ESTIV board 2022/2023

European Society of Toxicology In Vitro > ESTIV board 2022/2023

President: Helena Kandarova

Vice-president: Clive Roper

Treasurer: Jochem Louisse

Members: Anne-Marie Vinggaard, Tim Allen, Arno Gutleb

ASCCT liaison: Erin Hill

JSAAE liaison: Yasunari Kanda

ESTIV Working Teams:

Communication Team: Clive Roper, Marketa Dvořáková, Helena Kandarova

ASCCT-ESTIV Webinars Teams: Anne-Marie Vinggaard, Erin Hill, Helena Kandarova,

ESTIV 2023 Applied Training Courses: Arno Gutleb, Helena Kandarova

Awards and Bursaries: Clive Roper, Tim Allen, Jochem Louisse, Helena Kandarova,

Audit Committee overseeing ESTIV processes:

Chantra Eskes (Chair, member of the supervisory committee), Switzerland

Mathieu Vinken (member of the supervisory committee) , Belgium

Helena Kandarova (Slovak republic) – President

Helena Kandárová is a senior scientist at Centre of Experimental Medicine, Slovak Academy of Science and at the Faculty of Chemical and Food Technology, STU. Her scientific interest is focusing on the development and validation of in vitro methods for topical toxicity testing of chemicals, cosmetics, pesticides and medical devices.

Helena has been a member of ESTIV since 2004. As a Board member, from 2016 through 2020, she has been responsible for communication activities and later on also for membership. Helena took care of the new website development and communication activities via LinkedIn. She assisted the board in the switch to the professional secretarial services that include, e.g. the improved membership database, or launch of the electronic newsletter.

In the period 2020-2024, she would like to support the ESTIV activities in the position of President and together with the newly established board strengthen the collaboration between the ESTIV members and affiliated societies and expand the ESTIV activities to support the implementation of the in vitro and silico toxicology into the research and education.

Clive Roper (UK) – Vice-president

Clive is a member of the board of the UK NA3RsC, The 3Rs Collaborative and ESTIV and is on the Scientific Advisory Board of Toxys BV. He is a member of the Roundtable of Toxicology Consultants and Society of Toxicology. He is a Chartered Biologist, Chartered Scientist, European Registered Toxicologist and a Fellow of the Royal Society of Biology. Clive has  (co)authored many abstracts and papers, peer reviews for toxicology journals and has been a regular speaker and conference organiser for many years.

Clive runs his own consulting business, Roper Toxicology Consulting Limited. He aids his clients in the development and regulatory adoption and acceptance of NAMs (usually with SMEs\/ CROs) and testing using NAMs for biotech, mid-tier, and multinational clients.Clive has developed models resulting in direct replacement of animals in dermal absorption and acute toxicology and inhalation toxicology.As Vice President of ESTIV, Clive plans to bring in more industry members and increase their profile at ESTIV meetings. Clive is part of the communications and awards and bursaries teams.

Annemarie Vingaard (Denmark) – Webinars and TIV Special Issues

Anne Marie Vinggaard is a professor in molecular toxicology at the National Food Institute, Technical University of Denmark with expertise within chemicals’ endocrine activity and mechanisms of action, cocktail effects and risk assessment of chemicals. AMV has published 119 publications with, got 5504 citations and an HI of 44 (WoS, May 2020).

At ESTIV board, Anne Marie is responsible for ESTIV/ASCCT webinars activities in 2020-2024 and planning of the Special issue of TIV from the ESTIV Congress in 2022.

Jochem Louisse (The Netherlands) – ESTIV Applied toxicology courses

Jochem Louisse works as scientific researcher Toxicology at Wageningen Food Safety Research, which is part of Wageningen University and Research in the Netherlands. Jochem is a lecturer of ESTIV’s applied in vitro toxicology course since the start of the course in 2015. Jochem is trained as a biologist and performed his PhD research in Toxicology on the combination of in vitro toxicity data and physiologically based kinetic (PBK) modelling to predict in vivo toxic dose levels. Jochem worked as a postdoctoral researcher at EURL ECVAM of the Joint Research Centre (JRC) and as an assistant professor in Toxicology at Wageningen University. Currently, at Wageningen Food Safety Research, he mainly works on the application of in vitro and in silico approaches to identify and prioritize chemical hazards in the food chain. To that end, integrated toxicokinetic and toxicodynamic methods are being developed and applied. As a member of the ESTIV board, Jochem represents the in vitro kinetic field and promotes the application of in vitro kinetic data in chemical safety evaluations.

Erin Hill (USA) – ASCCT liaison

After receiving her bachelor’s degree in 1990 in Cell Biology and Biochemistry from the University of California, San Diego, Ms. Hill joined a tissue engineering company (Advanced Tissue Sciences) and assisted in the business development, marketing and sales of 3- Dimensional human tissue constructs to the personal care and household products market.  Ms. Hill then expanded her interest in in vitro methods during work for a developer of hollow fiber bioreactors for the production of monoclonal antibodies. In 1995 she joined the In Vitro Toxicology Unit at Microbiological Associates (now BioReliance) where she assisted industry toxicologists in the application of a variety of in vitro methods for safety, efficacy and product development.  In 1997 Ms. Hill co-founded the Institute for In Vitro Sciences, Inc. (IIVS) and assumed the role of an officer and member of the board of directors. In 2015 Ms. Hill became President of the Institute where she is responsible for planning, directing and coordinating activities to achieve IIVS’ mission of increasing the use and acceptance of in vitro methods worldwide.  She actively engages with industry, animal protection organizations and regulatory agencies, both domestic and international, to help coordinate efforts for the advancement of non-animal testing methods.  In 2010 Erin cofounded the American Society for Cellular and Computational Toxicology (ASCCT) where she currently serves as president and treasurer.  She is a member of the Society of Toxicology (SOT), and the European Society for Toxicology In Vitro (ESTIV) and the European Society of Toxicology (EuroTox). She also serves as an advisory board member for Johns Hopkins University’s Center for Alternatives to Animal Testing (CAAT) and Singapore’s Agency for Science, Technology and Research (A*STAR) Innovations in Food and Chemical Safety Program.

Erin worked with the ESTIV board to create a Memorandum of Understanding between the society and ASCCT. Since that time she has been an Ad Hoc board member helping to organize and participate in the annual meetings. Under the MOU ASCCT and ESTIV joined together to greatly expand the ASCCT webinar program. Society members are given priority to sign up for the webinars and also access to the library of recorded webinars. Erin is fostering more opportunities with its American counterpart, ASCCT.

Yasunari Kanda (Japan) – JSAAE liaison

Markéta Dvořáková (Czech Republic) – Newsletter, communication

Marketa Dvorakova works as a Senior Scientific Researcher at the Unit for Alternative Toxicological Methods at National Institute of Public Health, Centre of Toxicology and Health Safety in Prague, Czech Republic. She is focused on implementation of in vitro toxicological methods, particularly on the optimized approaches for hazard evaluation of complex test items like cosmetics, consumer products and medical devices. Marketa has implemented or optimized methods for screening the potential of endocrine disruption or skin sensitization. Her research scope also includes reprotoxicity, genotoxicity and immunotoxicity. Marketa represents the National Reference Laboratory for Experimental Immunotoxicology, one of the EU-NETVAL facilities in the network of nominated EU laboratories which contribute to development of in vitro methods for identification thyroid disruptors, under the supervision of the EURL-ECVAM of the Joint Research Centre (JRC). As one of the experts in the OECD working group for endocrine disruption, she has the chance to contribute to the development of OECD test guidelines. As a member of the ESTIV board, Marketa hopes to represent in vitro methods based on cell lines and more complex test systems, e.g. reconstructed tissues and organ models and promote the applicability of optimized in vitro methods for evaluation of complex mixtures.

Matketa supports the distribution of information on the in in vitro and in silico toxicology by means of hands-on trainings and social media, in order to widely open the current topics for better communication, understanding and raised awareness.

Timothy Allen (United Kingdom) – ESTIV Applied toxicology courses

Tim Allen is a computational toxicologist and post-doctoral researcher at the MRC Toxicology Unit, University of Cambridge in the UK. His work involves the construction of in silico models for toxicity prediction, specifically in the area of molecular initiating events and adverse outcome pathways (AOPs). This has involved methods including machine learning deep neural networks, 3D quantitative structure-activity relationships and density functional theory quantum chemistry calculations. He has also been involved in developing in-house computational tools for use by his industrial partners at Unilever’s Safety and Environmental Assurance Centre for use in safety decision making. Tim has also served as a member of ILSI Europe’s expert group on AOPs in food ingredient assessment and presented his research at over 20 national and international conferences.

As a member of the ESTIV board, Tim represents computational toxicology, specifically with the goals of greater understanding and accessibility of current algorithms and approaches. Through education and training courses, scientific workshops, and better communication the idea of the “black box” computational algorithm with unknown workings can be unravelled to make these powerful tools more applicable across toxicology.

Arno Gutleb (Luxembourg) – ESTIV Applied toxicology courses

Dr. Arno Gutleb is Group Leader Environmental Health at the Luxembourg Institute of Science and Technology (LIST). The group is developing in vitro assays with a focus on the alveolar region of the lung and inflammation and respiratory sensitization as the main endpoints. He graduated from the University of Veterinary Medicine, Vienna, Austria and holds a PhD (2006) in Environmental Sciences from Wageningen University, The Netherlands. He has a habilitation from the University Lorraine, France (2018) and is a European Registered Toxicologist (ERT). He is Distinguished Professor at the University Iuliu Hatieganu, Cluj, Romania and Visiting Professor at the Universidad Andrés Bello, Santiago de Chile. He is a member of the Network for Preliminary Assessment of Regulatory Relevance (PARERE) of the European Union Reference Laboratory for Alternatives to Animal Testing (ECVAM). Since 2020 he is Co-chair of the US-EU NanoEHS CoR Human Toxicology.
Arno has a special interest in the transfer of knowledge and is interested to use his experience from chairing the WGA Education of the Nanosafety Cluster to further interest young scientists in areas of interest for ESTIV.

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