ESTIV Congress 2024 > Programme

Programme

This programme is still subject of minor changes

Scientific Programme – Confirmed sessions


Instructions for Oral and Poster Presenters


Draft Scientific Programme – Session details

The programme may still be subject to minor changes

Monday, June 3rd, 2024

09:00-13:00: Pre-conference workshop -How to write and manage a successful EU Horizon proposal: From initial idea to execution (organised with ONTOX)
Chairs: Prof Mathieu Vinken & Dr Helena Kandarova

13:00-14:00: Lunch break

14:00-14:20: Opening of ESTIV 2024 Congress
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia) & Dr Clive Roper (Roper Toxicology Consulting Limited, Edinburgh, UK)

14:20-15:00: Keynote lecture I – t.b.a.
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia) & Dr Clive Roper (Roper Toxicology Consulting Limited, Edinburgh, UK)

15:00-15:30: ESTIV Early Scientific Career Award ceremony 2024 and Lecture
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia) & Dr Clive Roper (Roper Toxicology Consulting Limited, Edinburgh, UK)

15:30-16:00: BEMF Award ceremony and BEMA Lecture
Chair: Prof. Stina Oredsson (Björn Ekwall Memorial Foundation, Sweden)
BEMA Lecture: Prof. Marcel Leist

16:00-16:30: Coffee break, visiting exhibition area & poster viewing

16:30-18:30: Session 1 – ECHA, EMA and EFSA perspectives on the use of NAMs / Funding the development, validation, and implementation of NAMs
Chairs: Dr. Costanza Rovida, Dr. Helena Kandarova

  • Costanza Rovida – Counting the number of animals that REACH and CLP are requesting as the first step to start accepting NAMs
  • Lucian Farcal – Guidance on the use of biomarkers of effect in regulatory risk assessment of chemicals – integration of new approach methodologies
  • Maria Chiara Astuto – EFSA’s ongoing and planned activities in the application of NAMs for the risk assessment of chemicals
  • Anne Milcamps – EU-NETVAL validation studies
  • Philippe Hubert – Validating NAMs ; Experience gained on the PEPPER Platform


19:00-20:30: Welcome reception & poster session


Tuesday, June 4th, 2024

08:30-09:00 Keynote Lecture II – t.b.a

09:00-10:30: Session 2a – Models, biomarkers and assays for endocrine disruption
Chairs: t.b.a.

  • Daniela Lange – Evaluation of in vitro and in silico new alternative methods for the identification of potential endocrine effects
  • Christian Pellevoisin – A 3d model applicable to reproductive toxicology
  • Kim Heikamp – Human based brain barrier models for studying thyroid hormone transport
  • Petra Mikušová – The identification of thyroid hormone-disrupting chemicals from complex environmental mixtures using pull-down assay coupled with non-target analysis
  • Runze Liu – Novel in vitro assay for thyroperoxidase inhibition – comparison of different models and detection methods

09:00-10:30: Session 2b – Challenges in cosmetics safety
Chairs: t.b.a.

  • Andy Forreryd – Improved confidence of quantitative sensitizing potency assessment for point of departure using Gardskin dose-response
  • Fleur Tourneix  – Deriving a continous point of departure for skin sensitization assessment using a bayesian network model  
  • Johanna Ebmeyer – A novel 3d Nrf2-are reporter epidermis model for skin sensitization testing
  • Océane Guyot – 3D porous hyaluronic acid-based extracellular matrix: to skin organoids



10:30-11:00: Coffee break, visiting exhibition area & poster viewing


11:00-13:00: Session 3a – Models, biomarkers and assays for systemic and immune toxicity
Chairs: t.b.a.

  • Anouk Verhoeven  – A stem cell-based in vitro test battery to predict liver steatotic potential of diverse chemicals
  • Bente Nissen – Comparative assessment of pesticide products and active ingredients – combined effects leading to mixture toxicity
  • Mélanie Mourot-Bousquenaud – In vitro assessment of the sensitizing potential of bisphenol A substitutes

11:00-13:00: Session 3b – Organ-on-a-chip & Microphysiology systems
Chairs: t.b.a.

  • Erika Ferrari – Evaluating the potential of novel physiologic-like liver-on-chip models for in vitro hepatotoxicity screening
  • Kaushal Joshi – A pilot study to evaluate the kinetics, metabolism, and toxicity of a fragrance material (coumarin) in an in vitro three-organ integrated microphysiological system (MPS) model
  • Maria-Jose Ruiz – Cytotoxic effects induced by individual and combined exposure to sterigmatocystin, ochratoxin A, and patulin on sh-sy5y spheroids
  • Marie-Gabrielle Zurich – Novel strategy to assess the neurotoxicity of organic solvents such as glycol ethers: combining in vitro and in silico methods with human-controlled exposure experiments
  • Ovidiu Novac – A sensitive and robust human liver microphysiological system for assessing drug-induced liver

13:00-14:00: Lunch break, visiting exhibition area & poster viewing

13:00-14:00: ASPIS Training Academy session – Organised by Early Career scientists
of ONTOX, RiskHunt3Rs and PrecisionTox


14:00-16:00: Session 4a – Computational toxicology – in silico modelling, read-across, artificial intelligence
Chairs: t.b.a.

  • Emily Reinke – Case studies for the sara-ice defined approach for skin sensitization – application to different chemistries
  • Fresnais Louison – Metabolic mechanisms of action modelling to sustain safety evaluation of cosmetic ingredients
  • Prachi Pradeep – New approach methods for regulatory risk assessment of azo dyes in textiles
  • Simon Perera del Rosario – Anthrodrugs-tox: personalized toxicology through population genetics
  • Vijay Gombar – Integration of multi-domain data and interpretable in-silico models for computational toxicology

14:00-16:00: Session 4b – Local toxicity testing (safety and efficacy)
Chairs: t.b.a.

  • Marco Pelin – Adoption of OECD TG 439 and 431 for the assessment of skin irritation and corrosion properties of 2D nanomaterials
  • Martina Daniela Benedetti – Eye damage reversibility in an in vitro model of bovine cornea to replace the Draize test completely
  • Rodrigo Azevedo Loiola – The Interleukin-18 is an in vitro biomarker for the prediction of photosensitization in reconstructed human epidermis: the development of photosensil-18 method for the safety assessment of raw materials and finished products
  • Enzo Zini Moreira Silva – Epigenetics biomarkers to evaluate early toxicity effects: a dermal toxicity case study of aluminum diethylphosphinate
  • Vérane Bard – Toxicity of polylactic acid and polyethylene terephthalate nanoplastics, aged in environmental conditions, on human intestinal cells

16:00-16:30: Coffee break, visiting exhibition area & poster viewing


16:30-17:30: Early Stage Researcher Session 1
Chairs: t.b.a.

  • Alkiviadis Stagkos-Georgiadis – Prioritisation of potential hepatotoxic co-formulants for chemical risk assessment using nams
  • Arunima Sengupta – A new lung-on-chip inhalation platform for toxicity and therapy assessment
  • Eliška Řehůřková – Utilizing human induced pluripotent stem cells to enhance in vitro leydig cell models for reproductive health research
  • Eliška Sychrová – Male reproductive toxicity of real-life pfas mixtures: an aop-based investigation
  • Giulia De Negri Atanasio – Evaluation of physiological repeated exposure of aluminium in a 3d intestinal tissue model

16:30-17:30: Industry session – In vitro inhalation toxicity and future trends for Fiber Safety assessment
Chairs: t.b.a.

  • Amy Madl – Toxicology of synthetic vitreous fibers (svfs): Historical overview and outlook for next generation new approach methods (NAMs)
  • Annette Bitsch – The problem of lung overload in animal studies
  • Samuel Constant – Advanced immunocompetent in vitro primary human lung models for point-of-contact toxicity evaluation of man-made vitreous fibres (mmvf)

17:30-18:30: Early Stage Researcher Session 2
Chairs: t.b.a.

  • Ignacio Risueño -A novel way to measure cell viability with electrochemical sensing for in vitro skin testing
  • Julia Nöth -Analysis of vascular disruptors in zebrafish embryos – an endpoint of developmental toxicity
  • Krupansh Desai -In vitro biocompatibility assessment of engineered living materials: a high throughput strategy
  • Laurie Perdigon -Successful generation of three-dimensional human precision-cut lung slices for pulmonary fibrosis modeling
  • Liyi Tan – Toxic effects of metal oxide nanoparticles on healthy and psoriatic-like human epidermal keratinocytes

18:30 – 19:30 Career development session

17:30-19:30: Peer Review for Validation Studies – building confidence and transparency into a new validation paradigm
Chairs: t.b.a.

  • Amanda Ulrey – Assessing data integrity: a deep dive into data review in method validation
  • Emily Reinke – Peer review for validation studies – building confidence and transparency into a new validation paradigm
  • G. Frank Gerberick – Ensuring transparency and rigor in the peer review of new approach methods for skin sensitization assessment
  • Hervé Groux – Peer review for validation studies – building confidence and transparency into a new validation paradigm- the test developer perspective
  • João Barroso -The art of validation and peer review: evolving practices while ensuring scientific confidence


19:30 Sponsored receptions


Wednesday, June 5th, 2024

08:30-09:00 Keynote Lecture III Prof. Mathieu Vinken – Ontologies as the basis for setting up animal-free test batteries: liver toxicity as a case study

09:00-10:30: Session 5a – In vitro methods for safety testing of biopharmaceuticals/biotherapies/vaccines
Chairs: t.b.a.

  • Antonella Di Paolo – Monocyte activation test (mat) as a potential assay for quality control of veterinary autogenous vaccines: preliminary data
  • Bas ter Braak – In vitro prediction of drug-induced liver injury using toxprofiler
  • Rajamuthu Srinivasan – Pragmatic Approach to inculcate New Approach Methodologies (NAMs) in Vaccine Safety Assessment
  • Ludovico Buti – Evaluation of 3d human intestinal organoids as a platform for ev-a71 antiviral drug discovery (ESR presentation)

09:00-10:30: Session 5b – Knowledge sharing and education
Chairs: t.b.a.

  • Bambou Xuezhu TAN – Storytelling skills for a more effective scientific communication
  • Beta Montemayer – Skills for Next-Generation Safety Scientists in Cosmetics: Bridging Academic Expertise to Industry Relevance
  • Erin Hill – International Collaboration for Cosmetics Safety (ICCS): Accelerating Global Adoption of Animal-Free Safety Science for Cosmetic Product and Ingredient Safety Assessment
  • Philipp Paulitschke – New non-invasive, label-free monitoring approach for 2D and 3D cell culture
  • Pascale Mora – Continuing education for next-generation risk assessment


10:30-11:00: Coffee break, visiting exhibition area & poster viewing


11:00-13:00: Session 6a – Toxicokinetics and in vitro–in vivo extrapolation
Chairs: t.b.a.

  • Andreas Schepky – Relevance of Toxicokinetics and ADME methods in Quantifying Exposure for Next generation Risk Assessment
  • Daniela Brenner – Toxicokinetic assessment of perfluorooctanoic acid and perfluorooctanesulfonic acid in a 2-dimensional in vitro liver model
  • Elena Reale – Next-generation risk assessment for diterpene glycosides
  • Evita Vandenbossche-Goddard – A workflow for true dose considerations of in vitro test systems which are used as part of next-generation risk assessment
  • René Geci – High-throughput PBK modelling providing insights into ADME/TK in systemic toxicity
  • Luiz Ladeira – Physiological maps and their curation guidelines: paving the way for mechanistic NGRA (ESR presentation)

11:00-13:00 Session 6b – In vitro systems to assess respiratory toxicity
Chairs: t.b.a.

  • Robert Bedford – An In Vitro Model to Mimic Immune and Vascular Responses Following Airway Inflammation in Humans
  • Sabina Burla – Responses insided by AEROSIL® R 504 using ALISENS®
  • Sonia Scarfì – Inflammatory and carcinogenic potential of mineral fibres assessed through a physiologically relevant 3d in vitro model of human alveolar tissue
  • Xiao-Yann Huang – Development of an in vitro model of Dry Nose
  • Nuria Roldan – Assessing lung metabolic competency for in vitro inhalation toxicology applications: a single-cell RNA sequencing strategy

13:00-14:00: Lunch break, visiting exhibition area & poster viewing

13:00-14:00: Sponsored lunch session II


14:00-15:00 Session 6c- Bio-engineering, stem cells and disease models

  • Véronique De Conto – Importance of the Extracellular Matrix in in vitro models for safety and efficacy drug assessment
  • Meryl Roudaut  – hiPSC-derived liver organoids grown on a Biomimesys® Hyaluronic Acid-based hydroscaffold as a new model for studying human lipoprotein metabolism
  • Anna Maria Bassi – Differentiation of retinal organoids from human iPSC  for modelling  neurodegenerative diseases
  • Alexandra Gatzios– Genetic predisposition for anti-mash drug response:  a population-based in vitro study

14:00-15:00 Session 6d- Towards Liver models – developing session

  • Anna Melina Steinbach – Towards in silico modelling of qAOPs for liver steatosis
  • Heeseung Jo – A framework for a chemically agnostic model for liver injury as a stepping stone to link in vitro outcomes to organ-level adverse outcomes.
  • Alkiviadis Stagkos-Georgiadis – Prioritisation of potential hepatotoxic co-formulants for chemical risk assessment using NAMs
  • Sara Sepehri – A next-generation risk assessment case study for the hair dye HC Yellow 13 focused on liver steatosis (ESR presentation)

15:00-16:00: Debate session and Panel discussion: t.b.a.


16:00-16:30: Coffee break, visiting exhibition area & poster viewing


16:30-18:30:  Session 7a – Case studies for successful use and implementation of complex in vitro models
Chairs: t.b.a.

  • Andreas O Stucki – The INSPIRE Initiative: Assessing respiratory toxicity of surfactants to human cell-based in vitro systems by pipetting and aerosol exposure
  • Tessa van Tongeren – Validation and implementation of the toxtracker assay for mechanistic genotoxicity assessment
  • Benoit Fischer – 2D and 3D human endothelial cell models to assess vascular toxicity
  • Els Adriaens – Breaching the surface: in vitro Eye Hazard Assessment of surfactants based on an innovative Defined Approach
  • Kristina Jochum – Comparative Case Studies on NAMs: A Step Towards Enhancing Specific Target Organ Toxicity Analysis
  • Paul Carmichael -New Approach Methodologies (NAMs) for use in Next Generation Risk Assessment (NGRA) for Systemic Safety: A pragmatic approach to ‘validation’ by establishing protectiveness and utility

16:30-18:30 Session 7b – Complex chemical mixtures – how can NAMs contribute?
Chairs: t.b.a.

  • Beate Escher – In vitro assays for quantification of adverse effects of chemical mixtures extracted from human serum
  • Wibke Busch – Prediction of Combined Effects of Chemical Mixtures at the Whole Transcriptome Scale
  • Lise Gehrt – Identifying the reproductive and neurotoxic potential of real-life chemical mixtures extracted from human cord blood
  • Iva Sovadinová – Unraveling the impact of a real-life organochlorine mixture on male reproductive health: an AOP-driven approach combined with lipidomics
  • Jiří Novák – Endocrine disruptive potencies of air and dust samples from different indoor environments

18:3019:30: ESTIV General Assembly
(ESTIV members)


19:30- … Congress gala dinner & social evening


Thursday, June 6th, 2024

08:30-09:30: Session 8a – Developmental Neurotoxicity (DNT)
Chairs: t.b.a.

  • Robin Pronk – High-throughput screening of FDA-approved compounds on human brain organoids for safety assessment
  • Jade Houghton – Evaluating the Reprotracker assay as a NAM for developmental and reproductive toxicity testing
  • Matthew Burbank – Advancing the use of New Approach Methodologies for assessing teratogenicity: A tiered approach
  • Chun-Wei Tung – Benchmarking in silico methods for identifying chemicals of developmental neurotoxicity concern

08:30-09:30: Session 8b – Regulatory considerations for complex NAMs
Chairs: t.b.a.

  • Nathalie Alepee – Quantifying the uncertainty of the new approach methodology U-SENS for skin sensitization assessment in a regulatory context
  • Patience Browne – The future of risk assessment at OECD
  • Philip Marx-Stoelting – NAMs in chemical mixture risk assessment
  • Raechel Puglisi – Survey results to identify nam use in agrochemical regulation

09:30 – 10:30 (Session in development)

09:30 – 10:30 (Session in development)


10:30-11:00: Coffee break


11:00-12:40: Session 9a – In vitro methods for safety assessment of medical devices
Chairs: t.b.a.

  • Christian Pellevoisin – Challenges in regulatory acceptance of NAMs for medical devices
  • Andy Forreryd – Regulatory approval of medical devices according to MDR using in vitro data from GARDskin Medical Device for skin sensitization assessment
  • Tom Meseberg – Developement of a macrophage-based in vitro assay for alternative prediction of foreign body reaction to implantable medical devices
  • Patrícia Gomes Ruivo – Reproductive Toxicity of vaginal lubricants: effects on oocyte maturation, fertilization and sperm viability
  • Peter Pôbiš – Development of sensitive in vitro protocols for biocompatibility testing of medical devices and pharmaceuticals intended for contact with eyes:

11:00-12:40: Session 9b – Cardiotoxicity and cardiac efficacy models
Chairs: t.b.a.

  • Alexandra Schaffert – A Comprehensive Approach to Cardiotoxicity Assessment using Adverse Outcome Pathways
  • S. Rodrigues Ribeiro – SmartHeart – Novel cardiac micro tissues to answer the evolving challenges of drug discovery
  • Georgia Papadimitriou – A weight of evidence approach for assessing cardiotoxicity in a regulatory context integrating New Approach Methodologies (NAMs)
  • Laura-Sophie Frommelt – Green chemistry, red flags: ensuring cardiovascular safety by performing multiparametric analysis of phytochemicals using hIPSC-CMs-MEA assay.

12:40-13:30: Congress closing ceremony
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia) & Dr Clive Roper (Roper Toxicology Consulting Limited, Edinburgh, UK)


POST-CONFERENCE ACTIVITIES


Friday, June 7th, 2024