Our corporate members help to shape the future of innovative toxicology. We are thankful for their ongoing support.
React4life is an Italian startup that developed MIVO® – Multi In Vitro Organ, a patented microphysiological system (MPS) able to reproduce portions of the human body improving the reliability of the testing outcome. It can easily accommodate and cultivate 3D human tissues, organoids or biopsies to suit every testing needs. MIVO® can be used as bioreactor, for enhancing tissues conditions and prolonging lifetime, for advanced drug testing assays on 3D tissues, for discovering new therapeutic approaches, and for basic research, without involving animal use. It is individually blistered, sterile, disposable, immediately ready-to-use.
For more information visit: www.react4life.com
acCELLerate is a specialist for large-scale production and cryopreservation of highly functional assay ready cells. The instant use of cells from a frozen stock became a widely accepted approach which is preferred to the use of continuously passaged cells. Based on 16 years of experience acCELLerate has developed freezing protocols and established well-controlled processes to prepare assay ready Frozen Instant Cells of high quality and robustness. Frozen Instant Cells can be used like a reagent without prior cultivation. acCELLerate provides assay ready cells from multiple cell lines, validated instaCELL bioassay kits, as well as custom cell banks of Frozen Instant Cells with comprehensive documentation to meet specific requirements of the different fields of application.
Altertox Academy is a SME (Small Medium Enterprise) with tailor made trainings as main activity. It provides hands-on training in human-relevant alternative methods and technologies for toxicologists, from a 3R perspective (replacement, reduction and refinement). Among other services, Altertox Academy also provides support as work package leader in training for EU calls.
For more information visit: https://academy.altertox.be/
Epithelix is a leader for in vitro assessment of drug efficacy and toxicity on the human respiratory tract. Epithelix has developed unique 3D in vitro human airway tissues (MucilAir™; SmallAir™ and AlveolAir™) and testing services for studying airway pathologies like Asthma, Cystic Fibrosis and Chronic Obstructive Pulmonary Diseases, Bacterial and Viral infections.
For more information visit: www.epithelix.com
EpiSkin Academy created in 2011 is an international program dedicated to promotion and education to alternatives to animal testing methods in toxicology. As a world leader in tissue engineering, EpiSkin Academy is committed to share knowledge and expertise with scientific community to support implementation of in vitro validated methods and development of new methods using human reconstructed tissues. They offer trainings on validated methods and take part in numerous congresses to present the latest advances in these fields. To go further, they are also engaged in several academic programs worldwide to raise awareness and to prepare the next generation of scientists and regulators for the challenges of 21st century toxicology.
For more information visit: https://www.episkin.com/Episkin-Academy
The Fraunhofer-Gesellschaft, headquartered in Germany, is the world’s leading applied research organization. With its focus on developing key technologies that are vital for the future and enabling the commercial exploitation of this work by business and industry, Fraunhofer plays a central role in the innovation process. As a pioneer and catalyst for groundbreaking developments and scientific excellence, Fraunhofer helps shape society now and in the future. Founded in 1949, the Fraunhofer-Gesellschaft currently operates 74 institutes and research institutions throughout Germany.
For more information visit: www.frauhofer.de
MatTek In Vitro Life Science Laboratories, a European subsidiary of MatTek Corporation (USA) produces reconstructed 3D human tissue models in Bratislava, Slovakia since 2011. MatTek develops, validates, and implements animal alternative testing methods and innovative 3D reconstructed human tissue models for more than 3 decades. Our EpiDerm and EpiOcular tissue models are used in regulatory toxicology (OECD, EU guidelines) and address toxicology and efficacy concerns throughout the cosmetics, chemical, pharmaceutical, and household product industries. In addition to these two, there are 11 more ready-to-use, highly reproducible reconstructed 3D human tissue models in the MatTek portfolio. In 2021, MatTek Corporation was acquired by a bioconvergence corporation CELLINK where it continues its mission toward more precise animal-free testing.
For more information visit: http://www.mattek.com
ReadyCell is a biotechnological company focused on providing cell-based in vitro tools for the ADME-Tox segment. Our current product portfolio covers a broad spectrum of drug discovery applications for in vitro screening, such as absorption, drug-transporter interactions, and toxicity. Furthermore, ReadyCell owns a patented technology that allows the shipment of living plated cells at room temperature, maintaining their viability and cellular characteristics and simplifying logistic times and procedures. Thanks to our well-position network of distributors worldwide, including the United States, India, and Japan, ReadyCell ensures an effective expansion and presence, encompassing over 100 active clients from industry and academia alike.
For more information visit: https://readycell.com/
The Regulatory Company aims to guarantee product safety and compliance in a rapidly developing context. They act with in dept toxicological and regulatory knowledge and pursue an effective and efficient way of working in cooperation with regulators, authorities, producers, distributors, brand-owners, service providers and other stakeholders.
To add the highest possible value The Regulatory Company contributes to the entire product lifecycle from information management, regulatory and toxicological perspective, by offering and executing complete services, in close and involved partnership with clients. They work fully digital making use of the latest available technology, making sure the experts can be contacted easily and directly.
For more information visit: https://www.theregulatorycompany.com/
Pepper is a non-profit association created in the context of the French National Strategy for Endocrine Disruptors. This public-private platform is financially supported by the French “Programme of Investments for the Future” as well as by Pepper’s members (private and public organisations).
Pepper carries out and finances:
• the identification and documentation of mature and scientifically documented methods meeting a need in terms of identification of EDs;
• the assessment of the transferability, repeatability and reproducibility of the method through ring testing;
• the support to method developers in forwarding their methods and the required scientific reports to international validation authorities
Form more information visit: https://ed-pepper.eu/en/
Senzagen is a spin-out company from Lund University, Sweden, with expertise in immunology, technology and genomics. SenzaGen develops, performs and sells animal-free tests for assessing a substance’s capacity to causes allergies. These tests replace animal testing with human cells in test tubes combined with artificial intelligence. As a scientific quality-orientated and innovative international company, SenzaGen supports its clients with stringent quality assessments.
SenzaGen markets, sells and performs the in vitro GARD® sensitization test which is recommended by ECHA and accepted by OECD for validation.
For more information visit: https://senzagen.com
Symrise is a global supplier of fragrances, flavors, food, nutrition and cosmetic ingredients. Its clients include manufacturers of perfumes, cosmetics, food and beverages, pharmaceuticals and producers of nutritional supplements and pet food. Its sales of € 3.5 billion in the 2020 fiscal year make Symrise a leading global provider. Headquartered in Holzminden, Germany, the Group is represented by more than 100 locations in Europe, Africa, the Middle East, Asia, the United States and Latin America. Symrise works with its clients to develop new ideas and market-ready concepts for products that form an integral part of everyday life. Economic success and corporate responsibility are inextricably linked as part of this process. In addition, Symrise has set up an animal testing policy in 2009 that aims to minimize such testing and Symrise is promoting alternative approaches wherever possible.
For more information visit: www.symrise.com
As the inventor of the drugstore concept in Germany, the company founder Dirk Roßmann opened the first store for drugstore articles in Hanover in 1972. Today, ROSSMANN (headquartered in Burgwedel near Hanover) is one of the largest drugstore chains in Europe (as of 1/2021). With 23,000 drugstore articles, including 4,600 of its 28 own ROSSMANN-Brands, ROSSMANN is presenting a particularly extensive product range covering all areas of daily life. Not only because every fourth product sold at ROSSMANN is a ROSSMANN-Brand product, but the strategic and sustainable direction is also particularly important to ROSSMANN. Along with several fields of action, ROSSMANN is constantly making the ROSSMANN-Brand products more sustainable, thus fulfilling the responsibility as a retail company. In addition, the ecological and social commitment is being further expanded in all areas of the company.
For more information visit: www.rossmann.de
Xenometrix develops and manufactures ready to use Ames Test Kits in a microplate fluctuation assay format (Ames MPF, ICH M7) or as agar plate test kit (MicroAmes6, MacroAmes1-471, OECD 471). The microplate format allows automation, low consumption of test compound, 11times less consumption of S9 (less test animals) and produces significantly less plastic waste. Xenometrix also produces ready to use test kits for the in vitro micronucleus test with pancentromeric probes to enable a clear identification of aneugenic and clastogenic compounds within 1 hour hands on time (Rapid MicroNucleus MoA, OECD 483). Ready to use test kits for the detection of compounds with endocrine activity towards estrogen and androgen receptors are available as well. Also available from Xenometrix are ex vivo human and porcine skin explants for the in vitro permeation testing, skin penetration, biodistribution (OECD 428, MDR 2017/745).
Xenometrix is involved in a network of small, efficient CRO partners with a strong expertise under GLP and offering a full range of studies/services in the field of genotoxicity and skin permeation : Ames Test including genotoxic impurities, in vitro Micronucleus, chromosomal Aberration, screening for estrogen and androgen active compounds, in vitro dermal permeation, skin penetration, biodistribution, in vitro skin irritation, sensitization for registration purposes of (agro)chemicals, biocides, pharmaceuticals, cosmetics, substance-based medical devices.
For more information visit: www.xenometrix.ch
Roper Toxicology Consulting was founded in March 2021. Our mission is to create and apply new approach methods (NAMs) in regulatory toxicology and non-animal technologies (NATs) in discovery. We believe that the quality, robustness and predictivity of the NAMs that we help you to create with our partners will translate into the safer, more efficacious drugs and chemicals, with superior value for money and in a shorter time resulting in improved patient, operator, and consumer safety via a greater level of human relevance than animal testing. We create and develop your strategic business and scientific needs with you and our partners and then incorporate tactical planning to these strategies with human relevant toxicology and the 3Rs central to this.
- Dermal absorption
- Dermal toxicology
- Inhalation toxicology
- Microphysiological systems (MPS).
- Company and technology evaluations
Our diverse customer portfolio include
- CROs (SMEs to multinationals)
- Crop protection
- Venture Capitalist