ESTIV is involved as an organisation supporting the dissemination of the science in the prestigious European H2020 research project ONTOX.

ONTOX stands for “ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next-generation risk assessment”. The project is aiming into the development of animal-free methods for testing chemical substances. ESTIV will be one of the major dissemination channels of the research activities. The ONTOX consortium consists of 19 European and American partners, and more than 60 scientists, many of them active members of  ESTIV. The ONTOX project started on 1 May 2021 for a period of 5 years and is coordinated by Prof. Mathieu Vinken (Vrije Universiteit Brussel-Belgium).

ESTIV President, Dr. Helena Kandarova and the project co-ordinator, Prof. Mathieu Vinken, signed an MoU on the collaboration on 19 October 2021.


ONTOX is conducting a research project in the context of the European H2020 Research and Innovation Programme SC1-BHC-11-2020 called “Advancing the safety assessment of chemicals without the use of animal testing”. The vision of the ONTOX consortium is to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animals in line with the principles of 21st century toxicity testing and next generation risk assessment. More at:

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Memorandum of Understanding