Date & Time: Monday, October 30, 2023 9:00 – 11:00 AM ET / 15:00 – 16:00 CET

Register for the Webinar on Zoom

Presenters: Olga Tcheremenskaia, PhD, Istituto Superiore di Sanità (ISS)
Andrea Gissi, PhD, European Chemicals Agency (ECHA)
Patience Browne, PhD, Organisation for Economic Co-operation and Development (OECD)

Abstract

This webinar will provide an overview new OECD (Quantitative) Structure-Activity Relationship ((Q)SAR) Assessment Framework (QAF) which is a systematic and harmonised framework for the regulatory assessment of (Q)SAR models, predictions, and results-based on multiple predictions. The framework includes new principles for the assessment of (Q)SAR predictions and results, a checklist of criteria, along with guidance for assessing each criterion, to help establish confidence in the use of (Q)SARs in evaluating chemical safety.  The QAF is meant to be applicable irrespective of the modelling technique used to build the model, the predicted endpoint, and the intended regulatory purpose. The primary audience of this document is regulatory authorities and their stakeholders. In addition, any other (Q)SAR user is encouraged to refer to the QAF when using (Q)SARs for regulatory purposes.

The webinar will start with an overview of the project. Then, two talks will cover the main aspects of the framework, namely the assessment of models and of results based on individual or multiple predictions. The presentations will also include example of assessment according to the checklists part of the OECD document.

Recordings and other materials from this webinar will be posted on the ASCCT webinar archive shortly after the webinar’s close.