ESTIV Congress 2024 > Programme

Programme

Instructions for Oral and Poster Presenters



Draft Scientific Programme – Session details

The programme may still be subject to minor changes

Monday, June 3rd, 2024

09:00-13:00: Pre-conference workshop -How to write and manage a successful EU Horizon proposal: From initial idea to execution (organised with ONTOX)
Chairs: Prof Mathieu Vinken (VUB, Brussels, Belgium) & Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia)

13:00-14:00: Lunch break

14:00-14:20: Opening Ceremony of the ESTIV 2024 Congress
XPLOSION Violin Trio
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia) & Dr Clive Roper (Roper Toxicology Consulting Limited, Edinburgh, UK)

14:20-15:00: Keynote lecture I PD Dr. Robert Landsiedel, DABT, FATS Star Wars on Ceres. Episode I – The irreproducibility menace
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia) & Dr Clive Roper (Roper Toxicology Consulting Limited, Edinburgh, UK)

15:00-16:00 ESTIV Early Scientific Career Award ceremony 2024 and Lecture
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia) & Dr Clive Roper (Roper Toxicology Consulting Limited, Edinburgh, UK)

16:00-16:30: Coffee break, visiting exhibition area & poster viewing

16:30-18:30: Session 1 – ECHA, EMA and EFSA perspectives on the use of NAMs / Funding the development, validation, and implementation of NAMs
Chairs: Dr Costanza Rovida (TEAM mastery S.r.l., Como, Italy) & Dr Clive Roper (Roper Toxicology Consulting Limited, Edinburgh, UK)

  • Costanza Rovida – Counting the number of animals that REACH and CLP are requesting as the first step to start accepting NAMs
  • Lucian Farcal – Guidance on the use of biomarkers of effect in regulatory risk assessment of chemicals – integration of new approach methodologies
  • Maria Chiara Astuto – EFSA’s ongoing and planned activities in the application of NAMs for the risk assessment of chemicals
  • Taina Palosaari – Accelerating Validation through In Vitro Method Automation and High Throughput Testing
  • Philippe Hubert – Validating NAMs: Experience gained on the PEPPER Platform


18:30-20:00: Welcome reception & Poster session I


Tuesday, June 4th, 2024

08:30-09:00 Keynote Lecture II Prof. Dr. Theo M. de Kok, ERT – Safety assessment of the food additives without animal testing: Case study – E171 (titanium dioxide) .

09:00-10:30: Session 2a – Models, biomarkers and assays for endocrine disruption
Chairs: Christian Pellevoisin (Urbilateria & Vitroscreen, France) and Prof Arno Gutleb (Invitrolize & Luxembourg Institute of Science and Technology LIST, Luxembourg, Luxembourg)

  • Daniela Lange – Evaluation of in vitro and in silico new alternative methods for the identification of potential endocrine effects
  • Christian Pellevoisin – A 3d model applicable to reproductive toxicology
  • Kim Heikamp – Human based brain barrier models for studying thyroid hormone transport
  • Petra Mikušová – The identification of thyroid hormone-disrupting chemicals from complex environmental mixtures using pull-down assay coupled with non-target analysis
  • Runze Liu – Novel in vitro assay for thyroperoxidase inhibition – comparison of different models and detection methods

09:00-10:30: Session 2b – Challenges in cosmetics safety
Chairs: Dr Bambou Tan (L’Oréal, Paris, France) and Erin Hill (ICCS, New York, USA)

  • Andy Forreryd – Improved confidence of quantitative sensitizing potency assessment for point of departure using Gardskin dose-response
  • Fleur Tourneix  – Deriving a continous point of departure for skin sensitization assessment using a bayesian network model  
  • Johanna Ebmeyer – A novel 3d Nrf2-are reporter epidermis model for skin sensitization testing



10:30-11:00: Coffee break, visiting exhibition area & poster viewing


11:00-13:00: Session 3a – Human Cells as New Approach Methodologies for Immunotoxicity Testing
Chairs:
Dr Victor J. Johnson (Burleson Research Technologies, Inc., Morrisville, NC, USA) and Prof Emanuela Corsini (Università degli Studi di Milano, Milan Italy)

  • Victor J. Johnson  – Building a comprehensive toolbox for Immunotoxicology safety assessment using human whole blood.
  • Emanuela Corsini – Using in vitro human immune system models to understand the immunotoxicity risks associated with PFAS exposure
  • Fenna Sillé – A Path Forward: Current and Future Perspectives of Alternatives to Developmental Immunotoxicity Testing
  • Norbert E. Kaminski – Human cord blood derived CD34+ hematopoietic stem cells as an in vitro model for investigating developmental immunotoxicity
  • Mélanie Mourot-Bousquenaud – In vitro assessment of the sensitizing potential of bisphenol A substitutes

11:00-13:00: Session 3b – Organ-on-a-chip & Microphysiology systems
Chairs: Dr Benoît Maisonneuve (NETRI, Lyon, France) and Dr Erika Ferrari (BiomimX, Milano, Italy)

  • Erika Ferrari – Evaluating the potential of novel physiologic-like liver-on-chip models for in vitro hepatotoxicity screening
  • Kaushal Joshi – A pilot study to evaluate the kinetics, metabolism, and toxicity of a fragrance material (coumarin) in an in vitro three-organ integrated microphysiological system (MPS) model
  • Maria-Jose Ruiz – Cytotoxic effects induced by individual and combined exposure to sterigmatocystin, ochratoxin A, and patulin on sh-sy5y spheroids
  • Marie-Gabrielle Zurich – Novel strategy to assess the neurotoxicity of organic solvents such as glycol ethers: combining in vitro and in silico methods with human-controlled exposure experiments
  • Ovidiu Novac – A sensitive and robust human liver microphysiological system for assessing drug-induced liver injury
  • Eileen Hallscheidt – Oral absorption and intestinal first-pass metabolism of pesticides using an in vitro human gut-model

13:00-14:00: Lunch break, visiting exhibition area & poster viewing

13:00-14:00: ASPIS Training Academy session – Organised by Early Career scientists of ONTOX, RiskHunt3Rs and PrecisionTox


14:00-16:00: Session 4a – Computational toxicology – in silico modelling, read-across, artificial intelligence
Chairs: Prof Thomas Hartung (Johns Hopkins Bloomberg School of Public Health and the Whiting School of Engineering, Baltimore, USA) and Emily Reinke (Inotiv, Research Triangle Park, NC, United States)

  • Emily Reinke – Case studies for the sara-ice defined approach for skin sensitization – application to different chemistries
  • Fresnais Louison – Metabolic mechanisms of action modelling to sustain safety evaluation of cosmetic ingredients
  • Prachi Pradeep – New approach methods for regulatory risk assessment of azo dyes in textiles
  • Simon Perera del Rosario – Anthrodrugs-tox: personalized toxicology through population genetics
  • Vijay Gombar – Integration of multi-domain data and interpretable in-silico models for computational toxicology

14:00-16:00: Session 4b – Local toxicity testing (safety and efficacy)
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia) and Dr Eugene Choi (OECD, Paris, France)

  • Marco Pelin – Adoption of OECD TG 439 and 431 for the assessment of skin irritation and corrosion properties of 2D nanomaterials
  • Maria Laura Gutierrez – Eye damage reversibility in an in vitro model of bovine cornea to replace the Draize test completely
  • Rodrigo Azevedo Loiola – The Interleukin-18 is an in vitro biomarker for the prediction of photosensitization in reconstructed human epidermis: the development of photosensil-18 method for the safety assessment of raw materials and finished products
  • Vérane Bard – Toxicity of polylactic acid and polyethylene terephthalate nanoplastics, aged in environmental conditions, on human intestinal cells

16:00-16:30: Coffee break, visiting exhibition area & poster viewing


16:30-17:30: Early Stage Researcher Session 1
Chairs: Marketa Dvořáková (NIPH Prague, Praha, Czech Republic) and Mohamed Fathi Abdallah Abdelmohsen (Ghent University, Ghent, Belgium)

  • Arunima Sengupta – A new lung-on-chip inhalation platform for toxicity and therapy assessment
  • Eliška Řehůřková – Utilizing human induced pluripotent stem cells to enhance in vitro leydig cell models for reproductive health research
  • Eliška Sychrová – Male reproductive toxicity of real-life PFAS mixtures: an AOP-based investigation
  • Giulia De Negri Atanasio – Evaluation of physiological repeated exposure of aluminium in a 3d intestinal tissue model

16:30-17:30: Industry session – In vitro inhalation toxicity and future trends for Fiber Safety assessment
Chairs
: Prof Arno Gutleb (Invitrolize & Luxembourg Institute of Science and Technology LIST, Luxembourg, Luxembourg) and Dr Samuel Constant (Epithelix, Plan-les-Ouates, Switzerland)

  • Amy Madl – Toxicology of synthetic vitreous fibers (svfs): Historical overview and outlook for next generation new approach methods (NAMs)
  • Annette Bitsch – The problem of lung overload in animal studies
  • Samuel Constant – Advanced immunocompetent in vitro primary human lung models for point-of-contact toxicity evaluation of man-made vitreous fibres (mmvf)


17:30-18:30: Early Stage Researcher Session 2
Chairs: Marketa Dvořáková (NIPH Prague, Praha, Czech Republic) and Mohamed Fathi Abdallah Abdelmohsen (Ghent University, Ghent, Belgium

  • Ignacio Risueño -A novel way to measure cell viability with electrochemical sensing for in vitro skin testing
  • Julia Nöth -Analysis of vascular disruptors in zebrafish embryos – an endpoint of developmental toxicity
  • Krupansh Desai -In vitro biocompatibility assessment of engineered living materials: a high throughput strategy
  • Laurie Perdigon -Successful generation of three-dimensional human precision-cut lung slices for pulmonary fibrosis modeling
  • Liyi Tan – Toxic effects of metal oxide nanoparticles on healthy and psoriatic-like human epidermal keratinocytes
  • Peter Pôbiš – Development of sensitive in vitro protocols for biocompatibility testing of medical devices and pharmaceuticals intended for contact with eyes:

17:30-19:30: Peer Review for Validation Studies – building confidence and transparency into a new validation paradigm
Chairs: Amanda Ulrey (IIVS, Gaithersburg, USA) and João Barroso (JRC, Ispra, Italy)

  • João Barroso -The art of validation and peer review: evolving practices while ensuring scientific confidence
  • G. Frank Gerberick – Ensuring transparency and rigor in the peer review of new approach methods for skin sensitization assessment
  • Hervé Groux – Peer review for validation studies – building confidence and transparency into a new validation paradigm- the test developer perspective
  • Sebastian Hofmann – Comprehensive reporting of validation studies starts at inception and ends with peer review
  • Amanda Ulrey – Assessing data integrity: a deep dive into data review in method validation
  • Emily Reinke – Peer review for validation studies – building confidence and transparency into a new validation paradigm


18:3019:30: ESTIV General Assembly
Poster Session II


Wednesday, June 5th, 2024

08:30-09:00 Keynote Lecture III Prof. Mathieu Vinken – Ontologies as the basis for setting up animal-free test batteries: liver toxicity as a case study

09:00-10:30: Session 5a – PARC session – Partnership for the Assessment of Risks from Chemicals
Chairs: Prof Denis Sarigiannis (Aristotle University of Thessaloniki, Greece) and prof Philip Marx-Stoelting (German Federal Institute for Risk Assessment, Berlin, Germany)

  • Denis Sarigiannis – Safe and Sustainable by Design
  • Gilles Riviere – Hazard Assessment in PARC
  • Sebastian Schmeisser – NGRAroute andd PARCopedia
  • Dimitra Nikopoulou – How PARC can contribute to promoting the regulatory uptake of NAMs

09:00-10:30: Session 5b – Knowledge sharing and education
Chairs: Dr. Bambou Tan (LOreal, Paris, France) and Erin Hill (ICCS, New York, USA)

  • Bambou Xuezhu TAN – Storytelling skills for a more effective scientific communication
  • Beta Montemayer – Skills for Next-Generation Safety Scientists in Cosmetics: Bridging Academic Expertise to Industry Relevance
  • Erin Hill – International Collaboration for Cosmetics Safety (ICCS): Accelerating Global Adoption of Animal-Free Safety Science for Cosmetic Product and Ingredient Safety Assessment
  • Philipp Paulitschke – New non-invasive, label-free monitoring approach for 2D and 3D cell culture
  • Pascale Mora – Continuing education for next-generation risk assessment


10:30-11:00: Coffee break, visiting exhibition area & poster viewing


11:00-13:00: Session 6a – Toxicokinetics and in vitro–in vivo extrapolation
Chairs: Jochem Louisse (European Food Safety Authority EFSA, Parma, Italy) and Andreas Schepky
(Beiersdorf AG, Hamburg, Germany)

  • Andreas Schepky – Relevance of Toxicokinetics and ADME methods in Quantifying Exposure for Next generation Risk Assessment
  • Daniela Brenner – Toxicokinetic assessment of perfluorooctanoic acid and perfluorooctanesulfonic acid in a 2-dimensional in vitro liver model
  • Elena Reale – Next-generation risk assessment for diterpene glycosides
  • Evita Vandenbossche-Goddard – A workflow for true dose considerations of in vitro test systems which are used as part of next-generation risk assessment
  • René Geci – High-throughput PBK modelling providing insights into ADME/TK in systemic toxicity
  • Jochem Louisse – Towards a quantitative interpretation of in vitro DNT data using PBK-modelling based QIVIVE

11:00-13:00 Session 6b – In vitro systems to assess respiratory toxicity
Chairs: Prof Arno Gutleb (Invitrolize & Luxembourg Institute of Science and Technology LIST, Luxembourg, Luxembourg) and Robert Bedford

  • Robert Bedford – An In Vitro Model to Mimic Immune and Vascular Responses Following Airway Inflammation in Humans
  • Sabina Burla – Responses insided by AEROSIL® R 504 using ALISENS®
  • Sonia Scarfì – Inflammatory and carcinogenic potential of mineral fibres assessed through a physiologically relevant 3d in vitro model of human alveolar tissue
  • Xiao-Yann Huang – Development of an in vitro model of Dry Nose
  • Sylvain Billet – Toxicity of mixtures: ethylbenzene and xylene have competitive effects in human lung cells
  • Nienke Ruijter – The Sabyna in vitro hazard testing strategy for adverse effects upon inhalation of nanomaterials: ‘safe and sustainable by design’ made practical


13:00-14:00: Lunch break, visiting exhibition area & poster viewing

13:00-14:00: Session organised by The Centre for Animal-Free [Proefdiervrij] Biomedical Translation: Co-creating a life long training program


14:00-15:00 Session 7a- Bio-engineering, stem cells and disease models

Chairs: Dr Yasunari Kanda (National Institute of Health Sciences, Kawasaki, Japan) and Prof Anna Maria Bassi, (Universita degli Studi di Genova, Genova, Italy)

  • Anna Maria Bassi – Differentiation of retinal organoids from human iPSC  for modelling  neurodegenerative diseases
  • Yasunari Kanda – Prediction of developmental neurotoxicity using an integrated in silico and in vitro approach.
  • Alexandra Gatzios– Genetic predisposition for anti-mash drug response:  a population-based in vitro study

14:00-15:00 Session 7b- Towards Liver models

Chairs: Mathieu Vinken (VUB, Brussels, Belgium) and Amer Jamalpoor (Toxys, Oegstgeest, The Netherlands)

  • Anna Melina Steinbach – Towards in silico modelling of qAOPs for liver steatosis
  • Heeseung Jo – A framework for a chemically agnostic model for liver injury as a stepping stone to link in vitro outcomes to organ-level adverse outcomes.
  • Alkiviadis Stagkos-Georgiadis – Prioritisation of potential hepatotoxic co-formulants for chemical risk assessment using NAMs
  • Anouk Verhoeven  – A stem cell-based in vitro test battery to predict liver steatotic potential of diverse chemicals

DALLE for ESTIV

15:00-16:00: Debate session and Panel discussion: Future of the validation process – where do we stand?

Debate on the recent development and sustainability of concepts of validation studies with experts from industry, regulatory fields, EURL-ECVAM and NGOs


16:00-16:30: Coffee break, visiting exhibition area & poster viewing


16:30-18:30:  Session 8a – Case studies for successful use and implementation of complex in vitro models
Chairs:
Dr Andreas Stucki (PETA Science Consortium International e.V., Stuttgart, Germany) and Paul Carmichael (Unilever, UK and Wageningen University (WUR), Wageningen, The Netherlands

  • Andreas O Stucki – The INSPIRE Initiative: Assessing respiratory toxicity of surfactants to human cell-based in vitro systems by pipetting and aerosol exposure
  • Giel Hendricks – Validation and implementation of the toxtracker assay for mechanistic genotoxicity assessment
  • Benoit Fischer – 2D and 3D human endothelial cell models to assess vascular toxicity
  • Els Adriaens – Breaching the surface: in vitro Eye Hazard Assessment of surfactants based on an innovative Defined Approach
  • Kristina Jochum – Comparative Case Studies on NAMs: A Step Towards Enhancing Specific Target Organ Toxicity Analysis
  • Paul Carmichael -New Approach Methodologies (NAMs) for use in Next Generation Risk Assessment (NGRA) for Systemic Safety: A pragmatic approach to ‘validation’ by establishing protectiveness and utility

16:30-18:30 Session 8b – Complex chemical mixtures – how can NAMs contribute?
Chairs: Prof Anne-Marie Vinggaard (DTU, Denemark) and Beate Escher (Helmholtz Centre for Environmental Research in Leipzig, Germany)

  • Beate Escher – In vitro assays for quantification of adverse effects of chemical mixtures extracted from human serum
  • Martin Scholze – Identifying the reproductive and neurotoxic potential of real-life chemical mixtures extracted from human cord blood
  • Wibke Busch – Combined effects of pesticide product ingredients in zebrafish and mixture effect predictions at the whole transcriptome scale
  • Iva Sovadinová – Unraveling the impact of a real-life organochlorine mixture on male reproductive health: an AOP-driven approach combined with lipidomics
  • Jiří Novák – Endocrine disruptive potencies of air and dust samples from different indoor environments


18:30 – 19:30 Career development session and poster session III

19:30 – Departures to Congress dinner & social evening


Thursday, June 6th, 2024

08:30 – 9:00 Keynote lecture IV Prof. Thomas Hartung – Probabilistic Risk Assessment  only becomes beautiful by AI

09:00-10:00: Session 9a – Developmental Toxicity and Developmental Neurotoxicity (DNT)
Chairs:
Dr Yasunari Kanda (National Institute of Health Sciences, Kawasaki, Japan) and Dr Amer Jamalpoor (Toxys, Oegstgeest, The Netherlands)

  • Robin Pronk – High-throughput screening of FDA-approved compounds on human brain organoids for safety assessment
  • Jade Houghton – Evaluating the Reprotracker assay as a NAM for developmental and reproductive toxicity testing
  • Matthew Burbank – Advancing the use of New Approach Methodologies for assessing teratogenicity: A tiered approach
  • Chun-Wei Tung – Benchmarking in silico methods for identifying chemicals of developmental neurotoxicity concern

09:00-10:00: Session 9b – Regulatory considerations for complex NAMs
Chairs:
Anne Gourmelon (OECD, Paris, France) and Dr Nathalie Alepee (L’Oreal, Paris, France)

  • Nathalie Alepee – Quantifying the uncertainty of the new approach methodology U-SENS for skin sensitization assessment in a regulatory context
  • Anne Gourmelon – The future of risk assessment at OECD
  • Philip Marx-Stoelting – NAMs in chemical mixture risk assessment
  • Raechel Puglisi – Survey results to identify nam use in agrochemical regulation

10:00-11:00: Session 10a – In vitro methods for safety testing of biopharmaceuticals/biotherapies/vaccines
Chairs:
Dr Yasunari Kanda (National Institute of Health Sciences, Kawasaki, Japan) and Dr Benoît Maisonneuve (NETRI, Lyon, France)

  • Bas ter Braak – In vitro prediction of drug-induced liver injury using toxprofiler
  • Rajamuthu Srinivasan – Pragmatic Approach to inculcate New Approach Methodologies (NAMs) in Vaccine Safety Assessment
  • Ludovico Buti – Evaluation of 3d human intestinal organoids as a platform for ev-a71 antiviral drug discovery (ESR presentation)
  • Josephine Blersch – A human ex vivo model for assessing the immunotoxicity risk of engineered nanomaterials.

10:00-11:00:  Early Stage Researcher Session 3

Chairs: Dr Andreas Stucki (PETA Science Consortium International e.V., Stuttgart, Germany) and Dr Bambou Tan (L’Oréal, Paris, France)

  • Luiz Ladeira – Physiological maps and their curation guidelines: paving the way for mechanistic NGRA
  • Eliska Kuchovska – Ontology-based AI-driven innovative approach using DNT NAMs for NGRA
  • Ruchir Shah – Artificial intelligence (AI)-driven morphological assessment of zebrafish embryo for developmental toxicity chemical screening
  • Sara Sepehri – A next-generation risk assessment case study for the hair dye HC Yellow 13 focused on liver steatosis

11:00-11:30: Coffee break


11:30-12:45: Session 11a – In vitro methods for safety assessment of medical devices
Chairs: Helena Kandarova (CEM SAS, Bratislava, Slovakia) and Christian Pellevoisin
(Urbilateria & Vitroscreen, France)

  • Christian Pellevoisin – Challenges in regulatory acceptance of NAMs for medical devices
  • Andy Forreryd – Regulatory approval of medical devices according to MDR using in vitro data from GARDskin Medical Device for skin sensitization assessment
  • Tom Meseberg – Developement of a macrophage-based in vitro assay for alternative prediction of foreign body reaction to implantable medical devices
  • Patrícia Gomes Ruivo – Reproductive Toxicity of vaginal lubricants: effects on oocyte maturation, fertilization and sperm viability

11:30 – 12:45: Session 11b – Cardiotoxicity and cardiac efficacy models
Chairs: Marketa Dvořáková (NIPH Prague, Praha, Czech Republic) and Andreas Stucki (PETA Science Consortium International e.V., Stuttgart, Germany)

  • Georgia Papadimitriou – A weight of evidence approach for assessing cardiotoxicity in a regulatory context integrating New Approach Methodologies (NAMs)
  • S. Rodrigues Ribeiro – SmartHeart – Novel cardiac-microtissues to answer the evolving challenges of drug discovery
  • Laura-Sophie Frommelt – Green chemistry, red flags: ensuring cardiovascular safety by performing multiparametric analysis of phytochemicals using hIPSC-CMs-MEA assay.
  • Niall Macquaide – Chronic Assessment of hERG Trafficking on Repolarisation and Cytotoxicity in iPSC Cardiomyocytes

12:45-13:30: Congress closing ceremony
Chairs: Dr Helena Kandarova (CEM SAS, Bratislava, Slovakia) & Dr Clive Roper (Roper Toxicology Consulting Limited, Edinburgh, UK)


POST-CONFERENCE ACTIVITIES


Friday, June 7th, 2024