste of electrical and electronic equipment (WEEE) plants – preliminary metabolomics and toxicological data from the VAISAL project.

Stefano Lorenzetti^P1, Milena Mikhail¹, Laura Di Benedetto¹, Anton Vremere¹, Stefano Di Bona², Alessandra Di Veroli², Emanuele Artino², Carolina Barola³, Francesca Buiarelli⁴, Patrizia Di Filippo⁵, Roberta Galarini³, Franco Lucarelli⁶, Simone Moretti³, Giulia Pazzi⁶, Donatella Pomata⁵, Carmela Riccardi⁵, Gabriele Cruciani², Laura Goracci^2
1 ISS – Istituto Superiore di Sanità
² University of Perugia
³ Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche
⁴ University Sapienza of Rome
⁵ DIT-INAIL
⁶ University of Florence
^P Presenting author

P125

Increases in disinfection byproduct generation potentiate to trigger anti-estrogenic endocrine disruption in zebrafish estrogen receptor alpha

Sang-Ah Lee¹, Maranda  Esterhuizen², Chang Seon Ryu^P3, Hyunki  Cho³, Indong Jun^3
1 Jeju National University
² University of Helsinki
³ KIST Europe
^P Presenting author

P126

Adipocytes 3D scaffold free microtissues for toxicology and preclinical applications

Francesca Rescigno¹, Francesco Carriero¹, Christian Pellevoisin², Marisa Meloni^1
1 VitroScreen, Milan, Italy
² Urbilateria, Tours, France
^P Presenting author

P127

REPURPOSING TRANSGENDER TESTICULAR TISSUE: ANDROGENIC TESTICULAR ORGANOIDS FOR HIGH-THROUGHPUT APPLICATIONS

Samuel Madureira Silva^P1, Guillaume Richer¹, Andrea Errico², Katerina Papageorgiou^1,3, Tamara Vanhaecke³, Ellen Goossens¹, Yoni Baert^1,3
1 Biology of the Testis laboratory – Genetics, Reproduction and Development, Vrije Universiteit Brussel, Belgium
² Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy
³ In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Belgium
^P Presenting author

P128

Toxicity of microplastics and additives in a complex cellular liver model.

Lucas Gaillard^P1,2, Léo  Sportes-Milot^1,2, Béatrice Legrand^1,2, Kévin  Bernal ^1,2, Jules  Imler^1,2, Etienne Blanc^1,2, Antonietta Messina³, Jean-Charles Duclos-Vallée³, Xavier  Coumoul^1,2, Karine  Andréau^1,2
1 INSERM UMR-S 1124 – T3S, environmental Toxicity, Therapeutic Targets, cellular Signaling and Biomarkers, 45 rue des Saints-Pères, 75006 Paris, France
² Université Paris Cité, UFR des Sciences Fondamentales et Biomédicales, 45 rue des Saints-Pères, 75006 Paris, France
³ INSERM UMR-S 1193, Physiopathogénèse et Traitement des Maladies du Foie, Centre Hépatobiliaire, Hôpital Paul Brousse, 94800 Villejuif, France
^P Presenting author

P129

Assessment of endocrine disruptor impacts on carbohydrate metabolism in the HepaRG human hepatic cell line

Kévin Bernal^P1,2, Béatrice Le-Grand^2,1, Arnaud Tête^2,1, Min Ji Kim^3,1, Xavier Coumoul^2,1, Etienne Blanc^2,1
1 INSERM UMRS 1124, Team Metatox, Paris, France
² Université Paris Cité, Paris, France
³ Université Sorbonne Paris Nord, Paris, France
^P Presenting author

P130

Impact of endocrine disruptors on prostate organoid structure and integrity

Jules Imler^P1, Amel Ait Mouffok², Sylvie Bortoli¹, Stephan  Clavel², Xavier Coumoul¹, Arnaud Tête^1
1 Inserm UMR S-1124, Université Paris Cité, 75006 Paris, France
² CNRS UMR 7275, Institut de Pharmacologie Cellulaire et Moléculaire, 06560 Valbonne, France
^P Presenting author

P131

THYROID HORMONE DISRUPTING POTENTIAL OF ENVIRONMENTAL POLLUTANTS AND SAMPLES ASSESSED BY MOLECULAR-INITIATING EVENTS-BASED IN VITRO SCREENING BATTERY

Jiri Novak^P1, Marie Smutna¹, Zuzana Tousova¹, Puja Kumari¹, Saskia Finckh^2,3, Werner Brack^2,3, Klara Hilscherova^1
1 RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic
² Department of Effect-Directed Analysis, UFZ – Helmholtz Centre for Environmental Research, Leipzig, Germany
³ Department of Evolutionary Ecology and Environmental Toxicology, Faculty of Biological Sciences, Goethe University Frankfurt, Max-Von-Laue-Strasse 13, Frankfurt am Main, 60438, Germany
^P Presenting author

P132

DEVELOPMENT OF A HUMAN STEM CELL-BASED IN VITRO MODEL TO ASSESS DEVELOPMENTAL LIVER TOXICITY INDUCED BY THYROID HORMONE DISRUPTORS

Lorna Marchandise^P1, Robim Marcelino Rodrigues¹, Yoni Baert¹, Tamara Vanhaecke^1
1 In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium
^P Presenting author

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Models, biomarkers and assays for systemic and immune toxicity

P133

Human Cells as New Approach Methodologies for Immunotoxicity Testing

Victor Johnson^P1, Emanuela  Corsini², Fenna  Sillé³, Norbert  Kaminski^4
1 Burleson Research Technologies, Inc.
² Università degli Studi di Milano
³ Johns Hopkins University, Bloomberg School of Public Health & Center for Alternatives to Animal Testing
⁴ Michigan State University
^P Presenting author

P134

IN VITRO ASSESSMENT OF mRNA-DRUGS OFF-TARGET EFFECTS: FOCUS ON OXIDATIVE STRESS, ENDOPLASMIC RETICULUM STRESS, MITOCHONDRIAL STRESS AND AUTOPHAGY

Gloria Melzi^P1, Valeria Bettinsoli^1,2, Valentina Galbiati¹, Marina Marinovich¹, Emanuela Corsini^1
1 Department of Pharmacological and Biomolecular Science (DiSFeB) “Rodolfo Paoletti”, Università degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.
² Department of Pharmacy, Università degli Studi di Napoli Federico II, Naples, Italy.
^P Presenting author

P135

Micro-/nano-plastics activate the NF-κB pathway in an in vitro model of inflammatory bowel disease.

Alice  De Groote^P1,2, Julie Laloy², Vincent  Maloteau², Jonathan Decarpentrie^1,2, Jean-Michel Dogné^1,2
1 Clinical Pharmacology and Toxicology Research Unit (URPC), University of Namur, 5000 Namur, Belgium
² Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, Belgium
^P Presenting author

P136

Evaluation of the impact of microplastics on neutrophil activation.

Alice De Groote^P1,2, Jean-Michel Dogné^1,2, Jonathan Douxfils^1,2,3, Constant Gillot^1,2
1 Clinical Pharmacology and Toxicology Research Unit (URPC), University of Namur, 5000 Namur, Belgium
² Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, Belgium
³ Qualiblood s.a., QUALIresearch, 5000 Namur, Belgium
^P Presenting author

P137

Assessment of the respiratory sensitizing potential of substances on in vitro macrophage model

Rhamiya Mahendran¹, Louis Scott^P1, Ewelina  Hoffman¹, Victoria Hutter^1,2
1 ImmuONE Limited, Sycamore House, Stevenage, Herts, UK, SG1 2BP  
² Centre for Topical Drug Delivery and Toxicology, University of Hertfordshire, Hatfield, Herts, UK, AL10 9AB 
^P Presenting author

P138

EVALUATION OF SENESCENCE GLYCOBIOMARKERS IN TWO DIFFERENT IN VITRO AGING MODELS

Lucia Rackova^P1,2, Rebeka Kodrikova², Maria Sediva², Marek Nemcovic², Zuzana Brnoliakova¹, Zuzana Pakanova^2
1 Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Dúbravská cesta 9, 841 04 Bratislava, Slovak Republic
² Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 845 38 Bratislava, Slovak Republic
^P Presenting author

P139

BIOACTIVE COMPOUNDS EXTRACTED FROM TUNA BY-PRODUCTS

Mª Mercedes Alonso Martínez^P1, Rebeca Vázquez Sobrado¹, Diego Méndez Paz¹, Giorgia  Allaria², Elena Grasselli², Celina Costas Iglesias^1
1 ANFACO-CECOPESCA, Ctra Colexio Universitario 16, 36310 Vigo, Spain
² Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
^P Presenting author

P140

Human Cell Line Activation Test (h-CLAT) with alternative experimental design and fluorophores

Eliska  Pacalova^P1, Lada Svobodova¹, Marketa Dvorakova¹, Kristina Kejlova¹, Alena Vlkova¹, Marian Rucki¹, Hana Bendova¹, Dagmar Jirova¹, Gabriela Goffova^1
1 Centre of Toxicology and Health Safety, National Institute of Public Health, Prague, Czech Republic
^P Presenting author

P141

The BMDC model, a performant cell-based test to assess the sensitizing potential and potency of chemicals

Fabrice Battais^P1, Sandrine JACQUENET¹, Mélanie Mourot-Bousquenaud^1
1 French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS)
^P Presenting author

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Non-animal methods for safety testing of biopharmaceuticals/biotherapies/vaccines

P142

Implementation of primary culture systems to investigate substance related toxicity in steatotic hepatocytes

Tanja Krimmling^P1, Anett Ullrich¹, Tim Brecklinghaus², Jan G. Hengstler², Dieter Runge^1
1 PRIMACYT Cell Culture Technology GmbH, Schwerin, Germany
² Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Dortmund, Germany
^P Presenting author

P143

CELL PAINTING ASSAY AS HAZARD ASSESSMENT TOOL IN THE EARLY DRUG DISCOVERY PIPELINE

Jeroen  Esselink¹, Gurvan  Mahe¹, Andre van Marle¹, Ludovico Buti^P1, Peter Imre Racz^1
1 Charles River Laboratories
^P Presenting author

P144

When high-resolution chemical imaging bridges toxicology testing: the example of PFOA

Charlotte B. A. Stoffels^P1,2, Sébastien Cambier², Tom Wirtz¹, Muriel  Mercier-Bonin³, Arno C. Gutleb², Jean-Nicolas Audinot^1
1 Advanced Instrumentation for Nano-Analytics, Materials Research and Technology (MRT) department, Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg
² Environmental Health, Environmental Research and Innovation (ERIN) department, Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg
³ Toxalim, Université de Toulouse, INRAE, INP-ENVT, INP-EI-Purpan, Université de Toulouse 3 Paul Sabatier, Toulouse, France
^P Presenting author

P145

Size-dependent pulmonary mucus penetration and cellular uptake of liposomes: insights for application in pulmonary drug delivery

Juliana  Carrillo Romero ^P1,2, Laura  Fernández Méndez ^2,3,4, Alberto  Katsumiti ¹, Jesús  Ruiz-Cabello ^2,3,5, Susana  Carregal Romero ^2,3,5, Felipe  Goñi-de-Cerio ^1
1 GAIKER Technology Centre, Basque Research and Technology Alliance (BRTA), Zamudio, 48170 Spain
² Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebastián, 20014 Spain
³ CIBER de Enfermedades Respiratorias (CIBERES), Madrid, 28029 Spain
⁴ Euskal Herriko Unibertsitatea (UPV/EHU), Donostia, 20018 Spain
⁵ Ikerbasque, Basque Foundation for Science, Bilbao, 48013 Spain
^P Presenting author

P146

DEVELOPMENT OF RECONSTRUCTED INTESTINAL MICRONUCLEI CYTOME (RICYT) ASSAY IN 3D HUMAN GUT MODEL FOR GENOTOXICITY ASSESSMENT OF ORALLY INGESTED SUBSTANCES

Hui Kheng  LIM^P1,2, Christopher Owen  HUGHES^1,2, Choon Wee Joseph  TAN¹, Michelle Jing Sin  LIM², Jia’En Jasmine  LI³, Moumita  RAKSHIT⁴, Calvin  YEO³, Kern Rei  CHNG³, Angela  LI³, Joanne Sheot Harn  CHAN³, Kee Woei  NG^4,5,6, David Ian  LEAVESLEY^2,7, Benjamin Paul Chapman  SMITH^1,2
1 Future Ready Food Safety Hub (a joint initiative of A*STAR, SFA & NTU), Nanyang Technological University, Singapore
² Innovations in Food and Chemical Safety (IFCS) Programme, Agency for Science, Technology and Research, Singapore
³ National Centre for Food Science, Singapore Food Agency, Singapore
⁴ School of Materials Science & Engineering, Nanyang Technological University, Singapore
⁵ Environmental Chemistry & Materials Centre, Nanyang Environment and Water Research Institute, Singapore
⁶ Harvard T. H. Chan School of Public Health, Harvard University, USA
⁷ Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research, Singapore
^P Presenting author

P147

Assessing Immune-Related Toxicity Using a 3D In Vitro Hepatotoxic Model

Mi-lang Kyun^P1, Hyewon Jung^1,2, Inhye Kim^1,3, Ji-in  Kwon^1,3, Jeong Ha  Kim¹, Ju-Kang  Kim¹, Myeongjin  Choi¹, Jung Yun  Lee¹, Minseong  Jo^1,4, Seungyeon  Lim¹, Dong Ho  Woo¹, Chang Hoon  Choi¹, Seo Yule  Jeong¹, Hyun-A  Oh¹, Ye-Ji  Kim^1,2, Yu Yeong  Jeong^1,5, Hye-Won  Lim¹, Daeui  Park⁶, Yu Bin Lee¹, Kyoung-Sik  Moon^1
1 Department of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea
² Human and Environmental Toxicology, University of Science and Technology, Daejeon 34113, Republic of Korea
³ Department of Food and Nutrition, Hannam University
⁴ Department of Microbiology and Molecular Biology, Chungnam National University
⁵ Department of Biological Science, Chungnam National University
⁶ Department of Predictive Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea
^P Presenting author

P148

EVALUATION OF CYTOTOXICITY AND REGENERATION CAPACITY OF ARTSKIN™, A NOVEL HUMAN DERMAL SKIN SUBSTITUTE

Manuella Godoi^P1, Caroline  Peruzzi², Guilherme  Colla², João  Hoepers¹, Janice Koepp², Juliano Ferreira^1
1 UFSC
² Biocelltis
^P Presenting author

P149

A primary human podocyte assay enables sensitive in vitro detection of dedifferentiation and effacement by high-content imaging

Nicholas  Brittain^P1, Ben Coker¹, Kirsten Ramsay¹, Kate Gilroy¹, Kathryn Garner^1
1 Newcells Biotech Limited, The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK
^P Presenting author

P150

A high-throughput, human in vitro proximal tubule cell model for drug safety assessment in the kidney.

Keith Pye^P1, Jamie Jordan¹, Robert Liang¹, Kathryn Garner¹, Colin  Brown^1
1 Newcells Biotech
^P Presenting author

P151

Silkworms as a novel invertebrate model for toxicity testing: bridging the gap between traditional and alternative methods

Atsushi Miyashita^P1, Masaki Ishii², Kazuhisa Sekimizu^1
1 Teikyo University
² Musashino University
^P Presenting author

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Organ-on-a-chip & Microphysiological Systems

P152

A novel exposure device for airborne materials to investigate toxic potential and uptake after inhalation exposure using innovative organ-on-a-chip technology

Tanja Hansen^P1, Detlef Ritter¹, Nico Sonnenschein¹, Carsten Brodbeck², Cristian  Hoyer^3,4, Uwe Marx⁴, Katharina Schimek^4
1 Fraunhofer ITEM, Hannover, Germany
² Fraunhofer SCAI, Sankt Augustin, Germany
³ TU Berlin, Berlin, Germany
⁴ TissUse GmbH, Berlin, Germany
^P Presenting author

P153

COMPARATIVE STUDY OF SPHEROIDS (3D) AND MONOLAYERS CULTURE (2D) FOR EVALUATING THE TOXICITY OF CYCLOPIAZONIC ACID IN in vitro USING HUMAN NEUROBLASTOMA SH-SY5Y CELLS

Carmen Martínez-Alonso ^1,2, Yelko Rodríguez-Carrasco^1,2, Maria-Jose Ruiz^P1,2
1 Research Group in Alternative Methods for Determining Toxics Effects and Risk Assessment of Contaminants and Mixtures (RiskTox)
² Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia
^P Presenting author

P154

IN VITRO IMMUNE-COMPETENT, VASCULARIZED SKIN MODEL DEVELOPED IN PHYSIOXIA CONDITIONS USING A MICROPHYSIOLOGICAL SYSTEM FOR TESTING AND EVALUATION OF SKIN SENSITIVITY

Edith  Filaire^P1,2, Marina Simon¹, Pierre Gaudriault³, Dario Fassini³, Christian Poinsot^1
1 ICARE Group
² UMR 1019 INRAE-University Clermont-Auvergne
³ CherryBiotech
^P Presenting author

P155

TRACK-ETCHED MEMBRANES FOR DRUG PHARMACEUTICAL RESEARCH

Karina Cuanalo-Contreras^P1, Dennis Benkmann^1
1 SABEU GmbH & Co. KG
^P Presenting author

P156

COMPARATIVE STUDY OF THE IMPACT OF STATIC AND DYNAMIC CULTIVATION CONDITIONS ON THE CYTOTOXICITY INDUCED BY THE MYCOTOXIN PATULIN ON SH-SY5Y SPHEROIDS

Veronica Zingales^P1,2,3, Elisa Cimetta^2,3, María-José Ruiz^1
1 Laboratory of Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100, Valencia, Spain.
² Department of Industrial Engineering (DII), University of Padua, Via Marzolo 9, 35131, Padova, Italy.
³ Fondazione Istituto di Ricerca Pediatrica Cittá Della Speranza (IRP) – Lab BIAMET, Corso Stati Uniti 4, 35127, Padova, Italy
^P Presenting author

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Other NAMs relevant topics

P157

DYES UNDER THE REACH REGULATION: A STRATEGY FOR GENOTOXICITY ASSESSMENT USING NAMs

Elena Campagnoli^P1, Monica Locatelli¹, Andrea Mauri^2
1 Kahlberg Consulting srl
² Alvascience
^P Presenting author

P158

A CRITICAL REVIEW ON THE UTILISATION AND CHARACTERISATION OF EXTERNAL BIOTRANSFORMATION SYSTEMS IN IN VITRO TOXICOLOGY

Sebastian Lungu-Mitea^P1,2,3, Matilda  Stein Åslund⁴, Inska  Reichstein⁵, Felipe  Vidal³, Andreas  Schiwy^5,6, Henner  Hollert^5,6, Miriam Naomi  Jacobs⁷, Klára  Hilscherová^3
1 Linnaeus University, Department of Biology and Environmental Science, Kalmar, Sweden
² Uppsala University, Department of Pharmaceutical Biosciences, Toxicology and Drug Safety, Sweden
³ Masaryk University, Faculty of Science, RECETOX, Brno, Czech Republic
⁴ Swedish University of Agricultural Sciences, Department of Forest Mycology and Plant Pathology, Uppsala, Sweden
⁵ Goethe University Frankfurt, Department of Evolutionary Ecology and Environmental Toxicology, Germany
⁶ Department of Environmental Media Related Ecotoxicology, Fraunhofer Institute for Molecular Biology and Applied Ecology (FhG-IME), Schmallenberg, Germany
⁷ UK Health Security Agency, Harwell Science and Innovation Campus, Chilton, OXON, UK
^P Presenting author

P159

Centro 3R: Advancing 3Rs Principles in Education, Research, and Beyond

Elena  Grasselli^P1, Arti Ahluwalia ¹, Valeria Chiono ¹, Paolo Fabene¹, Gianfranco Fiore¹, Monica Mattioli Belmonte ¹, Gabriella  Nicolini¹, Alberto Rainer¹, Sonia Scarfì¹, Livia Visai^1
1 3R Centre, Inter-University Centre for the Promotion of the 3R Principles in Education and Research, University of Pisa, Pisa, Italy.
^P Presenting author

P160

TOWARDS THE APPLICATION OF NEW APPROACH METHODOLOGIES (NAMs) TO FOOD MIXTURES

Maricel  Marin-Kuan^P1, Breanne Holmes¹, Paul Rogeboz¹, Helia Latado¹, Anna Voiland¹, Claudine Cottet-Fontannaz¹, Bastien Gentili¹, Julie Mollergues¹, Virginie Bechmann¹, Danilo Basili¹, Amaury Patin^1
1 Société des Produits Nestlé
^P Presenting author

P161

Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response

Julia Huchthausen^P1, Beate I. Escher^1,2, Nico Grasse³, Maria König¹, Stephan Beil⁴, Luise Henneberger^1
1 Helmholtz Centre for Environmental Research – UFZ, Department of Cell Toxicology, Permoserstr. 15, 04318 Leipzig, Germany
² Eberhard Karls University Tübingen, Environmental Toxicology, Center for Applied Geosciences, 72076 Tübingen, Germany
³ Helmholtz Centre for Environmental Research – UFZ, Department of Analytical Chemistry, Permoserstr. 15, 04318 Leipzig, Germany
⁴ Technische Universität Dresden, Institute of Water Chemistry, 01069 Dresden, Germany
^P Presenting author

P162

DEVELOPMENT OF SKINPIX, A HUMAN SKIN PERMEABILITY DATASET

Lisa Chedik¹, Shamkhal  Baybekov², Frédéric Cosnier¹, Gilles Marcou², Alexandre  Varnek², Catherine Champmartin^P1
1 Institut national de recherche et de sécurité pour la prévention des accidents du travail et des maladies professionnelles (INRS), Dept Toxicologie et Biométrologie, 1 rue du Morvan, 54519 Vandœuvre-lès-Nancy, France
² University of Strasbourg, Laboratory of Chemoinformatics UMR 7140 CNRS, 4, rue B. Pascal, Strasbourg 67081, France
^P Presenting author

P163

Impact of Tiger Nut products on the bioavailability of mycotoxins: An In Vitro Assessment Using Caco-2 Cells

Paula Llorens¹, Paloma Arjona-Mudarra², Raquel Penalva-Olcina^P1, Olga Pardo², Ana Juan-García¹, Juan Carlos Moltó¹, Cristina Juan^1
1 Laboratory of Food Chemistry and Toxicology, University of Valencia
² Department of Analytical Chemistry, University of Valencia
^P Presenting author

P164

Acceleration of scientific confidence-building in non-animal approaches in Germany

Tina Stibbe^P1, Annette  Bitsch², Simin Chelopaz Amini³, Jan Hengstler⁴, Robert Landsiedel^3,5, Marcel Leist^6,7, Andreas Schepky⁸, Andreas Stucki^1
1 PETA Science Consortium International e.V., Stuttgart, Germany
² Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany
³ BASF SE, Experimental Toxicology and Ecology, Ludwigshafen, Germany
⁴ Technical University Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
⁵ German Toxicology Society (GT e.V.), Mainz, Germany
⁶ University of Konstanz, CAAT-Europe, Konstanz, Germany
⁷ University of Konstanz, Department of In Vitro Toxicology and Biomedicine, Konstanz, German
⁸ Beiersdorf AG, Hamburg, Germany
^P Presenting author

P165

SKIN IRRITATION AND GENOTOXICITY OF MICROFIBRILLATED CELLULOSE AND SILICA NANOPARTICLES

Juliana Varella Cruz^P1,2, Viviana Costa Gagosian¹, Emanoela  Lundgren Thá¹, Washington  Luiz Esteves Magalhães³, Pedro Henrique Gonzalez de Cademartori⁴, Cynthia  Bonfim Pestana¹, Danielle  Palma de Oliveira², Daniela  Morais Leme^1
1 Department of Genetics, Federal University of Paraná, Curitiba, PR, Brazil
² School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil
³ Embrapa Florestas, Colombo, PR, Brazil
⁴ Graduate Program in Engineering and Science of Materials – PIPE, Federal University of Paraná, Curitiba, PR, Brazil
^P Presenting author

P166

Chemical and biological assessment of a Heated Herbal Product reveals marked reductions in aerosol toxicants and in vitro toxicity compared cigarette smoke

Robert-Daniel Vasile^P1, Ourania Komini¹, Georgiana Cava¹, Fiona Chapman¹, Mike Brown¹, Roman Wieczorek², Edgar Trelles Sticken², Ole Dethloff², Liam Simms¹, Matthew Stevenson^1
1 Imperial Brands PLC
² Reemtsma Cigarettenfabriken GmbH
^P Presenting author

P167

Policy for science in 3Rs: What was done? What is ahead of us? What changes can we expect?

Francois Busquet^P1,2, Leonie K Mueller^3
1 altertox
² caat-europe
³ Altertox
^P Presenting author

P168

GENOMARK: a transcriptomic biomarker in human HepaRG cells to modernize genotoxicity assessment

Anouck Thienpont^P1, Eunnara  Cho², Andrew  Williams², Matthew J. Meier², Carole L. Yauk³, Vera Rogiers¹, Tamara  Vanhaecke¹, Birgit Mertens^4
1 Department of In Vitro Toxicology and Dermato-cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
² Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada
³ Department of Biology, University of Ottawa, Ottawa, ON, Canada
⁴ Department of Chemical and Physical Health Risks, Sciensano, Juliette Wytsmanstraat 14, 1050 Brussels, Belgium
^P Presenting author

P169

ALTERTOX MARKETPLACE: UNITING THE HEROES OF 3RS

francois busquet^P1
1 altertox
^P Presenting author

P170

The COST Action Networking Activity IMPROVE: 3Rs concepts to improve the quality of biomedical science

WINFRIED NEUHAUS^P1,2
1 AIT Austrian Institute of Technology GmbH, Competence Unit Molecular Diagnostics, 1210 Vienna, Austria
² Danube Private University (DPU), Department of Medicine, 3500 Krems, Austria
^P Presenting author

P171

In vitro based testing strategy for the identification of non-genotoxic carcinogens

Mariam SALEH^P1, Ludovic LE HEGARAT ¹, Kevin HOGEVEEN ^1
1 ANSES: French Agency for Food, Environmental and Occupational Health and Safety, Fougeres Laboratory, Toxicology of Contaminants Unit, Fougères, France
^P Presenting author

P172

Toxicological assessment of porous silica nanoparticles: cytotoxicity, genotoxicity and immunogenicity

Trisha Patel^P1, Zeeshan Ahmad², Umakhanth Venkatraman Girija¹, Tarsem Sahota², Neenu Singh^1
1 De Montfort University, Leicester School of Allied Health Sciences, Leicester, UK
² De Montfort University, Leicester School of Pharmacy, Leicester, UK
^P Presenting author

P173

CHARACTERIZATION OF HUMAN ISOGENIC EPITHELIAL CELL LINES AS A RELEVANT TOOL TO STUDY COLON CARCINOGENESIS AND INTERACTION BETWEEN GENES AND ENVIRONMENT

Arnaud Tête^P1, Arnaud Liana², Hélène Le Mentec³, Nathalie Poupin², Isabelle Gallais³, Noémie Tournade³, Carolina Duarte-Hospital¹, Yannick Lippi², Fanny Mathevet⁴, Gaelle Lefort⁴, Catherine Lavau³, Agnès Burel⁵, Reggie Surya⁶, Jerry W. Shay⁷, Xavier Coumoul¹, Nathalie Vialaneix⁴, Sylvie Bortoli¹, Dominique Lagadic-Gossmann⁸, Laurence Huc^9,3
1 INSERM UMRS1124 – Université Paris Cité
² INRAE UMR 1331 ToxAlim
³ Université de Rennes – INSERM – EHESP – IRSET – UMRS 1085
⁴ INRAE UR875 MIA-T
⁵ Université de Rennes – Biosit – UMS 3480
⁶ Department of Food Technology – Faculty of Engineering – Bina Nusantara University
⁷ Department of Cell Biology – University of Texas Southwestern Medical Center
⁸ Université de Rennes – INSERM – EHESP – IRSET – UMR_S 1085
⁹ LISIS UMR CNRS INRAE – Université Eiffel UGE
^P Presenting author

P174

Comparison of neurotoxic organophosphorous compounds through in vitro determination of the biochemical half maximal inhibitory concentration

Manon  Verger¹, Elsa Cantabella^P1, Jennifer Millerioux¹, Anne Bossée^2
1 DGA CBRN Defence, Toxicology Department
² DGA CBRN Defence, Chemistry Division
^P Presenting author

P175

A toxic Western diet that causes liver damage can also lead to Alzheimer’s disease.

Anna Mietelska-Porowska^P1, Angelika  Więckowska-Gacek¹, Justyna Domańska¹, Dominika Tkaczyk¹, Dominik Chutorański¹, Urszula Wojda^1
1 Nencki Institue of Experimental Biology Polish Academy of Scences in Warsaw
^P Presenting author

P176

DRUG INDUCED FATTY LIVER DISEASE (DIFLD): A REVIEW OF THE MOST REPORTED CLINICAL MANIFESTATIONS AND MECHANISMS, AND THEIR CONSISTENCY WITH CURRENT ADVERSE OUTCOME PATHWAYS.

Ernesto  Lopez¹, Anna  Rapisarda^P1, Ivan Rienda², Thomas Luechtefeld³, José Vicente Castell¹, Ramiro Jover^1
1 Joint Research Unit in Experimental Hepatology, University of Valencia, Health Research Institute Hospital La Fe & CIBEREHD, Spain.
² Pathological Anatomy Service, La Fe University and Polytechnic Hospital, Valencia, Spain.
³ ToxTrack, Baltimore, MD, USA.
^P Presenting author

P177

Comparing the transcriptomes of Daphnia and zebrafish for the evolutionary conservation of a gene network for fatty liver disease

Shaleen Glasgow^P1, Yavor  Hadzhiev¹, Ferenc  Mueller¹, John .K Colbourne^1
1 University of Birmingham
^P Presenting author

P178

Applicability of Standard in vitro Alternative Testing Method for Acute Fish Toxicity

Jing Yang^P1, Xiaoqian Chen¹, Feng Tao^1
1 Shanghai Academy of Public Measurement
^P Presenting author

P179

Exploring the use of NAMs for the identification and characterisation of biomarkers of effect applied in risk assessment

Georgia Bompola^P1, Sara Levorato¹, Lucian Farcal¹, Claudia Rocancio-Peña.^1
1 European Food Safety Authority (EFSA)
^P Presenting author

P203

Unlocking the intestinal transport of low molecular mass AGEs: Insights from a new approach methodology

Xiyu Li^P1,2, Sebastiaan Wesseling¹, Yaxin Sang², Ivonne Rietjens^1
1 Wageningen University & Research
² Hebei Agricultural University
^P Presenting author

P205

Investigating the impacts of hyperglycemia and gemcitabine co-exposure on mitochondrial genotype in human lymphoblastoid cell lines

Shaurya Mathur^P1, Katherine Chapman^1
1 In Vitro Toxicology Group, Swansea University, Swansea, UK
^P Presenting author

P206

Influence of Static and Dynamic Conditions on the Morphology and Viability of Cell and Tissue Cultures

Júlia  Kubalcova^1,2, Peter Pôbiš¹, Helena Kandarova^P1,2
1 Center of Experimental Medicine, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia
² Faculty of Chemical and Food Technology, Slovak Technical University, Radlinského 9, 812 37  Bratislava, Slovakia
^P Presenting author

P208

PHYSIOLOGICALLY BASED KINETIC MODELING REVEALS AN INFLUENCE OF DOSE AND STRUCTURAL CHARACTERISTICS ON THE RELATIVE POTENCY (REP) VALUES FOR PA N-OXIDES.

Yasser Alhejji^P1,2, Frances Widjaja¹, Sebastiaan Wesseling¹, Ivonne Rietjens^1
1 Division of Toxicology, Wageningen University, PO Box 8000, Wageningen, 6700 EA, The Netherlands
² Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah, 51452, Saudi Arabia
^P Presenting author

P216

NAMs for EFSA’s Nano regulatory risk assessment

Adriana Scattareggia Marchese¹, Maria Chiara Astuto^P1, Irene  Cattaneo¹, Claudia Roncancio-Peña^1
1 European Food Safety Authority (EFSA)
^P Presenting author

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