Scientific papers and book chapters

European Society of Toxicology In Vitro > Scientific papers and book chapters

2023

Brackin T, Gayes H, Johnson I, Fox D, and Roper C. (2024). Skin barrier function for regulatory skin absorption tests and effects on testosterone and sucrose absorption. Toxicology in Vitro 95; 105735. https://doi.org/10.1016/j.tiv.2023.105735.

Page K, Westerink W, Sullivan K, McDonald T, Roper C. Assessment of the utility of the novel Phenion® full thickness human skin model for detecting the skin irritation potential of antimicrobial cleaning products. Toxicol In Vitro. 2023 Nov 4:105726. doi: 10.1016/j.tiv.2023.105726. Epub ahead of print. PMID: 37931828

Ashammakhi N, Nakipoglu M, Hartung T. Lessons, insights from the first Microphysiological World Summit. Journal of Cranofacial Surgery Open 2023, 1:e0011. DOI: 10.1097/SC9.0000000000000011.

Barreras P, Pamies D, Hartung T, Pardo CA. Human brain microphysiological systems in the study of neuroinfectious disorders. Experimental Neurology 365:114409. Doi: 10.1016/j.expneurol.2023.114409

Bishop PL, Brescia S, Brunner R, Casey W, Conlee-Griffin K, Craenen K, Currie RA, Domoradzki J, Embry M, Harris MI, Hartung T, Hilton GM, Hooberman B, Ingle B, Jang K-J, Kinter L, Krall C, Leedale J, Lowit A, Mehta J, Mendez E, Mingoia B, Munarriz E, Murphy L, Myer A, Ottoni A,  Panzarea M, Perron M, Pina J, Ramsingh D, Sewell F, Swanson J, Tan C, Tan Y-M, Terron A, Trainer MA, Valadares MC, Webb S, Webb E, Willett C, Wolf DC. Challenges and opportunities for overcoming dog use in agrochemical evaluation and registration. ALTEX 2023, 40:534-540. doi: 10.14573/altex.2302151.

Butera A, Smirnova L, Ferrando-May E, Hartung T, Brunner T, Leist M, Amelio I. Deconvoluting Gene and Environment interactions to develop “epigenetic score meter” of disease. EMBO Molecular Medicine 2023, e18208. https://doi.org/10.15252/emmm.202318208.

Caloni F, Fossati P, Hartung T, Martino PA, Mormino G, Vitale A, De Angelis I.
Summer Meeting Alternative Methods, CitiZen Science. ALTEX 2023, 39:159–160.

Caloni F, De Angelis I, Gribaldo L, Heinonen T, Kandarova H, Kral V, Letasiova S, Sillé F, Smirnova L, Pilar Vinardell M, Hartung T. Women in Alternatives. ALTEX 2023, 40:545-548, doi: 10.14573/altex.2303211

De Silva A, Ramesh R, Ungar L, Shuler HM, Cowan NJ, Platt M, Li C, Isik L, Roh S-E, Charles A, Venkataraman A, Caffo B, How JJ, Kebschull JM, Krakauer JW, Bichuch M, Kinfu KA, Yezerets E, Jayaraman D, Shin JM, Villar S, Phillips I, Priebe CE, Hartung T, Miller MI, Vidal R, Dey J, Huang N, Eaton E, Etienne-Cummings R, Ogburn EL, Burns R, Osuagwu O, Mensh B, Muotri AR, Brown J, White C, Yang W, Rusu AA, Verstynen T, Kording KP, Chaudhari P, Vogelstein JT. Prospective Learning: Principled Extrapolation to the Future. Conference on Lifelong Learning Agents, 2023.

Diemar M, Vinken M, Teunis M, Krul C, Busquet F, Zajac J, Kandarova H, Corvi R, Russo M, Kharina A, Bryndum L, Santillo M, Bloch D, Kucheryavenko O, Panagiotakos D, Rogiers V, Beekhuijzen M, Giusti A, Najjar A, Courage C, Koenig T, Kolle S, Boonen H, Dhalluin S, Boberg J, Müller B, Kukic P, Ritskes-Hoitinga M, Grasselli E, Zietek T, Stoddart G, Heusinkveld H, Castell J, Benfenati E, Yang H, Perera S, Paini A, Kramer N, Hartung T, Janssen M, Fritsche E, Jennen D, Piumatti M, Rathman J, Marusczyk J, Milec L,, Roggen E. Report of the first ONTOX Stakeholder Network meeting: digging under the surface of ONTOX together with the stakeholders. ATLA, in press.

Golden E, Ukaegbu DC, Ranslow P, Brown R, Hartung T, Maertens A. The Good, The Bad, and The Perplexing: Structural Alerts and Read-Across for Predicting Skin Sensitization Using Human Data. Chem. Res. Toxicol. 2023, 36:734–746. Doi: 10.1021/acs.chemrestox.2c00383.

Hartung T. A call for a Human Exposome Project. ALTEX 2023, 40:4–33. doi: 10.14573/altex.2301061.

Hartung T. ToxAIcology –  AI as the New Frontier in Chemical Risk Assessment. Frontiers in AI, Sec. Medicine and Public Health 2023, 40:559–570. doi: 10.3389/frai.2023.1269932

Hartung T, Smirnova L, Morales Pantoja IE Akwaboah A, Alam El Din D-M, Berlinicke CA, Boyd JL, Caffo BS, Cappiello B, Cohen-Karni T, Curley L, Etienne-Cummings R, Dastgheyb R, Gracias DH, Gilbert F, Habela CW, Han F, Harris T, Herrmann K, Hill E, Huang Q, Jabbour RE, Johnson EC, Kagan BJ, Krall C, Levchenko A, Locke P, Maertens A, Metea M, Muotri AR, Parri R,  Paulhamus BL, Plotkin J, Roach P, Romero JC, Schwamborn JC, Sillé F, Szalay A, Tsaioun K, Tornero D, Vogelstein JT, Wahlin K,, Zack DJ. The Baltimore Declaration toward the exploration of organoid intelligence. Frontiers in Science 2023, 1:1017235. doi: 10.3389/fsci.2023.1017235

Hartung T. Tierversuche ersetzen: Wie und wann? Frontiers for Young Minds 2023, in press.

Hartung T. Can you take AI out of the wild and should you? Frontiers Policy Labs 2023, https://policylabs.frontiersin.org/content/commentary-ai-data-thomas-hartung

Hartung T. ToxAIcology – the Evolving Role of Artificial Intelligence in Advancing Toxicology and Modernizing Regulatory Science. ALTEX 2023, 40: 559-570. doi: 10.14573/altex.2309191.

Hartung T. Book Review: Rat Trap – Breaking Free from the Illusion of Progress in Animal Research by Pandora Pound”, ALTEX 2023, 40:705. Available at: https://www.altex.org/index.php/altex/article/view/2697

Holzer A-K, Dreser N, Pallocca G, Mangerich A, Stacey G, Dipalo M, van de Water B, Rovida C, Wirtz PH, van Vugt B, Panzarella G, Hartung T, Terron A, Mangas I, Herzler M, Marx-Stoelting P, Coecke S, Leist M. Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I, ALTEX 2023, 40:706–712. doi: 10.14573/altex.2310021.

Jordan R, Ford-Scheimer SL, Alarcon RM, Atala A, Borenstein JT, Brimacombe KR, Cherry S, Clevers H, Davis MI, Funnell SGP, Gehrke L, Griffith LG, Grossman AC, Hartung T,  Ingber DE,  Kleinstreuer NC, Kuo CJ, Lee EM, Mummery CL, Pickett TE, Ramani S, Rosado-Olivieri EA, Struble EB, Wan Z, Williams MS, Hall MD, Ferrer M, Markossian S. Report of the Assay Guidance Workshop on 3D Tissue Models for Antiviral Drug Development. J. Inf. Dis. 2023, 228:S337–S354, doi: 10.1093/infdis/jiad334

Kincaid B, Piechota P, Golden E, Maertens M, Hartung T, Maertens A. When exposures are more than the sum of their parts: using in silico tools to predict flame retardant metabolites for more informative exposomics-based approaches. Front. Toxicol., Sec. Environmental Toxicology 2023, 5. doi: 10.3389/ftox.2023.1216802 

Knight J, Hartung T, Rovida C. 4.2 million and counting…the animal toll for REACH systemic toxicity studies. ALTEX 2023, 40:389-407. Doi: 10.14573/altex.2303201.

Morales Pantoja IE, Smirnova L, Muotri AR, Wahlin KJ, Kahn J, Boyd L, Gracias DH, Cohen-Karni T, Caffo BS, Szalay AS, Han F, Zack DJ, Etienne-Cummings R, Akwaboah A,  Romero JC, Alam El Din D-M, Plotkin JD, Paulhamus BL, Johnson EC, Gilbert F, Curley JL, Cappiello B, Schwamborn JC, Hill EJ, Roach P, Tornero D, Krall C, Parri R, Sillé F, Levchenko A, Jabbour RA, Kagan BJ, Berlinicke CA, Huang Q, Maertens A, Herrmann K, Tsaioun K, Dastgheyb R,  Habela CW, Vogelstein JT, Hartung T. First Organoid Intelligence (OI) Workshop to Form an OI Community, Frontiers Artificial Intelligence 2023, Section Organoid Intelligence, 6: 1116870. doi: 10.3389/frai.2023.1116870.

Najjar A, Kramer N, Gardner I, Hartung T, Steger-Hartmann T. Perspectives in Predictive Toxicology. Front. Pharmacol. 2023, Sec. Predictive Toxicology 14: 1257423. doi:   10.3389/fphar.2023.1257423

Rovida C, Busquet F, Leist M, Hartung T. REACH out-numbered! The future of REACH and animal numbers. ALTEX 2023, 40:367-388. Doi: 10.14573/altex.2307121

Schmeisser S, Miccoli A, von Bergen M, Berggren E, Braeuning A, Busch W, Desaintes C, Gourmelon A, Grafström R, Harrill J, Hartung T, Herzler M, Kass G, Kleinstreuer N, Leist M, Luijten M, Marx-Stoelting P, Poetz O, van Ravenzwaay B, Roggeband R, Rogiers V, Roth A, Sanders P, Thomas RS, Vinggaard AM, Vinken M, van de Water B, Luch A, Tralau T. New Approach Methodologies in human regulatory toxicology – not if, but how and when!, Environment International 2023, 178:108082. doi: 10.1016/j.envint.2023.108082

Smirnova L, Caffo BS, Gracias DH, Huang Q, Morales Pantoja IE, Tang B, Zack DJ, Berlinicke CA, Boyd JL, Harris TD, Johnson EC, Kagan BJ, Kahn J, Muotri AR, Paulhamus BL, Schwamborn JC, Plotkin J, Szalay AS, Vogelstein JT, Worley PF, Hartung T. Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish, Frontiers in Science, 2023, 1:1017235. doi: 10.3389/fsci.2023.1017235.

Smirnova L, Morales Pantoja IE, Hartung T. Brain-cell cultures: the future of computers and more? Frontier for Young Minds 2023, 11:1049593. doi: 10.3389/frym.2023.1049593.

Smirnova L, Morales Pantoja IE, Hartung T. Organoid Intelligence (OI) – the ultimate functionality of a brain microphysiological system. ALTEX 2023, 40:191-203. doi:10.14573/altex.2303261

Ezechiáš M, The agonistic bioanalytical equivalent concentration: A novel tool for assessing the endocrine activity of environmental mixtures. Environ Toxicol Pharm. 2022 Jan; 89:103781. https://doi.org/10.1016/j.etap.2021.103781

L. Svobodova, K. Kejlova, M. Rucki, J. Chrz, P. Kubincova, M. Dvorakova, H. Kolarova, D. Jirova. Health safety of parabens evaluated by selected in vitro methods. Regulatory Toxicology and Pharmacology, Volume 137, 2023, 105307, ISSN 0273-2300. https://doi.org/10.1016/j.yrtph.2022.105307.

dos Santos Rodrigues B., Leroy K., Mihajlovic M., De Boever S., Vanbellingen S., Cogliati B., Aerts J.L., Vinken M. (2023) “Evaluation of functional candidate biomarkers of non-genotoxic hepatocarcinogenicity in human liver spheroid co-cultures.” Archives of Toxicology 97: 1739-1751 (impact factor2022: 6.1). PMID: 36941454, DOI: 10.1007/s00204-023-03486-4

Jiang J., van Ertvelde J., Ertaylan G., Peeters R., Jennen D., de Kok T.M., Vinken M. (2023) “Unraveling the mechanisms underlying drug-induced cholestatic liver injury: identifying key genes using machine learning techniques on human in vitro data sets.” Archives of Toxicology 97: 2969-2981 (impact factor2022: 6.1). PMID: 37603094, PMCID: PMC10504391, DOI: 10.1007/s00204-023-03583-4

Schmeisser S., Miccoli A., von Bergen M., Berggren E., Braeuning A., Busch W., Desaintes C., Gourmelon A., Grafström R., Harrill J., Hartung T., Herzler M., Kass G., Kleinstreuer N., Leist M., Luijten M., Marx-Stoelting P., Poetz O., van Ravenzwaay B., Roggeband R., Rogiers V., Roth A., Sanders P., Thomas R.S., Vinggaard A.M., Vinken M., van de Water B., Luch A., Tralau T. (2023) “New approach methodologies in human regulatory toxicology: not if, but how and when!” Environment International 178: 108082 (impact factor2022: 11.8). PMID: 37422975, DOI: 10.1016/j.envint.2023.108082

van Ertvelde J., Verhoeven A., Maerten A., Cooreman A., dos Santos Rodrigues B., Sanz Serrano J., Mihajlovic M., Tripodi I., Teunis M., Jover R., Luechtefeld T., Vanhaecke T., Jiang J., Vinken M. (2023) “Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification.” Journal of Biomedical Informatics 145: 104465 (impact factor2022: 4.5). PMID: 37541407, DOI: 10.1016/j.jbi.2023.104465

Roper CS, and Neill DR. (2023). Transitioning Acute In Vitro Inhalation Toxicology Testing to Chronic and Repeat Dose Testing; the Challenge of Mucus Depletion in Upper Airway Test Systems and Use of Sputum Mimics. Open Acc J of Toxicol. 5(4):555669. DOI:10.19080/JOJDC.2023.05.555669.

Dvořáková M, Svobodová L, Rucki M, Ševčík V, Hošíková B, Chrz J, Bendová H, Kejlová K, Očadlíková D, Malý M, Kolářová H, Mannerström M, Kanďárová H, Jírová D. The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis. Altern Lab Anim. 2023 Jul;51(4):224-248. https://journals.sagepub.com/doi/10.1177/02611929231184635

Schmeisser S, Miccoli A, Barton-Maclaren T, von Bergen M, Berggren E, Braeuning A, Busch W, Desaintes C, Ellero-Simatos S, Gourmelon A, Grafstoem R, Harrill J, Hartung T, Herzler M, Kass G, Kawanishi T, Kleinstreuer N, Leist M, Luijten M, Marx-Stoelting P, Monti S, Poetz O, van Ravenzwaay B, Roggeband R, Rogiers V, Roth A, Sanders P, Schuette K, Simeonov A, Sobanski T, Thomas R, Tong W, Vinggaard AM, Vinken M, Walter J, van de Water B, Wittwehr C, Luch A, Tralau T. New Approach Methodologies in regulatory toxicology – not a question of if, but how and when! Environ. Int. 178, 108082, 2023.  https://dx.doi.org/10.1016/j.envint.2023.108082.

Rodriguez-Carillo et al. Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge. Int J Hy Environ Health, 249, 114140, 2023. doi: 10.1016/j.ijheh.2023.114140.

Ma Y, Taxvig C, Rodríguez-Carrillo A, Mustieles V, Reiber L, Kiesow A, Löbl NM, Fernández MF, Alstrup Hansen TV, Valente MJ and Vinggaard AM. Human risk associated with exposure to mixtures of antiandrogenic chemicals evaluated using in vitro hazard and human biomonitoring data. Environ. Int. 173, 107815, 2023. https://doi.org/10.1016/j.envint.2023.107815 

Escher BI, Lamoree M, Antignac J-P, Scholze M, Herzler M, Hamers T, Jensen TK, Audebert M, Busquet F, Maier D, Oelgeschläger M, Valente MJ, Boye H, Schmeisser S, Dervilly G, Piumatti M, Moteau S, König M, Renko K, Jornet MM, Cariou R, Ma Y, Treschow AF, Kortenkamp A, Vinggaard AM. Mixture Risk Assessment of Complex Real-Life Mixtures—The PANORAMIX Project. Int. J. Environ. Res. Public Health 19(20), 12990, 2022. https://doi.org/10.3390/ijerph192012990 

Lauschke K, Dalgaard Md, Emnéus J, Vinggaard Am. Transcriptomic changes upon epoxiconazole exposure in a human stem cell-based model of developmental toxicity. Chemosphere, 284, 131225, 2021. https://doi.org/10.1016/j.chemosphere.2021.13122

Altmaier S, Meiser I, Lemesre E, Chanrion B, Steeg R, Leonte LE, Holst B, Nielsen BS, Clausen C, Schmidt K, Bur S, Vinggaard AM, Zimmermann H, Neubauer JC, Rasmussen MA. Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicology studies. Reprod. Tox., 111, 68-80, 2022. https://doi.org/10.1016/j.reprotox.2022.05.00

Lauschke K, Volpini L, Liu Y, Vinggaard AM, Hall VJ. A comparative assessment of marker expression between cardiomyocyte differentiation of human iPSCs and the developing pig heart. Stem Cells and Development 30 (7), 374-385, 2021. doi:10.1089/scd.2020.0184 

Lauschke K, Treschow AF, Rasmussen MA, Davidsen N, Holst B, Emnéus JK, Taxvig C and Vinggaard AM. Creating a human NKX2.5 reporter stem cell line for developmental toxicity testing. Arch Toxicol 95, 1659–1670, 2021. doi:10.1007/s00204-021-03018-y

CALONI, Francesca – DE ANGELIS, Isabella – GRIBALDO, Laura – HEINONEN, Tuula – KANDAROVA, Helena – KRAL, Vivian – LETAŠIOVÁ, Silvia – SILLÉ, Fenna – SMIRNOVA, Lena – VINARDELL, Maria Pilar – HARTUNG, Thomas. Women in Alternatives. In ALTEX : Alternatives to Animal Experimentation, 2023, vol. 40, no. 3, pp. 545-548. . ISSN 1868-596X. https://doi.org/10.14573/altex.2303211

VISKUPIČOVÁ, Jana – REZBÁRIKOVÁ, Petronela – KOVÁČIKOVÁ, Lucia – KANDAROVA, Helena – MÁJEKOVÁ, Magdaléna. Inhibitors of SARS-CoV-2 main protease: Biological efficacy and toxicity aspects. In Toxicology in vitro: the official journal of the European Society for Toxicology in Vitro, 2023, vol. 92, art. no. 105640. ISSN 0887-2333. Dostupné na: https://doi.org/10.1016/j.tiv.2023.105640

Naik NN, Vadloori B, Poosala S, Srivastava P, Coecke S, Smith A, Akhtar A, Roper C, Radhakrishnan S, Bhyravbhatla B, Damle M, PullaVK, Hackethal J, Horland R, Li AP, Pati F, Singh MS, Occhetta P, Bisht R, Dandekar P, Bhagavatula K, Pajkrt D, Johnson M, Weber T, Huang J, Hysenaj L, Mallar B, Ramray B, Dixit S, Joshi S, and Kulkarni K (2023). Advances in animal models and cutting-edge research in alternatives: proceedings of the third international conference on 3Rs research and progress, Vishakhapatnam, 2022. Alternatives to Laboratory Animals 51(4): 263-288. https://doi:10.1177/02611929231180428

Turner J, Pound P, Owen C, Hutchinson I, Hop M, Chau DYS, Barrios Silva LV, Coleman M, Dubourg A, Harries LW, Hutter V, Kenna JG, Lauschke VM, Neuhaus W, Rper C, Watkins PB, Welch J, Alvarez LR and Taylor K (2023). Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment. ALTEX 40(3): 519-533. doi: 10.14573/altex.2212081.

Wallace J, Jackson GR, Kaluzhny Y, Ayehunie S, Lansley AB, Roper C, and Hayden PJ. (2023). Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing. Toxicological Sciences 194 (2); 178‑190. doi: 10.1093/toxsci/kfad058.

2022

Barreras P, Pamies D, Monaco MC, Munoz LS, Zhong X, Major EO, Hogberg HT; Hartung T, Pardo CA. A human derived 3D brain microphysiological system as a model to study JC virus infection. Journal Neurovirology 2022, 28:17-26..doi: 10.1007/s13365-022-01062-7.

Caloni F, De Angelis I, Hartung T. Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi. Archives of Toxicology 2022, 96:1935-1950. doi: 10.1007/s00204-022-03299-x.

Deng J, Hartung T, Capobianco E, Chen JY, Emmert-Streib F. Artificial Intelligence for Precision Medicine. Front. Artif. Intell. 4:834645. doi: 10.3389/frai.2021.834645

Fu Y, Luechtefeld T, Karmaus A, Hartung T. The use of artificial intelligence and big data for the safety evaluation of US food-relevant chemicals. In: Knowles ME, Anelich L, Boobis A and Popping B (eds). Present knowledge in food safety – a risk-based approach throughout the food chain, Elsevier, 575-588.

Farhat N, Tsaioun K, Saunders-Hastings P, Morgan RL, Ramoju S, Hartung T, Krewski D. Systematic review in evidence-based risk assessment. ALTEX 39:463–479. doi: 10.14573/altex.2004111.

Hartung T, Krewski D. Editorial: Special Issue Development of an Evidence-Based Risk Assessment Framework.  ALTEX 39:442. doi: doi:10.14573/altex.22S2.

Hartung T, Tsatsakis AM. Safety Science in the 21st Century – a Scientific Revolution in its Making. In: Tsatsakis AM (ed). Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. p. 51-59.  Elsevier, 2022.

Hartung T. Replacing Animal Testing: How and When? Frontier for Young Minds 2022, 10:959496. doi: 10.3389/frym.2022.959496.

Hoffmann S, Aiassa E, Angrish M, Beausoleil C, Bois FY, Ciccolallo L, Craig PS, de Vries RBM, Dorne JLCM, Druwe IL, Edwards SW, Eskes C, Georgiadis M, Hartung T, Kienzler A, Kristjansson EA, Lam J, Martino L, Meek B, Morgan RL, Munoz-Guajardo I, Noyes PD, Parmelli E, Piersma A, Rooney A, Sena E, Sullivan K, Tarazona J, Terron A, Thayer K, Turner J, Verbeek J, Verloo D, Vinken M, Watford S, Whaley P, Wikoff D, Willett K, Tsaioun K. Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks, ALTEX 2022, 39:499–518. doi: 10.14573/altex.2202141.

Huang Q, Tang B, Romero JC, Yang Y, Elsayed SK, Pahapale G, Lee T-J, Pantoja IEM, Han F, Berlinicke C, Xiang T, Solazzo M, Hartung T, Qin Z, Caffo BS, Smirnova L, Gracias DH. Shell Microelectrode Arrays (MEAs) for brain organoids. Science Advances 2022, 8:eabq5031. Doi: 10.1126/sciadv.abq5031.

Hutt A, Gruning A, Hansen A, Hartung T, Robeva R. Editorial on Machine Learning in Natural Complex Systems. Frontiers in Applied Mathematics and Statistics, Front. Appl. Math. Stat. 8:869999. doi: 10.3389/fams.2022.869999.

Karaulov AV, Smolyagin AI, Mikhailova IV, Stadnikov AA, Ermolina EV, Filippova YV, Kuzmicheva NV, Vlata ZK, Buha Djordjevic A, Christina, Hartung T, Hernandez AF, Tsatsakis AM. Assessment of the combined effects of chromium and benzene on the rat neuroendocrine and immune systems. Environmental Research 2022, 207:112096.  doi: 10.1016/j.envres.2021.112096.

Krewski D, Saunders-Hastings P, Baan R, Barton-Maclaren T, Browne P, Chiu WA, Gwinn M, Hartung T, Kraft A, Lam J, Lewis JR, Sanaa M, Morgan RL, Paoli G, Rhomberg L, Rooney A, Sand S, Schünemann HJ, Straif K, Thayer K, Tsaioun, K. Workshop Report: Development of an Evidence-Based Risk Assessment Framework. ALTEX 2022, 39:667–693. doi: 10.14573/altex.2004041.

Lippa KA, Aristizabal-Henao JJ, Beger RD, Bowden JA, Broeckling C, Beecher C, Davis WC, Dunn WB, Flores R, Goodacre R, Gouveia GJ, Harms AC, Hartung T, Jones CM, Lewis CM, Ntai I, Percy AJ, Raftery D, Schock TB, Sun J, Theodoridis G, Tayyari F, Torta F, Ulmer CZ, Wilson I, Ubhi BK. Reference Materials for MS-based Untargeted Metabolomics and Lipidomics: A Review by the Metabolomics Quality Assurance and Quality Control Consortium (mQACC). Metabolomics 2022, 18:24. Doi: 10.1007/s11306-021-01848-6.

Maertens A, Golden E, Luechtefeld TH, Hoffmann S, Tsaioun K, Hartung T. Probabilistic Risk Assessment – the Keystone for the Future of Toxicology. ALTEX 2022, 39:3-29. doi:10.14573/altex.2201081.

Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, J´ırova D, Kejlova K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thone-Reineke C, Hartung T, Pallocca G, Leist M, Hippenstiel S, Lang A, Retter I, Kramer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kranzlin B, Seeger B, von Kockritz-Blickwede M, Sanchez-Morgado JM, Galligioni V, Ruiz-Perez D, Movia D, Prina-Mello A, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, Stepnik M, Sobanska Z, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Cederroth CR, Sandstrom J, Ragan I, Bubalo N, Spielmann H. The rise of 3R centres and platforms in Europe. ATLA 2022, 50:90-120.

Neuhaus W, Reininger-Gutmann B, Rinner B, Plasenzotti R, Wilflingseder D, De Kock J, Vanhaecke T, Rogiers V, Jírová D, Kejlová K, Knudsen LE, Nielsen RN, Kleuser B, Kral V, Thöne-Reineke C, Hartung T, Pallocca G, Rovida C, Leist M, Hippenstiel S, Lang A, Retter I, Krämer S, Jedlicka P, Ameli K, Fritsche E, Tigges J, Kuchovska E, Buettner M, Bleich A, Baumgart N, Baumgart J, Meinhardt MW, Spanagel R, Chourbaji S, Kränzlin B, Seeger B, von Köckritz-Blickwede M, Sánchez-Morgado JM, Galligioni V, Ruiz-Pérez D, Movia D, Prina-Mello D, Ahluwalia A, Chiono V, Gutleb AC, Schmit M, van Golen B, van Weereld L, Kienhuis A, van Oort E, van der Valk J, Smith A, Roszak J, Stępnik M, Sobańska Z, Reszka E, Olsson IAS, Franco NH, Sevastre B, Kandarova H, Capdevila S, Johansson J, Svensk E, Cederroth CR, Sandström J, Ragan I, Bubalo N, Kurreck J, Spielmann H. The current status and work of 3R centres and platforms in Europe. ATLA – Alternatives to Laboratory Animals 2022, 50:381-413.

Pamies D, Wiersma D, Katt ME, Zhong L, Burtscher J, Harris G, Smirnova L, Searson PC, Hartung T, Hogberg H. Human organotypic brain model as a tool to study chemical-induced dopaminergic neuronal toxicity. Neurobiology of Disease 2022, 169:105719.  doi: 10.1016/j.nbd.2022.105719.

Pamies D, Leist M, Coecke S, Bowe G, Allen D, Gstraunthaler G, Bal-Price A, Pistollato F, DeVries R, Hogberg HT, Hartung T, Stacey G. Guidance Document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0). ALTEX, 2022, 39:30–70. doi: 10.14573/altex.2111011.

Sillé FCM, McCormack M, Hartung T. The Exposome applied: a step toward defining the totality of environmental exposures in asthma. American Journal of Respiratory and Critical Care Medicine 2022, 206:1187-1188. doi: 10.1164/rccm.202207-1430ED

Smirnova L, Hartung T. Neuronal cultures playing Pong – first steps toward advanced screening and biological computing. Neuron 2022, 110:3855-3856, doi: 10.1016/j.neuron.2022.11.010.

Steimberg N, Alloisio S, Vincentini O, Caloni F, Baderna D, Dellambra E, Delle Monache F, Sbrana T, Scaglione S, Letasiova S, Cattaneo A, Ludovico A, Hartung T, Colacci A, Markus J, Rescigno F, Piccapane F, Occhetta P, Scagnoli F. CellTox Days 2022 – Inside the barriers: In vitro models and their applications. ALTEX 2023, 40:160-164. doi: 10.14573/altex.2211101

von Aulock S, Busquet F, Locke P, Herrmann K, Hartung T. Engagement of scientists with the public and policymakers to promote alternative methods. ALTEX 2022, 39:543–559. doi: 10.14573/altex.2209261.

Benoit L., Jornod F., Zgheib E., Tomkiewicz C., Koual M., Coustillet T., Barouki R., Audouze K., Vinken M., Coumoul X. (2022) “Adverse outcome pathway from activation of the AhR to breast cancer-related death.” Environment International 165: 107323 (impact factor2022: 11.8). PMID: 35660951, DOI: 10.1016/j.envint.2022.107323

Clerbaux L.-A.,  Amigó N., Amorim M.J., Bal-Price A., Batista Leite S., Beronius A., Bezemer G.F.G., Bostroem A.-C., Carusi A., Coecke S., Concha R., Daskalopoulos E.P., Debernardi F., Edrosa E., Edwards S.W., Filipovska J., Garcia-Reyero N., Gavins F.N.E., Halappanavar S., Hargreaves A.J., Hogberg H., Huynh M.T., Jacobson D., Josephs-Spaulding J., Kim Y.J., Kong H.J., Krebs C.E., Lam A., Landesmann B., Racanelli Layton A., Lee Y.O., Macmillan D.S., Mantovani A., Margiotta-Casaluci L., Martens M., Masereeuw R., Mayasich S.A., Mei L.M., Mortensen H., Munoz Pineiro A., Nymark P., Ohayon E., Ojasi J.M., Paini A., Parissis N., Parvatam S., Pistollato F., Sachana M., Birkelund Sørli J., Sullivan K.M., Sund J., Tanabe S., Tsaioun K., Vinken M., Viviani L., Waspe J., Willett C., Wittwehr C. (2022) “COVID-19 through adverse outcome pathways: building networks to better understand the disease: report of the 3rd CIAO AOP design workshop.” ALTEX 39: 322-335 (impact factor2022: 5.6). PMID: 35032963, PMCID: PMC10069302, DOI: 10.14573/altex.2112161

Daston G.P., Mahony C., Thomas R.S., Vinken M. (2022) “Assessing safety without animal testing: the road ahead.” Toxicological Sciences 187- 214-218 (impact factor2022: 3.8). PMID: 35357465, DOI: 10.1093/toxsci/kfac039

Hoffmann S., Aiassa E., Angrish M., Beauso leil C., Bois F.Y., Ciccolallo L., Craig P.S., de Vries R.M.B., Dorne J.L.C.M. , Druwe I.L., Edwards S.W., Eskes C., Georgiadis M., Hartung T., Kienzler A., Kristjansson E.A., Lam J., Martino L., Meek B., Morgan R.L., Munoz-Guajardo I., Noyes P.D., Parmelli E., Piersma A., Rooney A., Sena E., Sullivan K., Tarazona J., Terron A., Thayer K., Turner J., Verbeek J., Verloo D., Vinken M., Watford S., Whaley P., Wikoff D., Willett K., Tsaioun K. (2022) “Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks.” ALTEX 39: 499-518 (impact factor2022: 5.6). PMID: 35258090, PMCID: PMC9466297, DOI: 10.14573/altex.2202141

Mihajlovic M., Vinken M. (2022) “Mitochondria as target of hepatotoxicity and drug-induced liver injury: molecular mechanisms and detection methods.” International Journal of Molecular Sciences 23: 3315 (impact factor2022: 5.6). PMID: 35328737, PMCID: PMC8951158, DOI: 10.3390/ijms23063315

Sonawane A., Vadloori B., Poosala S., Kandarova H., Kulkarni M., Olayanju A., Dey T., Saxena U., Smirnova L., Kanda Y., Reddy J., Dravida S., Biswas S., Vinken M., Gettayacamin M., Ahluwalia A., Mondini F., Bhattacharya S., Kulkarni P., Jacobsen K., Vangala S., Millas A. (2022) “Advances in animal models and cutting-edge research in alternatives: proceedings of the second international conference on 3Rs research and progress, Hyderabad, 2021.” ATLA 50: 156-171 (impact factor2022: 2.7). PMID: 35410493, DOI: 10.1177/02611929221089216

Vinken M. (2022) “Toxic talk: pannexin1 channel communication as an emerging mechanism of toxicity.” Toxicology 478: 153295 (impact factor2022: 4.5). PMID: 35998787, DOI: 10.1016/j.tox.2022.153295

Hummer J, Birngruber T, Sinner F, Page L, Toner F, Roper CS, Moore, DJ, Baker MB, and Boncheva Bettex M (2022). Optimization of topical formulations using a combination of in vitro methods to quantify the transdermal passive diffusion of drugs. International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2022.121737.

CALONI, Francesca – INTROZZI, Olga – CAZZANIGA, Alessandra – BUZANSKA, Leonora – GUTLEB, Arno C. – KANDAROVA, Helena – CERIOTTI, Laura – RANALDI, Giulia – RASHIDI, Hassan – WILFLINGSEDER, Doris. Third Virtual Summer School 3Rs for ONE Science: Alternative methods: From complexity to predictivity : meeting report. In ALTEX : Alternatives to Animal Experimentation, 2022, vol. 39, no. 4, p. 710-711. https://doi.org/10.14573/altex.2207112 

Kluxen FM, Roper CS, Jensen SM and Koenig CM (2022). Characterizing local acute irritation properties of captan and folpet with new approach methods. Applied In Vitro Toxicology 8 (3); 83-101. https://doi.org/10.1089/aivt.2022.0004

NEUHAUS, Winfried – REININGER-GUTMANN, Birgit – RINNER, Beate – WILFLINGSEDER, Doris – JÍROVÁ, Dagmar – KEJLOVÁ, Kristína – KANDAROVA, Helena – SPIELMANN, Horst. The Current Status and Work of Three Rs Centres and Platforms in Europe. In Alternatives to Laboratory Animals (ATLA) : Fund for the Replacement of Animals in Medical Experiments, 2022, vol. 50, no. 6, p. 381-413. ISSN 0261-1929.  https://doi.org/10.1177/02611929221140909 

NEUHAUS, Winfried – REININGER-GUTMANN, Birgit – RINNER, Beate – PLASENZOTTI, Roberto – WILFLINGSEDER, Doris – KANDAROVA, Helena. The rise of three Rs centres and platforms in Europe. In Alternatives to Laboratory Animals (ATLA), 2022, vol. 50, no. 2, p. 90-120. ISSN 0261-1929.  https://doi.org/10.1177/02611929221099165 

Roper CS, Hargrove MM, Sullivan K and Wolf D (2022). Case study on the use of an Integrated Approach for Testing and Assessment (IATA) for New Approach Methodology (NAM) for refining inhalation risk assessment from point of contact toxicity of the pesticide, chlorothalonil. ENV/CBC/MONO(2022)31. OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 367.  https://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/cbc/mono(2022)31&doclanguage=en

SEIDLE, Troy – KANĎÁROVÁ, Helena – HARTUNG, Thomas – LEIST, Marcel – NEUHAUS, Winfried – SPIELMANN, Horst – ROVIDA, Costanza. Open letter: Selection of a new Executive Director of the European Chemicals Agency (ECHA) provides an opportunity for the EU to lead in the field of chemicals management and implementation of innovative science = Selection of a new Executive Director of the European Chemicals Agency (ECHA) provides an opportunity for the EU to lead in the field of chemicals management and implementation of innovative science. In ALTEX : Alternatives to Animal Experimentation, 2022, vol. 39, no. 1, p. 149-150. ISSN 1868-596X. https://doi.org/10.14573/altex.2110271 

SONAWANE, Akshay – VADLOORI, Bharadwaja – POOSALA, Suresh – KANĎÁROVÁ, Helena – KULKARNI, Mandar – OLAYANJU, Adedamola – DEY, Tuli – SAXENA, Uday – SMIRNOVA, Lena – KANDA, Yasunari – REDDY, Jaganmohan – DRAVIDA, Subhadra – BISWAS, Saikat – VINKEN, Mathieu – GETTAYACAMIN, Montip – AHLUWALIA, Arti – MONDINI, Franco – BHATTACHARYA, Somshuvra – KULKARNI, Pushkar – JACOBSEN, Kirsten Rosenmay – VANGALA, Subrahmanyam – MILLÁS, Ana Luiza. Advances in animal models and cutting-edge research in alternatives: Proceedings of the Second nternational Conference on 3Rs research and progress, Hyderabad, 2021. In Alternatives to Laboratory Animals (ATLA), 2022, vol. 50, no. 2, p. 156-171. ISSN 0261-1929. https://doi.org/10.1177/02611929221089216 

2021

Anderson WA, Bosak A, Hogberg HT, Hartung T, Moore MJ. Advances in 3D neuronal microphysiological systems: towards a functional nervous system on a chip. In Vitro Cellular & Developmental Biology – Animal 2021, 57:191–206 Doi: 10.1007/s11626-020-00532-8

Aschner M, Paoliello MMB, Tsatsakis A, Bowman AB, Dorea JG, Hartung T, Domingo JL, Barbosa F J. Social Injustice in Environmental Health: A Call for Fortitude. Environmental Research 2021, 194: 110675. doi: 10.1016/j.envres.2020.110675

Brown J, Clippinger AJ, Goode J, Ghosh M, Briglia C, Casey W, Coleman K, Fritsch A, Hartung T, Maouyo D, Muller T, Reich J, Robert L, Roeder R, Sanchez G, Sawyer A, Solati S, Tirumalai R, Zwislr W, Allen D. Using the Monocyte Activation Test as a Stand-alone Release Test for Medical Devices: A Workshop Report. ALTEX 2021, 38;151-156.

Calina D, Hartung T, Mardare I, Mitroi M, Poulas K, Tsatsakis A, Rogoveanu I, DoceaOA.  COVID-19 pandemic and alcohol consumption: impacts and interconnections. Toxicology Reports 2021, 8:529-535. Doi: 10.1016/j.toxrep.2021.03.

Chesnut M, Hartung T, Hogberg HT, Pamies D. Human oligodendrocytes and myelin in vitro to evaluate developmental neurotoxicity. International Journal of Molecular Sciences 2021, 22:7929. doi: 10.3390/ijms22157929.

Chesnut M, Paschoud H, Repond C, Smirnova L, Hartung T, Zurich M-G, Hogberg HT, Pamies D. Human 3D iPSC-derived brain model to study chemical-induced myelin disruption. International Journal of Molecular Sciences, 22:9473. doi: 10.3390/ijms22179473.

de Vries RBM, Angrish M, Browne P, Brozek J, Rooney AA, Wikoff DS, Whaley P, Edwards SW, Morgan RL, Druwe IL, Hoffmann S, Hartung T, Thayer K, Avey MT, Beverly BEJ, Falavigna M, Gibbons C, Goyak K, Kraft A, Klugar M, Klugarova J, Nampo F, Qaseem A, Sears M, Singh JA, Willett K, Yost EY, Schünemann H, Tsaioun K. Applying evidence-based methods to the development and use of adverse outcome pathways construct mechanistic frameworks for the development and use of non-animal toxicity tests. ALTEX 2021, 38:336-347. doi:10.14573/altex.2101211

Farsalinos K, Poulas K, Kouretas D, Vantarakis A, Leotsinidis M, Kouvelas D, Docea AO, Kostoff R, Gerotziafas GT, Antoniou MN, Polosa R, Barbouni A, Yiakoumaki V, Giannouchos TV, Bagos PG, Lazopoulos G, Izotov BN, Tutelyan VA, Aschner M, Hartung T, Wallace HM, Carvalho F, Domingo JL, Tsatsakis A. Improved strategies to counter the COVID-19 pandemic: Lockdowns vs. Primary and Community Healthcare. Toxicology Reports 2021, 8:1-9. Doi: 10.1016/j.toxrep.2020.12.001

Golden E, Macmillan DS, Dameron G, Kern P, Hartung T, Maertens A. Evaluation of the global performance of eight in silico skin sensitization models using human data. ALTEX 2021, 38:33-48. doi: 10.14573/altex.1911261

Golden E, Maertens M, Hartung T, Maertens A. Mapping Respiratory Sensitization: How Useful Are Our Current Tools? Chemical Research in Toxicology 2021, 34:473-482.  doi: 10.1021/acs.chemrestox.0c00320.

Hartung T. Pyrogen testing revisited on occasion of the 25th anniversary of the whole blood test. ALTEX 2021, 38:3-19. doi: 10.14573/altex.2101051.

Hartung T. Evidence integration in the era of information flooding – the advent of the comprehensive review. Frontiers in Public Health 2021, 9:763828. doi: 10.3389/fpubh.2021.763828.

Hartung T, Tsatsakis AM. The state of the Scientific Revolution in Toxicology. ALTEX 2021, 38:379-386. doi:10.14573/altex.2106101.

Hoffmann S, Margliani B, Akgün-Ölmez SG, Ireland D, Cruz R, Busquet F, Flick B, Lalu M, Ghandakly EC, de Vries R, Witters H, Wright RA, Ölmez M, Willett C, Hartung T, Stephens ML, Tsaioun K. A systematic review to compare chemical hazard predictions of the zebrafish embryo test with mammalian prenatal developmental toxicity. Toxicological Sciences 2021, 183:14–35. doi: 10.1093/toxsci/kfab072

Hogberg HT, de Cássia da Silveira e Sá R, Kleensang A, Bouhifd M, Cemiloglu Ulker O, Smirnova L, Behl M, Maertens A, Zhao L, Hartung T. Organophosphorus flame retardants are developmental neurotoxicants in a rat primary BrainSphere in vitro model, Arch Toxicol 2021, 95:207-228, doi: 10.1007/s00204-020-02903-2

Kang I, Smirnova L, Kuhn JH, Hogberg HT, Kleinstreuer NC, Hartung T. COVID-19 – prime time for microphysiological systems, as illustrated for the brain, ALTEX 2021, 38:535-549. doi: 10.14573/altex.2110131

Knight J, Rovida C, Kreiling R, Zhu C, Knudsen M, Hartung T. Continuing animal tests on cosmetic ingredients for REACH in the EU. ALTEX, 2021 38:653-668. doi: 10.14573/altex.2104221

Locke PA, Singer M, Hartung T. The Humane Research and Testing Act:  Advancing Science by Creating a New Center for Alternatives at the US National Institutes of Health. ALTEX 2021, 38:678-680. doi: 10.14573/altex.2106031

Maertens A, Golden E, Hartung T. Avoiding Regrettable Substitutions: Green Toxicology for Sustainable Chemistry. ACS Sustainable Chemistry & Engineering 2021, 9, 23, 7749–7758

Mansouri K, Karmaus A, Fitzpatrick J, Patlewicz G, Pradeep P, Alberga D, Alepee N, Allen T, Allen D, Alves VM, Andrade CH, Auernhammer TT, Ballabio D, Bell S, Benfenati E, Bhattacharya S, Bastos JV, Boyd S, Brown JB, Capuzzi SJ, Chushak Y, Ciallella H, Clark AM, Consonni V, Daga PR, Ekins S, Farag S, Fedorov M, Fourches D, Gadaleta D, Gao F, Gearhart JM, Goh G, Goodman JM, Grisoni F, Grulke CM, Hartung T, Hirn M, Karpov P, Korotcov A, Lavado GJ, Lawless M, Li X, Luechtefeld T, Lunghini F, Mangiatordi GF, Marcou G, Marsh D, Martin T, Mauri A, Muratov EN, Myatt GJ, Nguyen D-T, Nicolotti O, Note R, Pande P, Parks AK, Peryea T, Polash A, Rallo R, Roncaglioni A, Rowlands C, Ruiz P, Russo D, Sayed A, Sayre R, Sheils T, Siegel C, Silva AC, Simeonov A, Sosnin S, Southall N, Strickland J, Tang Y, Teppen B, Tetko IV, Thomas D, Tkachenko V, Todeschini R, Toma C, Tripodi I, Trisciuzzi D, Tropsha A, Varnek A, Vukovic K, Wang Z, Wang L, Waters KM, Wedlake AJ, Wijeyesakere SJ, Wilson D, Xiao Z, Yang H, Zahoranszky-Kohalmi G, Zakharov AV, Zhang FF, Zhang Z, Zhao T, Zhu H, Zorn KM, Casey W, Kleinstreuer NC. CATMoS: Collaborative Acute Toxicity Modeling Suite. Environmental Health Perspectives 2021, 129:47013.  doi: 10.1289/EHP8495

Modafferi S, Zhong X, Kleensang A, Murata Y, Fagiani F, Pamies D, Hogberg HT, Calabrese V, Lachman H, Hartung T, Smirnova L. Gene–environment interactions in developmental neurotoxicity: a case study of synergy between chlorpyrifos and CHD8 knockout in human BrainSpheres. Environmental Health Perspectives 2021, 129:77001. Doi: 10.1289/EHP8580

Roth A, MPS-WS Berlin 2019 [Marx U, Vilén L, Ewart L, Griffith LG, Hartung T, Ingber DE, Mendrick DL, Steger-Hartmann T, Tagle DA]. Human microphysiological systems for drug development. Science 2021, 373:1304-1306

Sarigiannis DA, Hartung T, Karakitsios SP. The exposome—a new paradigm for non-animal toxicology and integrated risk assessment. In: Tsatsakis AM. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. Elsevier, Academic Press, London, 2021, 23-30.

Spoladore J, Lopes IG, Bachinski RF, Negherbon JP, Hartung T, Granjeiro JM, Alves GG. Standardized pyrogen testing of health products with bacterial endotoxin tests (BET) as a substitute for rabbit pyrogen testing (RPT): a scoping review. Toxicology In Vitro, 2021, 74, 105160. Available online: doi: 10.1016/j.tiv.2021.105160

Tran V, Kim R, Maertens M, Hartung T, Maertens A. Similarities and differences in gene expression networks between the breast cancer cell line MCF-7 and invasive human breast cancer tissues. Frontiers in Artificial Intelligence, section Medicine and Public Health 2021, 4:674370. doi: 10.3389/frai.2021.674370

Vinken M, Benfenati E, Busquet F, Castell J, Clevert D-A, de Kok T, Dirven H, Fritsche E, Geris L, Gozalbes R, Hartung T, Jennen D, Jover R, Kandarova H, Kramer N, Krul C, Luechtefeld T, Masereeuw R, Roggen E, Schaller S, Vanhaecke T, Yang C,, Piersma AH. Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology 2021, 458, 152846, doi: 10.1016/j.tox.2021.152846

Wang T, Liu H, Itoh K, Oh S, Zhao L, Murata D, Sesaki H, Hartung T, Na CH, Wang J. C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly. Cell Metabolism 2021, 33:531-546.e9. doi: 10.1016/j.cmet.2021.01.005

Arnesdotter E., Rogiers V., Vanhaecke T., Vinken M. (2021) “An overview of current practices for regulatory risk assessment with lessons learnt from cosmetics in the European Union.” Critical Reviews in Toxicology 51: 395-417(impact factor2021: 6.184). PMID: 34352182, DOI: 10.1080/10408444.2021.1931027

Arnesdotter E., Spinu N., Firman J., Ebbrell D., Cronin M.T.D., Vanhaecke T., Vinken M. (2021) “Derivation, characterisation and analysis of an adverse outcome pathway network for human hepatotoxicity.” Toxicology 459: 152856 (impact factor2021: 4.571). PMID: 34252478, DOI: 10.1016/j.tox.2021.152856

Firman J.W., Pestana C.B., Rathman J.F., Vinken M., Yang C., Cronin M.T.D. (2021) “A robust, mechanistically based in silico structural profiler for hepatic cholestasis.” Chemical Research In Toxicology 34: 641-655 (impact factor2021: 3.973). PMID: 33314907, DOI: 10.1021/acs.chemrestox.0c00465

Gijbels E., Devisscher L., Vinken M. (2021) “Testing in vitro tools for the prediction of cholestatic liver injury induced by non-pharmaceutical chemicals.” Food and Chemical Toxicology 152: 112165 (impact factor2021: 5.572). PMID: 33819548, DOI: 10.1016/j.fct.2021.112165

Gijbels E., Devisscher L., Vinken M. (2021) “Dataset on transcriptomic profiling of cholestatic liver injury induced by food additives and a cosmetic ingredient.” Data in Brief 38: 107373 (no impact factor2021). PMID: 34589561, PMCID: PMC8461341, DOI: 10.1016/j.dib.2021.107373

Leroy K., Pieters A., Cooreman A., Van Campenhout R. Cogliati B., Vinken M. (2021) “Connexin-based channel activity is not specifically altered by hepatocarcinogenic chemicals.” International Journal of Molecular Sciences 22: 17424 (impact factor2021: 6.208). PMID: 34769157, PMCID: PMC8584159, DOI: 10.3390/ijms222111724

Leroy K., Silva Costa C.J., Pieters A., dos Santos Rodrigues B., Van Campenhout R., Cooreman A., Tabernilla A., Cogliati B., Vinken M. (2021) “Expression and functionality of connexin-based channels in human liver cancer cell lines.” International Journal of Molecular Sciences 22: 12187 (impact factor2021: 6.208). PMID: 34830068, PMCID: PMC8623148, DOI: 10.3390/ijms222212187

Oorts M., Van Brantegem P., Deferm N., Chatterjee S., Dreesen E., Cooreman A., Vinken M., Richert L., Annaert P. (2021) “Bosentan alters endo- and exogenous bile salt disposition in sandwich-cultured human hepatocytes.” Journal of Pharmacology and Experimental Therapeutics 379: 20-32(impact factor2021: 4.441). PMID: 34349015, DOI: 10.1124/jpet.121.000695

Pieters A., Gijbels E., Cogliati B., Annaert P., Devisscher L., Vinken M. (2021) “Biomarkers of cholestasis.” Biomarkers in Medicine 15: 437-454 (impact factor2021: 2.498). PMID: 33709780, DOI: 10.2217/bmm-2020-0691

Tabernilla A., dos Santos Rodrigues B., Pieters A., Caufriez A., Leroy K., Van Campenhout R., Cooreman A., Gomes A.R., Arnesdotter E., Gijbels E., Vinken M. (2021) “In vitro liver toxicity testing of chemicals: a pragmatic approach” International Journal of Molecular Sciences 22: 5038 (impact factor2021: 6.208). PMID: 34068678, PMCID: PMC8126138, DOI: 10.3390/ijms22095038

Vilas-Boas V., Vinken M. (2021) “Hepatotoxicity induced by nanomaterials: mechanisms and in vitro models.” Archives of Toxicology 95: 27-52 (impact factor2021: 6.168). 

Vilas-Boas V., Gijbels E., Leroy K., Pieters A., Baze A., Parmentier C., Vinken M. (2021) “Primary human hepatocyte spheroids as tools to study the hepatotoxic potential of non-pharmaceutical chemicals.” International Journal of Molecular Sciences 22: 11005 (impact factor2021: 6.208). PMID: 34681664, PMCID: PMC8537720, DOI: 10.3390/ijms222011005

Vinken M. (2021) “COVID-19 and the liver: an adverse outcome pathway perspective.” Toxicology 455: 152765 (impact factor2021: 4.571). PMID: 33771662, PMCID: PMC7986318. DOI: 10.1016/j.tox.2021.152765

Vinken M., Benfenati E., Busquet E., Castell J., Clevert D.-A., de Kok T., Dirven H., Fritsche E., Geris L., Gozalbes R., Hartung T., Jennen D., Jover R., Kandarova H., Kramer N., Krul C., Luechtefeld T., Masereeuw R., Roggen E., Schaller S., Vanhaecke T., Yang C., Piersma A.H. (2021) “Safer chemicals using less animals: kick-off of the European ONTOX project.” Toxicology 458: 152846 (impact factor2021: 4.571). PMID: 34216698, DOI: 10.1016/j.tox.2021.152846

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