Sponsors and Exhibitors

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Website:  https://www.alveolix.com/
Company page LinkedIn: AlveoliX
Contact person via LinkedIn: Janick Stucki 

BiomimX S.r.l. is a pioneer in Organ on a Chip (OoC) technology, producing the next generation of clinically relevant in-vitro models for pharmaceutical drug discovery and testing. Its proprietary platform integrates microfluidics, 3D cell culture, live human cells, and mechanical stimuli to produce “Beating OoC” . These recapitulate, with unprecedented precision and predictability, clinically relevant models reflective of human physiology and pathophysiology. Pharma R&D is an area where animal models continue to fall short due to lack of translatability and/or lack of relevant models. Regulatory agencies in the US and Europe are now moving forward to encourage biopharma’s use of more predictive non-animal models. BiomimX is poised to be a leader in this space and has gained early traction with industry.

The advantage of BiomimX approach is its patented uBeat platform which provides 3D microtissues with controlled mechanical stimulation that revolutionizes how new drugs are tested for safety and efficacy, offering advantages over the current 2D models.

BiomimX lead model is uHeart (Visone, Tox Sciences, 2023; +4 additional cardiac publications), a functional beating heart on a chip for cardiotoxicity and safety testing early in the pipeline. uHeart was recently qualified with 12 drugs as a predictor of functional cardiotoxicity, showing 83.3% sensitivity, 100% specificity, and 91.6% accuracy. Our pipeline includes a range of predictive physiological and pathophysiology models. uKnee (osteoarthritis; Occhetta, Nature Biomed Eng, 2019), uScar (fibrosis; Visone, Adv Health Mat, 2023), uGut (Ballerini, Nature Biomed Eng, under review), uLung and uLiver-Heart (Ferrari, Adv Mat Tech, 2023).

BiomimX founders, with expertise in microfluidics, microtechnology, and advanced 3D in-vitro cell culture, serve in academia and have notable leadership roles in key societies such as the European Organ on Chip Society. They are in communication with the EMA regarding BiomimX models and have a strong publication record and EU grant success in advancing the field of OoC. BiomimX offers advanced in vitro human models as visionary tools to reduce animal testing in preclinical development, aligning with the 3R principle and encouraging the adoption of alternative methods in drug testing.

Website:  https://www.biomimx.com/
Company page LinkedIn:  BiomimX® Srl
Contact person via LinkedIn: Erika Ferrari

cellQART made by SABEU

IN STOCK! cellQART® Cell Culture Inserts – Direct from the original manufacturer. Meet us in person at the ESTIV 2024. With our brand of cellQART®, we make the highest quality Cell Culture Inserts available at affordable prices. We offer a wide portfolio of Cell Culture Inserts in diverse pore sizes, membrane optics, individually packed and pre-loaded cellQART® Well Plates. Our product portfolio comes with PET membranes in translucent, clear extended culture or clear optics in 6-, 12- and 24-Well format. The Inserts are tissue culture treated, sterile, RNase / DNase free and non-pyrogenic.

We work with industry leading quality standards to ensure 100% membrane parameter consistency and reproducible cell culture results. We are beyond excited to be part of the 3Rs transformation. For more information, visit our webshop and contact us on www.cellQART.com! Follow us on Twitter, LinkedIn and YouTube or Instagram.

Website:  https://cellqart.com/
Company page LinkedIn:  cellQART ®
Contact person via LinkedIn: Karina Cuanalo-Contreras

CN Bio, a leading organ-on-a-chip (OOC) company, offers solutions to improve the accuracy and efficiency of preclinical drug discovery. Our PhysioMimix® suite of microphysiological systems, 3D-validated cells, consumable plates, and Contract Research Services facilitate the prediction of human responses to drug exposure, in the presence or absence of disease, so new medicines can be brought to market rapidly and cost-effectively. Utilizing primary human cells, our perfused 3D liver-on-a-chip recapitulates the organ’s microarchitecture, environment and function in vitro. It provides a viable alternative to animal models where translatability to humans is poor and for testing advanced drug modalities that require human-specific targets. The model used in our drug-induced liver injury (DILI) assay generates physiologically relevant, translatable, mechanistic toxicity data that facilitates the progress of the safest drugs into in vivo studies or provides insights for human clinical trials.

Website: https://cn-bio.com/
Company page LinkedIn:  CN Bio
Contact person via LinkedIn: Ciara McGahey

Creatio is a benchmark academic Production and Validation center of Advanced Therapies of the University of Barcelona accredited by the AEMPs to produce Advanced Therapy Medicinal Products (ATMPs). It is a technological developer center with TECNIO accreditation that bridges the gap between research and the clinic promoting innovation.

Creatio has the commitment to offer support and solutions based on Advanced Therapies to increase the efficiency of the healthcare system and improve the quality of life of society.

At Creatio we offer a tailored support along the entire product development with our four areas: basic and translational research, preclinical studies, clinical production, and management, and skilled and experienced professionals.

The basic and translational research area is dedicated to conducting state of art research on advanced therapies for the treatment of neurological diseases. We have various models and techniques available to test your products and validate your research hypotheses.

The preclinical studies area is dedicated to the validation of new technologies and healthcare products under development. We offer a wide range of preclinical studies conducted under high quality standards, ISO 9001:2015 and/or GLP quality standards, as well as technical and scientific advisory services.

The clinical production area is dedicated to the production of ATMPs of cell, gene and tissue engineering, for clinical use. Clinical production follows high quality standards, ISO 9001:2015 and/or good manufacturing standards (GMP)..

The managing area is the backbone of Creatio, responsible for managing and promoting all activities, establishing strategic alliances, and identifying collaborative opportunities and projects.

All our work is carried out to the highest quality standards: ISO 9001:2015, GLP and GMP.

Creatio encourages the establishment of strategic alliances with all the stakeholders of the healthcare ecosystem to promote the development of innovative technologies and therapies for the wellbeing of society.

Website: https://www.ub.edu/creatio/
Company page LinkedIn:  Creatio UB
Contact person via LinkedIn: Andrea Comella Bolla

More information will be available soon. 

Website: https://www.erbc-group.com/
Company page LinkedIn: ERBC(European Research Biology Center)
Contact person via LinkedIn: Aurélie Quentin

Epithelix is Biotech Company, specialized in tissue engineering, leader for in vitro assessment of drug efficacy and toxicity on human respiratory tract. We provides in vitro alternatives to animal testing (NAMs).

Epithelix has developed a unique technology for long-term culture of fully primary in vitro human reconstituted tissues. The company commercialize ready-to-use nasal, tracheal, bronchi (MucilAir™), small-airways (SmallAir™) and alveolar (AlveolAir™) epithelia and advanced immunocompetent models integrating macrophages, neutrophils or dendritic cells.

Epithelix also provide testing services (CRO activity) offering a panel of assays to study airway pathologies like Asthma, Cystic Fibrosis and Chronic Obstructive Pulmonary Diseases, Viral and Bacterial infections. A wide range of applications are available: toxicity assays, disease modelling, permeability of inhaled drugs, efficacy testing of novel antiviral or antimicrobial therapy, etc

Website: www.epithelix.com
Company page LinkedIn: Epithelix
Contact person via LinkedIn: Xiao-Yann Huang

More information will be available soon. 

Website:  https://www.episkin.com/
Company page LinkedIn:  EPISKIN SA
Contact person via LinkedIn: Christelle Videau

More information will be available soon. 

Website: www.immuone.com
Company page LinkedIn: ImmuONE
Contact person via LinkedIn: Louis Scott

IIVS is a GLP-compliant Contract Research Organization focused on non-animal alternatives to toxicology and product safety testing.  We work with industry (including chemical, pharmaceutical, cosmetic and personal care companies) as well as academic and government organizations, performing testing services in non-animal models. In addition, IIVS assists in the validation of New Approach Methodologies (NAMs) to traditional assays. As a non-profit entity, our laboratory activities and contributions fund our Education and Outreach programs, providing extensive training and active involvement in the advocacy and promotion of non-animal methods worldwide. For more information, visit www.iivs.org.

Website:  www.iivs.org
Company LinkedIn:  Institute for In Vitro Sciences, Inc.
Contact person via LinkedIn: Brent Gilbert

More information will be available soon. 

Website: https://www.iccs-cosmetics.org
Company page LinkedIn:  International Collaboration on Cosmetics Safety
Contact person via LinkedIn: Kelly Semrau

INVITROLIZE offers safety assessments for inhalable materials.

We help you to identify respiratory irritants and sensitizers early in product development.

Get peace of mind with our award-winning patented technology. Our human cell-based in vitro model allows for the first time the identification and differentiation of respiratory sensitizers and respiratory irritants under air-liquid interphase realistic exposure conditions.

Website:  https://invitrolize.com/
Company page LinkedIn: invitrolize
Contact person via LinkedIn: Arno Gutleb

IVTech is an Italian biotech company, founded in January 2014 by 4 bioengineers. We started as a spin-off of the University of Pisa. Now we are PMI, providing our technology and services to clients, involved in the biological research field. Our mission is to provide technology and services to fill the lack between a 3D and static in-vitro model and a 5D in-vitro model, highly representative of the human reality. The 5D concept means a three-dimensional model (I-IIIrd degree of complexity), based on cells or ex-vivo explants, immersed in a dynamic environment (IVth degree of complexity), which recreates the native stimuli and exposed to a cross communication with other tissues (Vth dimension). IVTech offers: 1. A fluidic platform to overcome the limitation of the obsolete in-vitro technology. The use of our systems permits the study of a complex biological scenario, characterized by a dynamic environment, a cross modulation between different tissues, and a stimulation pathway, mimicking even a disease condition. 2. Engineering service in the design of an advanced in-vitro model. We strongly think that the development of a 5D in-vitro model is a multidisciplinary matter. Therefore, we help our customer, basing on our engineering background. We develop computational models and mathematical models to scale down the physiological dimensions to the in-vitro scenario, increasing the correlation with the reality. 3. Biological service. We offer the opportunity to test drug compound or a new material, basing on our biological model. This service is developed in collaboration with our partners. “All our efforts are focused on the design and development of next generation products to push towards ever better in-vitro models of integrative human patho-physiology”

Website: www.ivtech.it
Company page LinkedIn: IVTech
Contact person via LinkedIn: Tommaso Sbrana

J-TEC supports a variety of in vitro testing for the animal alternatives by providing reconstructed living human 3-D tissue products, LabCyte. Our technologies are backed by the reliable tissue engineering techniques developed in manufacturing regenerative medicine products for decades. LabCyte have a structure and morphology that parallels those of human tissues, which support researchers to perform experiments in highly physiological conditions.

J-TEC offers two LabCyte product lines: EPI-MODEL (reconstructed human epidermis, listed in OECD TG431 and TG439) and CORNEA-MODEL (reconstructed human corneal epithelium, listed in OECD TG492). The recent release of the draft OECD TG442D, in vitro skin sensitization test EpiSensA which uses LabCyte EPI-MODEL, has expanded the applicability of LabCyte models in safety testing.

Website: https://www.jpte.co.jp/en/
Company page LinkedIn: LabCyte by J-TEC
Contact person via LinkedIn: Hiromichi Mitake

More information will be available soon. 

Website: www.locsense.nl
Company page LinkedIn: Locsense
Contact person via LinkedIn: Susan Roelofs

At L’Oréal, we are committed for beauty with no animal testing.

L’Oréal Groupe continuously invests in the development of non-animal testing methods and rallies the scientific communities in this journey. We share our scientific advances, knowledge and expertise to foster the use of non-animal testing methods, while engaging with regulators and decision makers to cease animal testing for cosmetics everywhere in the world.

Click here for more information: https://www.loreal.com/en/commitments-and-responsibilities/for-the-planet/for-beauty-with-no-animal-testing/

Website:  https://www.loreal.com/en/
Company page LinkedIn:  L’Oréal
Contact person via LinkedIn: Emilie Planel

MatTek is at the forefront of tissue engineering and is a world leader in the production of in vitro 3D reconstructed human tissue models for regulatory toxicology. Our skin, ocular, mucosal, and respiratory tissue models address toxicology and efficacy concerns throughout the cosmetics, chemical, pharmaceutical, and household product industries.

The outstanding reproducibility and high relevance of MatTek’s human cell-derived 3D tissue models provided impressive results in many international multi-laboratory validation studies. Our EpiDerm and EpiOcular models are validated by the OECD as an alternative to animal testing. At the moment, MatTek Corporation offers commercially 15 reconstructed human tissue models, animal models, and “beta” models of the colon, kidney, and liver.  

In 2009, the subsidiary of MatTek Corporation, with the business name MatTek In Vitro Life Sciences Laboratories s.r.o. (IVLSL) was established in Slovakia, Bratislava. In 2012, the commercial production of the EpiDerm tissue model in MatTek IVLSL started, and the production of the EpiOcular tissue model followed in 2013. At the moment EpiDerm, EpiDerm Full-Thickness, EpiOcular, EpiIntestinal, EpiAirway, EpiOral, EpiGingival, and MelanoDerm are available from the EU. 

Extension of production capabilities in Europe enabled MatTek partners better accessibility to products in a shorter time and eliminated administrative processes related to customs clearance. We also offer free of charge training in our laboratories in Bratislava. Training is always personalized and number of participants is 3 persons. During one training week, attendees can be trained for 3 assays. After training, the certificates of training are issued for each person.

The core business of our company is the research and development of new tissue models and methods, which allow us to reduce or replace using of animals in laboratory tests for chemicals, cosmetics, pharmaceuticals, household products, pesticides, medical devices, etc. MatTek IVLS is, therefore, a member of many scientific societies, organizations such as SETOX (Slovak Toxicology Society), ESTIV (European Society of Toxicology In Vitro), EUSAAT (European Society For Alternatives To Animal Testing), CELLTOX (Associazione Italiana Tossicologia In Vitro), Adebiotech France.

Website: www.mattek.com
Company page LinkedIn: MatTek Life Sciences
Contact person via LinkedIn: Miroslav Kandar

Newcells Biotech provides clients with validated in vitro tools to understand how drugs interact with tissues. We build functional in vitro models of the kidney, retina and lung to improve clinical translation and drug discovery. By applying our expertise in induced pluripotent stem cells (iPSCs), primary tissues, a deep understanding of cellular physiology and organoid technology, we have built validated models and assays that have proven to be predictive of how drugs interact with tissues and organs.

Website:  https://www.newcellsbiotech.co.uk/
Company page LinkedIn: Newcells Biotech Ltd
Contact person via LinkedIn: Jenny Cheung

The Nikon BioImaging Lab (NBIL) is a Contract Research Organization (CRO) that provides microscope-based imaging and analysis services to the biotech, pharma, and larger research communities, offering contract research services from the company that knows imaging.

The NBIL provides:

• • Imaging Services – A diverse range of samples can be imaged, from plates to histology slides (2D and 3D; live or fixed specimens). This includes time-lapse imaging of dynamic cellular processes, along with high-content image acquisition capabilities.
  • Analysis – Nikon’s AI-powered analysis software enables automation and standardization in data generation and offers a higher and more refined data yield than standard microscopy services.
  • Experimental Design – Expertise in assay development and execution as well as project consulting with the NBIL’s team of biologists and microscopy imaging professionals.

At the Nikon BioImaging Lab (NBIL), we are passionate about helping you get insights by providing solutions to your microscope-based imaging needs. We offer services for both imaging and analysis to organizations in biotech, pharma, and larger research communities that trust us with their projects.

Our center, the first in Europe, hosts Nikon’s unique cutting-edge microscopy instrumentation and software. NBIL’s full-service capabilities also include access to expert biologists and microscopists, who are available to provide quality cell and tissue culture, data acquisition, analysis, and reporting.

At the Nikon BioImaging Lab, we have a team of highly experienced scientists ready to turn your vision into quantitative data. We have experience ranging from single molecule assays, cell culture in 2D and 3D, organoids and spheroids, to complex thick tissues, as well as MPS (organ-on-a-chip microphysiological systems). With all of our expertise, we are confident that Nikon is the ideal imaging partner to support your research.

Website: https://www.microscope.healthcare.nikon.com/en_EU/bioimaging-centers/nikon-bioimaging-labs/leiden-nl
Company page LinkedIn: Nikon Biolmaging Lab
Contact person via LinkedIn: Andreas Kompatscher

PETA Science Consortium International e.V. advances the development, use, and global regulatory acceptance of reliable and relevant non-animal testing methods that protect human health and the environment. It does so by designing and funding experiments to build confidence in non-animal toxicity testing, conducting retrospective data analyses, donating in vitro human tissue models and equipment to researchers, and leading efforts to standardise in vitro testing protocols. The Science Consortium strives to ensures that information regarding the use of non-animal tests is accessible to all by hosting free webinars and workshops, publishing articles in peer-reviewed journals, and presenting its work at scientific conferences. It also develops informative factsheets, organises free training opportunities for scientists, and provides travel awards for early-career scientists to attend workshops. More information about PETA Science Consortium International e.V. can be found at www.thePSCI.eu

Website:  www.thepsci.eu
Company page LinkedIn: PETA Science Consortium International e.V.
Contact person via LinkedIn: Andreas Stucki

PRIMACYT is a German biotechnology company and GLP certified contract researcher. We offer one of the world’s most comprehensive portfolios of liver related products obtained from human and animal species including non-human primates, dogs, birds, fresh and seawater fish, rodents, and farm animals. Our product portfolio includes fresh and cryopreserved primary human and animal cells, liver subcellular fractions, ex vivo human skin explants, full thickness and dermatomed skin discs, blood derived products, and consumables for applications in environmental toxicology, preclinical drug testing and product development in human and animal health. Products are manufactured in accordance with OECD test guidelines when applicable.

We have a validated technology platform to assay drug transporter activities in stably transfected HEK293-cells and primary hepatocytes. We are GLP certified and serve as a reference laboratory for the EU.

Website: https://www.primacyt.com
Company page LinkedIn: PRIMACYT Cell Culture Technology GmbH
Contact person via LinkedIn: Dieter Runge

More information will be available soon. 

Website:  https://protoqsar.com/en/
Company page LinkedIn:  ProtoQSAR
Contact person via LinkedIn: Simon Perera

SenzaGen is dedicated to advancing in vitro science and testing, driving the transition from animal testing to methods that better reflects human biology. The Group offers state-of-the-art non-animal tests and tailored consulting services. Utilizing our unique GARD® technology, which combines genomic data from human cells with machine learning, we possess a distinct capability to identify and analyze whether a chemical could cause allergic reactions on the skin or in the respiratory tract. With demonstrated applicability for both pure chemicals and mixtures, GARD®skin (OECD TG442E) meets the needs of multiple industries, bringing new opportunities to the field of in vitro skin sensitization testing.

Website:  www.senzagen.com
Company page LinkedIn:  SenzaGen
Contact person via LinkedIn:  Tina Lawesson

More information will be available soon. 

Website: https://www.team-mastery.eu/
Company page LinkedIn: TEAM mastery s.r.l.
Contact person via LinkedIn: Sofia Gallicchio

Unilever manufactures a range of home, personal care, beauty & wellbeing, and food products that are sold throughout the world in over 190 countries, with over 400 brand names.  On any given day, 3.4 billion consumers use Unilever products sold under many well-known brands, including Dove, AXE, Lifebuoy, Comfort, Sunlight, and Knorr.

Safety and Environmental Assurance Centre (SEAC) is a key part of Unilever R&D with responsibility for ensuring that Unilever’s innovations are designed to be safe and sustainable.  Our leading-edge approach to assuring the safety of Unilever’s products for people and the planet has one clear purpose: to guarantee that our products are safe, without the need for animal testing. That’s why we say #UseScienceNotAnimals.

Our ability to innovate using non-animal safety assessment approaches is underpinned by scientific partnerships with over 70 leading research teams globally to develop and apply new capability. We look to openly share the experience gained from these collaborations through publications, presentations and through our website: https://seac.unilever.com/

Website: https://seac.unilever.com/
Company page LinkedIn: Unilever
Contact person via LinkedIn: Carl Westmoreland

VITROCELL® is specialized in the development of advanced in vitro exposure systems for inhalation toxicology: mammalian cells can be exposed to gases, environmental atmospheres, nano particles and complex mixtures at the air/liquid interface. VITROCELL® Skin modules and autosamplers are designed for the exposure of tissue. Our customers are leading research institutes, contract research organizations, regulatory authorities as well as the pharmaceutical and other industries throughout the world.

Website: https://www.vitrocell.com/
Company page LinkedIn: Vitrocell Systems GmbH
Contact person via LinkedIn: Melanie Bucher

Xenometrix develops and manufactures ready to use, quality-controlled assay kits for the genotoxicity assessment of chemicals, pharmaceuticals, or biologicals, for the detection of endocrine active compounds as well as ex vivo explants for in vitro skin permeation testing:

Ames Test Kits in agar plate format with Petri dishes (MacroAmes1 in line with OECD 471) or in 6 well plate format (MicroAmes6). The microplate fluctuation assay format (Ames MPF in line with ICH M7 guideline) allows automation, has a low consumption of test compound, 11x less consumption of S9 (in line with 3Rs and less test animals) and produces significantly less plastic waste.

Rapid Micronucleus MoA Test kit offers a fast and clear detection of chromosomal aberrations like micronuclei, N-Buds, bridges with pancentromeric probes and enables a clear identification of clastogenic compounds (OECD 483, 473).

Ready to use test kits for the detection of compounds with agonistic and antagonistic endocrine activity, towards estrogen and androgen receptors.

Also available from Xenometrix are ex vivo human and porcine skin explants for the in vitro permeation testing of chemicals, skin penetration, biodistribution (OECD 428, MDR 2017/745).

Together with its partners Xenometrix offers analytical services under GLP and non GLP condition: Ames Test for screening, for the detection of impurities, for mixtures or for OECD TG471, in vitro micronucleus (TG483), chromosomal aberration (TG471), screening for estrogen and androgen active compounds, in vitro permeation testing, for registration purposes of (agro)chemicals, biocides, pharmaceuticals, cosmetics, substance-based medical devices.

Website: www.xenometrix.ch
Company page LinkedIn: XENOMETRIX
Contact person via LinkedIn: Csaba Boglári